Author: "Shtukaturov MIu" - Searchworks@Jio Institute Digital Library Search Results

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Author: Og, Ogloblina, La, Belova, Vladimir Malakhov, Shtukaturov MIu, and Ei, Brekhov
Subjects: Hemoperfusion, Dogs, Pancreatic Elastase, Pancreatitis, Acute Disease, Animals, Chymotrypsin, Trypsin
Abstract: An effective method of plasma proteinases (trypsin, chymotrypsin. elastases) removal in dogs with acute pancreatitis has been suggested. The method is based on plasmasorption, using human urine acid-stable proteinase inhibitor immobilized on sepharose. The procedure of plasmasorption reduces proteinase levels in dogs with acute pancreatitis to 35-70%, with the animal life-span prolonged 8-fold.

Author: La, Belova, Gv, Privalov, Ge, Bazhenova, Shtukaturov MIu, Vv, Makarovskiĭ, Ei, Brekhov, Vladimir Malakhov, and Og, Ogloblina
Subjects: Male, Dogs, Pancreatitis, Acute Disease, Animals, Female, Protease Inhibitors
Abstract: Changes of proteinase-inhibitory system values in blood plasma of dogs with experimental acute pancreatitis (EAP) were studied in dynamics. Their diagnostic and prognostic values was appraised. Essential shifts were revealed in the proteinase-inhibitory balance in blood plasma of dogs with EAP of various severity. The concentration of trypsin- and chymotrypsin-like proteinases exceeded the normal values 1.8-3.3 times in these animals. Coefficients expressing the relation of antitryptic and antichymotryptic activities to the activities of the corresponding proteinases in the blood plasma of animals with EAP were indicative of diminished blood plasma inhibitory potential as compared to that in intact animals. The authors are the first to show the diagnostic and prognostic value of the antichymotryptic activity/chymotrypsin in blood plasma of dogs with EAP.

Author: Belova LA, Privalov GV, Bazhenova GE, Shtukaturov MIu, Makarovskiĭ VV, Brekhov EI, Malakhov VN, and Ogloblina OG
Subjects: Acute Disease, Animals, Dogs, Female, Male, Pancreatitis blood, Protease Inhibitors blood
Abstract: Changes of proteinase-inhibitory system values in blood plasma of dogs with experimental acute pancreatitis (EAP) were studied in dynamics. Their diagnostic and prognostic values was appraised. Essential shifts were revealed in the proteinase-inhibitory balance in blood plasma of dogs with EAP of various severity. The concentration of trypsin- and chymotrypsin-like proteinases exceeded the normal values 1.8-3.3 times in these animals. Coefficients expressing the relation of antitryptic and antichymotryptic activities to the activities of the corresponding proteinases in the blood plasma of animals with EAP were indicative of diminished blood plasma inhibitory potential as compared to that in intact animals. The authors are the first to show the diagnostic and prognostic value of the antichymotryptic activity/chymotrypsin in blood plasma of dogs with EAP.
Published: 1991

Author: Ogloblina OG, Belova LA, Malakhov VN, Shtukaturov MIu, and Brekhov EI
Subjects: Acute Disease, Animals, Chymotrypsin blood, Dogs, Pancreatic Elastase blood, Pancreatitis blood, Trypsin blood, Hemoperfusion methods, Pancreatitis therapy
Abstract: An effective method of plasma proteinases (trypsin, chymotrypsin. elastases) removal in dogs with acute pancreatitis has been suggested. The method is based on plasmasorption, using human urine acid-stable proteinase inhibitor immobilized on sepharose. The procedure of plasmasorption reduces proteinase levels in dogs with acute pancreatitis to 35-70%, with the animal life-span prolonged 8-fold.
Published: 1988

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