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1. ARDS clinical practice guideline 2021

Author

Nakashima, Takuro, Masunaga, Aiko, Tanaka, Aiko, Inoue, Akihiko, Higashi, Akiko, Tanikawa, Atsushi, Ujiro, Atsushi, Takayama, Chihiro, Kasugai, Daisuke, Kawakami, Daisuke, Ueno, Daisuke, Satoh, Daizoh, Kai, Shinichi, Ota, Kohei, Hagiwara, Yoshihiro, Hamaguchi, Jun, Fujii, Ryo, Hongo, Takashi, Kishihara, Yuki, Masunaga, Naohisa, Yamamoto, Ryohei, Okazaki, Satoru Robert, Uchimido, Ryo, Terayama, Tetsuro, Hokari, Satoshi, Sakamoto, Hitoshi, Dongli, Nakataki, Emiko, Tabata, Erina, Okazawa, Seisuke, Kotajima, Futoshi, Ishimaru, Go, Hoshino, Haruhiko, Yoshida, Hideki, Iwai, Hidetaka, Nakagawa, Hiroaki, Sugimura, Hiroko, Narumiya, Hiromichi, Okano, Hiromu, Nakamura, Hiroshi, Sugimoto, Hiroshi, Hashimoto, Hiroyuki, Ito, Hiroyuki, Dote, Hisashi, Imahase, Hisashi, Sato, Hitoshi, Katsurada, Masahiro, Osawa, Ichiro, Kamei, Jun, Maki, Jun, Sugihara, Jun, Takeshita, Jun, Fujimoto, Junichi, Ishikawa, Junichi, Kosaka, Junko, Shibata, Junpei, Hashimoto, Katsuhiko, Nakano, Yasushi, Kikuyama, Kazuki, Shimizu, Kazushige, Okada, Kazuya, Kawano, Keishi, Anan, Keisuke, Ota, Keisuke, Kano, Ken-ichi, Asano, Kengo, Hondo, Kenichi, Ishii, Kenji, Fujita, Kensuke, Ogawa, Kenta, Ito, Kentaro, Tokunaga, Kentaro, Ishii, Kenzo, Kusumoto, Kohei, Takimoto, Kohei, Yamada, Kohei, Naito, Koichi, Yamashita, Koichi, Yoshinaga, Koichi, Yamauchi, Kota, Murata, Maki, Konda, Makiko, Hamamoto, Manabu, Aga, Masaharu, Kashiura, Masahiro, Ishikawa, Masami, Ozaki, Masayuki, Kono, Michihiko, Kyo, Michihito, Hayashi, Minoru, Abe, Mitsuhiro, Sato, Mitsunori, Sakai, Mizu, Kainuma, Motoshi, Tominaga, Naoki, Iguchi, Naoya, Nakagawa, Natsuki, Aoki, Nobumasa, Nishioka, Norihiro, Miyashita, Norihisa, Seki, Nozomu, Ikebe, Ryo, Imai, Ryosuke, Tate, Ryota, Sato, Ryuhei, Miyakawa, Sachiko, Kazuma, Satoshi, Nakano, Satoshi, Tetsumoto, Satoshi, Yoshimura, Satoshi, Yoshitake, Shigenori, Hoshi, Shin-etsu, Ohki, Shingo, Sato, Shintaro, Yoshihiro, Shodai, Ihara, Shoichi, Yamamoto, Shota, Koide, Shunichi, Kimata, Shunsuke, Saito, Shunsuke, Yasuo, Shunsuke, Sekine, Shusuke, Mimuro, Soichiro, Wada, Soichiro, Sugimura, Sosuke, Ishihara, Tadashi, Kaneko, Tadashi, Nagato, Tadashi, Maruhashi, Takaaki, Tamura, Takahiro, Ohno, Takanori, Ichiyama, Takashi, Niwa, Takashi, Ueji, Takashi, Ogura, Takayuki, Kawasaki, Takeshi, Tanaka, Takeshi, Umegaki, Takeshi, Furukawa, Taku, Omura, Taku, Nagao, Takumi, Mayumi, Takuya, Taniguchi, Takuya, Yoshida, Takuya, Shimatani, Tatsutoshi, Murata, Teppei, Sato, Tetsuya, Sawamoto, Tohru, Koukei, Yoshifumi, Takehara, Tomohiro, Ueda, Tomomi, Katsuta, Tomoya, Nishino, Tomoya, Yokoyama, Toshiki, Higashijima, Ushio, Iwanaga, Wataru, Inoue, Yasushi, Iwashita, Yoshiaki, Yamada, Yoshie, Kubota, Yoshifumi, Suido, Yoshihiro, Tomioka, Yoshihiro, Fujimoto, Yoshihisa, Fujita, Yoshihito, Yamaguchi, Yoshikazu, Nakamura, Yoshimi, Abe, Yoshinobu, Eguchi, Yoshitomo, Oshima, Yoshiyasu, Fukuda, Yosuke, Iwasaki, Yudai, Yasufuku, Yuichi, Shono, Yuji, Nakatani, Yuka, Nakamori, Yuki, Ito, Yukie, Tanabe, Yuko, Nagamine, Yusuke, Nakamura, Yuta, Kurihara, Yutaro, Tasaka, Sadatomo, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Yasuda, Hideto, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu, Matsumoto, Shotaro, Nango, Eishu, Okada, Yohei, Hayashi, Kenichiro, Sakuraya, Masaaki, Nakajima, Mikio, Okamori, Satoshi, Miura, Shinya, Fukuda, Tatsuma, Kamo, Tetsuro, Yatabe, Tomoaki, Norisue, Yasuhiro, Aoki, Yoshitaka, Iizuka, Yusuke, Kondo, Yutaka, Narita, Chihiro, Taito, Shunsuke, Hayashi, Takuya, Terayama, Takero, Kataoka, Jun, Nishimura, Tetsuro, Yonekura, Hiroshi, Ando, Koichi, Yoshida, Takuo, Masuyama, Tomoyuki, and Sanui, Masamitsu

