Search

Your search keyword '"Shuai, Xiaoming"' showing total 173 results
Start Over Author "Shuai, Xiaoming"
173 results on '"Shuai, Xiaoming"'

2. Machine learning based peri-surgical risk calculator for abdominal related emergency general surgery: a multicenter retrospective study

Author

Chen, Biao, primary, Sheng, Weiyong, additional, Wu, Zhixin, additional, Ma, Bingqing, additional, Cao, Nan, additional, Li, Xushu, additional, Yang, Jia, additional, Yuan, Xiaowei, additional, Yan, Lizhao, additional, Zhu, Gaobo, additional, Zhou, Yuanhong, additional, Huang, Zhonghua, additional, Zhu, Meiwei, additional, Ding, Xuehui, additional, Du, Hansong, additional, Wan, Yanqing, additional, Gao, Xuan, additional, Cheng, Xing, additional, Xu, Peng, additional, Zhang, Teng, additional, Tao, Kaixiong, additional, Shuai, Xiaoming, additional, Cheng, Ping, additional, Gao, Yong, additional, and Zhang, Jinxiang, additional

Published
2024
Full Text
View/download PDF

9. Neoadjuvant tislelizumab and tegafur/gimeracil/octeracil (S-1) plus oxaliplatin in patients with locally advanced gastric or gastroesophageal junction cancer: Early results of a phase 2, single-arm trial

Author

Yin, Yuping, primary, Lin, Yao, additional, Yang, Ming, additional, Lv, Jianbo, additional, Liu, Jiaying, additional, Wu, Ke, additional, Liu, Ke, additional, Li, Anshu, additional, Shuai, Xiaoming, additional, Cai, Kailin, additional, Wang, Zheng, additional, Wang, Guobin, additional, Shen, Jianfeng, additional, Zhang, Peng, additional, and Tao, Kaixiong, additional

Published
2022
Full Text
View/download PDF

18. Long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 cooperates with enhancer of zeste homolog 2 to promote hepatocellular carcinoma development by modulating the microRNA‐22/Snail family transcriptional repressor 1 axis

Author

Chen, Shaofei, primary, Wang, Guobin, additional, Tao, Kaixiong, additional, Cai, Kailin, additional, Wu, Ke, additional, Ye, Lin, additional, Bai, Jie, additional, Yin, Yuping, additional, Wang, Jiliang, additional, Shuai, Xiaoming, additional, Gao, Jinbo, additional, Pu, Jiarui, additional, and Li, Hang, additional

Published
2020
Full Text
View/download PDF

19. Correction to “Sustained Local Release of NGF from a Chitosan-Sericin Composite Scaffold for Treating Chronic Nerve Compression”

Author

Zhang, Lei, primary, Yang, Wen, additional, Tao, Kaixiong, additional, Song, Yu, additional, Xie, Hongjian, additional, Wang, Jian, additional, Li, Xiaolin, additional, Shuai, Xiaoming, additional, Gao, Jinbo, additional, Chang, Panpan, additional, Wang, Guobin, additional, Wang, Zheng, additional, and Wang, Lin, additional

Published
2020
Full Text
View/download PDF

20. A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer

Author

Hu, Yuhang, primary, Wang, Fan, additional, Xu, Fengyu, additional, Fang, Kaifeng, additional, Fang, Zhi, additional, Shuai, Xiaoming, additional, Cai, Kailin, additional, Chen, Jinhuang, additional, Hu, Ping, additional, Chen, Ding, additional, Xu, Peng, additional, Hu, Chaojie, additional, Zeng, Zhu, additional, Zhong, Jianxin, additional, Li, Wei, additional, Tang, Jiang, additional, Huang, Mengqi, additional, Zhao, Yong, additional, Wang, Chunyou, additional, and Zhao, Gang, additional

Published
2020
Full Text
View/download PDF

25. Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus

Author

Chang Weilong, Liu Xinghua, Cai Ming, Shuai Xiaoming, Tao Kaixiong, Chen Junhua, Wang Guobin, Xu Fei, and Bai Jie

Subjects
Senescence, macromolecular substances, Biology, Methylation, Biochemistry, Histones, Histone demethylation, Stomach Neoplasms, Cell Line, Tumor, Tumor Suppressor Protein p14ARF, Histone methylation, Polycomb-group proteins, Humans, Enhancer of Zeste Homolog 2 Protein, Epigenetics, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p15, Cell Cycle, EZH2, Polycomb Repressive Complex 2, Cell Biology, Chromatin, Cancer research, biology.protein, PRC2
Abstract

