Ray, Patrick, Arthaud, Martine, Lefort, Yannick, Birolleau, Sophie, Beigelman, Catherine, and Riou, Bruno
Byline: Patrick Ray (1), Martine Arthaud (2), Yannick Lefort (3), Sophie Birolleau (3), Catherine Beigelman (4), Bruno Riou (1) Keywords: Acute dyspnea; Elderly patients; Emergency department; Cardiogenic pulmonary edema; B-type natriuretic peptide Abstract: Objective Differentiating cardiogenic pulmonary edema (CPE) from respiratory causes of dyspnea is particularly difficult in elderly patients. The aim of our study was to evaluate B-type natriuretic peptide (BNP) in patients older than 65 years presenting with acute dyspnea. Design Prospective study. Setting Medical emergency department of a 2000-bed urban teaching hospital. Patients Patients aged over 65 years presenting with acute dyspnea and a respiratory rate more than 25/min or a PaO.sub.2 below 70 mmHg, Sp[O.sub.2 ]less than 92%, PaCO.sub.2 higher than 45 mmHg with pH less than 7.35, were included. BNP levels, measured blind at admission were compared with the final diagnosis (CPE or no CPE) as defined by experts. Intervention None. Measurements and results Three hundred eight patients (mean age of 80 years) were enrolled in the study. The median BNP was 575 pg/ml [95% confidence interval (CI): 410--898] in the CPE group (n=141) versus 75 pg/ml (95% CI: 59--98) in the no CPE group (n=167) (p Conclusion Analysis of BNP is useful in elderly patients with acute dyspnea, but the threshold value is higher than that previously determined. Author Affiliation: (1) Department of Emergency Medicine and Surgery, Centre Hospitalo-Universitaire (CHU) Pitie-Salpetriere Hospital, Assistance-Publique Hopitaux de Paris (AP-HP), Universite Pierre et Marie Curie, 47 boulevard de l'Hopital, 75013, Paris, France (2) Laboratory of Emergency Biology, Centre Hospitalo-Universitaire (CHU) Pitie-Salpetriere Hospital, Assistance-Publique Hopitaux de Paris (AP-HP), Universite Pierre et Marie Curie, 47 boulevard de l'Hopital, 75013, Paris, France (3) Department of Pneumology, Centre Hospitalo-Universitaire (CHU) Pitie-Salpetriere Hospital, Assistance-Publique Hopitaux de Paris (AP-HP), Universite Pierre et Marie Curie, 47 boulevard de l'Hopital, 75013, Paris, France (4) Department of Radiology, Centre Hospitalo-Universitaire (CHU) Pitie-Salpetriere Hospital, Assistance-Publique Hopitaux de Paris (AP-HP), Universite Pierre et Marie Curie, 47 Boulevard de l'Hopital, 75013, Paris, France Article History: Registration Date: 24/09/2004 Received Date: 07/12/2003 Accepted Date: 15/09/2004 Online Date: 22/10/2004 Article note: Presented, in part, at the 30th annual congress of the Societe de Reanimation de Langue Francaise, Paris, January 2002 (abstract no. SP 94).