Published
2022
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3. Body temperature in the acute phase and clinical outcomes after acute ischemic stroke.

Author

Mezuki, Satomi, Matsuo, Ryu, Irie, Fumi, Shono, Yuji, Kuwashiro, Takahiro, Sugimori, Hiroshi, Wakisaka, Yoshinobu, Ago, Tetsuro, Kamouchi, Masahiro, and Kitazono, Takanari

Subjects
ISCHEMIC stroke, BODY temperature, STROKE patients, TREATMENT effectiveness, LOGISTIC regression analysis
Abstract

Background: This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. Methods: We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3–6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes. Results: The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65–0.99] vs. Q1) to Q5 (0.33 [0.28–0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03–1.79]) to Q5 (6.44 [5.19–8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1–3 and with longer duration with body temperature >37.0°C. Conclusions: Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Hyperoxemia is Associated With Poor Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry

Author

Nishihara, Masaaki, primary, Hiasa, Ken-ichi, additional, Enzan, Nobuyuki, additional, Ichimura, Kenzo, additional, Iyonaga, Takeshi, additional, Shono, Yuji, additional, Kashiura, Masahiro, additional, Moriya, Takashi, additional, Kitazono, Takanari, additional, and Tsutsui, Hiroyuki, additional

Published
2022
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9. Delayed administration of epinephrine is associated with worse neurological outcomes in patients with out-of-hospital cardiac arrest and initial pulseless electrical activity: insight from the nationwide multicentre observational JAAM-OHCA (Japan Association for Acute Medicine) registry

Author

Enzan, Nobuyuki, primary, Hiasa, Ken ichi, additional, Ichimura, Kenzo, additional, Nishihara, Masaaki, additional, Iyonaga, Takeshi, additional, Shono, Yuji, additional, Tohyama, Takeshi, additional, Funakoshi, Kouta, additional, Kitazono, Takanari, additional, and Tsutsui, Hiroyuki, additional

Published
2022
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11. Impact of Antithrombin Activity Levels Following Recombinant Antithrombin Gamma Therapy in Patients with Sepsis-Induced Disseminated Intravascular Coagulation

