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638 results on '"Shong, Minho"'

1. Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses.

Author

Lee, Seong, Park, Seongyeol, Yi, Shinae, Choi, Na, Lim, Mi, Chang, Jae, Won, Ho-Ryun, Kim, Je, Ko, Hye, Chung, Eun-Jae, Park, Young, Cho, Sun, Yu, Hyeong, Choi, June, Yeo, Min-Kyung, Yi, Boram, Yi, Kijong, Lim, Joonoh, Koh, Jun-Young, Lee, Min, Heo, Jun, Yoon, Sang, Kwon, Sung, Park, Jong-Lyul, Chu, In, Kim, Jin, Kim, Seon-Young, Shan, Yujuan, Liu, Lihua, Hong, Sung-A, Choi, Dong, Park, Junyoung, Ju, Young, Shong, Minho, Kim, Seon-Kyu, Koo, Bon, and Kang, Yea

Abstract

The role of the serine/glycine metabolic pathway (SGP) has recently been demonstrated in tumors; however, the pathological relevance of the SGP in thyroid cancer remains unexplored. Here, we perform metabolomic profiling of 17 tumor-normal pairs; bulk transcriptomics of 263 normal thyroid, 348 papillary, and 21 undifferentiated thyroid cancer samples; and single-cell transcriptomes from 15 cases, showing the impact of mitochondrial one-carbon metabolism in thyroid tumors. High expression of serine hydroxymethyltransferase-2 (SHMT2) and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is associated with low thyroid differentiation scores and poor clinical features. A subpopulation of tumor cells with high mitochondrial one-carbon pathway activity is observed in the single-cell dataset. SHMT2 inhibition significantly compromises mitochondrial respiration and decreases cell proliferation and tumor size in vitro and in vivo. Collectively, our results highlight the importance of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer and suggest that SHMT2 is a potent therapeutic target.

Published
2024

2. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism

Author

Heo, Jun Young, Park, Ah Hyung, Lee, Min Joung, Ryu, Min Jeong, Kim, Yong Kyung, Jang, Yun Seon, Kim, Soo Jeong, Shin, So Yeon, Son, Hyo Jin, Stein, Thor D., Huh, Yang Hoon, Chung, Sookja K., Choi, Song Yi, Kim, Jin Man, Hwang, Onyou, Shong, Minho, Hyeon, Seung Jae, Lee, Junghee, Ryu, Hoon, Kim, Daesoo, and Kweon, Gi Ryang

Published
2023
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6. Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Author

Kim, Yuna, Jung, Kwan-Young, Kim, Yun Hak, Xu, Pan, Kang, Baeki E., Jo, Yunju, Pandit, Navin, Kwon, Jeongho, Gariani, Karim, Gariani, Joanna, Lee, Junguee, Verbeek, Jef, Nam, Seungyoon, Bae, Sung-Jin, Ha, Ki-Tae, Yi, Hyon-Seung, Shong, Minho, Kim, Kyun-Hwan, Kim, Doyoun, Jung, Hee Jung, Lee, Chang-Woo, Kim, Kwang Rok, Schoonjans, Kristina, Auwerx, Johan, and Ryu, Dongryeol

Published
2024
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8. Lactation improves pancreatic β cell mass and function through serotonin production

Author

Moon, Joon Ho, Kim, Hyeongseok, Kim, Hyunki, Park, Jungsun, Choi, Wonsuk, Choi, Wongun, Hong, Hyun Jung, Ro, Hyun-Joo, Jun, Sangmi, Choi, Sung Hee, Banerjee, Ronadip R, Shong, Minho, Cho, Nam Han, Kim, Seung K, German, Michael S, Jang, Hak Chul, and Kim, Hail

Subjects
Nutrition, Diabetes, Reproductive health and childbirth, Metabolic and endocrine, Animals, Blood Glucose, Breast Feeding, Female, Humans, Insulin, Insulin-Secreting Cells, Lactation, Mice, Serotonin, Biological Sciences, Medical and Health Sciences
Abstract

