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8. The gut microbiota in persistent post-operative pain following breast cancer surgery

Author

Science Foundation Ireland, Cabrera Rubio, Raul [0000-0003-3652-9558], Masaud, Khaled, Collins, James M., Cabrera Rubio, Raul, Corrigan, Mark, Cotter, Paul D., O'Brien, Niall, Bluett, Ronan, Jimenez, Clare Keaveney, O'Mahony, Siobhain M., Shorten, George D, Science Foundation Ireland, Cabrera Rubio, Raul [0000-0003-3652-9558], Masaud, Khaled, Collins, James M., Cabrera Rubio, Raul, Corrigan, Mark, Cotter, Paul D., O'Brien, Niall, Bluett, Ronan, Jimenez, Clare Keaveney, O'Mahony, Siobhain M., and Shorten, George D

Abstract

Persistent post-surgical pain (PPSP) is defined as pain which continues after a surgical operation in a significant form for at least three months (and is not related to pre-existing painful conditions). PPSP is a common, under-recognised, and important clinical problem which affects millions of patients worldwide. Preventative measures which are currently available include the selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. More recently, a role for the gut microbiota in pain modulation has become increasingly apparent. This study aims to investigate any relationship between the gut microbiota and PPSP. A prospective observational study of 68 female adult patients undergoing surgery for management of breast cancer was carried out. Stool samples from 45 of these patients were obtained to analyse the composition of the gut microbiota. Measures of pain and state-trait anxiety were also taken to investigate further dimensions in any relationship between the gut microbiota and PPSP. At 12 weeks postoperatively, 21 patients (51.2%) did not have any pain and 20 patients (48.8%) reported feeling pain that persisted at that time. Analysis of the gut microbiota revealed significantly lower alpha diversity (using three measures) in those patients reporting severe pain at the 60 min post-operative and the 12 weeks post-operative timepoints. A cluster of taxa represented by Bifidobacterium longum, and Faecalibacterium prausnitzii was closely associated with those individuals reporting no pain at 12 weeks postoperatively, while Megamonas hypermegale, Bacteroides pectinophilus, Ruminococcus bromii, and Roseburia hominis clustered relatively closely in the group of patients fulfilling the criteria for persistent post-operative pain. We report for the first time specific associations between the gut microbiota composition and the presence or absence of PPSP. This may provide further insights into mechanisms behind t

Published
2024

12. A consensus statement on the meaning, value and utility of training programme outcomes, with specific reference to anaesthesiology

Author

Shorten, George, primary, Bahrey, Lisa, additional, Bardia, Amit, additional, De Hert, Stefan, additional, Guasch, Emilia, additional, Holmboe, Eric, additional, McCormack, Martin, additional, O’Brien, Brian, additional, Power, Camillus, additional, Rock, Bernadette, additional, and Sabelnikovs, Olegs, additional

Published
2023
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16. Applying a Web and Simulation-Based System for Adaptive Competence Assessment of Spinal Anaesthesia

Author

Hockemeyer, Cord, Nussbaumer, Alexander, Lövquist, Erik, Aboulafia, Annette, Breen, Dorothy, Shorten, George, Albert, Dietrich, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Spaniol, Marc, editor, Li, Qing, editor, Klamma, Ralf, editor, and Lau, Rynson W. H., editor

Published
2009
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17. Novel Technology for Learning in Medicine

Author

Luengo, Vanda, Aboulafia, Annette, Blavier, Adélaïde, Shorten, George, Vadcard, Lucile, Zottmann, Jan, Balacheff, Nicolas, editor, Ludvigsen, Sten, editor, de Jong, Ton, editor, Lazonder, Ard, editor, and Barnes, Sally, editor

Published
2009
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18. Competence Assessment for Spinal Anaesthesia

Author

Albert, Dietrich, Hockemeyer, Cord, Kulcsar, Zsuzsanna, Shorten, George, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Holzinger, Andreas, editor

Published
2007
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21. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project

Author

Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene R., Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S., Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, Moran, E M Louise, Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene R., Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S., Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, and Moran, E M Louise

Abstract

Background and objectives: Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. Methods: Following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as ≥75% agreement and weak consensus as 50%-74% agreement. Results: Seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. Conclusion: By means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia.