Author

Akahoshi, Tomohiko, primary, Kaku, Noriyuki, additional, Shono, Yuji, additional, Yamamoto, Yuzo, additional, Takahashi, Keita, additional, Iyonaga, Takeshi, additional, Momii, Kenta, additional, Nishihara, Masaaki, additional, Maki, Jun, additional, Tokuda, Kentaro, additional, and Yamaura, Ken, additional

Published
2022
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18. Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient

Author

Nakashima, Ryosuke, primary, Nishihara, Masaaki, additional, Iyonaga, Takeshi, additional, Iwasaka, Sho, additional, Yamamoto, Yuzo, additional, Shono, Yuji, additional, Maki, Jun, additional, Tokuda, Kentaro, additional, Akahoshi, Tomohiko, additional, Higo, Taiki, additional, Kitazono, Takanari, additional, and Tsutsui, Hiroyuki, additional

Published
2021
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22. Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate

Author

Iwasaka, Sho, primary, Shono, Yuji, additional, Tokuda, Kentaro, additional, Nakashima, Kosuke, additional, Yamamoto, Yuzo, additional, Maki, Jun, additional, Nagasaki, Yoji, additional, Shimono, Nobuyuki, additional, Akahoshi, Tomohiko, additional, and Taguchi, Tomoaki, additional

Published
2020
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26. Abstract 154: Hyperoxemia is Associated with Poor Neurological Outcomes in Patients with Out-of-hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry

Author

Nishihara, Masaaki, primary, Hiasa, Ken-ichi, additional, Enzan, Nobuyuki, additional, Ichimura, Kenzo, additional, Iyonaga, Takeshi, additional, Shono, Yuji, additional, Kitazono, Takanari, additional, and Tsutsui, Hiroyuki, additional

Published
2020
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29. ARDS clinical practice guideline 2021

