199 results on '"Shu-Yu, Yang"'
Search Results
2. Nationwide survey of physicians’ familiarity and awareness of diabetes guidelines in China: a cross-sectional study
- Author
-
Bing Yan, Shu-Yu Yang, Jian-Ping Liu, Le Li, Na Zhan, Li-yan Jia, Cao-xin Huang, Neng-jiang Zhao, Bao-yong Lai, Zhi-hai Zhang, Yuan-bing Lin, Miao-na Cai, and Shun-qin Wang
- Subjects
Medicine - Abstract
Objective This study aims to investigate physicians’ familiarity and awareness of four diabetes guidelines and their practice of the recommendations outlined in these guidelines.Design A cross-sectional study.Setting An online questionnaire survey was conducted among physicians affiliated with the Specialist Committee for Primary Diabetes Care of China Association of Chinese Medicine, using the snowball sampling method to ensure a broader representation of physicians.Participants 1150 physicians from 192 cities across 30 provinces in China provided complete data.Results Tertiary care hospital physicians (TCPs) exhibited the highest familiarity with the Guideline for the Prevention and Treatment of Type 2 Diabetes Mellitus in China (91.3%), followed by the National Guidelines for the Prevention and Control of Diabetes in Primary Care (76.8%), the Standards of Medical Care in Diabetes (72.2%) and the Guidelines for Prevention and Treatment of Diabetes in Chinese Medicine (63.8%). Primary care practitioners (PCPs) exhibited familiarity with these four guidelines at about 50% or less. Self-reported reference to modern diabetes guidelines by physicians is more frequent than traditional Chinese medicine (TCM) diabetes guidelines, with rates at 73.2% and 33.8%, respectively. Approximately 90% of physicians provided instructions on self-monitoring of blood glucose to their patients with diabetes. Less than one-third of physicians referred patients to a specialised nutritionist. In terms of health education management, TCPs reported having a diabetes health management team at the rate of 75.7%, followed by secondary care hospital physicians at 57.0% and PCPs at 27.5%. Furthermore, approximately 40% of physicians did not fully grasp hypoglycaemia characteristics.Conclusions Familiarity and awareness of the screening guidelines varied among physicians in different hospital settings. Importantly, significant discrepancies were observed between physicians’ awareness and their self-reported reference to modern medicine guidelines and TCM guidelines. It is essential to consistently provide education and training on diabetes management for all physicians, particularly PCPs. more...
- Published
- 2023
- Full Text
- View/download PDF
Catalog
3. A visual self-positioning method for inspection robot based on symmetrical tangential artificial landmarks.
- Author
-
Shu-Yu Yang, Shun-Ming Deng, Peng-Peng Zhao, and Jin-Ping Li
- Published
- 2018
- Full Text
- View/download PDF
4. Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP study
- Author
-
Yong Chon Park, Min-Soo Lee, Tian-Mei Si, Helen F.K. Chiu, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Pichet Udomratn, Kok Yoon Chee, Andi J. Tanra, Golam Rabbani, Afzal Javed, Samudra Kathiarachchi, Win Aung Myint, Tran Van Cuong, Kang Sim, Shu-yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka Shinfuku, and Seon-Cheol Park more...
- Subjects
Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P more...
- Published
- 2019
- Full Text
- View/download PDF
5. Design of a Multi-Sensor System for Exploring the Relation between Finger Spasticity and Voluntary Movement in Patients with Stroke
- Author
-
Bor-Shing Lin, I-Jung Lee, Pei-Chi Hsiao, Shu-Yu Yang, Chen-Yu Chen, Si-Huei Lee, Yu-Fang Huang, Mao-Hsu Yen, and Yu Hen Hu
- Subjects
stroke ,voluntary movement ,spasticity ,inertial measurement unit ,wearable ,modified Ashworth scale ,Chemical technology ,TP1-1185 - Abstract
A novel wearable multi-sensor data glove system is developed to explore the relation between finger spasticity and voluntary movement in patients with stroke. Many stroke patients suffer from finger spasticity, which is detrimental to their manual dexterity. Diagnosing and assessing the degrees of spasticity require neurological testing performed by trained professionals to estimate finger spasticity scores via the modified Ashworth scale (MAS). The proposed system offers an objective, quantitative solution to assess the finger spasticity of patients with stroke and complements the manual neurological test. In this work, the hardware and software components of this system are described. By requiring patients to perform five designated tasks, biomechanical measurements including linear and angular speed, acceleration, and pressure at every finger joint and upper limb are recorded, making up more than 1000 features for each task. We conducted a preliminary clinical test with 14 subjects using this system. Statistical analysis is performed on the acquired measurements to identify a small subset of features that are most likely to discriminate a healthy patient from patients suffering from finger spasticity. This encouraging result validates the feasibility of this proposed system to quantitatively and objectively assess finger spasticity. more...
- Published
- 2022
- Full Text
- View/download PDF
6. Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade
- Author
-
Cheng-fu Cai, Guo-dong Ye, Dong-yan Shen, Wei Zhang, Mao-li Chen, Xin-xin Chen, Da-xiong Han, Yan-jun Mi, Qi-cong Luo, Wang-yu Cai, and Shu-yu Yang
- Subjects
Chibby ,Warburg effect ,Wnt/β-Catenin signaling ,Nasopharyngeal carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Great progress has been achieved in the study of the aerobic glycolysis or the so-called Warburg effect in a variety of cancers; however, the regulation of the Warburg effect in Nasopharyngeal carcinoma (NPC) has not been completely defined. Methods Gene expression pattern of NPC cells were used to test associations between Chibby and β-catenin expression. Chibby siRNAs and over-expression vector were transfected into NPC cells to down-regulate or up-regulate Chibby expression. Loss- and gain-of function assays were performed to investigate the role of Chibby in NPC cells. Western blot, cell proliferation, Glucose uptake, Lactate release, ATP level, and O2 consumption assays were used to determine the mechanism of Chibby regulation of underlying targets. Finally, immunohistochemistry assay of fresh NPC and nasopharyngeal normal tissue sample were used to detect the expression of Chibby, β-Catenin, and PDK1 by immunostaining. Results We observed that Chibby, a β-catenin-associated antagonist, is down-regulated in nasopharyngeal carcinoma cell lines and inhibits Wnt/β-Catenin signaling induced Warburg effect. Mechanism study revealed that Chibby regulates aerobic glycolysis in NPC cells through pyruvate dehydrogenase kinase 1(PDK1), an important enzyme involved in glucose metabolism. Moreover, Chibby suppresses aerobic glycolysis of NPC via Wnt/β-Catenin-Lin28/let7-PDK1 cascade. Chibby and PDK1 are critical for Wnt/β-Catenin signaling induced NPC cell proliferation both in vitro and in vivo. Finally, immunostaining assay of tissue samples provides an important clinical relevance among Chibby, Wnt/β-Catenin signaling and PDK1. Conclusions Our study reveals an association between Chibby expression and cancer aerobic glycolysis, which highlights the importance of Wnt/β-catenin pathway in regulation of energy metabolism of NPC. These results indicate that Chibby and PDK1 are the potential target for NPC treatment. more...
- Published
- 2018
- Full Text
- View/download PDF
7. To use the brief psychiatric rating scale to detect disorganized speech in schizophrenia: Findings from the REAP-AP study
- Author
-
Yong Chon Park, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Roy Abraham Kallivayalil, Ajit Avasthi, Sandeep Grover, Kok Yoon Chee, Andi J. Tanra, Marigarita M. Maramis, Shu-Yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka Shinfuku, and Seon-Cheol Park more...
- Subjects
Brief Psychiatric Rating Scale (BPRS) ,Conceptual disorganization ,Disorganized speech ,Excitement ,Uncooperativeness ,Medicine (General) ,R5-920 - Abstract
Our study aimed to assess the psychometric validity of the conceptual disorganization item and other items of the Brief Psychiatric Rating Scale (BPRS) for detecting disorganized speech in patients with schizophrenia. We included 357 schizophrenia patients with disorganized speech and 1082 without disorganized speech from the survey centers in India, Indonesia, Japan, Malaysia, and Taiwan, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. After adjusting the effects of confounding variables, a binary logistic regression model was fitted to identify BPRS items independently associated with disorganized speech. Receiver operating characteristic (ROC) curves were used to identify optimum cut-off scores and their sensitivities and specificities for detecting disorganized speech. After adjusting the effects of confounding variables, the fitted binary logistic regression model indicated that conceptual disorganization (P more...
- Published
- 2018
- Full Text
- View/download PDF
8. Data glove embedded with 9-axis IMU and force sensing sensors for evaluation of hand function.
- Author
-
Pei-Chi Hsiao, Shu-Yu Yang, Bor-Shing Lin, I-Jung Lee, and Willy Chou
- Published
- 2015
- Full Text
- View/download PDF
9. The updated PIM-Taiwan criteria: a list of potentially inappropriate medications in older people
- Author
-
Chirn-Bin Chang, Hsiu-Yun Lai, Shinn-Jang Hwang, Shu-Yu Yang, Ru-Shu Wu, Lo-Yu Chang, I-Shan Lee, Hsing-Cheng Liu, and Ding-Cheng Chan
- Subjects
Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Explicit criteria for potentially inappropriate medications (PIMs) developed for other countries are difficult to apply to a specific territory. This study aimed to update the PIM-Taiwan criteria from a qualitative review of several published PIM criteria, followed by consensus among regional experts in Taiwan. Methods: After a review of the literature, we selected four sets of published PIM criteria to construct preliminary core PIMs. The Beers criteria, Fit fOR The Aged (FORTA), and Japan criteria were used for PIMs, without consideration of chronic diseases. The Beers criteria, Screening Tool of Older Persons’ Prescriptions (STOPP) criteria, and Japan criteria were used for PIMs with respect to chronic diseases. We asked experts ( n = 24) to rate their agreement with each statement, including in the final PIM criteria, after two rounds of modified Delphi methods. The intraclass coefficient (ICC) was used to examine the reliability of the modified Delphi method. Results: Overall, two categories of PIMs were established: 131 individual drugs and 9 drugs with combinations that should generally be avoided; and 9 chronic diseases with their corresponding PIMs that have drug–disease interactions. The ICC estimates for PIMs to be avoided generally were 0.634 and 0.557 (round 1 and 2) and those for PIMs with respect to chronic diseases were 0.866 and 0.775 (round 1 and 2) of the Delphi method, respectively. Conclusions: The 2018 version of PIM-Taiwan criteria was established and several modifications were made to keep the criteria updated and relevant. Clinicians can use them to reduce polypharmacy and PIMs among older patients. more...
- Published
- 2019
- Full Text
- View/download PDF
10. Correction: Antipsychotic medications and stroke in schizophrenia: A case-crossover study.
- Author
-
Wen-Yin Chen, Lian-Yu Chen, Hsing-Cheng Liu, Chi-Shin Wu, Shu-Yu Yang, Chun-Hung Pan, Shang-Ying Tsai, Chiao-Chicy Chen, and Chian-Jue Kuo
- Subjects
Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0179424.].