Published
2022

22. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene, Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S, Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, Moran, E M Louise, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene, Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S, Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, and Moran, E M Louise

Abstract

Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. Following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as ≥75% agreement and weak consensus as 50%-74% agreement. Seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. By means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia.

Published
2022

23. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project

Author

Gürkan, Yavuz (ORCID 0000-0002-2307-6943 & YÖK ID 154129), Ahmed, Hassan M.; Atterton, Benjamin P.; Crowe, Gillian G.; Barratta, Jaime L.; Johnson, Mark; Viscusi, Eugene; Adhikary, Sanjib; Albrecht, Eric; Boretsky, Karen; Boublik, Jan; Breslin, Dara S.; Byrne, Kelly; Ch'ng, Alan; Chuan, Alwin; Conroy, Patrick; Daniel, Craig; Daszkiewicz, Andrzej; Delbos, Alain; Dirzu, Dan Sebastian; Dmytriiev, Dmytro; Fennessy, Paul; Fischer, H. Barrie J.; Frizelle, Henry; Gadsden, Jeff; Gautier, Philippe; Gupta, Rajnish K.; Hardman, Harold David; Harrop-Griffiths, William; Hebbard, Peter; Hernandez, Nadia; Hlasny, Jakub; Iohom, Gabriella; Ip, Vivian H. Y.; Jeng, Christina L. .; Johnson, Rebecca L.; Kalagara, Hari; Kinirons, Brian; Lansdown, Andrew Kenneth; Leng, Jody C.; Lim, Yean Chin; Lobo, Clara; Ludwin, Danielle B.; Macfarlane, Alan James Robert; Machi, Anthony T.; Mahon, Padraig; Mannion, Stephen; McLeod, David H.; Merjavy, Peter; Miscuks, Aleksejs; Mitchell, Christopher H.; Moka, Eleni; Moran, Peter; Ngui, Ann; Nin, Olga C.; O'Donnell, Brian D.; Pawa, Amit; Perlas, Anahi; Porter, Steven; Pozek, John-Paul; Rebelo, Humberto C.; Roques, Vicente; Schroeder, Kristopher M.; Schwartz, Gary; Schwenk, Eric S.; Sermeus, Luc; Shorten, George; Srinivasan, Karthikeyan; Stevens, Markus F.; Theodoraki, Kassiani; Turbitt, Lloyd R.; Valdes-Vilches, Luis Fernando; Volk, Thomas; Webster, Katrina; Wiesmann, T.; Wilson, Sylvia H.; Wolmarans, Morne; Woodworth, Glenn; Worek, Andrew K.; Moran, E. M. Louise, Koç University Hospital, School of Medicine, Gürkan, Yavuz (ORCID 0000-0002-2307-6943 & YÖK ID 154129), Ahmed, Hassan M.; Atterton, Benjamin P.; Crowe, Gillian G.; Barratta, Jaime L.; Johnson, Mark; Viscusi, Eugene; Adhikary, Sanjib; Albrecht, Eric; Boretsky, Karen; Boublik, Jan; Breslin, Dara S.; Byrne, Kelly; Ch'ng, Alan; Chuan, Alwin; Conroy, Patrick; Daniel, Craig; Daszkiewicz, Andrzej; Delbos, Alain; Dirzu, Dan Sebastian; Dmytriiev, Dmytro; Fennessy, Paul; Fischer, H. Barrie J.; Frizelle, Henry; Gadsden, Jeff; Gautier, Philippe; Gupta, Rajnish K.; Hardman, Harold David; Harrop-Griffiths, William; Hebbard, Peter; Hernandez, Nadia; Hlasny, Jakub; Iohom, Gabriella; Ip, Vivian H. Y.; Jeng, Christina L. .; Johnson, Rebecca L.; Kalagara, Hari; Kinirons, Brian; Lansdown, Andrew Kenneth; Leng, Jody C.; Lim, Yean Chin; Lobo, Clara; Ludwin, Danielle B.; Macfarlane, Alan James Robert; Machi, Anthony T.; Mahon, Padraig; Mannion, Stephen; McLeod, David H.; Merjavy, Peter; Miscuks, Aleksejs; Mitchell, Christopher H.; Moka, Eleni; Moran, Peter; Ngui, Ann; Nin, Olga C.; O'Donnell, Brian D.; Pawa, Amit; Perlas, Anahi; Porter, Steven; Pozek, John-Paul; Rebelo, Humberto C.; Roques, Vicente; Schroeder, Kristopher M.; Schwartz, Gary; Schwenk, Eric S.; Sermeus, Luc; Shorten, George; Srinivasan, Karthikeyan; Stevens, Markus F.; Theodoraki, Kassiani; Turbitt, Lloyd R.; Valdes-Vilches, Luis Fernando; Volk, Thomas; Webster, Katrina; Wiesmann, T.; Wilson, Sylvia H.; Wolmarans, Morne; Woodworth, Glenn; Worek, Andrew K.; Moran, E. M. Louise, Koç University Hospital, and School of Medicine