Author

Tasaka, Sadatomo, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Yasuda, Hideto, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu, Matsumoto, Shotaro, Nango, Eishu, Okada, Yohei, Hayashi, Kenichiro, Sakuraya, Masaaki, Nakajima, Mikio, Okamori, Satoshi, Miura, Shinya, Fukuda, Tatsuma, Ishihara, Tadashi, Kamo, Tetsuro, Yatabe, Tomoaki, Norisue, Yasuhiro, Aoki, Yoshitaka, Iizuka, Yusuke, Kondo, Yutaka, Narita, Chihiro, Kawakami, Daisuke, Okano, Hiromu, Takeshita, Jun, Anan, Keisuke, Okazaki, Satoru Robert, Taito, Shunsuke, Hayashi, Takuya, Mayumi, Takuya, Terayama, Takero, Kubota, Yoshifumi, Abe, Yoshinobu, Iwasaki, Yudai, Kishihara, Yuki, Kataoka, Jun, Nishimura, Tetsuro, Yonekura, Hiroshi, Ando, Koichi, Yoshida, Takuo, Masuyama, Tomoyuki, Sanui, Masamitsu, Nakashima, Takuro, Masunaga, Aiko, Tanaka, Aiko, Inoue, Akihiko, Higashi, Akiko, Tanikawa, Atsushi, Ujiro, Atsushi, Takayama, Chihiro, Kasugai, Daisuke, Kawakami, Daisuke, Ueno, Daisuke, Satoh, Daizoh, Kai, Shinichi, Ota, Kohei, Hagiwara, Yoshihiro, Hamaguchi, Jun, Fujii, Ryo, Hongo, Takashi, Kishihara, Yuki, Masunaga, Naohisa, Yamamoto, Ryohei, Okazaki, Satoru Robert, Uchimido, Ryo, Terayama, Tetsuro, Hokari, Satoshi, Sakamoto, Hitoshi, Dongli, Nakataki, Emiko, Tabata, Erina, Okazawa, Seisuke, Kotajima, Futoshi, Ishimaru, Go, Hoshino, Haruhiko, Yoshida, Hideki, Iwai, Hidetaka, Nakagawa, Hiroaki, Sugimura, Hiroko, Narumiya, Hiromichi, Okano, Hiromu, Nakamura, Hiroshi, Sugimoto, Hiroshi, Hashimoto, Hiroyuki, Ito, Hiroyuki, Dote, Hisashi, Imahase, Hisashi, Sato, Hitoshi, Katsurada, Masahiro, Osawa, Ichiro, Kamei, Jun, Maki, Jun, Sugihara, Jun, Takeshita, Jun, Fujimoto, Junichi, Ishikawa, Junichi, Kosaka, Junko, Shibata, Junpei, Hashimoto, Katsuhiko, Nakano, Yasushi, Kikuyama, Kazuki, Shimizu, Kazushige, Okada, Kazuya, Kawano, Keishi, Anan, Keisuke, Ota, Keisuke, Kano, Ken-ichi, Asano, Kengo, Hondo, Kenichi, Ishii, Kenji, Fujita, Kensuke, Ogawa, Kenta, Ito, Kentaro, Tokunaga, Kentaro, Ishii, Kenzo, Kusumoto, Kohei, Takimoto, Kohei, Yamada, Kohei, Naito, Koichi, Yamashita, Koichi, Yoshinaga, Koichi, Yamauchi, Kota, Murata, Maki, Konda, Makiko, Hamamoto, Manabu, Aga, Masaharu, Kashiura, Masahiro, Ishikawa, Masami, Ozaki, Masayuki, Kono, Michihiko, Kyo, Michihito, Hayashi, Minoru, Abe, Mitsuhiro, Sato, Mitsunori, Sakai, Mizu, Kainuma, Motoshi, Tominaga, Naoki, Iguchi, Naoya, Nakagawa, Natsuki, Aoki, Nobumasa, Nishioka, Norihiro, Miyashita, Norihisa, Seki, Nozomu, Ikebe, Ryo, Imai, Ryosuke, Tate, Ryota, Sato, Ryuhei, Miyakawa, Sachiko, Kazuma, Satoshi, Nakano, Satoshi, Tetsumoto, Satoshi, Yoshimura, Satoshi, Yoshitake, Shigenori, Hoshi, Shin-etsu, Ohki, Shingo, Sato, Shintaro, Yoshihiro, Shodai, Ihara, Shoichi, Yamamoto, Shota, Koide, Shunichi, Kimata, Shunsuke, Saito, Shunsuke, Yasuo, Shunsuke, Sekine, Shusuke, Mimuro, Soichiro, Wada, Soichiro, Sugimura, Sosuke, Ishihara, Tadashi, Kaneko, Tadashi, Nagato, Tadashi, Maruhashi, Takaaki, Tamura, Takahiro, Ohno, Takanori, Ichiyama, Takashi, Niwa, Takashi, Ueji, Takashi, Ogura, Takayuki, Kawasaki, Takeshi, Tanaka, Takeshi, Umegaki, Takeshi, Furukawa, Taku, Omura, Taku, Nagao, Takumi, Mayumi, Takuya, Taniguchi, Takuya, Yoshida, Takuya, Shimatani, Tatsutoshi, Murata, Teppei, Sato, Tetsuya, Sawamoto, Tohru, Koukei, Yoshifumi, Takehara, Tomohiro, Ueda, Tomomi, Katsuta, Tomoya, Nishino, Tomoya, Yokoyama, Toshiki, Higashijima, Ushio, Iwanaga, Wataru, Inoue, Yasushi, Iwashita, Yoshiaki, Yamada, Yoshie, Kubota, Yoshifumi, Suido, Yoshihiro, Tomioka, Yoshihiro, Fujimoto, Yoshihisa, Fujita, Yoshihito, Yamaguchi, Yoshikazu, Nakamura, Yoshimi, Abe, Yoshinobu, Eguchi, Yoshitomo, Oshima, Yoshiyasu, Fukuda, Yosuke, Iwasaki, Yudai, Yasufuku, Yuichi, Shono, Yuji, Nakatani, Yuka, Nakamori, Yuki, Ito, Yukie, Tanabe, Yuko, Nagamine, Yusuke, Nakamura, Yuta, and Kurihara, Yutaro

Abstract

The joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021.

