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5 results on '"Shota Tanase"'

1. Effects of galantamine on social interaction impairments in cholecystokinin receptor-2 overexpression mice

Author

Shota Tanase, Takayoshi Mamiya, Shogo Nagata, Yusuke Ikawa, Ya-Ping Tang, Masayuki Hiramatsu, and Toshitaka Nabeshima

Subjects
Galantamine, Social interaction, Cholecystokinin receptor transgenic mice, Therapeutics. Pharmacology, RM1-950
Abstract

We examined whether galantamine (GAL), a cholinesterase inhibitor and allosteric potentiating ligand for α7 nicotinic acetylcholine receptor (nAChR), had an impact on emotional abnormalities in forebrain-specific cholecystokinin receptor-2 overexpressed transgenic mice. Treatment with GAL (1 mg/kg, s.c.) attenuated the decrease of social interaction time, but failed to attenuate anxiety-like behavior in the elevated plus-maze test. The effect of GAL was blocked by an α7 nAChR antagonist, methyllycaconitine (3 mg/kg, i.p.). These results suggest that GAL improved social interaction impairments via α7 nAChR and could be useful to treat sociability-related emotional abnormalities.

Published
2022
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2. Effects of galantamine on social interaction impairments in cholecystokinin receptor-2 overexpression mice

Author

Shota Tanase, Takayoshi Mamiya, Shogo Nagata, Yusuke Ikawa, Ya-Ping Tang, Masayuki Hiramatsu, and Toshitaka Nabeshima

Subjects
Pharmacology, Mice, alpha7 Nicotinic Acetylcholine Receptor, Galantamine, Social Interaction, Molecular Medicine, Animals, Social Behavior Disorders, Cholinesterase Inhibitors, Receptor, Cholecystokinin B
Abstract

We examined whether galantamine (GAL), a cholinesterase inhibitor and allosteric potentiating ligand for α7 nicotinic acetylcholine receptor (nAChR), had an impact on emotional abnormalities in forebrain-specific cholecystokinin receptor-2 overexpressed transgenic mice. Treatment with GAL (1 mg/kg, s.c.) attenuated the decrease of social interaction time, but failed to attenuate anxiety-like behavior in the elevated plus-maze test. The effect of GAL was blocked by an α7 nAChR antagonist, methyllycaconitine (3 mg/kg, i.p.). These results suggest that GAL improved social interaction impairments via α7 nAChR and could be useful to treat sociability-related emotional abnormalities.

Published
2021

5. PT563. Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex

Author

Kiyofumi Yamada, Toshitaka Nabeshima, Yuka Soh, Eriko Ueda, Nami Sakakibara, Masayuki Hiramatsu, Taku Nagai, Yuki Aoyama, Akihiro Mouri, Kazuya Toriumi, Takayoshi Mamiya, Tomoya Hattori, Hyoung-Chun Kim, Akane Shimato, and Shota Tanase

Subjects
Pharmacology, Tuesday Abstracts, Prenatal nicotine, business.industry, 03 medical and health sciences, Psychiatry and Mental health, Glutamatergic, Abstracts, 0302 clinical medicine, Text mining, 030228 respiratory system, Medicine, Pharmacology (medical), Progenitor cell, Prefrontal cortex, business, Neuroscience, 030217 neurology & neurosurgery
Published
2016

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