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1. Efficacy and safety of a fixed‐dose combination of dapagliflozin and linagliptin (AJU‐A51) in patients with type 2 diabetes mellitus: A multicentre, randomized, double‐blind, parallel‐group, placebo‐controlled phase III study

Author

Hong, Jun Hwa, Kim, Myung Jin, Min, Kyung Wan, Won, Jong Chul, Kim, Tae Nyun, Lee, Byung‐Wan, Kang, Jun Goo, Kim, Jae Hyeon, Park, Jung Hwan, Ku, Bon Jeong, Lee, Chang Beom, Kim, Sang Yong, Shon, Ho Sang, Lee, Woo Je, and Park, Joong‐Yeol

Subjects
TYPE 2 diabetes, SODIUM-glucose cotransporter 2 inhibitors, GLYCEMIC control, LINAGLIPTIN, HYPOGLYCEMIA, DAPAGLIFLOZIN
Abstract

Aims: To evaluate the efficacy and safety of add‐on dapagliflozin in patients with type 2 diabetes mellitus (T2D) who had inadequate glycaemic control with metformin and linagliptin. Materials and Methods: A total of 235 patients with inadequate response to metformin (≥1000 mg/day) plus linagliptin (5 mg/day) were randomized to receive either dapagliflozin/linagliptin fixed‐dose combination (FDC [AJU‐A51]) 10/5 mg/day (n = 117) or linagliptin 5 mg plus placebo (n = 118) for 24 weeks. After the main treatment period, patients who received linagliptin plus placebo were treated with AJU‐A51 for an additional 28 weeks. Change in glycated haemoglobin (HbA1c) from baseline to Week 24 was the primary endpoint. Results: AJU‐A51 significantly reduced HbA1c levels (from 7.93% ± 0.82% to 7.11% ± 0.61%) compared with linagliptin plus placebo (from 7.80% ± 0.71% to 7.87% ± 0.94%), with a least squares mean difference of −0.88% (95% confidence interval −1.07 to −0.68; p < 0.0001) at 24 weeks. The AJU‐A51 group had a significantly higher proportion of patients who achieved HbA1c <7.0% at Week 24 than the control group (44.8% vs. 18.6%; p < 0.001). The AJU‐A51 group maintained glycaemic efficacy up to 52 weeks, whereas the control group showed a substantial reduction in HbA1c after switching to AJU‐A51 in the extension study period. Both groups had similar incidence of treatment‐emergent and serious adverse events, and no cases of symptomatic hypoglycaemia were reported. Conclusions: Dapagliflozin and linagliptin FDC (AJU‐A51) showed potent glucose‐lowering effects, with good tolerability, in patients with T2D who had poor glycaemic control on metformin and linagliptin (ClinicalTrials.gov [NCT06329674]). [ABSTRACT FROM AUTHOR]