Published
2022
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30. Supplemental material for Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm

Author

Shono, Yuji, Sugimori, Hiroshi, Matsuo, Ryu, Fukushima, Yoshihisa, Wakisaka, Yoshinobu, Kuroda, Junya, Ago, Tetsuro, Kamouchi, Masahiro, and Kitazono, Takanari

Subjects
FOS: Clinical medicine, education, Cardiology, Medicine, cardiovascular diseases, health care economics and organizations, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material for Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm by Yuji Shono, Hiroshi Sugimori, Ryu Matsuo, Yoshihisa Fukushima, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Masahiro Kamouchi and Takanari Kitazono: on behalf of the Fukuoka Stroke Registry Investigators: International Study of Unruptured Intracranial Aneurysms Investigators in International Journal of Stroke

Published
2018
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31. Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient: A case report.

Author

Ryosuke Nakashima, Masaaki Nishihara, Takeshi Iyonaga, Sho Iwasaka, Yuzo Yamamoto, Yuji Shono, Jun Maki, Kentaro Tokuda, Tomohiko Akahoshi, Taiki Higo, Takanari Kitazono, Hiroyuki Tsutsui, Nakashima, Ryosuke, Nishihara, Masaaki, Iyonaga, Takeshi, Iwasaka, Sho, Yamamoto, Yuzo, Shono, Yuji, Maki, Jun, and Tokuda, Kentaro

Published
2021
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32. Use of venovenous extracorporeal membrane oxygenation for perioperative management of acute respiratory distress syndrome caused by fat embolism syndrome: A case report and literature review.

Author

Kenta Momii, Yuji Shono, Kanji Osaki, Yoshinori Nakanishi, Takeshi Iyonaga, Masaaki Nishihara, Tomohiko Akahoshi, Yasuharu Nakashima, Momii, Kenta, Shono, Yuji, Osaki, Kanji, Nakanishi, Yoshinori, Iyonaga, Takeshi, Nishihara, Masaaki, Akahoshi, Tomohiko, and Nakashima, Yasuharu

Published
2021
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34. Sarcopenia is a predictive factor for prolonged intensive care unit stays in high‐energy blunt trauma patients

Author

Akahoshi, Tomohiko, primary, Yasuda, Mitsuhiro, additional, Momii, Kenta, additional, Kubota, Kensuke, additional, Shono, Yuji, additional, Kaku, Noriyuki, additional, Tokuda, Kentaro, additional, Nagata, Takashi, additional, Yoshizumi, Tomoharu, additional, Shirabe, Ken, additional, Hashizume, Makoto, additional, and Maehara, Yoshihiko, additional

Published
2016
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36. Subscriber Number Forecasting Tool Based on Subscriber Attribute Distribution for Evaluating Improvement Strategies

Author

Hiramatsu, Ayako, Shono, Yuji, Oiso, Hiroaki, Komoda, Norihisa, Jifa, Gu, and Gerhard, Chroust

Subjects
modeling, simulation, customer retention
Abstract

In this paper, a subscriber number forecasting tool that evaluates quiz game mobile content improvement strategies is developed. Unsubscription rates depend on such subscriber attributes such as consecutive months, stages, rankings, and so on. In addition, content providers can anticipate change in unsubscription rates for each content improvement strategy. However, subscriber attributes change dynamically. Therefore, a method that deals with dynamic subscriber attribute changes is proposed. According to the features of content improvement strategies, content providers decide the conditions and the rates of unsubscription changes. Then the unsubscription rate for each segment is recalculated. In the period doing which a content improvement strategy has not been launched, prediction accuracy in the following there months of the proposed (subscriber-based) prediction method was compared with the segment-based prediction method., The original publication is available at JAIST Press http://www.jaist.ac.jp/library/jaist-press/index.html, IFSR 2005 : Proceedings of the First World Congress of the International Federation for Systems Research : The New Roles of Systems Sciences For a Knowledge-based Society : Nov. 14-17, 2102, Kobe, Japan, Symposium 3, Session 6 : Intelligent Information Technology and Applications Knowledge Management