- Published
- 2019
- Full Text
- View/download PDF
11. Genetic Underpinnings and Audiological Characteristics in Children With Unilateral Sensorineural Hearing Loss
- Author
-
Chen-Yu Lee, Pei-Hsuan Lin, Yu-Ting Chiang, Cheng-Yu Tsai, Shu-Yu Yang, You-Mei Chen, Chao-Hsuan Li, Chun-Yi Lu, Tien-Chen Liu, Chuan-Jen Hsu, Pei-Lung Chen, Jacob Shujui Hsu, and Chen-Chi Wu
- Subjects
Otorhinolaryngology ,Surgery - Abstract
ObjectiveUnilateral sensorineural hearing loss is a condition commonly encountered in otolaryngology clinics. However, its molecular pathogenesis remains unclear. This study aimed to investigate the genetic underpinnings of childhood unilateral sensorineural hearing loss and analyze the associated audiological features.Study DesignRetrospective analysis of a prospectively recruited cohort Setting: Tertiary referral center Methods: We enrolled 38 children with unilateral sensorineural hearing loss and performed physical, audiological, imaging, and congenital cytomegalovirus examinations as well as genetic testing using next-generation sequencing targeting 30 deafness genes. The audiological results were compared across different etiologies.ResultsCausative genetic variants were identified in eight (21.1%) patients, including five withGJB2variants, two withPAX3variants, and one withEDNRBvariant.GJB2variants were associated with mild-to-moderate unilateral sensorineural hearing loss in various audiogram configurations, whereasPAX3andEDNRBvariants were associated with profound unilateral sensorineural hearing loss in flat audiogram configurations. In addition, whole genome sequencing and extended next-generation sequencing targeting 213 deafness genes were performed in two multiplex families compatible with autosomal recessive inheritance; yet no definite causative variants were identified. Cochlear nerve deficiency and congenital cytomegalovirus infection were observed in nine and two patients without definite genetic diagnoses.ConclusionGenetic underpinnings can contribute to approximately 20% of childhood unilateral sensorineural hearing loss, and different genotypes are associated with various audiological features. These findings highlight the utility of genetic examinations in guiding the diagnosis, counseling, and treatment of unilateral sensorineural hearing loss in children. more...
- Published
- 2023
- Full Text
- View/download PDF
12. Data Glove Embedded with 6-DOF Inertial Sensors for Hand Rehabilitation.
- Author
-
Bor-Shing Lin, I-Jung Lee, Pei-Chi Hsiao, Shu-Yu Yang, and Willy Chou
- Published
- 2014
- Full Text
- View/download PDF
13. Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study
- Author
-
Yuxi Wang, Qian Hui Chew, Shih-Ku Lin, Shu-Yu Yang, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Jun Hyuk Park, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy Abraham Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Paing Phyo Aung, Norman Sartorius, Yu-Tao Xiang, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, and Kang Sim more...
- Subjects
Male ,Psychotropic Drugs ,Psychiatry and Mental health ,Bipolar Disorder ,Prescriptions ,Antimanic Agents ,Humans ,Anticonvulsants ,Pharmacology (medical) ,Lithium ,Practice Patterns, Physicians' ,Antipsychotic Agents - Abstract
Because use and dosing of mood stabilizers (MSs) to treat bipolar disorder (BD) patients in Asia are not well documented, we examined prevalence and clinical correlates of treatment of Asian BD patients with relatively high doses of MSs.We conducted a pharmacoepidemiological survey across 13 Asian countries and territory in the Research on Asian Psychotropic Prescription Patterns Consortium. Mood stabilizer doses were converted to lithium carbonate equivalents (Li-eq milligrams per day). We compared relatively high (900 Li-eq mg/day) versus lower MS doses by bivariate comparisons, followed by multivariable linear regression to identify factors associated with higher MS doses.Among 1647 participants, MS dose averaged 584 (confidence interval, 565-603 Li-eq mg/d). Preliminarily, the 13.1% of the subjects given greater than 900 mg/d versus those given lower doses were younger, male, currently hospitalized, not currently depressed, and reported lifetime suicidal ideation; they also received relatively high doses of antipsychotics, received electroconvulsive treatment within the previous 12 months, and had greater ratings of tremors and sedation. By linear regression modeling, the mean proportion given high doses of MS was associated significantly and independently with higher doses of antipsychotics, younger age, male sex, hospitalized, more years of illness, country, higher body mass index, recent electroconvulsive treatment, and being in illness remission.Relatively high doses of MSs for BD are prevalent, but vary markedly among Asian countries, and are particularly likely among young males, ill for many years, and given high doses of antipsychotics or ECT. These characteristics allow better identification of patient profiles that can guide treatment of BD patients. more...
- Published
- 2022
- Full Text
- View/download PDF
14. Kaempferitrin-Treated HepG2 Differentially Expressed Exosomal Markers and Affect Extracellular Vesicle Sizes in the Secretome
- Author
-
Wei-Chi Ku, Badrinathan Sridharan, Jiann-Yeu Chen, Jen-Ying Li, Shu-Yu Yang, and Meng-Jen Lee
- Subjects
Kaempferitrin ,Cinnamomum osmophloeum ,proteomics ,mass spectrometry ,HepG2 ,exosome ,Microbiology ,QR1-502 - Abstract
Kaempferitrin is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum, which belongs to a group of plant species that comes under the genus Cinnamomum, well-known for its established anti-diabetic property in Chinese medicine. Oral administration of kaempferitrin and Cinnamomum osmophloeum extract reduced blood sugar in alloxan-induced diabetic rats and improved the lipid profile in hamsters respectively. In this paper we studied the differential protein expression profile using mass spectrometry approach in the kaempferitrin-treated conditioned medium of liver cancer cell line HepG2. We discovered that 33 genes were up/down-regulated consistently between two biological samples. A slightly different version of the analysis software selected 28 genes, and the final 18 genes that appeared in both lists were selected. Interestingly, 5 proteins out of 18 were either exosomal markers or reported in high frequency of occurrence in exosome/secreted vesicles. We also examined the extracellular particles with atomic force microscopy (AFM), which showed that the conditioned medium of kaempferitrin treated had larger vesicles and fewer small vesicles. Expression of some lipid-regulating genes were also altered. Our data suggested that extracellular vesicle secretions may be regulated by kaempferitrin, and regulation of lipid profile by kampeferitrin involves multiple mechanisms. more...
- Published
- 2021
- Full Text
- View/download PDF
15. Effect of Chinese Herbal Medicine Jinlida Granule in Treatment of Patients with Impaired Glucose Tolerance
- Author
-
Ya-Lin Shi, Wen-Juan Liu, Xiao-Fang Zhang, Wei-Juan Su, Ning-Ning Chen, Shu-Hua Lu, Li-Ying Wang, Xiu-Lin Shi, Zhi-Bin Li, and Shu-Yu Yang
- Subjects
Clinical Observation ,Diabetes Mellitus ,Impaired Glucose Tolerance ,Jinlida Granule ,Medicine - Abstract
Background: Diabetes mellitus (DM) remains a major health problem worldwide. Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM. This study aimed to evaluate the efficacy of Jinlida (JLD) granule, a Chinese herbal recipe, in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM. Methods: Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group, n = 34) or no drug intervention (control group, n = 31) for 12 weeks. Oral glucose tolerance test, glycated hemoglobin A1c (HbA1c), body mass index, blood lipids levels, fasting insulin, and insulin resistance calculated using homeostatic model assessment (HOMA-IR) of all the patients were observed and compared before and after the treatment. Results: Sixty-one participants completed the trial (32 in JLD group and 29 in the control group). There were statistically significant decreases in HbA1c (P < 0.001), 2-h plasma glucose (P < 0.001), and HOMA-IR (P = 0.029) in JLD group compared with the control group after 12 weeks of treatment. After 12 weeks of treatment, two (6.9%) patients returned to normal blood glucose, and five (17.2%) patients turned into DM in control group, while in the JLD group, 14 (43.8%) returned to normal blood glucose and 2 (6.2%) turned into DM. There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups (P = 0.001). Conclusions: JLD granule effectively improved glucose control, increased the conversion of IGT to normal glucose, and improved the insulin resistance in patients with IGT. This Chinese herbal medicine may have a clinical value for IGT. more...
- Published
- 2016
- Full Text
- View/download PDF
16. Effect of Cynanchum paniculatum (Bge.) Kitag. on various diseases: an overview of current research progress
- Author
-
Badrinathan Sridharan, Shu-Yu Yang, Jen-Ying Li, and Meng-Jen Lee
- Subjects
Numerical Analysis ,Control and Optimization ,General Chemical Engineering ,General Engineering ,General Agricultural and Biological Sciences - Published
- 2022
- Full Text
- View/download PDF
17. AI-Based Automatic System for Assessing Upper-Limb Spasticity of Patients with Stroke Through Voluntary Movement
- Author
-
I-Jung Lee, Yu Hen Hu, Pei-Chi Hsiao, Shu-Yu Yang, Hsin-Te Lin, Yu-Chung Chen, and Bor-Shing Lin
- Subjects
Health Information Management ,Health Informatics ,Electrical and Electronic Engineering ,Computer Science Applications - Abstract
Spasticity is a common complication for patients with stroke, but only few studies investigate the relation between spasticity and voluntary movement. This study proposed a novel automatic system for assessing the severity of spasticity (SS) of four upper-limb joints, including the elbow, wrist, thumb, and fingers, through voluntary movements. A wearable system which combined 19 inertial measurement units and a pressure ball was proposed to collect the kinematic and force information when the participants perform four tasks, namely cone stacking (CS), fast flexion and extension (FFE), slow ball squeezing (SBS), and fast ball squeezing (FBS). Several time and frequency domain features were extracted from the collected data, and two feature selection approaches based on recursive feature elimination were adopted to select the most influential features. The selected features were input into five machine learning techniques for assessing the SS for each joint. The results indicated that using CS task to assess the SS of elbow and fingers and using FBS task to assess the SS of thumb and wrist can reach the highest weighted-average F1-score. Furthermore, the study also concluded that FBS is the optimal task for assessing all the four upper-limb joints. The overall result shown that the proposed automatic system can assess four upper-limb joints through voluntary movements accurately, which is a breakthrough of finding the relation between spasticity and voluntary movement. more...
- Published
- 2022
18. Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study
- Author
-
Chih-Ken Chen, Shu-Yu Yang, Seon-Cheol Park, Ok-Jin Jang, Xiaomin Zhu, Yu-Tao Xiang, Wen-Chen Ouyang, Afzal Javed, M. Nasar Sayeed Khan, Sandeep Grover, Ajit Avasthi, Roy Abraham Kallivayalil, Kok Yoon Chee, Norliza Chemi, Takahiro A. Kato, Kohei Hayakawa, Pornjira Pariwatcharakul, Margarita Maramis, Lakmi Seneviratne, Kang Sim, Wai Kwong Tang, Tin Oo, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Naotaka Shinfuku, and Shih-Ku Lin more...