Polycomb group proteins are epigenetic transcriptional repressors that function through recognition and modification of histone methylation and chromatin structure. As a member of PcG proteins, enhancer of zeste homolog 2 (EZH2) targets cell cycle regulatory proteins which govern cell cycle progression and cellular senescence. In previous work, we reported that EZH2 depletion functionally induced cellular senescence in human gastric cancer cells with mutant p53. However, whether EZH2 expression contributes to the change of key cell cycle regulators and the mechanism involved are still unclear. To address this issue, we investigated the effects of EZH2 depletion on alteration of histone methylation pattern. In gastric cancer cells, INK4/ARF locus was activated to certain extent in consequence of a decrease of H3K27me3 along it caused by EZH2 silence, which contributed substantially to an increase in the expression of p15(INK4b), p14(ARF) and p16(INK4a) and resulted in cellular senescence ultimately. Furthermore, MKN28 cells, which did not express p16(INK4a) and p21(cip), could be induced to senescence via p15(INK4b) activation and suppression of p15(INK4b) reversed senescence progression induced by EZH2 downregulated. These data unravel a crucial role of EZH2 in the regulation of INK4/ARF expression and senescence procedure in gastric cancer cells, and show that the cellular senescence could just depend on the activation of p15(INK4b)/Rb pathway, suggesting the cell-type and species specificity involved in the mechanisms of senescence inducement.

Published
2015

26. Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient

Author

Li, Huili, Huang, Kun, Wang, Hui, Wang, Lin, Yang, Ming, Wang, Lixia, Lin, Rong, Liu, Hongli, Gao, Jinbo, Shuai, Xiaoming, Liu, Xinghua, Tao, Kaixiong, Wang, Guobin, and Wang, Zheng

Subjects
Male, Neurons, sporadic adolescent carcinoma, Adolescent, colon signet-ring cell carcinoma, Enteric Nervous System, Colonic Neoplasms, Humans, Clinical Case Report, Carcinoma, Signet Ring Cell, immature ganglion cells, Research Article, early diagnosis, genetic defects
Abstract

Rationale: All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old boy has never been reported elsewhere, which may suggest some linkage between them. Patient Concern: A 13-year-old boy presented with progressive abdominal pain and melena for 3 months. Computed tomography (CT) scan and endoscopic ultrasonography showed significant abnormality in the transverse colon characteristic of marked mural thickening. The biopsy results indicated signet ring cell carcinoma. Diagnoses: A 13-year-old male patient with advanced colon signet ring cell carcinoma. In addition, immature but not mature ganglion cells could be observed in almost all of the slices of the resected nontumorous area of the specimen. Interventions: The transverse colon tumor was resected and the subsequent histopathological examination confirmed the diagnosis of primary colon signet ring cell carcinoma. Then the patient received adjuvant chemotherapy and biological target therapies subsequently. Outcomes: After 6 cycles of adjuvant chemotherapy and biological target therapies, metastasis was however detected within a year. Lessons: In this case, a 13-year-old male patient with advanced colon signet ring cell carcinoma were presented. Unexpectedly, immature ganglion cells could be observed in almost all of the slices of the resected nontumorous area of the specimen. It is critical to raise medical awareness and improve the diagnosis and treatment of the signet ring cell carcinoma. This malignancy and the immature ganglion cells may be associated, possibly caused by some unidentified genetic defects. Genome sequencing, histopathological examination, and long-term follow-up of young patients with related diseases, would help further reveal the potential relationship between tumorigenesis and ganglion cells’ immaturity, contributing to understanding the molecular mechanisms.

Published
2017

28. Oncological consequence of emergent resection of perforated colon cancer with complete obstruction after stent insertion as a bridge to surgery

Author

Cao, Yinghao, primary, Deng, Shenghe, additional, Wu, Ke, additional, Zheng, Hai, additional, Cheng, Ping, additional, Zhang, Jingxiang, additional, Chen, Libo, additional, Tang, Shouyuan, additional, Wang, Pingfa, additional, Liao, Xiaofeng, additional, Zhang, Yongkang, additional, Zhu, Gaobo, additional, Tong, Qiaoyun, additional, Wang, Jiliang, additional, Gao, Jinbo, additional, Shuai, Xiaoming, additional, Tao, KaiXiong, additional, Wang, Guobin, additional, Li, Jiang, additional, and Cai, Kailin, additional