Published
2025
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3. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Elbert, Alicia, Vallejos, Augusto, Alvarisqueta, Andres, Maffei, Laura, Juncos, Luis, de Arteaga, Javier, Greloni, Gustavo, Farias, Eduardo, Zucchini, Alfredo, Vogel, Daniel, Cusumano, Ana, Santos, Juan, Fraenkel, Margaret, Gallagher, Martin, Davis, Tim, Acharya, Shamasunder, Cooke, Duncan, Suranyi, Michael, Roger, Simon, Toussaint, Nigel, Pollock, Carol, Chan, Doris, Stranks, Stephen, MacIsaac, Richard, Endre, Zoltan, Schmidt, Alice, Prager, Rudolf, Mayer, Gert, Warling, Xavier, Jadoul, Michel, Hougardy, Jean, Vercammen, Chris, Van Vlem, Bruno, Gillard, Pieter, Costa e Forti, Adriana, Borges, Joao Lindolfo, Santos Canani, Luis, Eliaschewitz, Freddy, Leite, Silmara, Fraige Filho, Fadlo, Paschoalin, Raphael, Moura Neto, Jose Andrade, Deboni, Luciane, de Lourdes Noronha, Irene, Cercato, Cintia, Prompt, Carlos Alberto, Zanella, Maria, Rassi, Nelson, D'Avila, Domingos, Milagres, Rosangela, Felicio, Joao, Pecoits Filho, Roberto, Riella, Miguel Carlos, Salles, Joao, Keitel, Elizete, Draibe, Sergio, Amodeo, Celso, Youmbissi, Joseph, Roy, Louise, Cournoyer, Serge, Jolly, Shivinder, Pichette, Vincent, Nesrallah, Gihad, Bajaj, Harpreet Singh, Khandwala, Hasnain, Aronson, Ronnie, Goluch, Richard, Tam, Paul, Rabbat, Christian, Tobe, Sheldon, Bailey, Gordon, Chow, Stephen, Castillo, Alvaro, Danin Vargas, Alfredo, Gonzalez, Fernando, Munoz, Rodrigo, Gutierrez, Vicente, Godoy, Gonzalo, Zhao, Hongwen, Liu, Zhangsuo, Zhao, Minghui, Guo, Xiaohui, Su, Benli, Fu, Shuxia, Xu, Yan, Yang, Jinkui, Shi, Bingyin, Xiao, Guanqing, Shi, Wei, Hao, Chuanming, Xing, Changying, Hou, Fanfan, Luo, Qun, Li, Yuxiu, Ji, Linong, Zuo, Li, Wang, Song, Ni, Zhaohui, Ding, Guohua, Chen, Nan, Zhao, Jiajun, Jia, Weiping, Yu, Shengqiang, Weng, Jian, Xu, Gang, Fu, Ping, Sun, Shiren, Liu, Bicheng, Ding, Xiaoqiang, Rychlik, Ivan, Oplustilova, Alexandra, Bartaskova, Dagmar, Honova, Vaclava, Chmelickova, Hana, Petr, Martin, Bucek, Petr, Tesar, Vladimir, Zahumensky, Emil, Povlsen, Johan, Egstrup, Kenneth, Oczachowska-Kulik, Anna, Rossing, Peter, Lahtela, Jorma, Strand, Jorma, Kantola, Ilkka, Petit, Catherine, Combe, Christian, Zaoui, Philippe, Esnault, Vincent, Urena Torres, Pablo, Halimi, Jean-Michel, Dussol, Bertrand, Bieler, Tasso, Budde, Klemens, Dellanna, Frank, Segiet, Thomas, Kosch, Christine, Schmidt-Guertler, Hans, Schenkenberger, Isabelle, Vielhauer, Volker, Pistrosch, Frank, Alscher, Mark, Hasslacher, Christoph, Hugo, Christian, Muehlfeld, Anja, Wanner, Christoph, Passadakis, Ploumis, Apostolou, Theofanis, Tentolouris, Nikolaos, Stefanidis, Ioannis, Mavromatidis, Konstantinos, Liakopoulos, Vasilios, Goumenos, Dimitrios, Siamopoulos, Konstantinos, Yeung, Vincent, Ozaki, Risa, Fung, Samuel, Tan, Kathryn, Tang, Sydney, Lui, Sing Leung, Cheung, Siu Fai, Sreenan, Seamus, Eustace, Joseph, O'Shea, Donal, Lavin, Peter, Stack, Austin, Yagil, Yoram, Wainstein, Julio, Knobler, Hilla, Cohen, Josef, Kenis, Irina, Daoud, Deeb, Bar-Dayan, Yosefa, Frajewicki, Victor, Adawi, Faiad, Gesualdo, Loreto, Santoro, Domenico, Marino, Francesco, Galfre, Andrea, Brunati, Chiara, Ruggenenti, Piero, Rombola, Giuseppe, Pugliese, Giuseppe, Ravera, Maura, Malberti, Fabio, Pontoriero, Giuseppe, Rampino, Teresa, De Cosmo, Salvatore, Esposito, Ciro, Nappi, Felice, Abaterusso, Cataldo, Conte, Giuseppe, Panichi, Vincenzo, Lauro, Davide, Capasso, Giovambattista, Russo, Domenico, Anzai, Jiichi, Naka, Motoji, Ato, Keita, Tsujimoto, Tetsuro, Nimura, Toshinori, Nakashima, Eitaro, Takeda, Tetsuro, Fujii, Shinya, Kobayashi, Kunihisa, Iwaoka, Hideaki, Nagayama, Koji, Harada, Hiroyuki, Maeda, Hajime, Kishimoto, Rui, Iitsuka, Tadashi, Itabashi, Naoki, Furuya, Ryuichi, Maeda, Yoshitaka, Yamada, Daishiro, Sasaki, Nobuhiro, Sasaki, Hiromitsu, Ueda, Shinichiro, Kashihara, Naoki, Watanabe, Shuichi, Nakamura, Takehiro, Kanai, Hidetoshi, Makita, Yuichiro, Ono, Keiko, Iehara, Noriyuki, Goto, Daisuke, Kosuge, Keiichiro, Tsuchida, Kenichi, Sato, Toshiaki, Sekikawa, Takashi, Okamoto, Hideki, Tanaka, Tsuyoshi, Ikeda, Naoko, Tadika, Takenobu, Mukasa, Koji, Osonoi, Takeshi, Hirano, Fuminori, Nishimura, Motonobu, Yambe, Yuko, Tanaka, Yukio, Ujihara, Makoto, Sakai, Takashi, Imura, Mitsuo, Umayahara, Yutaka, Makino, Shinya, Nakazawa, Jun, Yamaguchi, Yukinari, Kashine, Susumu, Miyaoka, Hiroaki, Suzuki, Katsunori, Inoue, Toshihiko, Nagai, Sou, Sato, Nobuyuki, Yamamoto, Masahiro, Taya, Noriyasu, Fujita, Akira, Matsutani, Akira, Shibagaki, Yugo, Sato, Yuichi, Yamauchi, Akira, Tsutsui, Masahiro, Ishiko, Tamayo, Kaneko, Shizuka, Azuma, Nobuyuki, Matsuda, Hirofumi, Hashiguchi, Yasuhiro, Onishi, Yukiko, Tokui, Mikiya, Matsuhisa, Munehide, Kiyosue, Arihiro, Shinoda, Junji, Ishikawa, Kazuo, Ahmad, Ghazali, Vijayasingham, Shalini, Aziz, Nor Azizah, Hussein, Zanariah, Fung, Yin Khet, Hassan, Wan Hasnul Halimi Wan, Wong, Hin Seng, Goh, Bak Leong, Ali, Norhaliza Mohd, Merican, Nor Shaffinaz Yusuf Azmi, Vaithilingam, Indralingam, Nik Ahmad, Nik Nur Fatnoon, Adam, Noor, Sukor, Norlela, Vengadasalam, V Paranthaman P, Abdul Kadir, Khalid, Mohamed, Mafauzy, Renoirte Lopez, Karina, Leguizamo-Dimas, Aniceto, Chew Wong, Alfredo, Chevaile-Ramos, Jose, Gonzalez Gonzalez, Jose, Rico Hernandez, Raul, Nino-Cruz, Jose, Sauque Reyna, Leobardo, Gonzalez-Galvez, Guillermo, Madero Rovalo, Magdalena, Bochicchio-Ricardelli, Tomasso, Aldrete, Jorge, Carranza-Madrigal, Jaime, Vogt, Liffert, Smak Gregoor, Peter, Barendregt, JNM, Luik, Peter, Gansevoort, Ronald, Laverman, Gozewijn, Pilmore, Helen, Lunt, Helen, Baker, John, Miller, Steven, Rabindranath, Kannaiyan, Zapata-Rincon, Luis, Vargas-Gonzales, Rolando, Calderon Ticona, Jorge, Dextre Espinoza, Augusto, Burga Nunez, Jose, Zea-Nunez, Carlos Antonio, Herrada Orue, Benjamin, Medina-Santander, Boris, Delgado-Butron, Cesar, Farfan-Aspilcueta, Julio, Mazur, Stanislaw, Necki, Miroslaw, Wruk, Michal, Klodawska, Katarzyna, Popenda, Grazyna, Skokowska, Ewa, Arciszewska, Malgorzata, Wiecek, Andrzej, Ciechanowski, Kazimierz, Nowicki, Michal, Birne, Rita, Cabrita, Antonio, Ramos, Aura, Antunes Ferreira, Manuel Anibal, Matta Fontanet, Evelyn, Alcantara-Gonzalez, Altagracia Aurora, Comulada-Rivera, Angel, Galindo Ramos, Eugenia, Cangiano, Jose, Quesada-Suarez, Luis, Calderon Ortiz, Ricardo, Vazquez-Tanus, Jose, Burgos-Calderon, Rafael, Rosado, Carlos, Hancu, Nicolae, Pintilei, Ella, Mistodie, Cristina, Bako, Gabriel, Ionutiu, Lavinia, Petrica, Ligia, Timar, Romulus, Tuta, Liliana, Duma, Livia, Tutescu, Adriana, Ivanova, Svetlana, Essaian, Ashot, Zrazhevskiy, Konstantin, Tomilina, Natalia, Smolyarchuk, Elena, Kuzin, Anatoly, Lantseva, Olga, Karpova, Irina, Shamkhalova, Minara, Liberanskaya, Natalia, Yavdosyuk, Andrey, Shvarts, Yuri, Bardymova, Tatiana, Blagoveshchenskaya, Olga, Solovev, Oleg, Rechkova, Elena, Pikalova, Natalia, Pavlova, Maria, Kolmakova, Elena, Sayfutdinov, Rustam, Villevalde, Svetlana, Koziolova, Natalya, Martynenko, Vladimir, Marasaev, Vyacheslav, Maksudova, Adelya, Sigitova, Olga, Mordovin, Viktor, Klimontov, Vadim, Samoylova, Yulia, Karonova, Tatiana, Yeoh, Lee Ying, Teo, Boon Wee, Foo, Marjorie Wai Yin, Liew, Adrian, Tkac, Ivan, Oroszova, Aniko, Fekete, Jozef, Rosenberger, Jaroslav, Obetkova, Ida, Fulopova, Alla, Kolesarova, Eva, Raslova, Katarina, Smolko, Peter, Oksa, Adrian, Distiller, Larry, Trokis, Julien, Adams, Luthando, Makan, Hemant, Ramlachan, Padaruth, Mitha, Essack, Coetzee, Kathleen, Punt, Zelda, Bhorat, Qasim, Naiker, Puvenesvari, Ellis, Graham, Van Zyl, Louis, Lee, Kwan Woo, Kim, Min Seon, Yoo, Soon-Jib, Yoon, Kun Ho, Cho, Yong-Wook, Park, Tae-Sun, Kim, Sang Yong, Choi, Moon-Gi, Oh, Tae Keun, Lee, Kang-Wook, Shon, Ho Sang, Suh, Sung Hwan, Kim, Byung-Joon, Doo-Man, Kim, Yi, Joo Hark, Lee, Sang Ah, Cho, Ho Chan, Kim, Sin-Gon, Cha, Dae-Ryong, Seo, Ji A, Choi, Kyung Mook, Woo, Jeong-Taek, Ahn, Kyu Jeung, Lee, Jae Hyuk, Kim, In-Joo, Lee, Moon-Kyu, Jang, Hak Chul, Park, Kyong-Soo, Kim, Beom Seok, Mok, Ji Oh, Shin, Mijung, Yoon, Sun Ae, Nam-Goong, Il-Seong, Chung, Choon Hee, Yu, Tae Yang, Lee, Hyoung Woo, Soto Gonzalez, Alfonso, Almirall, Jaume, Egido, Jesus, Calero Gonzalez, Francesca, Fernandez Fresnedo, Gema, Valera Cortes, Ildefonso, Praga Terente, Manuel, Garcia Mendez, Isabel, Navarro Gonzalez, Juan, Herrero Calvo, Jose, Cigarran Guldris, Secundino, Prieto Velasco, Mario, Minguela Pesquera, Jose Ignacio, Galan, Antonio, Pascual, Julio, Marques Vidas, Maria, Martins Munoz, Judith, Rodriguez-Perez, Jose, Castro-Alonso, Cristina, Bonet Sol, Josep, Seron, Daniel, Fernandez Giraldez, Elvira, Arrieta Lezama, Javier, Montero, Nuria, Hernandez-Jaras, Julio, Santamaria Olmo, Rafael, Molas Coten, Jose Ramon, Hellberg, Olof, Fellstrom, Bengt, Bock, Andreas, Pei, Dee, Lin, Ching-Ling, Tien, Kai-Jen, Chen, Ching-Chu, Huang, Chien-Ning, Jiang, Ju-Ying, Wu, Du-An, Chu, Chih-Hsun, Tseng, Shih-Ting, Chen, Jung-Fu, Bau, Cho-Tsan, Sheu, Wayne, Wu, Mai-Szu, Sari, Ramazan, Sezer, Siren, Yildiz, Alaattin, Satman, Ilhan, Kalender, Betul, Mankovskyy, Borys, Fushtey, Ivan, Stanislavchuk, Mykola, Kolenyk, Mykola, Dudar, Iryna, Zolotaikina, Viktoriia, Abrahamovych, Orest, Kostynenko, Tetyana, Petrosyan, Olena, Kuskalo, Petro, Galushchak, Olga, Legun, Oleg, Topchii, Ivan, Martynyuk, Liliya, Stryzhak, Vasyl, Panina, Svitlana, Tkach, Sergii, Korpachev, Vadym, Maxwell, Peter, Gnudi, Luigi, Kon, Sui Phin, Tindall, Hilary, Kalra, Phillip, Mark, Patrick, Patel, Dipesh, El-Shahawy, Mohamed, Bai, Liqun, Nica, Romanita, Lien, Yeong-Hau, Menefee, Judson, Busch, Robert, Miller, Alan, Ahmed, Azazuddin, Arif, Ahmed, Lee, Joseph, Desai, Sachin, Bansal, Shweta, Bentsianov, Marie, Belledonne, Mario, Jere, Charles, Gaona, Raul, Greenwood, Gregory, Brusco, Osvaldo, Boiskin, Mark, Belo, Diogo, Minasian, Raffi, Atray, Naveen, Lawrence, Mary, Taliercio, John, Pergola, Pablo, Scott, David, Alvarez, German, Marder, Bradley, Powell, Thomas, Bakdash, Wa'el, Stoica, George, McFadden, Christopher, Rendell, Marc, Wise, Jonathan, Jones, Audrey, Jardula, Michael, Madu, Ivy-Joan, Varghese, Freemu, Tulloch, Brian, Ahmed, Ziauddin, Hames, Melanie, Nazeer, Imran, Shahid, Newman, John, Rekha, Montero, Manuel, Fitz-Patrick, David, Phillips, Lawrence, Guasch, Antonio, Christofides, Elena, Gundroo, Aijaz, Amin, Mohammad, Bowman-Stroud, Cynthia, Link, Michael, Mulloy, Laura, Nammour, Michael, Lalwani, Tarik, Hanson, Lenita, Whaley-Connell, Adam, Herman, Lee, Chatha, Rupi, Osama, Sayed, Liss, Kenneth, Kayali, Zeid, Bhargava, Anuj, Israel, Ezra, Peguero-Rivera, Alfredo, Fang, Michael, Slover, Judith, Barengolts, Elena, Flores, Jose, Muoneke, Rosemary, Savin, Virginia, Awua-Larbi, Stella, Levine, Andrew, Newman, George, Golestaneh, Laden, Bohm, Guillermo, Reisin, Efrain, Cruz, Lucita, Weiss, Robert, Zieve, Franklin, Horwitz, Edward, Chuang, Peale, Mersey, James, Manley, John, Graf, Ronald, Bedros, Fadi, Joshi, Sudhir, Frias, Juan, Assefi, Ali, O'Shaughnessy, Andrew, Brantley, Roman, Minga, Todd, Tietjen, David, Kantor, Samuel, Jamal, Aamir, Guadiz, Ramon, Hershon, Kenneth, Bressler, Peter, Kopyt, Nelson, Cathcart, Harold, Bloom, Scott, Reichel, Ronald, Nakhle, Samer, Dulude, Emily, Tarkan, Joshua, Baker, Penelope, Zeig, Steven, Moya Hechevarria, Jaynier, Ropero-Cartier, Armando, De la Calle, Gilda, Doshi, Ankur, Saba, Fadi, Sligh, Teresa, Shaw, Sylvia, Kumar, Jayant, Szerlip, Harold, Bayliss, George, Perlman, Alan, Sakhrani, Lakhi, Gouge, Steven, Argoud, Georges, Acosta, Idalia, Elder, John, Joshi, Sucharit, Sensenbrenner, John, Vicks, Steven, Mangoo-Karim, Roberto, Galphin, Claude, Leon-Forero, Carlos, Gilbert, John, Brown, Eric, Ijaz, Adeel, Butt, Salman, Markell, Mariana, Arauz-Pacheco, Carlos, Sloan, Lance, Alvarado, Odilon, Jabbour, Serge, Simon, Eric, Rastogi, Anjay, James, Sam, Bakris, George, Hall, Karen, Melish, John, Dixon, Brad, Adolphe, Allen, Kovesdy, Csaba, Beddhu, Srinivasan, Solomon, Richard, Fernando, Ronald, Levin, Ellis, Thakar, Charuhas, Robey, Brooks, Goldfarb, David, Fried, Linda, Maddukuri, Geetha, Thomson, Stephen, Annand, Andrew, Kronfli, Saeed, Kalirao, Paramjit, Schmidt, Rebecca, Dahl, Neera, Blumenthal, Samuel, Weinstein, Debra, Ostergaard, Ove, Weinstein, Talia, Ono, Yasuhiro, Yalcin, Murat, Karim, Shahana, Heerspink, Hiddo J L, Parving, Hans-Henrik, Andress, Dennis L, Correa-Rotter, Ricardo, Hou, Fan-Fan, Kitzman, Dalane W, Kohan, Donald, Makino, Hirofumi, McMurray, John J V, Melnick, Joel Z, Miller, Michael G, Pergola, Pablo E, Perkovic, Vlado, Yi, Tingting, Wigderson, Melissa, and de Zeeuw, Dick