Pregnancy imposes a substantial metabolic burden on women through weight gain and insulin resistance. Lactation reduces the risk of maternal postpartum diabetes, but the mechanisms underlying this benefit are unknown. Here, we identified long-term beneficial effects of lactation on β cell function, which last for years after the cessation of lactation. We analyzed metabolic phenotypes including β cell characteristics in lactating and non-lactating humans and mice. Lactating and non-lactating women showed comparable glucose tolerance at 2 months after delivery, but after a mean of 3.6 years, glucose tolerance in lactated women had improved compared to non-lactated women. In humans, the disposition index, a measure of insulin secretory function of β cells considering the degree of insulin sensitivity, was higher in lactated women at 3.6 years after delivery. In mice, lactation improved glucose tolerance and increased β cell mass at 3 weeks after delivery. Amelioration of glucose tolerance and insulin secretion were maintained up to 4 months after delivery in lactated mice. During lactation, prolactin induced serotonin production in β cells. Secreted serotonin stimulated β cell proliferation through serotonin receptor 2B in an autocrine and paracrine manner. In addition, intracellular serotonin acted as an antioxidant to mitigate oxidative stress and improved β cell survival. Together, our results suggest that serotonin mediates the long-term beneficial effects of lactation on female metabolic health by increasing β cell proliferation and reducing oxidative stress in β cells.

Published
2020

9. Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure

Author

Hong, Hyun Jung, Joung, Kyong Hye, Kim, Yong Kyung, Choi, Min Jeong, Kang, Seul Gi, Kim, Jung Tae, Kang, Yea Eun, Chang, Joon Young, Moon, Joon Ho, Jun, Sangmi, Ro, Hyun-Joo, Lee, Yujeong, Kim, Hyeongseok, Park, Jae-Hyung, Kang, Baeki E., Jo, Yunju, Choi, Heejung, Ryu, Dongryeol, Lee, Chul-Ho, Kim, Hail, Park, Kyu-Sang, Kim, Hyun Jin, and Shong, Minho

Published
2022
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11. ASO Author Reflections: Active Surveillance may be Possible in Patients with T1b Papillary Thyroid Carcinoma Over 55 Years of Age Without High-Risk Features on Preoperative Examinations

Author

Won, Ho-Ryun, Jeon, Eonju, Heo, Da Beom, Chang, Jae Won, Shong, Minho, Kim, Je Ryong, Ko, Hyemi, Kang, Yea Eun, Yi, Hyon-Seung, Lee, Ju Hee, Joung, Kyong Hye, Kim, Ji Min, Lee, Younju, Kim, Sung-Woo, Jeong, Young Ju, Ji, Yong Bae, Tae, Kyung, and Koo, Bon Seok

Published
2023
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13. Brown fat-specific mitoribosomal function is crucial for preventing cold exposure-induced bone loss.

Author

Tian, Jingwen, Moon, Ji Sun, Nga, Ha Thi, Lee, Ho Yeop, Nguyen, Thi Linh, Jang, Hyo Ju, Setoyama, Daiki, Shong, Minho, Lee, Ju Hee, and Yi, Hyon-Seung

Subjects
BONE density, PHYSIOLOGICAL effects of cold temperatures, BONE health, BROWN adipose tissue, BONE metabolism, BONE remodeling, BONE marrow
Abstract

This study examines the interplay between ambient temperature, brown adipose tissue (BAT) function, and bone metabolism, emphasizing the effects of cold exposure and BAT mitochondrial activity on bone health. Utilizing ovariectomized (OVX) mice to model primary osteoporosis and BAT-specific mitochondrial dysfunction (BKO) mice, we evaluated the impact of housing temperature on bone density, immune modulation in bone marrow, and the protective role of BAT against bone loss. Cold exposure was found to universally reduce bone mass, enhance osteoclastogenesis, and alter bone marrow T-cell populations, implicating the immune system in bone remodeling under cold stress. The thermogenic function of BAT, driven by mitochondrial oxidative phosphorylation, was crucial in protecting against bone loss. Impaired BAT function, through surgical removal or mitochondrial dysfunction, exacerbated bone loss in cold environments, highlighting BAT's metabolic role in maintaining bone health. Furthermore, cold-induced changes in BAT function led to systemic metabolic shifts, including elevated long-chain fatty acids, which influenced osteoclast differentiation and activity. These findings suggest a systemic mechanism connecting environmental temperature and BAT metabolism with bone physiology, providing new insights into the metabolic and environmental determinants of bone health. Future research could lead to novel bone disease therapies targeting these pathways. [ABSTRACT FROM AUTHOR]

Published
2024
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14. CRIF1 deficiency induces FOXP3 LOW inflammatory non-suppressive regulatory T cells, thereby promoting antitumor immunity