Published
2018
Full Text
View/download PDF

35. Concurrent gastrointestinal stromal tumor and digestive tract carcinoma: a single institution experience in China

Author

Zhang, Peng, Deng, Rui, Xia, Zefeng, Shuai, Xiaoming, Chang, Weilong, Gao, Jinbo, Wang, Guobin, and Tao, Kaixiong

Subjects
Original Article, neoplasms, digestive system diseases
Abstract

The aim of this study was to review the clinicopathological characteristics and survival outcomes of patients with concurrent gastrointestinal stromal tumor (GIST) and digestive tract carcinoma. Among 585 patients diagnosed with GIST from January 2005 to July 2014, 32 (5.5%) had synchronous digestive tract carcinoma, including 19 (59.4%) men and 13 (40.6%) women. The median age was 64 years (range, 43-84). GIST was located in the stomach (n=24), small intestine (n=6), duodenum (n=1) and retroperitoneum (n=1). GISTs were intra- or postoperatively discovered (n=28) or preoperatively identified (n=4). The tumor size was less than 10 mm (microGIST) in 23 (71.9%) GIST patients. The preoperatively identified GIST subgroup showed a significantly larger tumor size, more mitotic figures and a higher risk grade than the intra- or postoperatively identified GIST subgroup. Concurrent digestive tract carcinomas were most frequently located in the stomach (24 cases, 75%). The other involved sites were the esophagus (n=5), duodenum (n=2) and colon (n=1). With a median follow-up of 32 months (range, 9-80), 24 patients were alive without evidence of disease, 6 patients had died of carcinoma progression, 1 patient had died from an accident, and 1 patient experienced GIST metastasis to the liver. In summary, we discovered that 5.5% of GIST patients also developed a concurrent digestive tract carcinoma in a series of 585 GIST cases. The majority of GISTs are incidentally identified microGISTs. The concurrent carcinoma seems to have a greater unfavorable effect on prognosis than the GIST. However, for a GIST that is identified preoperatively with a high risk of progression, adjuvant therapy is warranted.

Published
2015

41. Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression

Author

Cheng, Ji, Deng, Rui, Wu, Chuanqing, Zhang, Peng, Wu, Ke, Shi, Liang, Liu, Xinghua, Bai, Jie, Deng, Meizhou, Gao, Jinbo, Shuai, Xiaoming, Wang, Guobin, and Tao, Kaixiong

Subjects
integumentary system, Carcinogenesis, Cell Cycle, Apoptosis, Zinc Finger Protein GLI1, eye diseases, Gene Expression Regulation, Neoplastic, Cell Line, Tumor, Humans, Original Article, Neoplasm Invasiveness, Caco-2 Cells, Colorectal Neoplasms, Cell Proliferation, Transcription Factors
Abstract

Background: SALL4 is a novel oncogene mediating tumorigenesis in multiple carcinomas. However, its actual role and mechanisms participating in the development of colorectal cancer remains unclear. Methods: Immunohistochemical staining and Western blot were conducted to detect the expression of SALL4 and other molecules. siRNA of SALL4 was transfected to silence SALL4 expression in Caco-2 cell line. Flow cytometry was used for cell cycle and apoptosis analysis. Wound healing and transwell assay were used for invasion test. CCK-8 test was employed for cell proliferation and drug sensitivity assessment. Results: By inhibition of SALL4 expression, the proliferation, invasiveness and drug resistance were dramatically reduced while apoptosis rate was up-regulated. Gli1 was found to decrease its expression in SALL4 silencing cells. Moreover, the inhibition on tumorigenesis of Caco-2 by SALL4 silencing was antagonized by Gli1 up-regulation, suggesting Gli1 as a downstream target of SALL4 in cancer development. Conclusion: SALL4 inhibition limited oncogenesis on colorectal cancer by reducing Gli1 expression.

Published
2015

47. Sericin/Dextran Injectable Hydrogel as an Optically Trackable Drug Delivery System for Malignant Melanoma Treatment

Author

Liu, Jia, primary, Qi, Chao, additional, Tao, Kaixiong, additional, Zhang, Jinxiang, additional, Zhang, Jian, additional, Xu, Luming, additional, Jiang, Xulin, additional, Zhang, Yunti, additional, Huang, Lei, additional, Li, Qilin, additional, Xie, Hongjian, additional, Gao, Jinbo, additional, Shuai, Xiaoming, additional, Wang, Guobin, additional, Wang, Zheng, additional, and Wang, Lin, additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results