Published
2019
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4. Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea

Author

Kim,Hye Soon, Yu,Jae Myung, Jang,Hak Chul, Choi,Eui Kwang, Park,Jeong Hyun, Shon,Ho Sang, Chung,Choon Hee, Park,Keun-Gyu, Cho,Jae Hyoung, Kim,Won, Lee,Kyoung Hwa, Lee,Jee Hyun, Yoo,Soon Jib, Kim,Hye Soon, Yu,Jae Myung, Jang,Hak Chul, Choi,Eui Kwang, Park,Jeong Hyun, Shon,Ho Sang, Chung,Choon Hee, Park,Keun-Gyu, Cho,Jae Hyoung, Kim,Won, Lee,Kyoung Hwa, Lee,Jee Hyun, and Yoo,Soon Jib

Abstract

Hye Soon Kim,1 Jae Myung Yu,2 Hak Chul Jang,3 Eui Kwang Choi,4 Jeong Hyun Park,5 Ho Sang Shon,6 Choon Hee Chung,7 Keun-Gyu Park,8 Jae Hyoung Cho,9 Won Kim,10 Kyoung Hwa Lee,10 Jee Hyun Lee,10 Soon Jib Yoo11 1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; 2Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea; 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; 4Department of Internal Medicine, Naedang Dr. Choi’s Clinic, Seoul, Republic of Korea; 5Department of Internal Medicine, College of Medicine, Inje University, Busan, Republic of Korea; 6Department of Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu, Republic of Korea; 7Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; 8Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea; 9Department of Endocrinology and Metabolism, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 10Medical Department Sanofi-Aventis Korea, Seoul, Republic of Korea; 11Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Republic of KoreaCorrespondence: Soon Jib Yoo, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, 14647, Republic of Korea, Tel +82-32-340-7011, Fax +82-32-340-2039, Email sjyoomt@gmail.comPurpose: Although rapid-acting insulins (RAIs) are used frequently in Korean clinical settings, evidence on their use is limited. This study explores the pattern and clinical effectiveness of the use of RAIs in Korean patients with type 2 diabetes mellitus (T2DM).Patients and M