Author

Lee, Sangsin, primary, Song, Seung Geun, additional, Kim, Gwanghun, additional, Kim, Sehui, additional, Yoo, Hyun Jung, additional, Koh, Jaemoon, additional, Kim, Ye-Ji, additional, Tian, Jingwen, additional, Cho, Eunji, additional, Choi, Youn Soo, additional, Chang, Sunghoe, additional, Shin, Hyun Mu, additional, Jung, Kyeong Cheon, additional, Kim, Ji Hoon, additional, Kim, Tae Min, additional, Jeon, Yoon Kyung, additional, Kim, Hye Young, additional, Shong, Minho, additional, Kim, Ji Hyung, additional, and Chung, Doo Hyun, additional

Published
2024
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15. Adaptive thermogenesis is mediated by GDF15 via the GFRAL neuronal axis in mice

Author

Kim, Ji Eun, primary, Ju, Sang-Hyeon, additional, Lee, Minhee, additional, Hong, Hyun Jung, additional, Yaseen, Uzma, additional, Zhang, Benyuan, additional, Lee, Seong Eun, additional, Kang, Yea Eun, additional, Kim, Jung Tae, additional, Yi, Hyon-Seung, additional, Yi, Yoon-Sun, additional, Jun, Sangmi, additional, Park, Minsung, additional, Kim, Jinkuk, additional, Auwerx, Johan, additional, Sohn, Jong-Woo, additional, Lee, Ju Hee, additional, and Shong, Minho, additional

Published
2024
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23. Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Author

Huang, Hu, Lee, Seung-Hwan, Sousa-Lima, Ines, Kim, Sang Soo, Hwang, Won Min, Dagon, Yossi, Yang, Won-Mo, Cho, Sungman, Kang, Min-Cheol, Seo, Ji A., Shibata, Munehiko, Cho, Hyunsoo, Belew, Getachew Debas, Bhin, Jinhyuk, Desai, Bhavna N., Ryu, Min Jeong, Shong, Minho, Li, Peixin, Meng, Hua, Chung, Byung-Hong, Hwang, Daehee, Kim, Min Seon, Park, Kyong Soo, Macedo, Maria Paula, White, Morris, Jones, John, and Kim, Young-Bum

Subjects
Obesity -- Complications and side effects -- Genetic aspects, Fatty liver -- Risk factors -- Genetic aspects, Cellular signal transduction -- Research, Gene expression -- Research, Hepatocellular carcinoma, Insulin resistance, Carcinoma, Insulin, Liver diseases, Genes, Liver cirrhosis, Hyperglycemia, Type 2 diabetes, Biochemistry, Health care industry
Abstract

Obesity is a major risk factor for developing nonalcoholic fatty liver disease (NAFLD). NAFLD is the most common form of chronic liver disease and is closely associated with insulin resistance, ultimately leading to cirrhosis and hepatocellular carcinoma. However, knowledge of the intracellular regulators of obesity-linked fatty liver disease remains incomplete. Here we showed that hepatic Rho-kinase 1 (ROCK1) drives obesity-induced steatosis in mice through stimulation of de novo lipogenesis. Mice lacking ROCK1 in the liver were resistant to diet-induced obesity owing to increased energy expenditure and thermogenic gene expression. Constitutive expression of hepatic ROCK1 was sufficient to promote adiposity, insulin resistance, and hepatic lipid accumulation in mice fed a high-fat diet. Correspondingly, liver-specific ROCK1 deletion prevented the development of severe hepatic steatosis and reduced hyperglycemia in obese diabetic (ob/ob) mice. Of pathophysiological significance, hepatic ROCK1 was markedly upregulated in humans with fatty liver disease and correlated with risk factors clustering around NAFLD and insulin resistance. Mechanistically, we found that hepatic ROCK1 suppresses AMPK activity and a ROCK1/AMPK pathway is necessary to mediate cannabinoid-induced lipogenesis in the liver. Furthermore, treatment with metformin, the most widely used antidiabetes drug, reduced hepatic lipid accumulation by inactivating ROCK1, resulting in activation of AMPK downstream signaling. Taken together, our findings establish a ROCK1/AMPK signaling axis that regulates de novo lipogenesis, providing a unique target for treating obesity-related metabolic disorders such as NAFLD., IntroductionObesity has reached epidemic proportions in the United States and worldwide, and is associated with increased risk for type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), atherosclerotic disease, sleep apnea, [...]