- Subjects
Psychiatry and Mental health ,General Medicine ,General Psychology - Published
- 2023
- Full Text
- View/download PDF
19. Antipsychotic medications and stroke in schizophrenia: A case-crossover study.
- Author
-
Wen-Yin Chen, Lian-Yu Chen, Hsing-Cheng Liu, Chi-Shin Wu, Shu-Yu Yang, Chun-Hung Pan, Shang-Ying Tsai, Chiao-Chicy Chen, and Chian-Jue Kuo
- Subjects
Medicine ,Science - Abstract
BACKGROUND:The association between antipsychotic use and the risk of stroke in schizophrenic patients is controversial. We sought to study the association in a nationwide cohort with schizophrenia. METHODS:Using a retrospective cohort of patients with schizophrenia (N = 31,976) derived from the Taiwan National Health Insurance Research Database, 802 new-onset cases of stroke were identified within 10 years of follow-up (from 2000 through 2010). We designed a case-crossover study using 14-day windows to explore the risk factors of stroke and the association between antipsychotic drugs and the risk of stroke. We analyzed the risks of individual antipsychotics on various subgroups of stroke including ischemic, hemorrhagic, and other strokes, and the risks based on the antipsychotic receptor-binding profile of each drug. RESULTS:Use of any second-generation antipsychotic was associated with an increased risk of stroke (adjusted risk ratio = 1.45, P = .009) within 14 days while the use of any first-generation antipsychotic was not. Intriguingly, the use of any second-generation antipsychotic was associated with ischemic stroke but not hemorrhagic stroke. The antipsychotic receptor-binding profile analysis showed that the antihistamine 1 receptor was significantly associated with ischemic stroke (adjusted risk ratio = 1.72, P = .037), and the sensitivity analysis based on the 7-day window of exposure validated the association (adjusted risk ratio = 1.87, P = .015). CONCLUSIONS:Use of second-generation antipsychotic drugs appeared to be associated with an increased risk of ischemic stroke in the patients studied, possibly mediated by high affinity for histamine-1 receptor blockade. Further research regarding the underlying biological mechanism and drug safety is suggested. more...
- Published
- 2017
- Full Text
- View/download PDF
20. Effects of Water Extract of Cynanchum paniculatum (Bge.) Kitag. on Different Breast Cancer Cell Lines
- Author
-
Jen-Shu Wang, Badrinathan Sridharan, Jen Ying Li, Meng-Jen Lee, Kai-Ming Chang, Guan-Jhong Huang, and Shu-Yu Yang
- Subjects
0303 health sciences ,Mutation ,Article Subject ,Chemistry ,Cell migration ,Cynanchum paniculatum ,Pharmacology ,medicine.disease_cause ,medicine.disease ,Other systems of medicine ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Complementary and alternative medicine ,Breast cancer cell line ,030220 oncology & carcinogenesis ,Conditioned medium ,medicine ,Medicinal herbs ,Cytotoxicity ,RZ201-999 ,030304 developmental biology - Abstract
Cynanchum paniculatum (Bge.) Kitag. (CP) is an important medicinal herb used in Chinese herbal medicine, with a variety of biological activities including anticancer property. In this study, we explored the water extract of CP, for its anticancer effects against breast cancer cells with different mutation types. Cells were grouped as untreated (Control); CP direct treatment (dir-CP); Conditioned medium from CP treated (sup-CP), and untreated cells (sup-Control). Effects of dir-CP and sup-CP were compared to corresponding untreated cells on cytotoxicity, cell migration, and protein expression (cleaved caspase-3, caspase-9, and MMP-2 and 9). CP treatment showed time-dependent decrease in cell number of MDA-MB-231 and SK-Br-3 (both ER(−) PR(−)), while the decrease in cell number was not as significant in MCF-7 and ZR-75-1 cells (both ER(+) PR(+)). sup-CP treatment inhibited the cell migration of MDA-MB-231 and MCF-7 (Her2(−)) in a 24 h scratch assay. Our data suggested that ER(−) PR(−) cells are more sensitive to the CP in terms of direct cytotoxicity, which is not regulated by caspase-3. CP inhibited the migration of the two Her2(−) cells, and this correlated with MMP-2 regulation. The migration of ER(−) PR(−) cells was more sensitive to conditioned medium with CP treatment than to direct CP, and this is not regulated by MMP-2. Our data suggested that CP has anticancer potential on various breast cancer cells through different mechanisms and is specifically effective in inhibiting the migration of the triple negative MDA-MB-231. Our data provide insight into the mechanism of CP against breast cancer progression and would benefit the medical practitioners in better management with CP usage. more...
- Published
- 2021
- Full Text
- View/download PDF
21. Design of an Inertial-Sensor-Based Data Glove for Hand Function Evaluation.
- Author
-
Bor-Shing Lin, I-Jung Lee, Shu-Yu Yang, Yi-Chiang Lo, Junghsi Lee, and Jean-Lon Chen
- Published
- 2018
- Full Text
- View/download PDF
22. Antipsychotic Medications and Risk of Acute Coronary Syndrome in Schizophrenia: A Nested Case-Control Study.
- Author
-
Hsing-Cheng Liu, Shu-Yu Yang, Ya-Tang Liao, Chiao-Chicy Chen, and Chian-Jue Kuo
- Subjects
Medicine ,Science - Abstract
BACKGROUND:This study assessed the risk of developing acute coronary syndrome requiring hospitalization in association with the use of certain antipsychotic medications in schizophrenia patients. METHODS:A nationwide cohort of 31,177 inpatients with schizophrenia between the ages of 18 and 65 years whose records were enrolled in the National Health Insurance Research Database in Taiwan from 2000 to 2008 and were studied after encrypting the identifications. Cases (n = 147) were patients with subsequent acute coronary syndrome requiring hospitalization after their first psychiatric admission. Based on a nested case-control design, each case was matched with 20 controls for age, sex and the year of first psychiatric admission using risk-set sampling. The effects of antipsychotic agents on the development of acute coronary syndrome were assessed using multiple conditional logistic regression and sensitivity analyses to confirm any association. RESULTS:We found that current use of aripiprazole (adjusted risk ratio [RR] = 3.68, 95% CI: 1.27-10.64, p more...
- Published
- 2016
- Full Text
- View/download PDF
23. Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study
- Author
-
Kang Sim, Wing Aung Myint, Tian-Mei Si, Van Cuong Tran, Yanling He, Yong Chon Park, Ajit Avasthi, Takahiro A. Kato, Fung Kum Helen Chiu, Kok Yoon Chee, Naotaka Shinfuku, Norman Sartorius, Shigenobu Kanba, Qian Hui Chew, Sandeep Grover, Samudra Kathiarachchi, Mian-Yoon Chong, Andi J. Tanra, Ross J. Baldessarini, Chay Hoon Tan, Shih Ku Lin, Dulshika Waas, Afzal Javed, Adarsh Tripathi, Shu Yu Yang, Roy Abraham Kallivayalil, Wai Kwong Lim, Min Soo Lee, Pichet Udomratn, Seon Cheol Park, Golam Rabbani, Kim Viet Nguyen, and Yu-Tao Xiang more...
- Subjects
Adult ,Male ,medicine.medical_specialty ,Asia ,Dose ,Sedation ,medicine.medical_treatment ,Severity of Illness Index ,Young Adult ,Antimanic Agents ,Internal medicine ,Humans ,Medicine ,Pharmacology (medical) ,Dosing ,Practice Patterns, Physicians' ,Antipsychotic ,Dose-Response Relationship, Drug ,business.industry ,Middle Aged ,medicine.disease ,Hospitalization ,Psychiatry and Mental health ,Mood ,Neurology ,Schizophrenia ,Adjunctive treatment ,Drug Therapy, Combination ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Body mass index ,Antipsychotic Agents - Abstract
OBJECTIVE Studies examining coprescription and dosages of mood stabilizers (MSs) with antipsychotics for psychotic disorders are infrequent. Based on sparse extant data and clinical experience, we hypothesized that adjunctive MS use would be associated with certain demographic (e.g., younger age), clinical factors (e.g., longer illness duration), and characteristics of antipsychotic treatment (e.g., multiple or high antipsychotic doses). METHODS Within an Asian research consortium focusing on pharmaco-epidemiological factors in schizophrenia, we evaluated rates of MS coprescription, including high doses (>1000 mg/day lithium-equivalents) and clinical correlates. RESULTS Among 3557 subjects diagnosed with schizophrenia in 14 Asian countries, MSs were coprescribed with antipsychotics in 13.6% (n = 485) of the sample, with 10.9% (n = 53) on a high dose. Adjunctive MS treatment was associated (all p < 0.005) with demographic (female sex and younger age), setting (country and hospitalization), illness (longer duration, more hospitalizations, non-remission of illness, behavioral disorganization, aggression, affective symptoms, and social-occupational dysfunction), and treatment-related factors (higher antipsychotic dose, multiple antipsychotics, higher body mass index, and greater sedation). Patients given high doses of MSs had a less favorable illness course, more behavioral disorganization, poorer functioning, and higher antipsychotic doses. CONCLUSIONS Schizophrenia patients receiving adjunctive MS treatment in Asian psychiatric centers are more severely ill and less responsive to simpler treatment regimens. more...
- Published
- 2020
- Full Text
- View/download PDF
24. Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia: findings from research on Asian psychotropic prescription patterns for antipsychotics
- Author
-
Seon Cheol Park, Ajit Avasthi, Shih Ku Lin, Kang Sim, Roy Abraham Kallivayalil, Gyung Mee Kim, Toshiya Inada, Chay Hoon Tan, Yong Chon Park, Naotaka Shinfuku, Mian-Yoon Chong, Norman Sartorius, Sandeep Grover, Kok Yoon Chee, Takahiro A. Kato, Shu Yu Yang, Yu-Tao Xiang, and Andi J. Tanra more...