Published
2022

5. Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea

Author

Kim, Hye Soon, primary, Yu, Jae Myung, additional, Jang, Hak Chul, additional, Choi, Eui Kwang, additional, Park, Jeong Hyun, additional, Shon, Ho Sang, additional, Chung, Choon Hee, additional, Park, Keun-Gyu, additional, Cho, Jae Hyoung, additional, Kim, Won, additional, Lee, Kyoung Hwa, additional, Lee, Jee Hyun, additional, and Yoo, Soon Jib, additional

Published
2022
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6. Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes

Author

Kim, Ji-Hyun, Ahn, Ji-Hyun, Kim, Soo-Kyung, Lee, Dae-Ho, Kim, Hye-Soon, Shon, Ho-Sang, Jeon, Hyun-Jeong, Kim, Tae-Hwa, Cho, Yong-Wook, Kim, Jae-Taek, Han, Sung-Min, Chung, Choon-Hee, Ryu, Ohk-Hyun, Lee, Jae-Min, Lee, Soon-Hee, Kwon, Min-Jeong, Kim, Tae-kyun, Namgoong, Il-Seong, Kim, Eun-Sook, Jung, In-Kyung, Moon, Sung-Dae, Han, Je-Ho, Kim, Chong-Hwa, Cho, Eun-Hee, Kim, Ki-Young, Park, Hee-Baek, Lee, Ki-Sang, Lee, Sung-Woo, Lee, Sang-Cheol, Kang, Cheol-Min, Jeon, Byung-Sook, Song, Min-Seop, Yun, Seung-Baik, Chung, Hyung-Keun, Seong, Jong-Ho, Jeong, Jin-Yi, and Cha, Bong-Yun

Published
2015
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12. Efficacy and safety of lobeglitazone versus sitagliptin as an add‐on to metformin in patients with type 2 diabetes with two or more components of metabolic syndrome over 24 weeks

Author

Kim, Sin Gon, primary, Kim, Kyoung Jin, additional, Yoon, Kun Ho, additional, Chun, Sung Wan, additional, Park, Kyong Soo, additional, Choi, Kyung Mook, additional, Lim, Soo, additional, Mok, Ji‐Oh, additional, Lee, Hyoung Woo, additional, Seo, Ji A., additional, Cha, Bong‐Soo, additional, Kim, Mi Kyung, additional, Shon, Ho Sang, additional, Choi, Dong Seop, additional, and Kim, Doo Man, additional

