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27 results on '"Shubernetskaya, Olga"'

2. The Elderly Subjects and Their Troubles

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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3. Prevention and Treatment of the Troubles of the Elderly

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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4. Subtelomere-Telomere Aging Theory

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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5. Aging in the Human Species

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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6. Evolutionary Medicine

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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7. Introduction

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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8. Evolution and Phenoptosis

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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9. The Comparison Between the Two Paradigms

Author

Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, Gu, Danan, Series Editor, Feng, Qiushi, Series Editor, Libertini, Giacinto, Corbi, Graziamaria, Conti, Valeria, Shubernetskaya, Olga, Ferrara, Nicola, and Olovnikov, Alexey, Foreword by

Published
2021
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10. Subtelomere

Author

Olovnikov, Alexey M., Solovieva, Anna S., Shubernetskaya, Olga S., Libertini, Giacinto, Section Editor, Gu, Danan, editor, and Dupre, Matthew E., editor

Published
2021
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11. Telomeres

Author

Shubernetskaya, Olga S., Olovnikov, Alexey M., Libertini, Giacinto, Section editor, Gu, Danan, editor, and Dupre, Matthew E., editor

Published
2021
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14. Aging in the Human Species

Author

Libertini, Giacinto, primary, Corbi, Graziamaria, additional, Conti, Valeria, additional, Shubernetskaya, Olga, additional, and Ferrara, Nicola, additional

Published
2021
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15. Evolution and Phenoptosis

Author

Libertini, Giacinto, primary, Corbi, Graziamaria, additional, Conti, Valeria, additional, Shubernetskaya, Olga, additional, and Ferrara, Nicola, additional

Published
2021
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16. Evolutionary Medicine

Author

Libertini, Giacinto, primary, Corbi, Graziamaria, additional, Conti, Valeria, additional, Shubernetskaya, Olga, additional, and Ferrara, Nicola, additional

Published
2021
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21. Introduction

Author

Libertini, Giacinto, primary, Corbi, Graziamaria, additional, Conti, Valeria, additional, Shubernetskaya, Olga, additional, and Ferrara, Nicola, additional

Published
2021
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22. Telomeres

Author

Shubernetskaya, Olga S., primary and Olovnikov, Alexey M., additional

Published
2019
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23. Subtelomere

Author

Olovnikov, Alexey M., primary, Solovieva, Anna S., additional, and Shubernetskaya, Olga S., additional

Published
2019
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25. Interstitial telomeric repeats-associated DNA breaks

Author

Shubernetskaya, Olga, primary, Skvortsov, Dmitry, additional, Evfratov, Sergey, additional, Rubtsova, Maria, additional, Belova, Elena, additional, Strelkova, Olga, additional, Cherepaninets, Varvara, additional, Zhironkina, Oxana, additional, Olovnikov, Alexey, additional, Zvereva, Maria, additional, Dontsova, Olga, additional, and Kireev, Igor, additional

Published
2017
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27. Is Human Aging a Form of Phenoptosis?

Author

Giacinto Libertini, Graziamaria Corbi, Olga Shubernetskaya, Nicola Ferrara, Libertini, Giacinto, Corbi, Graziamaria, Shubernetskaya, Olga, and Ferrara, Nicola

Subjects
epigenetic change, telomere, cell senescence, phenoptosi, aging, Biophysics, gradual cell senescence, subtelomere, subtelomere–telomere theory, General Medicine, Geriatrics and Gerontology, Biochemistry, Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract

A much debated question is whether aging is the cumulative consequence of degenerative factors insufficiently opposed by natural selection, or, on the contrary, an ordered process, genetically determined and regulated, modeled by natural selection, and for which the definition of phenoptotic phenomenon would be entirely appropriate. In this review, theoretical arguments and empirical data about the two hypotheses are exposed, with more evidence in support of the thesis of aging as a form of phenoptosis. However, as the thesis of aging as an adaptive and programmed phenomenon necessarily requires the existence of specific mechanisms that determine to age, such as the subtelomere-telomere theory proposed for this purpose, the evidence supporting the mechanisms described by this theory is reported. In particular, it is highlighted that the recent interpretation of the role of TERRA sequences in the context of subtelomere-telomere theory is a fundamental point in supporting the hypothesized mechanisms. Furthermore, some characteristics of the mechanisms proposed by the theory, such as epigenetic modifications in aging, gradual cell senescence, cell senescence, limits in cell duplications, and fixed size of the telomeric heterochromatin hood, are exposed in their compatibility with both the thesis of aging as phenoptotic phenomenon and the opposite thesis. In short, aging as a form of phenoptosis appears a scientifically sound hypothesis while the opposite thesis should clarify the meaning of various phenomena that appear to invalidate it.

Published
2022

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