Abstract

Background and objectives: documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. Methods: following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as >= 75% agreement and weak consensus as 50%-74% agreement. Results: seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. Conclusion: by means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia., European Society of Regional Anaesthesia and Pain Therapy (ESRA); ASRA Pain Medicine

Published
2022

24. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project

Author

Ahmed, Hassan M, primary, Atterton, Benjamin P, additional, Crowe, Gillian G, additional, Barratta, Jaime L, additional, Johnson, Mark, additional, Viscusi, Eugene, additional, Adhikary, Sanjib, additional, Albrecht, Eric, additional, Boretsky, Karen, additional, Boublik, Jan, additional, Breslin, Dara S, additional, Byrne, Kelly, additional, Ch'ng, Alan, additional, Chuan, Alwin, additional, Conroy, Patrick, additional, Daniel, Craig, additional, Daszkiewicz, Andrzej, additional, Delbos, Alain, additional, Dirzu, Dan Sebastian, additional, Dmytriiev, Dmytro, additional, Fennessy, Paul, additional, Fischer, H Barrie J, additional, Frizelle, Henry, additional, Gadsden, Jeff, additional, Gautier, Philippe, additional, Gupta, Rajnish K, additional, Gürkan, Yavuz, additional, Hardman, Harold David, additional, Harrop-Griffiths, William, additional, Hebbard, Peter, additional, Hernandez, Nadia, additional, Hlasny, Jakub, additional, Iohom, Gabriella, additional, Ip, Vivian H Y, additional, Jeng, Christina L, additional, Johnson, Rebecca L, additional, Kalagara, Hari, additional, Kinirons, Brian, additional, Lansdown, Andrew Kenneth, additional, Leng, Jody C, additional, Lim, Yean Chin, additional, Lobo, Clara, additional, Ludwin, Danielle B, additional, Macfarlane, Alan James Robert, additional, Machi, Anthony T, additional, Mahon, Padraig, additional, Mannion, Stephen, additional, McLeod, David H, additional, Merjavy, Peter, additional, Miscuks, Aleksejs, additional, Mitchell, Christopher H, additional, Moka, Eleni, additional, Moran, Peter, additional, Ngui, Ann, additional, Nin, Olga C, additional, O'Donnell, Brian D, additional, Pawa, Amit, additional, Perlas, Anahi, additional, Porter, Steven, additional, Pozek, John-Paul, additional, Rebelo, Humberto C, additional, Roqués, Vicente, additional, Schroeder, Kristopher M, additional, Schwartz, Gary, additional, Schwenk, Eric S, additional, Sermeus, Luc, additional, Shorten, George, additional, Srinivasan, Karthikeyan, additional, Stevens, Markus F, additional, Theodoraki, Kassiani, additional, Turbitt, Lloyd R, additional, Valdés-Vilches, Luis Fernando, additional, Volk, Thomas, additional, Webster, Katrina, additional, Wiesmann, T, additional, Wilson, Sylvia H, additional, Wolmarans, Morné, additional, Woodworth, Glenn, additional, Worek, Andrew K, additional, and Moran, E M Louise, additional

Published
2022
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38. Acknowledgements

Author

Harmon, Dominic, primary, Barrett, Jack, additional, Loughane, Frank, additional, Finucane, Brendan, additional, and Shorten, George, additional

Published
2011
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50. PREFACE

Author

Shorten, George, primary, Carr, Daniel B., additional, Harmon, Dominic, additional, Puig, Margarita M., additional, and Browne, John, additional

Published
2006
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