Published
2020
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15. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Heerspink, Hiddo J L, primary, Parving, Hans-Henrik, additional, Andress, Dennis L, additional, Bakris, George, additional, Correa-Rotter, Ricardo, additional, Hou, Fan-Fan, additional, Kitzman, Dalane W, additional, Kohan, Donald, additional, Makino, Hirofumi, additional, McMurray, John J V, additional, Melnick, Joel Z, additional, Miller, Michael G, additional, Pergola, Pablo E, additional, Perkovic, Vlado, additional, Tobe, Sheldon, additional, Yi, Tingting, additional, Wigderson, Melissa, additional, de Zeeuw, Dick, additional, Elbert, Alicia, additional, Vallejos, Augusto, additional, Alvarisqueta, Andres, additional, Maffei, Laura, additional, Juncos, Luis, additional, de Arteaga, Javier, additional, Greloni, Gustavo, additional, Farias, Eduardo, additional, Zucchini, Alfredo, additional, Vogel, Daniel, additional, Cusumano, Ana, additional, Santos, Juan, additional, Fraenkel, Margaret, additional, Gallagher, Martin, additional, Davis, Tim, additional, Acharya, Shamasunder, additional, Cooke, Duncan, additional, Suranyi, Michael, additional, Roger, Simon, additional, Toussaint, Nigel, additional, Pollock, Carol, additional, Chan, Doris, additional, Stranks, Stephen, additional, MacIsaac, Richard, additional, Endre, Zoltan, additional, Schmidt, Alice, additional, Prager, Rudolf, additional, Mayer, Gert, additional, Warling, Xavier, additional, Jadoul, Michel, additional, Hougardy, Jean, additional, Vercammen, Chris, additional, Van Vlem, Bruno, additional, Gillard, Pieter, additional, Costa e Forti, Adriana, additional, Borges, Joao Lindolfo, additional, Santos Canani, Luis, additional, Eliaschewitz, Freddy, additional, Leite, Silmara, additional, Fraige Filho, Fadlo, additional, Paschoalin, Raphael, additional, Moura Neto, Jose Andrade, additional, Deboni, Luciane, additional, de Lourdes Noronha, Irene, additional, Cercato, Cintia, additional, Prompt, Carlos Alberto, additional, Zanella, Maria, additional, Rassi, Nelson, additional, D'Avila, Domingos, additional, Milagres, Rosangela, additional, Felicio, Joao, additional, Pecoits Filho, Roberto, additional, Riella, Miguel Carlos, additional, Salles, Joao, additional, Keitel, Elizete, additional, Draibe, Sergio, additional, Amodeo, Celso, additional, Youmbissi, Joseph, additional, Roy, Louise, additional, Cournoyer, Serge, additional, Jolly, Shivinder, additional, Pichette, Vincent, additional, Nesrallah, Gihad, additional, Bajaj, Harpreet Singh, additional, Khandwala, Hasnain, additional, Aronson, Ronnie, additional, Goluch, Richard, additional, Tam, Paul, additional, Rabbat, Christian, additional, Bailey, Gordon, additional, Chow, Stephen, additional, Castillo, Alvaro, additional, Danin Vargas, Alfredo, additional, Gonzalez, Fernando, additional, Munoz, Rodrigo, additional, Gutierrez, Vicente, additional, Godoy, Gonzalo, additional, Zhao, Hongwen, additional, Liu, Zhangsuo, additional, Zhao, Minghui, additional, Guo, Xiaohui, additional, Su, Benli, additional, Fu, Shuxia, additional, Xu, Yan, additional, Yang, Jinkui, additional, Shi, Bingyin, additional, Xiao, Guanqing, additional, Shi, Wei, additional, Hao, Chuanming, additional, Xing, Changying, additional, Hou, Fanfan, additional, Luo, Qun, additional, Li, Yuxiu, additional, Ji, Linong, additional, Zuo, Li, additional, Wang, Song, additional, Ni, Zhaohui, additional, Ding, Guohua, additional, Chen, Nan, additional, Zhao, Jiajun, additional, Jia, Weiping, additional, Yu, Shengqiang, additional, Weng, Jian, additional, Xu, Gang, additional, Fu, Ping, additional, Sun, Shiren, additional, Liu, Bicheng, additional, Ding, Xiaoqiang, additional, Rychlik, Ivan, additional, Oplustilova, Alexandra, additional, Bartaskova, Dagmar, additional, Honova, Vaclava, additional, Chmelickova, Hana, additional, Petr, Martin, additional, Bucek, Petr, additional, Tesar, Vladimir, additional, Zahumensky, Emil, additional, Povlsen, Johan, additional, Egstrup, Kenneth, additional, Oczachowska-Kulik, Anna, additional, Rossing, Peter, additional, Lahtela, Jorma, additional, Strand, Jorma, additional, Kantola, Ilkka, additional, Petit, Catherine, additional, Combe, Christian, additional, Zaoui, Philippe, additional, Esnault, Vincent, additional, Urena Torres, Pablo, additional, Halimi, Jean-Michel, additional, Dussol, Bertrand, additional, Bieler, Tasso, additional, Budde, Klemens, additional, Dellanna, Frank, additional, Segiet, Thomas, additional, Kosch, Christine, additional, Schmidt-Guertler, Hans, additional, Schenkenberger, Isabelle, additional, Vielhauer, Volker, additional, Pistrosch, Frank, additional, Alscher, Mark, additional, Hasslacher, Christoph, additional, Hugo, Christian, additional, Muehlfeld, Anja, additional, Wanner, Christoph, additional, Passadakis, Ploumis, additional, Apostolou, Theofanis, additional, Tentolouris, Nikolaos, additional, Stefanidis, Ioannis, additional, Mavromatidis, Konstantinos, additional, Liakopoulos, Vasilios, additional, Goumenos, Dimitrios, additional, Siamopoulos, Konstantinos, additional, Yeung, Vincent, additional, Ozaki, Risa, additional, Fung, Samuel, additional, Tan, Kathryn, additional, Tang, Sydney, additional, Lui, Sing Leung, additional, Cheung, Siu Fai, additional, Sreenan, Seamus, additional, Eustace, Joseph, additional, O'Shea, Donal, additional, Lavin, Peter, additional, Stack, Austin, additional, Yagil, Yoram, additional, Wainstein, Julio, additional, Knobler, Hilla, additional, Cohen, Josef, additional, Kenis, Irina, additional, Daoud, Deeb, additional, Bar-Dayan, Yosefa, additional, Frajewicki, Victor, additional, Adawi, Faiad, additional, Gesualdo, Loreto, additional, Santoro, Domenico, additional, Marino, Francesco, additional, Galfre, Andrea, additional, Brunati, Chiara, additional, Ruggenenti, Piero, additional, Rombola, Giuseppe, additional, Pugliese, Giuseppe, additional, Ravera, Maura, additional, Malberti, Fabio, additional, Pontoriero, Giuseppe, additional, Rampino, Teresa, additional, De Cosmo, Salvatore, additional, Esposito, Ciro, additional, Nappi, Felice, additional, Abaterusso, Cataldo, additional, Conte, Giuseppe, additional, Panichi, Vincenzo, additional, Lauro, Davide, additional, Capasso, Giovambattista, additional, Russo, Domenico, additional, Anzai, Jiichi, additional, Naka, Motoji, additional, Ato, Keita, additional, Tsujimoto, Tetsuro, additional, Nimura, Toshinori, additional, Nakashima, Eitaro, additional, Takeda, Tetsuro, additional, Fujii, Shinya, additional, Kobayashi, Kunihisa, additional, Iwaoka, Hideaki, additional, Nagayama, Koji, additional, Harada, Hiroyuki, additional, Maeda, Hajime, additional, Kishimoto, Rui, additional, Iitsuka, Tadashi, additional, Itabashi, Naoki, additional, Furuya, Ryuichi, additional, Maeda, Yoshitaka, additional, Yamada, Daishiro, additional, Sasaki, Nobuhiro, additional, Sasaki, Hiromitsu, additional, Ueda, Shinichiro, additional, Kashihara, Naoki, additional, Watanabe, Shuichi, additional, Nakamura, Takehiro, additional, Kanai, Hidetoshi, additional, Makita, Yuichiro, additional, Ono, Keiko, additional, Iehara, Noriyuki, additional, Goto, Daisuke, additional, Kosuge, Keiichiro, additional, Tsuchida, Kenichi, additional, Sato, Toshiaki, additional, Sekikawa, Takashi, additional, Okamoto, Hideki, additional, Tanaka, Tsuyoshi, additional, Ikeda, Naoko, additional, Tadika, Takenobu, additional, Mukasa, Koji, additional, Osonoi, Takeshi, additional, Hirano, Fuminori, additional, Nishimura, Motonobu, additional, Yambe, Yuko, additional, Tanaka, Yukio, additional, Ujihara, Makoto, additional, Sakai, Takashi, additional, Imura, Mitsuo, additional, Umayahara, Yutaka, additional, Makino, Shinya, additional, Nakazawa, Jun, additional, Yamaguchi, Yukinari, additional, Kashine, Susumu, additional, Miyaoka, Hiroaki, additional, Suzuki, Katsunori, additional, Inoue, Toshihiko, additional, Nagai, Sou, additional, Sato, Nobuyuki, additional, Yamamoto, Masahiro, additional, Taya, Noriyasu, additional, Fujita, Akira, additional, Matsutani, Akira, additional, Shibagaki, Yugo, additional, Sato, Yuichi, additional, Yamauchi, Akira, additional, Tsutsui, Masahiro, additional, Ishiko, Tamayo, additional, Kaneko, Shizuka, additional, Azuma, Nobuyuki, additional, Matsuda, Hirofumi, additional, Hashiguchi, Yasuhiro, additional, Onishi, Yukiko, additional, Tokui, Mikiya, additional, Matsuhisa, Munehide, additional, Kiyosue, Arihiro, additional, Shinoda, Junji, additional, Ishikawa, Kazuo, additional, Ahmad, Ghazali, additional, Vijayasingham, Shalini, additional, Aziz, Nor Azizah, additional, Hussein, Zanariah, additional, Fung, Yin Khet, additional, Hassan, Wan Hasnul Halimi Wan, additional, Wong, Hin Seng, additional, Goh, Bak Leong, additional, Ali, Norhaliza Mohd, additional, Merican, Nor Shaffinaz Yusuf Azmi, additional, Vaithilingam, Indralingam, additional, Nik Ahmad, Nik Nur Fatnoon, additional, Adam, Noor, additional, Sukor, Norlela, additional, Vengadasalam, V Paranthaman P, additional, Abdul Kadir, Khalid, additional, Mohamed, Mafauzy, additional, Renoirte Lopez, Karina, additional, Leguizamo-Dimas, Aniceto, additional, Chew Wong, Alfredo, additional, Chevaile-Ramos, Jose, additional, Gonzalez Gonzalez, Jose, additional, Rico Hernandez, Raul, additional, Nino-Cruz, Jose, additional, Sauque Reyna, Leobardo, additional, Gonzalez-Galvez, Guillermo, additional, Madero Rovalo, Magdalena, additional, Bochicchio-Ricardelli, Tomasso, additional, Aldrete, Jorge, additional, Carranza-Madrigal, Jaime, additional, Vogt, Liffert, additional, Smak Gregoor, Peter, additional, Barendregt, JNM, additional, Luik, Peter, additional, Gansevoort, Ronald, additional, Laverman, Gozewijn, additional, Pilmore, Helen, additional, Lunt, Helen, additional, Baker, John, additional, Miller, Steven, additional, Rabindranath, Kannaiyan, additional, Zapata-Rincon, Luis, additional, Vargas-Gonzales, Rolando, additional, Calderon Ticona, Jorge, additional, Dextre Espinoza, Augusto, additional, Burga Nunez, Jose, additional, Zea-Nunez, Carlos Antonio, additional, Herrada Orue, Benjamin, additional, Medina-Santander, Boris, additional, Delgado-Butron, Cesar, additional, Farfan-Aspilcueta, Julio, additional, Mazur, Stanislaw, additional, Necki, Miroslaw, additional, Wruk, Michal, additional, Klodawska, Katarzyna, additional, Popenda, Grazyna, additional, Skokowska, Ewa, additional, Arciszewska, Malgorzata, additional, Wiecek, Andrzej, additional, Ciechanowski, Kazimierz, additional, Nowicki, Michal, additional, Birne, Rita, additional, Cabrita, Antonio, additional, Ramos, Aura, additional, Antunes