- Subjects
medicine.medical_specialty ,Dyskinesias ,Schizophrenia (object-oriented programming) ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,Prescriptions ,0302 clinical medicine ,Basal Ganglia Diseases ,Dyskinesia ,Situated ,Schizophrenia ,medicine ,Humans ,medicine.symptom ,Medical prescription ,Psychiatry ,Psychology ,030217 neurology & neurosurgery ,Antipsychotic Agents - Abstract
Network analysis provides a new viewpoint that explicates intertwined and interrelated symptoms into dynamic causal architectures of symptom clusters. This is a process called 'symptomics' and is concurrently applied to various areas of symptomatology.Using the data from Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), we aimed to estimate a network model of extrapyramidal syndrome in patients with schizophrenia.Using data from REAP-AP, extrapyramidal symptoms of 1046 Asian patients with schizophrenia were evaluated using the nine items of the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). The estimated network of the ordered-categorical DIEPSS items consisted of nodes (symptoms) and edges (interconnections). A community detection algorithm was also used to identify distinctive symptom clusters, and correlation stability coefficients were used to evaluate the centrality stability.An interpretable level of node strength centrality was ensured with a correlation coefficient. An estimated network of extrapyramidal syndrome showed that 26 (72.2%) of all possible 35 edges were estimated to be greater than zero. Dyskinesia was most centrally situated within the estimated network. In addition, earlier antipsychotic-induced extrapyramidal symptoms were divided into three distinctive clusters - extrapyramidal syndrome without parkinsonism, postural instability and gait difficulty-dominant parkinsonism, and tremor-dominant parkinsonism.Our findings showed that dyskinesia is the most central domain in an estimated network structure of extrapyramidal syndrome in Asian patients with schizophrenia. These findings are consistent with the speculation that acute dystonia, akathisia, and parkinsonism could be the risk factors of tardive dyskinesia. more...
- Published
- 2020
- Full Text
- View/download PDF
25. Network analysis of psychiatric symptoms in schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP)
- Author
-
Wen Li, Qinge Zhang, Yilang Tang, Seon-Cheol Park, Yongchon Park, Shu-Yu Yang, Lian-Yu Chen, Shih-Ku Lin, Eunice Najoan, Roy Abraham Kallivayalil, Kittisak Viboonma, Ruzita Jamaluddin, Afzal Javed, Duong Thi Quynh Hoa, Hitoshi Iida, Kang Sim, Thiha Swe, Yan-Ling He, Helal Uddin Ahmed, Angelo De Alwis, Helen F.K. Chiu, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Naotaka Shinfuku, Ajit Avasthi, Sandeep Grover, Gabor S. Ungvari, Chee H. Ng, and Yu-Tao Xiang more...
- Subjects
Male ,Psychiatry and Mental health ,Psychotropic Drugs ,Prescriptions ,Hallucinations ,Schizophrenia ,Humans ,Female ,General Medicine ,General Psychology ,Antipsychotic Agents - Abstract
Schizophrenia is a major mental disorder with a wide range of psychiatric symptoms. This study explored the structure of psychiatric symptoms of schizophrenia using network analysis in a large representative Asian sample based on a survey of clinical features and treatment used in schizophrenia patients across 15 countries/territories in Asia.Data on the demographic characteristics and psychiatric symptoms in schizophrenia patients were extracted from the dataset of the fourth Research on Asia Psychotropic Prescription for Antipsychotics (REAP-AP) project. The presence of the following psychiatric symptoms including delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior, negative symptoms, social/occupational dysfunction, verbal aggression, physical aggression, and affective symptoms were analyzed.A total of 3681 patients were included. The network analysis revealed that verbal aggression, hallucinations, and social/occupational dysfunction were the most central symptoms, while the connections between social/occupational dysfunction and verbal aggression, and between hallucinations and disorganized speech were the two strongest edges. There were significant gender differences in the network structure based on the network structure invariance test (M=0.74, P = 0.03) and invariant edge strength test. The positive correlation between verbal aggression and hallucinations was significantly stronger in the female network than that in the male network (P = 0.03), while a negative correlation between affective symptoms and negative symptoms was found in the female, but not the male network (P 0.01).Central symptoms including verbal aggression, hallucinations, and socio-occupational dysfunction should be addressed in developing targeted treatment strategy for schizophrenia patients. more...
- Published
- 2022
26. Regioselectivity in the Ring Opening of Epoxides for the Synthesis of Aminocyclitols from D-(-)-Quinic Acid
- Author
-
Shu-Yu Yang and Tzenge-Lien Shih
- Subjects
aminocyclitols ,epoxides ,glycosidase inhibitors ,D-(-)-quinic acid ,regioselective ring opening ,Organic chemistry ,QD241-441 - Abstract
Efficient syntheses of four aminocyclitols are reported. Each synthesis is accomplished in eight steps starting from D-(-)-quinic acid. The key step involves a highly regioselective ring opening of epoxides by sodium azide. more...
- Published
- 2012
- Full Text
- View/download PDF
27. Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
- Author
-
Joonho Choi, Hyung-Jun Yoon, Jae Hong Park, Yukako Nakagami, Chika Kubota, Toshiya Inada, Takahiro A. Kato, Shu-Yu Yang, Sih-Ku Lin, Mian-Yoon Chong, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Andi Jaylangkara Tanra, Kok Yoon Chee, Yu-Tao Xiang, Kang Sim, Afzal Javed, Chay Hoon Tan, Norman Sartorius, Shigenobu Kanba, Naotaka Shinfuku, Yong Chon Park, and Seon-Cheol Park more...
- Subjects
schizophrenia ,precision medicine ,mental disorders ,Brief Psychiatric Rating Scale ,heterogeneity ,motor retardation ,network analysis ,Medicine (miscellaneous) ,Medicine ,behavioral disciplines and activities ,Article - Abstract
The symptom heterogeneity of schizophrenia is consistent with Wittgenstein’s analogy of a language game. From the perspective of precision medicine, this study aimed to estimate the symptom presentation and identify the psychonectome in Asian patients, using data obtained from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics. We constructed a network structure of the Brief Psychiatric Rating Scale (BPRS) items in 1438 Asian patients with schizophrenia. Furthermore, all the BPRS items were considered to be an ordered categorical variable ranging in value from 1–7. Motor retardation was situated most centrally within the BPRS network structure, followed by depressive mood and unusual thought content. Contrastingly, hallucinatory behavior was situated least centrally within the network structure. Using a community detection algorithm, the BPRS items were organized into positive, negative, and general symptom clusters. Overall, DSM symptoms were not more central than non-DSM symptoms within the symptom network of Asian patients with schizophrenia. Thus, motor retardation, which results from the unmet needs associated with current antipsychotic medications for schizophrenia, may be a tailored treatment target for Asian patients with schizophrenia. Based on these findings, targeting non-dopamine systems (glutamate, γ-aminobutyric acid) may represent an effective strategy with respect to precision medicine for psychosis. more...
- Published
- 2021
28. Prescription of antipsychotic and concomitant medications for adult Asian schizophrenia patients: Findings of the 2016 Research on Asian Psychotropic Prescription Patterns (REAP) survey
- Author
-
Roy Abraham Kallivayalil, Duong Thi Quynh Hoa, Gabor S. Ungvari, Chay Hoon Tan, Liang Nan Zeng, Norman Sartorius, Angelo De Alwis, Kittisak Viboonma, Yong-Chon Park, Thiha Swe, Kang Sim, Chee H. Ng, Yu-Tao Xiang, Sandeep Grover, Helen F.K. Chiu, Helal Uddin Ahmed, Qinge Zhang, Afzal Javed, Naotaka Shinfuku, Hitoshi Iida, Mian-Yoon Chong, Ajit Avasthi, Eunice Najoan, Yanling He, Shih Ku Lin, Lian Yu Chen, Min Dong, Shu Yu Yang, and Ruzita Jamaluddin more...
- Subjects
Adult ,Male ,medicine.medical_specialty ,Asia ,medicine.medical_treatment ,Drug Prescriptions ,Cholinergic Antagonists ,Benzodiazepines ,Pharmacotherapy ,medicine ,Humans ,Practice Patterns, Physicians' ,Medical prescription ,Psychiatry ,Antipsychotic ,Chlorpromazine ,General Psychology ,Polypharmacy ,business.industry ,General Medicine ,medicine.disease ,Health Surveys ,Antidepressive Agents ,Psychiatry and Mental health ,Cross-Sectional Studies ,Mood ,Schizophrenia ,Concomitant ,Female ,business ,Antipsychotic Agents ,medicine.drug - Abstract
Objective Regular surveys are important to monitor the use of psychotropic medications in clinical practice. This study examined the psychotropic prescription patterns in adult Asian schizophrenia patients based on the data of the Research on Asian Psychotropic Prescription (REAP) 2016 survey. Methods : This cross-sectional survey across 15 Asian countries/territories collected socio-demographic and clinical data with standardized procedures between March and May 2016. The socio-demographic and clinical characteristics of the patients were recorded with a standardized questionnaire. Results Altogether 3,537 adult patients with schizophrenia were consecutively screened and enrolled in the survey. The mean age was 38.66 ± 11.55 years and 59.7% of the sample were male. The mean dose of antipsychotics in chlorpromazine equivalents (CPZeq) was 424 ± 376 mg/day; 31.3% and 80.8% received first- and second- generation antipsychotics, respectively and 42.6% had antipsychotic polypharmacy, 11.7% had antidepressants, 13.7% had mood stabilizers, 27.8% had benzodiazepines, and 45.6% had anticholinergics. Conclusions Psychotropic prescription patterns in Asian adult patients with schizophrenia varied across countries. Regular surveys on psychotropic medications for schizophrenia are important to monitor pharmacotherapy practice in Asia. more...
- Published
- 2019
- Full Text
- View/download PDF
29. Concurrent antipsychotic use in older adults treated with antidepressants in Asia
- Author
-
Naotaka Shinfuku, Rathi Mahendran, Tian-Mei Si, Chay Hoon Tan, Andi J. Tanra, Kang Sim, Gabor S. Ungvari, Qinge Zhang, Margarita Maria Maramis, Mian-Yoon Chong, Pichet Udomratn, Winston W. Shen, Norman Sartorius, Min Dong, Liang Nan Zeng, Kok Yoon Chee, Shu Yu Yang, Yu-Tao Xiang, Shigenobu Kanba, Ajit Avasthi, Sandeep Grover, Min Soo Lee, Helen F.K. Chiu, Roy Abraham Kallivayalil, and Chee H. Ng more...
- Subjects
education.field_of_study ,Pediatrics ,medicine.medical_specialty ,030214 geriatrics ,business.industry ,medicine.medical_treatment ,Population ,medicine.disease ,Logistic regression ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Schizophrenia ,Adjunctive treatment ,Medicine ,Major depressive disorder ,Anxiety ,Geriatrics and Gerontology ,medicine.symptom ,business ,Antipsychotic ,education ,Gerontology ,030217 neurology & neurosurgery ,Diagnosis of schizophrenia - Abstract
Aim Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods This is a secondary analysis of the database of a multicentre study which recorded participants' basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used. more...
- Published
- 2019
- Full Text
- View/download PDF
30. Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP study
- Author
-
Tian-Mei Si, Norman Sartorius, Helen F.K. Chiu, Andi J. Tanra, Shu Yu Yang, Samudra Kathiarachchi, Win Aung Myint, Tran Van Cuong, Shigenobu Kanba, Golam Rabbani, Adarsh Tripathi, Afzal Javed, Min Soo Lee, Mian-Yoon Chong, Pichet Udomratn, Kok Yoon Chee, Yong Chon Park, Chay Hoon Tan, Kang Sim, Naotaka Shinfuku, and Seon Cheol Park more...