Published
2005

41. Clinical characteristics of type A acute aortic dissection with CNS symptom.

Author

Yuji Shono, Tomohiko Akahoshi, Satomi Mezuki, Kenta Momii, Noriyuki Kaku, Jun Maki, Kentaro Tokuda, Tetsuro Ago, Takanari Kitazono, Yoshihiko Maehara, Shono, Yuji, Akahoshi, Tomohiko, Mezuki, Satomi, Momii, Kenta, Kaku, Noriyuki, Maki, Jun, Tokuda, Kentaro, Ago, Tetsuro, Kitazono, Takanari, and Maehara, Yoshihiko

Abstract

Background and Purpose: Accurate diagnosis of acute aortic dissection (AAD) is sometimes difficult because of accompanying central nervous system (CNS) symptoms. The purpose of this study was to investigate the clinical characteristics of Type A AAD (TAAAD) with CNS symptoms.Methods: We retrospectively reviewed the medical records of 8403 patients ambulanced to our emergency and critical care center between April 2009 and May 2014.Results: We identified 59 TAAAD patients for the analysis (mean age, 67.3±10.5years; 37 (62.0%) male). Eleven patients (18.6%) presented CNS symptoms at the onset of TAAAD, and these patients complained less frequently of typical chest and back pain than those without CNS symptoms (p<0.0001). Initial systolic and diastolic blood pressure were lower (p=0.003, and p=0.049, respectively) and involvement of the supra-aortic artery was more frequent in patients with CNS symptoms (p<0.0001).Conclusion: Because CNS symptom can mask chest and back pain caused by TAAAD, physicians should always consider the possibility of TAAAD in patients with CNS symptoms in emergency medicine settings. [ABSTRACT FROM AUTHOR]

Published
2017
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42. Change in Intracellular pH Causes the Toxic Ca2+ Entry via NCX1 in Neuron- and Glia-Derived Cells.

Author

Shono, Yuji, Kamouchi, Masahiro, Kitazono, Takanari, Kuroda, Junya, Nakamura, Kuniyuki, Hagiwara, Noriko, Ooboshi, Hiroaki, Ibayashi, Setsuro, and Iida, Mitsuo

Subjects
*CEREBRAL anoxia, *HYDROGEN-ion concentration, *CALCIUM ions, *ACIDOSIS, *NEUROGLIA, *CELL death, *NEURONS
Abstract

Brain hypoxia or ischemia causes acidosis and the intracellular accumulation of Ca2+ in neuron. The aims of the present study were to elucidate the interaction between intracellular pH and Ca2+ during transient acidosis and its effects on the viability of neuronal and glial cells. Intracellular Ca2+ and pH were measured using the fluorescence of fura-2 and 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester in neuroblastoma (IMR-32), glioblastoma (T98G), and astrocytoma (CCF-STTG1) cell lines. The administration of 5 mM propionate caused intracellular acidification in IMR-32 and T98G cells but not in CCF-STTG1 cells. After the removal of propionate, the intracellular pH recovered to the resting level. The intracellular Ca2+ transiently increased upon the removal of propionate in IMR-32 and T98G cells but not in CCF-STTG1 cells. The transient Ca2+ increase caused by the withdrawal of intracellular acidification was abolished by the removal of external Ca2+, diminished by a reduction of external Na+, and inhibited by benzamil. Transient acidosis caused cell death, whereas the cells were more viable in the absence of external Ca2+. Benzamil alleviated cell death caused by transient acidosis in IMR-32 and T98G cells but not in CCF-STTG1 cells. These results suggest that recovery from intracellular acidosis causes a transient increase in cytosolic Ca2+ due to reversal of Ca2+ transport via Na+/Ca2+ exchanger coactivated with Na+/H+ exchanger, which can cause cell death. [ABSTRACT FROM AUTHOR]

Published
2010
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43. Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes

Author

Nakamura, Kuniyuki, Kamouchi, Masahiro, Kitazono, Takanari, Kuroda, Junya, Shono, Yuji, Hagiwara, Noriko, Ago, Tetsuro, Ooboshi, Hiroaki, Ibayashi, Setsuro, and Iida, Mitsuo