Ferreira, Manuel Anibal, additional, Matta Fontanet, Evelyn, additional, Alcantara-Gonzalez, Altagracia Aurora, additional, Comulada-Rivera, Angel, additional, Galindo Ramos, Eugenia, additional, Cangiano, Jose, additional, Quesada-Suarez, Luis, additional, Calderon Ortiz, Ricardo, additional, Vazquez-Tanus, Jose, additional, Burgos-Calderon, Rafael, additional, Rosado, Carlos, additional, Hancu, Nicolae, additional, Pintilei, Ella, additional, Mistodie, Cristina, additional, Bako, Gabriel, additional, Ionutiu, Lavinia, additional, Petrica, Ligia, additional, Timar, Romulus, additional, Tuta, Liliana, additional, Duma, Livia, additional, Tutescu, Adriana, additional, Ivanova, Svetlana, additional, Essaian, Ashot, additional, Zrazhevskiy, Konstantin, additional, Tomilina, Natalia, additional, Smolyarchuk, Elena, additional, Kuzin, Anatoly, additional, Lantseva, Olga, additional, Karpova, Irina, additional, Shamkhalova, Minara, additional, Liberanskaya, Natalia, additional, Yavdosyuk, Andrey, additional, Shvarts, Yuri, additional, Bardymova, Tatiana, additional, Blagoveshchenskaya, Olga, additional, Solovev, Oleg, additional, Rechkova, Elena, additional, Pikalova, Natalia, additional, Pavlova, Maria, additional, Kolmakova, Elena, additional, Sayfutdinov, Rustam, additional, Villevalde, Svetlana, additional, Koziolova, Natalya, additional, Martynenko, Vladimir, additional, Marasaev, Vyacheslav, additional, Maksudova, Adelya, additional, Sigitova, Olga, additional, Mordovin, Viktor, additional, Klimontov, Vadim, additional, Samoylova, Yulia, additional, Karonova, Tatiana, additional, Yeoh, Lee Ying, additional, Teo, Boon Wee, additional, Foo, Marjorie Wai Yin, additional, Liew, Adrian, additional, Tkac, Ivan, additional, Oroszova, Aniko, additional, Fekete, Jozef, additional, Rosenberger, Jaroslav, additional, Obetkova, Ida, additional, Fulopova, Alla, additional, Kolesarova, Eva, additional, Raslova, Katarina, additional, Smolko, Peter, additional, Oksa, Adrian, additional, Distiller, Larry, additional, Trokis, Julien, additional, Adams, Luthando, additional, Makan, Hemant, additional, Ramlachan, Padaruth, additional, Mitha, Essack, additional, Coetzee, Kathleen, additional, Punt, Zelda, additional, Bhorat, Qasim, additional, Naiker, Puvenesvari, additional, Ellis, Graham, additional, Van Zyl, Louis, additional, Lee, Kwan Woo, additional, Kim, Min Seon, additional, Yoo, Soon-Jib, additional, Yoon, Kun Ho, additional, Cho, Yong-Wook, additional, Park, Tae-Sun, additional, Kim, Sang Yong, additional, Choi, Moon-Gi, additional, Oh, Tae Keun, additional, Lee, Kang-Wook, additional, Shon, Ho Sang, additional, Suh, Sung Hwan, additional, Kim, Byung-Joon, additional, Doo-Man, Kim, additional, Yi, Joo Hark, additional, Lee, Sang Ah, additional, Cho, Ho Chan, additional, Kim, Sin-Gon, additional, Cha, Dae-Ryong, additional, Seo, Ji A, additional, Choi, Kyung Mook, additional, Woo, Jeong-Taek, additional, Ahn, Kyu Jeung, additional, Lee, Jae Hyuk, additional, Kim, In-Joo, additional, Lee, Moon-Kyu, additional, Jang, Hak Chul, additional, Park, Kyong-Soo, additional, Kim, Beom Seok, additional, Mok, Ji Oh, additional, Shin, Mijung, additional, Yoon, Sun Ae, additional, Nam-Goong, Il-Seong, additional, Chung, Choon Hee, additional, Yu, Tae Yang, additional, Lee, Hyoung Woo, additional, Soto Gonzalez, Alfonso, additional, Almirall, Jaume, additional, Egido, Jesus, additional, Calero Gonzalez, Francesca, additional, Fernandez Fresnedo, Gema, additional, Valera Cortes, Ildefonso, additional, Praga Terente, Manuel, additional, Garcia Mendez, Isabel, additional, Navarro Gonzalez, Juan, additional, Herrero Calvo, Jose, additional, Cigarran Guldris, Secundino, additional, Prieto Velasco, Mario, additional, Minguela Pesquera, Jose Ignacio, additional, Galan, Antonio, additional, Pascual, Julio, additional, Marques Vidas, Maria, additional, Martins Munoz, Judith, additional, Rodriguez-Perez, Jose, additional, Castro-Alonso, Cristina, additional, Bonet Sol, Josep, additional, Seron, Daniel, additional, Fernandez Giraldez, Elvira, additional, Arrieta Lezama, Javier, additional, Montero, Nuria, additional, Hernandez-Jaras, Julio, additional, Santamaria Olmo, Rafael, additional, Molas Coten, Jose Ramon, additional, Hellberg, Olof, additional, Fellstrom, Bengt, additional, Bock, Andreas, additional, Pei, Dee, additional, Lin, Ching-Ling, additional, Tien, Kai-Jen, additional, Chen, Ching-Chu, additional, Huang, Chien-Ning, additional, Jiang, Ju-Ying, additional, Wu, Du-An, additional, Chu, Chih-Hsun, additional, Tseng, Shih-Ting, additional, Chen, Jung-Fu, additional, Bau, Cho-Tsan, additional, Sheu, Wayne, additional, Wu, Mai-Szu, additional, Sari, Ramazan, additional, Sezer, Siren, additional, Yildiz, Alaattin, additional, Satman, Ilhan, additional, Kalender, Betul, additional, Mankovskyy, Borys, additional, Fushtey, Ivan, additional, Stanislavchuk, Mykola, additional, Kolenyk, Mykola, additional, Dudar, Iryna, additional, Zolotaikina, Viktoriia, additional, Abrahamovych, Orest, additional, Kostynenko, Tetyana, additional, Petrosyan, Olena, additional, Kuskalo, Petro, additional, Galushchak, Olga, additional, Legun, Oleg, additional, Topchii, Ivan, additional, Martynyuk, Liliya, additional, Stryzhak, Vasyl, additional, Panina, Svitlana, additional, Tkach, Sergii, additional, Korpachev, Vadym, additional, Maxwell, Peter, additional, Gnudi, Luigi, additional, Kon, Sui Phin, additional, Tindall, Hilary, additional, Kalra, Phillip, additional, Mark, Patrick, additional, Patel, Dipesh, additional, El-Shahawy, Mohamed, additional, Bai, Liqun, additional, Nica, Romanita, additional, Lien, Yeong-Hau, additional, Menefee, Judson, additional, Busch, Robert, additional, Miller, Alan, additional, Ahmed, Azazuddin, additional, Arif, Ahmed, additional, Lee, Joseph, additional, Desai, Sachin, additional, Bansal, Shweta, additional, Bentsianov, Marie, additional, Belledonne, Mario, additional, Jere, Charles, additional, Gaona, Raul, additional, Greenwood, Gregory, additional, Brusco, Osvaldo, additional, Boiskin, Mark, additional, Belo, Diogo, additional, Minasian, Raffi, additional, Atray, Naveen, additional, Lawrence, Mary, additional, Taliercio, John, additional, Pergola, Pablo, additional, Scott, David, additional, Alvarez, German, additional, Marder, Bradley, additional, Powell, Thomas, additional, Bakdash, Wa'el, additional, Stoica, George, additional, McFadden, Christopher, additional, Rendell, Marc, additional, Wise, Jonathan, additional, Jones, Audrey, additional, Jardula, Michael, additional, Madu, Ivy-Joan, additional, Varghese, Freemu, additional, Tulloch, Brian, additional, Ahmed, Ziauddin, additional, Hames, Melanie, additional, Nazeer, Imran, additional, Shahid, Newman, additional, John, Rekha, additional, Montero, Manuel, additional, Fitz-Patrick, David, additional, Phillips, Lawrence, additional, Guasch, Antonio, additional, Christofides, Elena, additional, Gundroo, Aijaz, additional, Amin, Mohammad, additional, Bowman-Stroud, Cynthia, additional, Link, Michael, additional, Mulloy, Laura, additional, Nammour, Michael, additional, Lalwani, Tarik, additional, Hanson, Lenita, additional, Whaley-Connell, Adam, additional, Herman, Lee, additional, Chatha, Rupi, additional, Osama, Sayed, additional, Liss, Kenneth, additional, Kayali, Zeid, additional, Bhargava, Anuj, additional, Israel, Ezra, additional, Peguero-Rivera, Alfredo, additional, Fang, Michael, additional, Slover, Judith, additional, Barengolts, Elena, additional, Flores, Jose, additional, Muoneke, Rosemary, additional, Savin, Virginia, additional, Awua-Larbi, Stella, additional, Levine, Andrew, additional, Newman, George, additional, Golestaneh, Laden, additional, Bohm, Guillermo, additional, Reisin, Efrain, additional, Cruz, Lucita, additional, Weiss, Robert, additional, Zieve, Franklin, additional, Horwitz, Edward, additional, Chuang, Peale, additional, Mersey, James, additional, Manley, John, additional, Graf, Ronald, additional, Bedros, Fadi, additional, Joshi, Sudhir, additional, Frias, Juan, additional, Assefi, Ali, additional, O'Shaughnessy, Andrew, additional, Brantley, Roman, additional, Minga, Todd, additional, Tietjen, David, additional, Kantor, Samuel, additional, Jamal, Aamir, additional, Guadiz, Ramon, additional, Hershon, Kenneth, additional, Bressler, Peter, additional, Kopyt, Nelson, additional, Cathcart, Harold, additional, Bloom, Scott, additional, Reichel, Ronald, additional, Nakhle, Samer, additional, Dulude, Emily, additional, Tarkan, Joshua, additional, Baker, Penelope, additional, Zeig, Steven, additional, Moya Hechevarria, Jaynier, additional, Ropero-Cartier, Armando, additional, De la Calle, Gilda, additional, Doshi, Ankur, additional, Saba, Fadi, additional, Sligh, Teresa, additional, Shaw, Sylvia, additional, Kumar, Jayant, additional, Szerlip, Harold, additional, Bayliss, George, additional, Perlman, Alan, additional, Sakhrani, Lakhi, additional, Gouge, Steven, additional, Argoud, Georges, additional, Acosta, Idalia, additional, Elder, John, additional, Joshi, Sucharit, additional, Sensenbrenner, John, additional, Vicks, Steven, additional, Mangoo-Karim, Roberto, additional, Galphin, Claude, additional, Leon-Forero, Carlos, additional, Gilbert, John, additional, Brown, Eric, additional, Ijaz, Adeel, additional, Butt, Salman, additional, Markell, Mariana, additional, Arauz-Pacheco, Carlos, additional, Sloan, Lance, additional, Alvarado, Odilon, additional, Jabbour, Serge, additional, Simon, Eric, additional, Rastogi, Anjay, additional, James, Sam, additional, Hall, Karen, additional, Melish, John, additional, Dixon, Brad, additional, Adolphe, Allen, additional, Kovesdy, Csaba, additional, Beddhu, Srinivasan, additional, Solomon, Richard, additional, Fernando, Ronald, additional, Levin, Ellis, additional, Thakar, Charuhas, additional, Robey, Brooks, additional, Goldfarb, David, additional, Fried, Linda, additional, Maddukuri, Geetha, additional, Thomson, Stephen, additional, Annand, Andrew, additional, Kronfli, Saeed, additional, Kalirao, Paramjit, additional, Schmidt, Rebecca, additional, Dahl, Neera, additional, Blumenthal, Samuel, additional, Weinstein, Debra, additional, Ostergaard, Ove, additional, Weinstein, Talia, additional, Ono, Yasuhiro, additional, Yalcin, Murat, additional, and Karim, Shahana, additional