- Subjects
Pharmacology ,business.industry ,Confounding ,lcsh:RM1-950 ,Pharmaceutical Science ,Context (language use) ,medicine.disease ,Logistic regression ,Article ,030227 psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Psychotropic drug ,Mood ,lcsh:Therapeutics. Pharmacology ,Schizophrenia ,medicine ,business ,Association (psychology) ,030217 neurology & neurosurgery ,Clinical psychology ,Diagnosis of schizophrenia - Abstract
Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P more...
- Published
- 2019
31. Thermal Deformation Behavior and Critical Conditions of Dynamic Recrystallization of QCr0.8 Alloy
- Author
-
Dong Mei Liu, Fang Liu, Guo Liang Xie, Shu Yu Yang, and Qiang Song Wang
- Subjects
Materials science ,Mechanics of Materials ,Mechanical Engineering ,Constitutive equation ,Alloy ,Thermal deformation ,engineering ,Dynamic recrystallization ,General Materials Science ,engineering.material ,Composite material ,Condensed Matter Physics ,Critical condition - Abstract
In this paper, the flow stresses, the constitutive equation, processing map and the critical conditions of dynamic recrystallization (DRX) of the hot forged QCr0.8 alloy are studied by hot compressive test in the 750-900°C temperature and 0.01-10s-1 strain rate ranges using Gleeble-1500D thermo-mechanical simulator. The compression reduction of thermal compression deformation is 50%. The results show that the thermal deformation temperatures and strain rates have a significant effect on the high temperature deformation behavior of the alloy. The higher the temperature, the smaller the strain rate and the easier the DRX of the alloy is found.The peak stresses of the alloy decreases with the increase of temperature and increases with the increase of the strain rates.The flow stresses during hot deformation can be described by a hyperbolic sine function. The activation energy Q of the thermal compression deformation is determined to be 370.8KJ/mol. The constitutive equation and processing map of the alloy are established. Critical strains of DRX εc are studied by the inflection point characteristic of the lnθ-ε curve of the alloy and the corresponding minimum value of the ∂θ (∂θ)/∂ε-ε curve. more...
- Published
- 2019
- Full Text
- View/download PDF
32. Patient- and clinic visit-related factors associated with potentially inappropriate medication use among older home healthcare service recipients.
- Author
-
Chirn-Bin Chang, Hsiu-Yun Lai, Shu-Yu Yang, Ru-Shu Wu, Hsing-Cheng Liu, Hsiu-Ying Hsu, Shinn-Jang Hwang, and Ding-Cheng Chan
- Subjects
Medicine ,Science - Abstract
OBJECTIVES: Taiwanese National Health Insurance (TNHI) provides home healthcare services to patients with skilled nursing needs who were homebound or lived in nursing homes. Studies on potentially inappropriate medications (PIMs) for older home healthcare service recipients (HHSRs) are growing, but comparisons among newer criteria of PIMs have not been applied. The aim of this study was to explore the prevalence and correlates of PIMs based on three different instruments published after 2010 among older HHSRs. MATERIALS AND METHODS: We performed cross-sectional analysis of the TNHI Research Database. A total of 25,187 HHSRs aged more than 65 years in 2009 were included. Medication lists independent of chronic conditions from the 2012 Beers criteria, PIM-Taiwan criteria, and the PRISCUS (Latin for "old and venerable") criteria were used. Analysis was performed separately at patient and clinic-visit level. T-tests, chi-square analysis, and multivariate logistic regressions were used where appropriate. RESULTS: The prevalence of having at least one PIM at patient and clinic-visit level was highest with the Beers (82.67%, 36.14% respectively), followed by the PRISCUS (68.49%, 25.13%) and PIM-Taiwan (63.04%, 19.21%) criteria. At patient level, polypharmacy (odds ratio (OR) 2.53 to 4.90), higher number of clinic (OR 1.15 to 1.41), hospital (OR 1.24 to 1.64), and physician (OR 1.15 to 1.41) visits were associated with PIM use for all 3 sets of criteria. At clinic-visit level, internist/family physicians (OR 1.26 to 1.72) and neurologists/psychiatrists (OR 1.73 to 5.87) were more likely to prescribe PIMs than others. Psychotropic drugs and first generation antihistamines accounted for most of the top ten PIMs. CONCLUSION: The prevalence of PIMs was high among older Taiwanese HHSRs. Polypharmacy and certain medical specialties were associated with a higher likelihood of PIM prescriptions. Provider education and medication review and reconciliation should be considered. more...
- Published
- 2014
- Full Text
- View/download PDF
33. The factor structure of extrapyramidal symptoms evaluated using the DIEPSS in patients with schizophrenia: results from the 2016 REAP AP-4 study
- Author
-
Shih-Ku Lin, Toshiya Inada, Roy Abraham Kallivayalil, Margarita Maria Maramis, Andi J. Tanra, Ajit Avasthi, Kok Yoon Chee, Sandeep Grover, Kang Sim, Norman Sartorius, Takahiro A. Kato, Chay Hoon Tan, Lian Yu Chen, Mian-Yoon Chong, Chika Kubota, Adarsh Tripathi, Seon Cheol Park, Isa Multazam Noor, Yu-Tao Xiang, Shu Yu Yang, and Naotaka Shinfuku more...
- Subjects
medicine.medical_specialty ,Text mining ,Extrapyramidal symptoms ,Schizophrenia ,business.industry ,medicine ,In patient ,medicine.symptom ,medicine.disease ,business ,Psychiatry ,Factor structure - Abstract
Drug-induced extrapyramidal syndrome (EPS) remains a major problem in clinical psychiatry. This study aimed to examine the factor structure of drug-induced extrapyramidal symptoms observed in patients with schizophrenia and assessed using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). The participants were 1,478 patients with a diagnosis of schizophrenia whose EPS was assessed using the DIEPSS in India, Indonesia, Japan, Malaysia, and Taiwan in the 2016 REAP AP-4 study. The records of the participants were randomly divided into two subgroups: the first for exploratory factor analysis of the eight DIEPSS items and the second for confirmatory factor analysis. The factor analysis identified three factors: F1 (sialorrhea, akathisia, dystonia, and dyskinesia), F2 (gait and bradykinesia), and F3 (muscle rigidity and tremor). The present results suggest that the eight individual items of the DIEPSS could be composed of three different mechanisms: central dopaminergic mechanisms with the pathophysiology other than acute parkinsonism (F1), acute parkinsonism observed during action (F2), and acute parkinsonism observed at rest (F3). more...
- Published
- 2021
- Full Text
- View/download PDF
34. Work-related musculoskeletal disorders among physical therapists in Taiwan
- Author
-
Chen-Yu Chen, Shiang-Ru Lu, Shu-Yu Yang, Fu-wen Liang, Jhi-Joung Wang, Chung-Han Ho, and Pei-Chi Hsiao
- Subjects
Adult ,Male ,Occupational Diseases ,Physical Therapists ,Taiwan ,Humans ,Female ,General Medicine ,Musculoskeletal Diseases ,Musculoskeletal System - Abstract
Work-related musculoskeletal disorders (WMSD) refer to musculoskeletal injuries caused by the occupation. Physical therapists (PTs) suffer from a high risk of WMSD despite their extensive knowledge in ergometrics and injury prevention. This study aims to discover the incidence and prevalence of WMSD among PTs using Taiwan's nationwide claims database. The trend of annual patients seeking rehabilitation and the prevalence of WMSD among PTs were presented. The age- and gender-specific incidence of WMSD were also calculated. The prevalence of WMSD in PTs varied from 6.1% to 75.2%, and the incidence ranged from 6.1 to 29.1 per 100 person-years during 1997 and 2012. For those aged ≤30 years, the incidence was higher in females than males (incidence rate ratio = 1.08, 95% confidence interval [CI]: 1.02-1.14, P = .011), whereas for those aged from 31 to40 years, females had lower incidence of WMSD than males (incidence rate ratio = 0.88, 95% CI: 0.80-0.96, P = .007). The patients/PTs ratio was higher (270.56-337.74) in 1998 and 2004 to 2007 and became stable (245.93-252.82) in 2008 to 2012, correlating with a rise in the WMSD prevalence in 1999 to 2007 and a steady prevalence after 2008 (63.5%-66.3%) in PTs. In conclusion, the risk of WMSD among PTs was positively correlated to the frequency of patients seeking rehabilitation service. In addition, age and gender were important risk factors for developing WMSD among PTs. more...
- Published
- 2021
35. Kaempferitrin-Treated HepG2 Differentially Expressed Exosomal Markers and Affect Extracellular Vesicle Sizes in the Secretome
- Author
-
Shu-Yu Yang, Badrinathan Sridharan, Jen-Ying Li, Meng-Jen Lee, Jiann-Yeu Chen, and Wei-Chi Ku
- Subjects
0301 basic medicine ,Proteomics ,HepG2 ,Cinnamomum osmophloeum ,lcsh:QR1-502 ,Exosomes ,Microscopy, Atomic Force ,Biochemistry ,Exosome ,lcsh:Microbiology ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Extracellular Vesicles ,0302 clinical medicine ,Extracellular ,Kaempferitrin ,exosome ,Humans ,atomic force microscopy (AFM) ,Kaempferols ,Medicine, Chinese Traditional ,Particle Size ,Databases, Protein ,Molecular Biology ,mass spectrometry ,Cinnamomum ,biology ,Chemistry ,Plant Extracts ,Vesicle ,Extracellular vesicle ,Hep G2 Cells ,biology.organism_classification ,Lipid Metabolism ,Plant Leaves ,030104 developmental biology ,Cell culture ,030220 oncology & carcinogenesis ,Culture Media, Conditioned ,Biomarkers ,Software - Abstract
Kaempferitrin is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum, which belongs to a group of plant species that comes under the genus Cinnamomum, well-known for its established anti-diabetic property in Chinese medicine. Oral administration of kaempferitrin and Cinnamomum osmophloeum extract reduced blood sugar in alloxan-induced diabetic rats and improved the lipid profile in hamsters respectively. In this paper we studied the differential protein expression profile using mass spectrometry approach in the kaempferitrin-treated conditioned medium of liver cancer cell line HepG2. We discovered that 33 genes were up/down-regulated consistently between two biological samples. A slightly different version of the analysis software selected 28 genes, and the final 18 genes that appeared in both lists were selected. Interestingly, 5 proteins out of 18 were either exosomal markers or reported in high frequency of occurrence in exosome/secreted vesicles. We also examined the extracellular particles with atomic force microscopy (AFM), which showed that the conditioned medium of kaempferitrin treated had larger vesicles and fewer small vesicles. Expression of some lipid-regulating genes were also altered. Our data suggested that extracellular vesicle secretions may be regulated by kaempferitrin, and regulation of lipid profile by kampeferitrin involves multiple mechanisms. more...