Published
2018
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25. Abstract 6069: Genomic and transcriptomic characterization of medullary thyroid cancer

Author

Lee, Seong Eun, primary, Park, Seongyeol, additional, Yi, Shinae, additional, Lim, Joonoh, additional, Choi, Na Rae, additional, Kwak, JungHak, additional, Koh, June-Young, additional, Yi, Boram, additional, Koo, Jaemo, additional, Chang, Jae Won, additional, Ju, Young Seok, additional, Koo, Bon Seok, additional, Kim, Jin Man, additional, Park, Young Joo, additional, Shong, Minho, additional, Lee, Eun Kyung, additional, Won, Jae Kyung, additional, Kang, Yea Eun, additional, and Lee, Kyu Eun, additional

Published
2023
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29. Supplementary Figures 1 - 4 from Aberrant L1 Cell Adhesion Molecule Affects Tumor Behavior and Chemosensitivity in Anaplastic Thyroid Carcinoma

Author

Kim, Koon Soon, primary, Min, Jeong-Ki, primary, Liang, Zhe Long, primary, Lee, Kyungmin, primary, Lee, Jung Uee, primary, Bae, Kwang-Hee, primary, Lee, Min Hee, primary, Lee, Seong Eun, primary, Ryu, Min Jeong, primary, Kim, Soung Jung, primary, Kim, Yong Kyoung, primary, Choi, Min Jeong, primary, Jo, Young Suk, primary, Kim, Jin-Man, primary, and Shong, Minho, primary

Published
2023
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30. Supplementary Figure Legend from Aberrant L1 Cell Adhesion Molecule Affects Tumor Behavior and Chemosensitivity in Anaplastic Thyroid Carcinoma

Author

Kim, Koon Soon, primary, Min, Jeong-Ki, primary, Liang, Zhe Long, primary, Lee, Kyungmin, primary, Lee, Jung Uee, primary, Bae, Kwang-Hee, primary, Lee, Min Hee, primary, Lee, Seong Eun, primary, Ryu, Min Jeong, primary, Kim, Soung Jung, primary, Kim, Yong Kyoung, primary, Choi, Min Jeong, primary, Jo, Young Suk, primary, Kim, Jin-Man, primary, and Shong, Minho, primary

Published
2023
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31. Data from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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32. Supplementary Figure 5 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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33. Supplementary Figure 7 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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34. Supplementary Figure 4 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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35. Supplementary Figure Legends 1-7, Methods from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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36. Supplementary Figure 1 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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37. Supplementary Figure 2 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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38. Supplementary Figure 3 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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39. Supplementary Figure 6 from Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death

Author

Piao, Longzhen, primary, Li, Yuwen, primary, Kim, Soung Jung, primary, Byun, Hee Sun, primary, Huang, Song Mei, primary, Hwang, Soon-Kyung, primary, Yang, Keum-Jin, primary, Park, Kyeong Ah, primary, Won, Minho, primary, Hong, Janghee, primary, Hur, Gang Min, primary, Seok, Jeong Ho, primary, Shong, Minho, primary, Cho, Myung-Haing, primary, Brazil, Derek P., primary, Hemmings, Brian A., primary, and Park, Jongsun, primary

Published
2023
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40. Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Author

Kim, Yuna, primary, Jung, Kwan-Young, additional, Kim, Yun Hak, additional, Xu, Pan, additional, Jo, Yunju, additional, Kang, Baeki E., additional, Pandit, Navin, additional, Kwon, Jeongho, additional, Gariani, Karim, additional, Gariani, Joanna, additional, Lee, Junguee, additional, Verbeek, Jef, additional, Nam, Seungyoon, additional, Bae, Sung-Jin, additional, Ha, Ki-Tae, additional, Yi, Hyon-Seung, additional, Shong, Minho, additional, Kim, Kyun-Hwan, additional, Kim, Doyoun, additional, Lee, Chang-Woo, additional, Jung, Hee Jung, additional, Kim, Kwang Rok, additional, Schoonjans, Kristina, additional, Ryu, Dongryeol, additional, and Auwerx, Johan, additional

Published
2023
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42. Single Cell Analysis of Human Thyroid Reveals the Transcriptional Signatures of Aging