Published
2019
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17. Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid with the Serial Ultrasound Findings

Author

Jeon, Eon Ju, Shon, Ho Sang, and Jung, Eui Dal

Subjects
endocrine system, endocrine system diseases, Article Subject, immune system diseases, hemic and lymphatic diseases
Abstract

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) of the thyroid gland is uncommon. Even though its natural history is not well defined, it is known to be indolent course. We present a case of primary MALT thyroid lymphoma with the serial sonographic findings in the patient presenting as the focal nodule. A 45-year-old woman visited our hospital for neck examination. Initially, fine-needle aspiration cytology in the focal hypoechoic lesion in the left thyroid lobe on ultrasound sonography was performed and consistent with Hashimoto’s thyroiditis. However, the results of serial ultrasounds and core-needle biopsy revealed an extranodal marginal zone lymphoma of MALT on 4-year follow-up. Patients with a focal hypoechoic nodule with linear echogenic strands and segmental pattern in the background of Hashimoto’s thyroiditis on ultrasonography should undergo careful surveillance for malignancy. Serial sonographic features in this case are meaningful in the understanding of the natural history of the extranodal marginal zone lymphoma of MALT of the thyroid.

Published
2016
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18. Delay of insulin initiation in patients with type 2 diabetes mellitus inadequately controlled with oral hypoglycemic agents (analysis of patient- and physician-related factors): A prospective observational DIPP-FACTOR study in Korea

Author

Kim, Sin Gon, primary, Kim, Nam Hoon, additional, Ku, Bon Jeong, additional, Shon, Ho Sang, additional, Kim, Doo Man, additional, Park, Tae Sun, additional, Kim, Yong-Seong, additional, Kim, In Joo, additional, and Choi, Dong Seop, additional

Published
2017
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23. Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes

Author

Kim, Ji‐Hyun, primary, Ahn, Ji‐Hyun, additional, Kim, Soo‐Kyung, additional, Lee, Dae‐Ho, additional, Kim, Hye‐Soon, additional, Shon, Ho‐Sang, additional, Jeon, Hyun‐Jeong, additional, Kim, Tae‐Hwa, additional, Cho, Yong‐Wook, additional, Kim, Jae‐Taek, additional, Han, Sung‐Min, additional, Chung, Choon‐Hee, additional, Ryu, Ohk‐Hyun, additional, Lee, Jae‐Min, additional, Lee, Soon‐Hee, additional, Kwon, Min‐Jeong, additional, Kim, Tae‐kyun, additional, Namgoong, Il‐Seong, additional, Kim, Eun‐Sook, additional, Jung, In‐Kyung, additional, Moon, Sung‐Dae, additional, Han, Je‐Ho, additional, Kim, Chong‐Hwa, additional, Cho, Eun‐Hee, additional, Kim, Ki‐Young, additional, Park, Hee‐Baek, additional, Lee, Ki‐Sang, additional, Lee, Sung‐Woo, additional, Lee, Sang‐Cheol, additional, Kang, Cheol‐Min, additional, Jeon, Byung‐Sook, additional, Song, Min‐Seop, additional, Yun, Seung‐Baik, additional, Chung, Hyung‐Keun, additional, Seong, Jong‐Ho, additional, Jeong, Jin‐Yi, additional, and Cha, Bong‐Yun, additional

Published
2014
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41. 833-P: Relationship between Prediabetes and Depression in Korean Adults.