- Published
- 2021
36. Use of clozapine in older Asian patients with schizophrenia between 2001 and 2009.
- Author
-
Yu-Tao Xiang, Robert W Buchanan, Gabor S Ungvari, Helen F K Chiu, Kelly Y C Lai, You-Hong Li, Tian-Mei Si, Chuan-Yue Wang, Edwin H M Lee, Yan-Ling He, Shu-Yu Yang, Mian-Yoon Chong, Ee-Heok Kua, Senta Fujii, Kang Sim, Michael K H Yong, Jitendra K Trivedi, Eun-Kee Chung, Pichet Udomratn, Kok-Yoon Chee, Norman Sartorius, Chay-Hoon Tan, and Naotaka Shinfuku more...
- Subjects
Medicine ,Science - Abstract
BackgroundTo date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009.MethodInformation on 1,157 hospitalized patients with schizophrenia aged 50 or older in five East Asian countries and territories (China, Hong Kong, Korea, Singapore and Taiwan) was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) project. Socio-demographic and clinical characteristics and prescription of psychotropic medications were recorded.ResultsClozapine was prescribed for 20.6% of the pooled sample; 19.0% in 2001, 19.4% in 2004 and 22.9% in 2009. Multiple logistic regression analysis of the whole sample revealed that patients taking clozapine had a longer duration of illness, more negative symptoms and were less likely to receive first generation antipsychotic and anticholinergic drugs, but more likely to report weight gain compared to those not receiving clozapine. Compared to those in other sites, older patients in China were more likely to receive clozapine.ConclusionsThe prescription of clozapine for older Asian schizophrenia inpatients has remained at a stable level during the past decade. The appropriateness of use of clozapine in China needs to be further explored. more...
- Published
- 2013
- Full Text
- View/download PDF
37. Cardiac complications associated with short-term mortality in schizophrenia patients hospitalized for pneumonia: a nationwide case-control study.
- Author
-
Ya-Tang Liao, Shu-Yu Yang, Hsing-Cheng Liu, Wei J Chen, Chiao-Chicy Chen, Yen-Ni Hung, and Chian-Jue Kuo
- Subjects
Medicine ,Science - Abstract
BACKGROUND: Pneumonia is one of most prevalent infectious diseases worldwide and is associated with considerable mortality. In comparison to general population, schizophrenia patients hospitalized for pneumonia have poorer outcomes. We explored the risk factors of short-term mortality in this population because the information is lacking in the literature. METHODS: In a nationwide schizophrenia cohort, derived from the National Health Insurance Research Database in Taiwan, that was hospitalized for pneumonia between 2000 and 2008 (n = 1,741), we identified 141 subjects who died during their hospitalizations or shortly after their discharges. Based on risk-set sampling in a 1∶4 ratio, 468 matched controls were selected from the study cohort (i.e., schizophrenia cohort with pneumonia). Physical illnesses were categorized as pre-existing and incident illnesses that developed after pneumonia respectively. Exposures to medications were categorized by type, duration, and defined daily dose. We used stepwise conditional logistic regression to explore the risk factors for short-term mortality. RESULTS: Pre-existing arrhythmia was associated with short-term mortality (adjusted risk ratio [RR] = 4.99, p more...
- Published
- 2013
- Full Text
- View/download PDF
38. Effects of Water Extract of
- Author
-
Shu-Yu, Yang, Jen Ying, Li, Guan-Jhong, Huang, Badrinathan, Sridharan, Jen-Shu, Wang, Kai-Ming, Chang, and Meng-Jen, Lee
- Subjects
Research Article - Abstract
Cynanchum paniculatum (Bge.) Kitag. (CP) is an important medicinal herb used in Chinese herbal medicine, with a variety of biological activities including anticancer property. In this study, we explored the water extract of CP, for its anticancer effects against breast cancer cells with different mutation types. Cells were grouped as untreated (Control); CP direct treatment (dir-CP); Conditioned medium from CP treated (sup-CP), and untreated cells (sup-Control). Effects of dir-CP and sup-CP were compared to corresponding untreated cells on cytotoxicity, cell migration, and protein expression (cleaved caspase-3, caspase-9, and MMP-2 and 9). CP treatment showed time-dependent decrease in cell number of MDA-MB-231 and SK-Br-3 (both ER(−) PR(−)), while the decrease in cell number was not as significant in MCF-7 and ZR-75-1 cells (both ER(+) PR(+)). sup-CP treatment inhibited the cell migration of MDA-MB-231 and MCF-7 (Her2(−)) in a 24 h scratch assay. Our data suggested that ER(−) PR(−) cells are more sensitive to the CP in terms of direct cytotoxicity, which is not regulated by caspase-3. CP inhibited the migration of the two Her2(−) cells, and this correlated with MMP-2 regulation. The migration of ER(−) PR(−) cells was more sensitive to conditioned medium with CP treatment than to direct CP, and this is not regulated by MMP-2. Our data suggested that CP has anticancer potential on various breast cancer cells through different mechanisms and is specifically effective in inhibiting the migration of the triple negative MDA-MB-231. Our data provide insight into the mechanism of CP against breast cancer progression and would benefit the medical practitioners in better management with CP usage. more...
- Published
- 2020
39. Relationship Between Body Mass Index and Extrapyramidal Symptoms in Asian Patients with Schizophrenia: The Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP)
- Author
-
Seon-Cheol, Park, Adarsh, Tripathi, Ajit, Avasthi, Sandeep, Grover, Andi J, Tanra, Takahiro A, Kato, Toshiya, Inada, Kok Yoon, Chee, Mian-Yoon, Chong, Shu-Yu, Yang, Sih-Ku, Lin, Kang, Sim, Yu-Tao, Xiang, Afzal, Javed, Norman, Sartorius, Naotaka, Shinfuku, and Yong Chon, Park more...
- Subjects
medicine.medical_specialty ,Asia ,Overweight ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Extrapyramidal symptoms ,Thinness ,Classification of obesity ,Internal medicine ,medicine ,Humans ,antipsychotics ,Asian, body mass index (BMI) ,extrapyramidal symptoms (EPS) ,muscle rigidity ,schizophrenia ,business.industry ,Confounding ,nutritional and metabolic diseases ,General Medicine ,medicine.disease ,Obesity ,030227 psychiatry ,Psychiatry and Mental health ,Schizophrenia ,medicine.symptom ,Underweight ,business ,Body mass index ,Antipsychotic Agents - Abstract
Background Although an inverse relationship between body mass index (BMI) and Parkinson disease (PD) has been repeatedly reported, to our knowledge, the relationship between BMI and antipsychotic-induced extrapyramidal symptoms (EPS) has rarely been studied in patients with schizophrenia. Our study aimed to evaluate the relationship between BMI and EPS in patients with schizophrenia. Subjects and methods Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP) study, we compared the prevalence of EPS in 1448 schizophrenia patients stratified as underweight, normal range, overweight pre-obese, overweight obese I, overweight obese II, and overweight obese III according to the World Health Organization (WHO) classification system for body weight status, and with underweight, normal range, overweight at risk, overweight obese I, and overweight obese II according to the Asia-Pacific obesity classification. Results In the first step of the WHO classification system for body weight status, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with greater rates of bradykinesia and muscle rigidity, and a lower rate of gait disturbance. In the second step of the Asia-Pacific obesity classification, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with a higher rate of muscle rigidity. Conclusion Findings of the present study consistently revealed that underweight was associated with a greater rate of muscle rigidity in a stepwise pattern among Asian patients with schizophrenia. Although the mechanism underlying the inverse relationship between BMI and muscle rigidity cannot be sufficiently explained, it is speculated that low BMI may contribute to the development of muscle rigidity regardless of antipsychotic "typicality" and dose in patients with schizophrenia. more...
- Published
- 2020
40. Performance Study of RC Hollow Core Slab with Cracks Based on Extended Finite Element Method (XFEM)
- Author
-
Chao Ma, Zhao-Hua Yuan, Pei-Zhi Wang, and Shu-Yu Yang
- Subjects
Hollow core ,Materials science ,business.industry ,Slab ,Structural engineering ,business ,Extended finite element method - Published
- 2020
- Full Text
- View/download PDF
41. Effects of Kinect exergames on balance training among community older adults: A randomized controlled trial
- Author
-
Shu-Yu Yang, Jun Scott Chen Hsieh, Hao-Chiang Koong Lin, Chi-Min Yang, and Yi-Chen Chen
- Subjects
Male ,medicine.medical_specialty ,Blinding ,balance training ,Balance training ,law.invention ,exergames ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Randomized controlled trial ,law ,medicine ,Humans ,Single-Blind Method ,030212 general & internal medicine ,Dynamic balance ,Postural Balance ,older adults ,Balance (ability) ,Aged ,Kinect ,business.industry ,General Medicine ,Clinical Trial/Experimental Study ,Middle Aged ,Test (assessment) ,Exercise Therapy ,Treatment Outcome ,Balance performance ,Video Games ,030220 oncology & carcinogenesis ,Feasibility Studies ,Accidental Falls ,Female ,Independent Living ,business ,Independent living ,Research Article - Abstract
Background: Recent years have witnessed wide applications of exergames to balance training among the older adults. However, research concerning balance training with the use of Kinect for Xbox has remained scarce. While previous studies have shown the positive effects of exergames on improving balance and preventing falling among the older adults, there has been a paucity of empirical evidence supporting the superiority of Kinect exercise to conventional exercise over balance training among the older adults. Therefore, this study aimed to compare the feasibility, safety, and effectiveness of Kinect exercise against conventional exercise over balance training among the community older adults. Method: A total of 20 participants were randomly assigned to the Kinect Exercise Group (N = 10) or the Conventional Exercise Group (N = 10) for a 5-week balance training (45 minutes a time, 2 times a week). Assessor blinding was employed to assess the participants’ performance before and after the treatment, including 30-Second Chair Stand Test (30-sec CST), Timed Up and Go (TUG), Functional Reach Test (FRT), and One-Leg Stance Test (OLST) respectively with eyes open and closed. Subjective feeling of the intensity of pain and side effects were recorded throughout the investigation period. Nonparametric statistics was used for data analysis. Results: Within-group comparison between the pre-test and post-test indicated that significant differences existed in all of the 5 tests (30-sec CST, TUG, FRT, OLST with eyes open, and OLST with eyes closed) in the Kinect exercise group. To the Conventional exercise group, however, significant differences were only observed in 30-sec CST, FRT and OLST with eyes open. With regard to between-group comparison, significant differences were only found in FRT. Conclusion: Such results indicated that both treatments were helpful in improving the participants’ balance performance, that Kinect exercise was more effective in terms of overall balance ability, and that Kinect exercise was particularly beneficial to functional reach enhancement in comparison with traditional exercise. Kinect exercise could be a feasible, safe, and effective alternative for dynamic balance training among older adults. more...