Author

Hong, Yourae, primary, Kim, Hyun Jung, additional, Park, Seongyeol, additional, Yi, Shinae, additional, Lim, Mi Ae, additional, Lee, Seong Eun, additional, Chang, Jae Won, additional, Won, Ho-Ryun, additional, Kim, Je-Ryong, additional, Ko, Hyemi, additional, Kim, Seon-Young, additional, Kim, Seon-Kyu, additional, Park, Jong-Lyul, additional, Chu, In-Sun, additional, Kim, Jin Man, additional, Kim, Kun Ho, additional, Lee, Jeong Ho, additional, Ju, Young Seok, additional, Shong, Minho, additional, Koo, Bon Seok, additional, Park, Woong-Yang, additional, and Kang, Yea Eun, additional

Published
2023
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43. Crif1deficiency in dopamine neurons triggers early-onset parkinsonism

Author

Heo, Jun Young, Park, Ah Hyung, Lee, Min Joung, Ryu, Min Jeong, Kim, Yong Kyung, Jang, Yun Seon, Kim, Soo Jeong, Shin, So Yeon, Son, Hyo Jin, Stein, Thor D., Huh, Yang Hoon, Chung, Sookja K., Choi, Song Yi, Kim, Jin Man, Hwang, Onyou, Shong, Minho, Hyeon, Seung Jae, Lee, Junghee, Ryu, Hoon, Kim, Daesoo, and Kweon, Gi Ryang

Abstract

Mitochondrial dysfunction has been implicated in Parkinson’s Disease (PD) progression; however, the mitochondrial factors underlying the development of PD symptoms remain unclear. One candidate is CR6-interacting factor1 (CRIF1), which controls translation and membrane insertion of 13 mitochondrial proteins involved in oxidative phosphorylation. Here, we found that CRIF1 mRNA and protein expression were significantly reduced in postmortem brains of elderly PD patients compared to normal controls. To evaluate the effect of Crif1deficiency, we produced mice lacking the Crif1gene in dopaminergic neurons (DAT-CRIF1-KO mice). From 5 weeks of age, DAT-CRIF1-KO mice began to show decreased dopamine production with progressive neuronal degeneration in the nigral area. At ~10 weeks of age, they developed PD-like behavioral deficits, including gait abnormalities, rigidity, and resting tremor. L-DOPA, a medication used to treat PD, ameliorated these defects at an early stage, although it was ineffective in older mice. Taken together, the observation that CRIF1 expression is reduced in human PD brains and deletion of CRIF1 in dopaminergic neurons leads to early-onset PD with stepwise PD progression support the conclusion that CRIF1-mediated mitochondrial function is important for the survival of dopaminergic neurons.

Published
2023
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47. Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions

Author

Kim, Jung Tae, primary, Lim, Mi Ae, additional, Lee, Seong Eun, additional, Kim, Hyun Jung, additional, Koh, Hyun Yong, additional, Lee, Jeong Ho, additional, Jun, Sang Mi, additional, Kim, Jin Man, additional, Kim, Kun Ho, additional, Shin, Hyo Shik, additional, Cho, Sun Wook, additional, Kim, Koon Soon, additional, Shong, Minho, additional, Koo, Bon Seok, additional, and Kang, Yea Eun, additional

Published
2022
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48. Mitochondrial SHMT2 is a crucial therapeutic target in dedifferentiated thyroid cancer

Author

Lee, Seong Eun, primary, Park, Seongyeol, additional, Yi, Shinae, additional, Lim, Mi Ae, additional, Chang, Jae Won, additional, Won, Ho-Ryun, additional, Kim, Je Ryong, additional, Ko, Hyemi, additional, Chung, Eun-Jae, additional, Park, Young Joo, additional, Cho, Sun Wook, additional, Yu, Hyeong Won, additional, Choi, June Young, additional, Yeo, Min-Kyung, additional, Yi, Boram, additional, Yi, Kijong, additional, Lim, Joonoh, additional, Lee, Min Joung, additional, Heo, Jun Young, additional, Yoon, Sang Jun, additional, Kwon, Sung Won, additional, Park, Jong-Lyul, additional, Chu, In-Sun, additional, Kim, Jin Man, additional, Kim, Seon-Young, additional, Hong, Suna-A, additional, Choi, Dong Wook, additional, Ju, Young Seok, additional, Shong, Minho, additional, Kim, Seon-Kyu, additional, Koo, Bon Seok, additional, and Kang, Yea, additional

Published
2022
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