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3. Clinical Characteristics of Children Infected with SARS-CoV-2 Omicron (B.1.1.529) in China’s Shanghai

Author

Shu,Jiaping, Jia,Lili, Zhang,Pei, Wang,Ren, Wang,Meiqiu, Sun,Xiaoyi, Peng,Yingchao, Wang,Peipei, Li,Xiaojie, Tang,Zilu, Han,Tingting, Ju,Tao, Wei,Yaqin, Pang,Wei, Gao,Chunlin, Xia,Zhengkun, Shu,Jiaping, Jia,Lili, Zhang,Pei, Wang,Ren, Wang,Meiqiu, Sun,Xiaoyi, Peng,Yingchao, Wang,Peipei, Li,Xiaojie, Tang,Zilu, Han,Tingting, Ju,Tao, Wei,Yaqin, Pang,Wei, Gao,Chunlin, and Xia,Zhengkun

Abstract

Jiaping Shu,1,* Lili Jia,2,* Pei Zhang,2 Ren Wang,2 Meiqiu Wang,2 Xiaoyi Sun,2 Yingchao Peng,2 Peipei Wang,2 Xiaojie Li,2 Zilu Tang,3 Tingting Han,3 Tao Ju,3 Yaqin Wei,4 Wei Pang,5 Chunlin Gao,2 Zhengkun Xia1 1Department of Pediatrics, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China; 2Department of Pediatrics, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, 210093, People’s Republic of China; 3Department of Pediatrics, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210093, People’s Republic of China; 4Department of Pediatrics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510000, People’s Republic of China; 5Department of Military Information, Chinese People’s Liberation Army 31102, Nanjing, Jiangsu, 210000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengkun Xia, Department of Pediatrics, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China, Email njxzk@126.com Chunlin Gao, Department of Pediatrics, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, 210093, People’s Republic of China, Email shuangmu34@163.comIntroduction: The pandemic of SARS-CoV-2 brings great challenge and threats to humans worldwide. Multiple variants of SARS-CoV-2 tend to be epidemic, among which Omicron is highly infectious within China. The aim of this study was to analyze the clinical characteristics of children infected with SARS-CoV-2 variant B.1.1.529 (Omicron) in the Shanghai, China.Methods: We included 9378 pediatric patients diagnosed with Omicron and treated in the Shanghai International Convention and Exhibition Center between April 1, 2022 and May 31, 2022. We recorded and summarized the clinical characteristics, infectious conditions and biological features of the children infected with Omicron.Results: A total of 9355

Published
2024

4. Clinical Characteristics of Children Infected with SARS-CoV-2 Omicron (B.1.1.529) in China’s Shanghai

Author

Shu, Jiaping, primary, Jia, Lili, additional, Zhang, Pei, additional, Wang, Ren, additional, Wang, Meiqiu, additional, Sun, Xiaoyi, additional, Peng, Yingchao, additional, Wang, Peipei, additional, Li, Xiaojie, additional, Tang, Zilu, additional, Han, Tingting, additional, Ju, Tao, additional, Wei, Yaqin, additional, Pang, Wei, additional, Gao, Chunlin, additional, and Xia, Zhengkun, additional

Published
2024
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6. Changes in circMyt1l/rno-let-7d-5p/brain-derived neurotrophic factor. A damaged periventricular white matter damage model in neonatal rats.

Author

Zhu, Lihua, Han, Yiwen, and Shu, Jiaping

Subjects
NERVE growth factor, BRAIN, ANIMAL experimentation, CEREBRAL anoxia-ischemia, GENE expression, WHITE matter (Nerve tissue), RATS, BIOINFORMATICS, DESCRIPTIVE statistics, ANIMALS
Abstract

To investigate the function of circMyt1l/rno-let-7d-5p/BDNF in the white matter damage of premature rats. Bioinformatic analysis was used to analyze the differential expression of circMyt1l and its interacting miRNAs and mRNAs in rats with periventricular white matter damage. Rats at postnatal day 3 had their right common carotid artery permanently ligated, and were then exposed for 2 h to 6 % O2, or sham surgery and exposure to normal O2 levels (sham). CircMyt1l and rno-let-7d-5p expression was detected and BDNF protein levels were analyzed at 24, 48, and 72 h post hypoxia–ischemia. Bioinformatic analysis suggested that circMyt1l, rno-let-7d-5p and BDNF interact. CircMyt1l expression decreased significantly relative to the sham-operated rats (p<0.01) in an exposure time-dependent manner. Contrastingly, rno-let-7d-5p increased significantly relative to the sham-operated rats (p<0.01) in an exposure time dependent manner. BDNF protein levels decreased significantly relative to the sham-operated rats (p<0.05) in an exposure time dependent manner. The expression levels of circMyt1l/rno-let-7d-5p/BDNF are interrelated in periventricular white matter damage. Decreased circMyt1l expression of promoted the effect of rno-let-7d-5p and decreased the level of its target, BDNF. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Glomerular capillary C3 deposition as a risk factor for unfavorable renal outcome in pediatric primary focal segmental glomerular sclerosis

Author

Peng, Yingchao, primary, Li, Banghai, additional, Li, Xiaojie, additional, Ju, Tao, additional, Zhang, Zhiqiang, additional, Wang, Peipei, additional, Sun, Tao, additional, Shu, Jiaping, additional, Wang, Meiqiu, additional, Sun, Xiaoyi, additional, Chen, Huangyu, additional, Gao, Chunlin, additional, and Xia, Zhengkun, additional

Published
2023
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11. Changes in circMyt1l/rno-let-7d-5p/brain-derived neurotrophic factor. A damaged periventricular white matter damage model in neonatal rats.

Author

Zhu L, Han Y, and Shu J

Subjects
Rats, Animals, Animals, Newborn, Brain-Derived Neurotrophic Factor metabolism, White Matter diagnostic imaging, White Matter metabolism, MicroRNAs metabolism
Abstract

Objectives: To investigate the function of circMyt1l/rno-let-7d-5p/BDNF in the white matter damage of premature rats., Methods: Bioinformatic analysis was used to analyze the differential expression of circMyt1l and its interacting miRNAs and mRNAs in rats with periventricular white matter damage. Rats at postnatal day 3 had their right common carotid artery permanently ligated, and were then exposed for 2 h to 6 % O 2 , or sham surgery and exposure to normal O 2 levels (sham). CircMyt1l and rno-let-7d-5p expression was detected and BDNF protein levels were analyzed at 24, 48, and 72 h post hypoxia-ischemia., Results: Bioinformatic analysis suggested that circMyt1l, rno-let-7d-5p and BDNF interact. CircMyt1l expression decreased significantly relative to the sham-operated rats (p<0.01) in an exposure time-dependent manner. Contrastingly, rno-let-7d-5p increased significantly relative to the sham-operated rats (p<0.01) in an exposure time dependent manner. BDNF protein levels decreased significantly relative to the sham-operated rats (p<0.05) in an exposure time dependent manner., Conclusions: The expression levels of circMyt1l/rno-let-7d-5p/BDNF are interrelated in periventricular white matter damage. Decreased circMyt1l expression of promoted the effect of rno-let-7d-5p and decreased the level of its target, BDNF., (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)

Published
2023
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