Subjects
*AMILORIDE, *CHEMICAL inhibitors, *HYDROGEN peroxide, *CALCIUM in the body, *CELLULAR signal transduction, *MESENCHYME, *CENTRAL nervous system, *REACTIVE oxygen species
Abstract

Abstract: The aims of the present study were to investigate the mechanisms of Ca2+ signaling caused by hydrogen peroxide in CNS pericytes. In cultured human brain microvascular pericytes, cytosolic Ca2+ concentration was measured by means of fura-2 fluorescence. Reverse transcription and polymerase chain reaction was performed to examine the expression of mRNA. Knockdown of Na+/H+ exchanger (NHE) was done by transfecting the cells with specific double-strand siRNAs for NHE. Externally applied hydrogen peroxide dose-dependently (100 μM–10 mM) increased cytosolic Ca2+ in human CNS pericytes. Cytosolic Ca2+ remained high after wash-out of hydrogen peroxide. However, the addition of dithiothreitol rapidly reversed cytosolic Ca2+ to the resting level. The hydrogen peroxide-induced Ca2+ increase was not inhibited by nicardipine, Gd3+, La3+, or omission of external Ca2+. Neither thapsigargin nor carbonyl cyanide 4-trifluoromethoxyphenylhydrazone attenuated the hydrogen peroxide-induced Ca2+ rise. Amiloride and its derivatives, benzamil and hexamethylene amiloride reversed the hydrogen peroxide-induced Ca2+ increase. Human CNS pericytes expressed acid sensing ion channel (ASIC) 1a, Na+/Ca2+ exchanger (NCX) 1, Na+/H+ exchanger (NHE) 1, and NHE7. However, the removal of external Na+, treatment with KB-R 7943 and mibefradil, or knockdown of NHE1 and NHE7 did not affect the hydrogen peroxide-induced Ca2+ increase. Hydrogen peroxide releases Ca2+ from intracellular Ca2+ pool via an amiloride-sensitive protein, which is controlled by oxidation of thiol group in human CNS pericytes. [Copyright &y& Elsevier]

Published
2009
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44. Predictive Value of the PaO 2 /FIO 2 Ratio for Mortality in Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-analysis.

Author

Yoshimura S, Hashimoto K, Shono Y, Tamura T, Uchimido R, Ando K, Okamori S, Yoshida T, Yoshitake S, and Okada Y

Abstract

Background Despite the controversy regarding its clinical utility, the PaO 2 /FIO 2 ratio has been used to define the severity of acute respiratory distress syndrome (ARDS). This systematic review and meta-analysis (SRMA) details summary estimates of the predictive performance of PaO 2 /FIO 2 ratio in predicting mortality in patients with ARDS. Methods To clarify the integrated diagnostic accuracy, we included studies in which the study population comprised patients with ARDS in any clinical setting, included adult patients (≥18 years old), and evaluated mortality. The MEDLINE and Cochrane Central Registry of Controlled Trials databases were searched for articles in English. We performed SRMA on the accuracy of the diagnostic prognostic tests using the Quality Assessment of Diagnostic Accuracy Studies-2 tool to evaluate the risk of bias. We obtained summary point estimates of sensitivity and specificity and calculated the area under the receiver operating characteristic (AUROC) curve of the summary receiver operating characteristic curve with 95% confidence intervals (CIs). Results Twenty-eight trials with 38270 patients were included in the quality assessment. Most of the studies were conducted in intensive-care units. Overall, the risk of bias is high. For PaO 2/ FIO 2 of 100 and 200 the pooled sensitivity, specificity, and AUROC were 44.8% (95% CI, 38.1%-51.7%), 70.6% (95% CI, 65.9%-74.9%), 0.60 (0.58-0.64) and 83.9% (95% CI, 78.9%-87.8%), 26.1% (95% CI, 20.8%-32.1%), 0.64 (0.60-0.69), respectively. Conclusion The PaO 2 /FIO 2 ratio alone did not have impressive prediction accuracy for mortality in patients with ARDS and might not be able to be used solely as a clinical prognostic tool.

Published
2024
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