- Published
- 2020
42. Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region
- Author
-
Mian-Yoon Chong, Shu Yu Yang, Ee Cheong Chua, Helen F.K. Chiu, Chay Hoon Tan, Adarsh Tripathi, Takahiro A. Kato, Qian Hui Chew, Wing Aung Myint, Van Cuong Tran, Seon Cheol Park, Norman Sartorius, Ross J. Baldessarini, Min Soo Lee, Pichet Udomratn, Yong Chon Park, Golam Rabbani, Kang Sim, Kim Viet Nguyen, Afzal Javed, Roy Abraham Kallivayalil, Shigenobu Kanba, Dulshika Waas, Naotaka Shinfuku, Yu-Tao Xiang, Kok Yoon Chee, Chao Tian Tang, Sandeep Grover, Andi J. Tanra, Shih Ku Lin, Tian-Mei Si, Yanling He, Samudra Kathiarachchi, and Ajit Avasthi more...
- Subjects
Adult ,Male ,medicine.medical_specialty ,viruses ,medicine.medical_treatment ,Drug Prescriptions ,Injections ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Internal medicine ,medicine ,Asian country ,Asia, Western ,Humans ,Medical prescription ,Antipsychotic ,Adverse effect ,Asia, Southeastern ,Aggression ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,030227 psychiatry ,Hospitalization ,Psychiatry and Mental health ,Long acting ,Schizophrenia ,Delayed-Action Preparations ,Female ,medicine.symptom ,business ,Psychosocial ,030217 neurology & neurosurgery ,Antipsychotic Agents - Abstract
Introduction Patterns of clinical use of long-acting injectable (LAI) antipsychotic drugs in many countries, especially in Asia, for treatment of patients diagnosed with chronic psychotic disorders including schizophrenia are not well established. Methods Within an extensive research consortium, we evaluated prescription rates for first- (FGA) and second-generation antipsychotic (SGA) LAI drugs and their clinical correlates among 3557 subjects diagnosed with schizophrenia across 15 Asian countries and region. Results Overall, an average of 17.9% (638/3557; range: 0.0%-44.9%) of treated subjects were prescribed LAI antipsychotics. Those given LAI vs orally administered agents were significantly older, had multiple hospitalizations, received multiple antipsychotics more often, at 32.4% higher doses, were more likely to manifest disorganized behavior or aggression, had somewhat superior psychosocial functioning and less negative symptoms, but were more likely to be hospitalized, with higher BMI, and more tremor. Being prescribed an FGA vs SGA LAI agent was associated with male sex, aggression, disorganization, hospitalization, multiple antipsychotics, higher doses, with similar risks of adverse neurological or metabolic effects. Rates of use of LAI antipsychotic drugs to treat patients diagnosed with schizophrenia varied by more than 40-fold among Asian countries and given to an average of 17.9% of treated schizophrenia patients. We identified the differences in the clinical profiles and treatment characteristics of patients who were receiving FGA-LAI and SGA-LAI medications. Discussion These findings behoove clinicians to be mindful when evaluating patients' need to be on LAI antipsychotics amidst multifaceted considerations, especially downstream adverse events such as metabolic and extrapyramidal side effects. more...
- Published
- 2020
43. The application of updating PIM-Taiwan criteria in clinic-visiting older patients with polypharmacy
- Author
-
Shinn Jang Hwang, Hsiu-Yun Lai, Ru-Shu Wu, Shu-Yu Yang, Hsing-Cheng Liu, Chirn-Bin Chang, and Ding-Cheng Chan
- Subjects
Polypharmacy ,medicine.medical_specialty ,business.industry ,Special Collection: The role of de-prescribing in polypharmacy and inappropriate medication use ,Potentially Inappropriate Medications ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,hemic and lymphatic diseases ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Multiple Chronic Conditions ,Intensive care medicine ,business ,030217 neurology & neurosurgery - Abstract
Background: PIM-Taiwan criteria were first established in 2010 for potentially inappropriate medications (PIMs). Currently, updating of PIM criteria is mandatory because of newly established evidence and newly developed medications. This study aims to evaluate the prevalence of PIM based on country-specific PIM criteria and factors associated with PIM use by applying 2010 version and newly updating PIM-Taiwan criteria in a cohort with polypharmacy. Methods: The baseline data of Medication Safety Review Clinic Taiwan (MSRC–Taiwan) study were used to investigate the prevalence of PIMs. Older patients (aged ⩾65 years) who were either having polypharmacy or visited ⩾3 different physicians were enrolled between August and October 2007. Bivariate analysis and multivariate logistic regressions were used to evaluate the factors associated with PIM use. Results: The prevalence of having at least one PIM was 46.1% for 2010 version and increased to 74.6% for 2018 version. The average number of PIMs generally to be avoided per patient also increased for 2018 version (0.2 versus 1.2, p < 0.0001). In contrast, the average number of PIMs considering chronic conditions per patient decreased (0.6 versus 0.3, p < 0.001). The associated chronic conditions of PIM users were distinct between 2010 and 2018 version. The major leading PIMs were benzodiazepines (BZDs) in both versions of criteria. Conclusions: As there were significant differences in medication lists between PIM-Taiwan version 2010 and 2018, the prevalence of PIM and factors associated with PIM users varied accordingly. Physicians should pay special attention before prescribing BZDs which keep being the major leading PIM. more...
- Published
- 2018
- Full Text
- View/download PDF
44. RELATIONSHIP BETWEEN BODY MASS INDEX AND EXTRAPYRAMIDAL SYMPTOMS IN ASIAN PATIENTS WITH SCHIZOPHRENIA: THE RESEARCH ON ASIAN PSYCHOTROPIC PRESCRIPTION PATTERNS FOR ANTIPSYCHOTICS (REAP-AP)
- Author
-
Seon-Cheol Park, Adarsh Tripathi, Ajit Avasthi, Sandeep Grover, Andi J. Tanra, Takahiro A. Kato, Toshiya Inada, Kok Yoon Chee, Mian-Yoon Chong, Shu-Yu Yang, Sih-Ku Lin, Kang Sim, Yu-Tao Xiang, Afzal Javed, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park, Seon-Cheol Park, Adarsh Tripathi, Ajit Avasthi, Sandeep Grover, Andi J. Tanra, Takahiro A. Kato, Toshiya Inada, Kok Yoon Chee, Mian-Yoon Chong, Shu-Yu Yang, Sih-Ku Lin, Kang Sim, Yu-Tao Xiang, Afzal Javed, Norman Sartorius, Naotaka Shinfuku, and Yong Chon Park more...
- Abstract
Background: Although an inverse relationship between body mass index (BMI) and Parkinson disease (PD) has been repeatedly reported, to our knowledge, the relationship between BMI and antipsychotic-induced extrapyramidal symptoms (EPS) has rarely been studied in patients with schizophrenia. Our study aimed to evaluate the relationship between BMI and EPS in patients with schizophrenia. Subjects and methods: Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP) study, we compared the prevalence of EPS in 1448 schizophrenia patients stratified as underweight, normal range, overweight preobese, overweight obese I, overweight obese II, and overweight obese III according to the World Health Organization (WHO) classification system for body weight status, and with underweight, normal range, overweight at risk, overweight obese I, and overweight obese II according to the Asia-Pacific obesity classification. Results: In the first step of the WHO classification system for body weight status, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with greater rates of bradykinesia and muscle rigidity, and a lower rate of gait disturbance. In the second step of the Asia-Pacific obesity classification, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with a higher rate of muscle rigidity. Conclusion: Findings of the present study consistently revealed that underweight was associated with a greater rate of muscle rigidity in a stepwise pattern among Asian patients with schizophrenia. Although the mechanism underlying the inverse relationship between BMI and muscle rigidity cannot be sufficiently explained, it is speculated that low BMI may contribute to the development of muscle rigidity regardless of antipsychotic "typicality more...
- Published
- 2020
45. Prescription of potentially inappropriate medication to older patients presenting to the emergency department: a nationally representative population study
- Author
-
Shu-Yu Yang, Ding-Cheng Chan, Hsiu-Yun Lai, Chirn-Bin Chang, Shinn Jang Hwang, Hsing-Cheng Liu, and Ru-Shu Wu
- Subjects
Male ,medicine.medical_specialty ,Databases, Factual ,Taiwan ,Beers Criteria ,lcsh:Medicine ,Inappropriate Prescribing ,030226 pharmacology & pharmacy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,Patient age ,hemic and lymphatic diseases ,Health care ,medicine ,Humans ,Medical prescription ,lcsh:Science ,Potentially Inappropriate Medication List ,Aged ,Aged, 80 and over ,Multidisciplinary ,business.industry ,lcsh:R ,030208 emergency & critical care medicine ,Emergency department ,Cross-Sectional Studies ,National health insurance ,Family medicine ,Population study ,Female ,lcsh:Q ,Emergency Service, Hospital ,business - Abstract
Potentially inappropriate medication (PIM) was associated with adverse clinical outcomes and higher healthcare resource utilization among older patients. In order to investigate the prevalence of PIM use based on three different sets of criteria and their associated factors among older patients in the emergency department (ED) in Taiwan. The National Health Insurance Research Database was used for this cross-sectional study. Older patients who visited the ED at least once in 2009 were enrolled. PIMs were identified based on the Beers Criteria, PIM-Taiwan criteria, and PRISCUS criteria. Average patient age was 76.7 ± 7.4 years and patients visited the ED 1.8 ± 2.1 times in 2009. The prevalence and frequency of being prescribed at least one PIM at each visit were high according to all three sets of criteria. Performance of the PIM-Taiwan criteria was only inferior to that of the Beers Criteria. The most important factor associated with PIM was the number of medications prescribed in the ED, and PIM use was associated with higher annual health resource utilization in the ED. PIM use was a significant issue and was associated with higher annual emergency care resource utilization in the ED. more...
- Published
- 2018
- Full Text
- View/download PDF
46. Physical comorbidities in older adults receiving antidepressants in Asia
- Author
-
Winston W. Shen, Rathi Mahendran, Chay Hoon Tan, Pichet Udomratn, Kang Sim, Sandeep Grover, Min Dong, Xiao Mei Zhong, Fei Wang, Shu Yu Yang, Ajit Avasthi, Tian-Mei Si, Helen F.K. Chiu, Qinge Zhang, Gabor S. Ungvari, Mian-Yoon Chong, Andi J. Tanra, Shigenobu Kanba, Yu-Tao Xiang, Norman Sartorius, Naotaka Shinfuku, Min Soo Lee, Roy Abraham Kallivayalil, Chee H. Ng, Margarita Maria Maramis, and Kok Yoon Chee more...