Author

JEON, EONJU, KIM, SUNG-WOO, LEE, JI-HYUN, and SHON, HO-SANG

Abstract

Objective: Currently, emotional well-being is becoming an increasingly important aspect of diabetes care and self-management. Routine screening for depressive symptoms is indicated in high-risk populations, including people with prediabetes and diabetes. However, a limited number of studies about the relationship between prediabetes and depression have been conducted in Asians. The aim of this study was to investigate the potential synergistic relationship between prediabetes and depression. Methods: This was a cross-sectional survey derived from the 2014 Korea National Health and Nutrition Examination Survey. 9-item Patient Health Questionnaire (PHQ-9) depression-screening test was used. Depression was defined as a score ≥10 on PHQ-9. Prediabetes was defined by the presence of impaired fasting glucose or A1c between 5.7 and 6.4%. Results: In total, 3848 subjects (1570 Men and 2278 women) aged 16 to 80 years without diabetes were studies. Among them, 1809 (47%) were prediabetes. The prevalence of depression was higher in the participants with prediabetes (4.7%) than without prediabetes (3.4%) (P<0.003). On multivariate logistic analyse, depression was significantly related with prediabetic participant with obesity (odds ratio (OR)= 3.103; 95% confidence interval (CI), 1.295-7.439). However, depression was not related with prediabeteic participant wit underweight (OR =1.001; CI, 0.662-1.514). Conclusion: This study shows the risk of depression in prediabetes with obesity. Future research is required to examine the mechanisms underlying the associations between prediabetes, mental health, and the risk of diabetes. Disclosure: E. Jeon: None. S. Kim: None. J. Lee: None. H. Shon: None. [ABSTRACT FROM AUTHOR]

Published
2019
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42. Heme Oxygenase-1 Overexpression Prevents Endoplasmic Reticulum Stress Induced by High Glucose in INS-1 Cells.

Author

Won, Kyu Chang, Eun, Mi Jung, Yoon, Ji Sung, Kim, Yong Woon, Park, Keun Gyu, Jung, Eui Dal, Shon, Ho Sang, Lee, In Kyu, and Lee, Hyoung Woo

Subjects
HEME oxygenase, PROTEINS, ENDOPLASMIC reticulum, PANCREATIC beta cells, OXIDATIVE stress, MESSENGER RNA, ISLANDS of Langerhans, GLUCOSE
Abstract

Heme oxygenase-1 (HO-1) is a cytoprotective protein that catalyzes the degradation of berne to biliverdin, iron, and carbon monoxide (CO). The endoplasmic reticulum (ER) is a dynamic membranous organelle that plays a critical role in the folding, transport, and processing of newly synthesized proteins. Numerous infectious agents, environmental toxins, and adverse metabolic conditions interfere with protein folding leading to ER stress. Also, ER stress is induced by adverse metabolic conditions in pancreatic β cells. We wanted to evaluate a protective role for HO-1 in pancreatic islets against ER stress by high glucose conditions. In the present study, we found ER stress markers (CRB-2, XBP-1, Phospho-elF-1) induced by high glucose condition via oxidative stress decreased by overexpression of HO-1 in INS-1 cells. The intracellular peroxide levels of INS-1 cells measured by flow cytometry were increased in the high glucose (30 mM) media compared to normal glucose (5.6 mM) media (p<0.05). The insulin mRNA levels, MafA, PDX-1 and glucose stimulated insulin secretion (GSIS) were decreased in high glucose media compared to 5.6 mM glucose media (p<0.05). ER stress was induced by high glucose condition via oxidative stress in INS-1 cells. We used HO-1 adenovirus for HO-1 overexpression. HO-1 overexpression decreased ROS, increased insulin mRNA, PDX-1, MafA and preserved the GSIS in the islets at a high glucose condition (p<0.05). These results suggest that HO-1 seems to mediate the protective response of pancreatic islets against the ER stress induced by high glucose condition via oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2007

43. Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial.

Author

Lee JE, Yu SH, Kim SR, Ahn KJ, Song KH, Lee IK, Shon HS, Kim IJ, Lim S, Kim DM, Chung CH, Lee WY, Lee SH, Kim DJ, Cho SR, Jung CH, Jeon HJ, Lee SH, Park KY, Rhee SY, Kim SG, Park SO, Kim DJ, Kim BJ, Lee SA, Kim YH, Kim KS, Seo JA, Nam-Goong IS, Lee CW, Kim DK, Kim SW, Cho CG, Kim JH, Kim YJ, Yoo JM, Min KW, and Lee MK

Subjects
Humans, Male, Female, Double-Blind Method, Middle Aged, Aged, Treatment Outcome, Adult, Atorvastatin therapeutic use, Atorvastatin administration & dosage, Metformin therapeutic use, Metformin administration & dosage, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 blood, Dyslipidemias drug therapy, Dyslipidemias blood, Drug Therapy, Combination, Glycated Hemoglobin analysis, Hypoglycemic Agents therapeutic use, Hypoglycemic Agents administration & dosage, Cholesterol, LDL blood
Abstract

Backgruound: It is well known that a large number of patients with diabetes also have dyslipidemia, which significantly increases the risk of cardiovascular disease (CVD). This study aimed to evaluate the efficacy and safety of combination drugs consisting of metformin and atorvastatin, widely used as therapeutic agents for diabetes and dyslipidemia., Methods: This randomized, double-blind, placebo-controlled, parallel-group and phase III multicenter study included adults with glycosylated hemoglobin (HbA1c) levels >7.0% and <10.0%, low-density lipoprotein cholesterol (LDL-C) >100 and <250 mg/dL. One hundred eighty-five eligible subjects were randomized to the combination group (metformin+atorvastatin), metformin group (metformin+atorvastatin placebo), and atorvastatin group (atorvastatin+metformin placebo). The primary efficacy endpoints were the percent changes in HbA1c and LDL-C levels from baseline at the end of the treatment., Results: After 16 weeks of treatment compared to baseline, HbA1c showed a significant difference of 0.94% compared to the atorvastatin group in the combination group (0.35% vs. -0.58%, respectively; P<0.0001), whereas the proportion of patients with increased HbA1c was also 62% and 15%, respectively, showing a significant difference (P<0.001). The combination group also showed a significant decrease in LDL-C levels compared to the metformin group (-55.20% vs. -7.69%, P<0.001) without previously unknown adverse drug events., Conclusion: The addition of atorvastatin to metformin improved HbA1c and LDL-C levels to a significant extent compared to metformin or atorvastatin alone in diabetes and dyslipidemia patients. This study also suggested metformin's preventive effect on the glucose-elevating potential of atorvastatin in patients with type 2 diabetes mellitus and dyslipidemia, insufficiently controlled with exercise and diet. Metformin and atorvastatin combination might be an effective treatment in reducing the CVD risk in patients with both diabetes and dyslipidemia because of its lowering effect on LDL-C and glucose.

Published
2024
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44. Effects of Yukmijihwang-tang, a Polyherb, on the Pharmacokinetics of Metformin.

Author

Kang SB, Shon HS, Park SJ, Lee YJ, Ku SK, and Song CH

Subjects
Animals, Area Under Curve, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 metabolism, Drug Therapy, Combination adverse effects, Hypoglycemic Agents pharmacokinetics, Hypoglycemic Agents pharmacology, Male, Metformin pharmacology, Rats, Rats, Sprague-Dawley, Drugs, Chinese Herbal pharmacology, Herb-Drug Interactions physiology, Metformin pharmacokinetics, Plants, Medicinal adverse effects
Abstract

Metformin is one of the most common medicines for the treatment of type 2 diabetes, however, recent studies suggest that concomitant antihyperglycemic agents should be administered for better efficacy. Yukmijihwang-tang (YMJHT) is a nephroprotective polyherb prescribed for renal disorders or diabetic mellitus in traditional Korean medicine. Therefore, the pharmacokinetics between metformin and YMJHT were examined for their coadministration. Rats were orally coadministered with metformin and YMJHT as a combination group or metformin and distilled water as the corresponding control. Then, the metformin concentration in plasma and its pharmacokinetic parameters including maximum concentration (C max ) and area under the plasma concentration time curve (AUC) were analyzed. There were no interactions between metformin and YMJHT in the single coadministration at intervals within 5 min. However, pretreatments with YMJHT for 6 days increased the metformin concentration and its C max and AUC (p<0.05). The repeated coadministration for 8 days increased the C max of metformin (p<0.05). Conversely, when the combination was coadministered at 2h -intervals, there were no interactions between metformin and YMJHT after a single dosing or repeated dosing of coadministration for 7 days. These results of the present study will help structure proper dosing regimens for the concomitant therapy of metformin and YMJHT.

Published
2019

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