- Subjects
medicine.medical_specialty ,030214 geriatrics ,business.industry ,medicine.disease ,Comorbidity ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Mood ,Quality of life ,Mood disorders ,Internal medicine ,Cohort ,medicine ,Psychiatric hospital ,Anxiety ,030212 general & internal medicine ,Bipolar disorder ,Geriatrics and Gerontology ,medicine.symptom ,business ,Gerontology - Abstract
BACKGROUND The present study explored the patterns of physical comorbidities and their associated demographic and clinical factors in older psychiatric patients prescribed with antidepressants in Asia. METHODS Demographic and clinical information of 955 older adults were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Standardized data collection procedure was used to record demographic and clinical data. RESULTS Proportion of physical comorbidities in this cohort was 44%. Multiple logistic regression analyses showed that older age (OR = 1.7, P more...
- Published
- 2018
- Full Text
- View/download PDF
47. Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade
- Author
-
Qi-Cong Luo, Chengfu Cai, Mao-Li Chen, Wang-Yu Cai, Yanjun Mi, Guo-Dong Ye, Dong-Yan Shen, Chen Xinxin, Han Daxiong, Wei Zhang, and Shu-Yu Yang
- Subjects
0301 basic medicine ,Cancer Research ,Pyruvate dehydrogenase kinase ,Protein Serine-Threonine Kinases ,LIN28 ,lcsh:RC254-282 ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Wnt/β-Catenin signaling ,Cell Line, Tumor ,otorhinolaryngologic diseases ,medicine ,Nasopharyngeal carcinoma ,Animals ,Humans ,beta Catenin ,Cell Proliferation ,Chemistry ,Cell growth ,Research ,Wnt signaling pathway ,Nuclear Proteins ,Pyruvate Dehydrogenase Acetyl-Transferring Kinase ,RNA-Binding Proteins ,Chibby ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Warburg effect ,Immunohistochemistry ,Aerobiosis ,Wnt Proteins ,Disease Models, Animal ,MicroRNAs ,030104 developmental biology ,Oncology ,Anaerobic glycolysis ,030220 oncology & carcinogenesis ,Catenin ,Cancer research ,Heterografts ,Female ,Carrier Proteins ,Glycolysis ,Protein Binding ,Signal Transduction - Abstract
Background Great progress has been achieved in the study of the aerobic glycolysis or the so-called Warburg effect in a variety of cancers; however, the regulation of the Warburg effect in Nasopharyngeal carcinoma (NPC) has not been completely defined. Methods Gene expression pattern of NPC cells were used to test associations between Chibby and β-catenin expression. Chibby siRNAs and over-expression vector were transfected into NPC cells to down-regulate or up-regulate Chibby expression. Loss- and gain-of function assays were performed to investigate the role of Chibby in NPC cells. Western blot, cell proliferation, Glucose uptake, Lactate release, ATP level, and O2 consumption assays were used to determine the mechanism of Chibby regulation of underlying targets. Finally, immunohistochemistry assay of fresh NPC and nasopharyngeal normal tissue sample were used to detect the expression of Chibby, β-Catenin, and PDK1 by immunostaining. Results We observed that Chibby, a β-catenin-associated antagonist, is down-regulated in nasopharyngeal carcinoma cell lines and inhibits Wnt/β-Catenin signaling induced Warburg effect. Mechanism study revealed that Chibby regulates aerobic glycolysis in NPC cells through pyruvate dehydrogenase kinase 1(PDK1), an important enzyme involved in glucose metabolism. Moreover, Chibby suppresses aerobic glycolysis of NPC via Wnt/β-Catenin-Lin28/let7-PDK1 cascade. Chibby and PDK1 are critical for Wnt/β-Catenin signaling induced NPC cell proliferation both in vitro and in vivo. Finally, immunostaining assay of tissue samples provides an important clinical relevance among Chibby, Wnt/β-Catenin signaling and PDK1. Conclusions Our study reveals an association between Chibby expression and cancer aerobic glycolysis, which highlights the importance of Wnt/β-catenin pathway in regulation of energy metabolism of NPC. These results indicate that Chibby and PDK1 are the potential target for NPC treatment. Electronic supplementary material The online version of this article (10.1186/s13046-018-0769-4) contains supplementary material, which is available to authorized users. more...
- Published
- 2018
- Full Text
- View/download PDF
48. Diagnostic consistency and interchangeability of schizophrenic disorders and bipolar disorders: A 7-year follow-up study
- Author
-
Shih Ku Lin, Shu Yu Yang, Chian Jue Kuo, and Yen Ni Hung
- Subjects
Psychosis ,Pediatrics ,medicine.medical_specialty ,Population ,Schizoaffective disorder ,03 medical and health sciences ,0302 clinical medicine ,Consistency (negotiation) ,medicine ,Bipolar disorder ,Medical diagnosis ,education ,Schizophrenic disorders ,education.field_of_study ,business.industry ,General Neuroscience ,General Medicine ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Neurology ,Cohort ,sense organs ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
AIM The change in psychiatric diagnoses in clinical practice is not an unusual phenomenon. The interchange between the diagnoses of schizophrenic disorders and bipolar disorders is a major clinical issue because of the differences in treatment regimens and long-term prognoses. In this study, we used a nationwide population-based sample to compare the diagnostic consistency and interchange rate between schizophrenic disorders and bipolar disorders. METHODS In total, 25 711 and 11 261 patients newly diagnosed as having schizophrenic disorder and bipolar disorder, respectively, were retrospectively enrolled from the Psychiatric Inpatient Medical Claims database between 2001 and 2005. We followed these two cohorts for 7 years to determine whether their diagnoses were consistent throughout subsequent hospitalizations. The interchange between the two diagnoses was analyzed. RESULTS In the schizophrenic disorder cohort, the overall diagnostic consistency rate was 87.3% and the rate of change to bipolar disorder was 3.0% during the 7-year follow-up. Additional analyses of subtypes revealed that the change rate from schizoaffective disorder to bipolar disorder was 12.0%. In the bipolar disorder cohort, the overall diagnostic consistency rate was 71.9% and the rate of change to schizophrenic disorder was 8.3%. CONCLUSION Changes in the diagnosis of a major psychosis are not uncommon. The interchange between the diagnoses of schizophrenic disorders and bipolar disorders might be attributed to the evolution of clinical symptoms and the observation of preserved social functions that contradict the original diagnosis. While making a psychotic diagnosis, clinicians should be aware of the possibility of the change in diagnosis in the future. more...
- Published
- 2018
- Full Text
- View/download PDF
49. Excess incidence and risk factors for recurrent pneumonia in bipolar disorder
- Author
-
Galen Chin-Lun Hung, Ya Tang Liao, Chian Jue Kuo, Min Shan Li, Shu Yu Yang, Chiao Chicy Chen, Shang Ying Tsai, and Chun Hung Pan
- Subjects
medicine.medical_specialty ,Population ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,030212 general & internal medicine ,Bipolar disorder ,education ,Asthma ,education.field_of_study ,business.industry ,General Neuroscience ,Incidence (epidemiology) ,General Medicine ,medicine.disease ,respiratory tract diseases ,Psychiatry and Mental health ,Pneumonia ,030228 respiratory system ,Neurology ,Concomitant ,Cohort ,Neurology (clinical) ,business - Abstract
Aim Patients with bipolar disorder (BD) tend to have poorer outcomes after pneumonia and could have a higher risk for recurrence of pneumonia. We aimed to investigate the incidence and risk factors of recurrent pneumonia in patients with BD. Methods In a nationwide cohort of BD patients (derived from the National Health Insurance Research Database in Taiwan) who were hospitalized for pneumonia between 1996 and 2012, we identified 188 patients who developed recurrent pneumonia after a baseline pneumonia episode. Applying risk-set sampling at a 1:2 ratio, 353 matched controls were selected from the study cohort. We used multivariate conditional logistic regression analysis to explore the association between recurrent pneumonia and physical illness, concomitant medications, and psychotropic drugs. Results The findings showed that the incidence of recurrent pneumonia in BD was 6.60 cases per 100 person-years, which was higher than that in the general population. About 10% (9.24%) of cases with recurrent pneumonia died within 30 days of hospitalization. Patients had increased risk of recurrent pneumonia if they had hypertension, diabetes mellitus, cancer, or asthma. Conversely, psychotropic drugs, both first- and second-generation antipsychotics, which are known to increase susceptibility to baseline pneumonia, were not associated with risk of pneumonia recurrence. Conclusion We found an excess incidence of recurring pneumonia in patients with BD, and this risk was associated with pre-existing medical conditions but not psychotropic agents. Physicians should carefully consider the comorbid medical conditions of patients with BD that could lead to recurrent pneumonia. more...
- Published
- 2018
- Full Text
- View/download PDF
50. More than Half of Patients with Schizophrenia Are Receiving Polypharmacy and Co-Prescription of Anxiolytics in Pakistan —Findings from Research on Asian Prescription Pattern in 2016
- Author
-
Mazhar Malik, Masaki Shinfuku, Shu Yu Yang, Mian-Yoon Chong, Munir Hamirani, Usman Ghani, Shih-Ku Lin, Winston W. Shen, Naotaka Shinfuku, Sandeep Grover, Liang-Yu Chen, Nasar Sayeed Kahn, Afzal Javed, Norman Sartorius, Nargis Munir, Chay Hoon Tan, and Nariman Awais more...
- Subjects
Polypharmacy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Guideline ,medicine.disease ,Psychotropic drug ,Mood ,Pharmacotherapy ,Schizophrenia ,Family medicine ,medicine ,Medical prescription ,business ,Antipsychotic - Abstract
Objective: Little is known about the prescription pattern of psychotropic drugs for patients with schizophrenia in Pakistan. The purpose of this study was to evaluate the characteristic features of psychotropic drug prescriptions for patients with schizophrenia in Pakistan. Methods: Three centers in Pakistan participated in a large scale collaborative study known as Research on Asian Prescription Pattern (REAP). The 2016 REAP survey included centers from 15 countries in Asia and used a unified research protocol. The design of the study was quantitative and of descriptive epidemiology. Analysis was made on the data collected from three centers i.e., Lahore, Karachi and Islamabad. The data collected in Pakistan were compared with those from other Asian countries. The details of REAP were presented on the homepage of REAP (http://www.REAP.Asia). Results: From Pakistan, 298 patients were included. Patients with schizophrenia in Pakistan received higher rate of antipsychotic polypharmacy and a higher rate of co-prescription of mood stabilizers and anxiolytics when compared with participants from other South Asian countries (India and Bangladesh). Conclusion: The main findings of the study were that a majority of the patients were prescribed antipsychotic polypharmacy drugs in Pakistan. Insufficient training on the use of psychotropic drugs and a lack of treatment guideline are considered to be the major contributing factors. Further education and training on the proper use of psychotropic drugs are recommended to psychiatrists in Pakistan. The guidelines on pharmacotherapy for patients with schizophrenia should also be developed and promoted in Pakistan. more...
- Published
- 2018
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.