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Biomass partitioning is one of the pivotal determinants of crop growth management, which is influenced by environmental cues. Light and CO2 are the main drivers of photosynthesis and biomass production in plants. In this study, the effects of CO2 levels: ambient 400 ppm (a[CO2]) and elevated to 1,000 ppm (e[CO2]) and different light intensities (75, 150, 300, 600 μmol·m−2·s−1 photosynthetic photon flux density – PPFD) were studied on the growth, yield, and biomass partitioning in chrysanthemum plants. The plants grown at higher light intensity had a higher dry weight (DW) of both the vegetative and floral organs. e[CO2] diminished the stimulating effect of more intensive light on the DW of vegetative organs, although it positively influenced inflorescence DW. The flowering time in plants grown at e[CO2] and light intensity of 600 μmol·m−2·s−1 occurred earlier than that of plants grown at a[CO2]. An increase in light intensity induced the allocation of biomass to inflorescence and e[CO2] enhanced the increasing effect of light on the partitioning of biomass toward the inflorescence. In both CO2 concentrations, the highest specific leaf area (SLA) was detected under the lowest light intensity, especially in plants grown at e[CO2]. In conclusion, elevated light intensity and CO2 direct the biomass toward inflorescence in chrysanthemum plants.

Introduction: Social anxiety is characterized by marked anxiety, cognitive and emotional dysfunction in social situations and can lead to social avoidance behavior. The purpose of this study was to investigate the mediating role of self-criticism in the relationship between the fear of negative evaluation and self-compassion with social anxiety in Yazd medical students. Methods: A correlational research study was conducted using structural equation modeling. The statistical population of the research consisted of all students of medicine, pharmacy and dentistry of Shahid Sadougi University of Medical Sciences in Yazd in the academic year of 2021-2022. The sample size of 250 people was determined; sampling was done by voluntary sampling method. Research instruments included social anxiety scale (Jarabek, 1996), fear of negative evaluation (Leary, 1983), short form of self-compassion (Rees et al., 2011) and self-criticism (Thompson and Zaroff, 2004), which were published online. Finally, the data of 227 students were analyzed by Pearson correlation and structural equation model using SPSS16 and Amos24 software. Results: The results showed that the direct effect of fear of negative evaluation and self-criticism on social anxiety was significant (P

Abstract Background Colibacillosis in broiler chickens is associated with economic loss and localized or systemic infection. Usually, the last resort is antibacterial therapy. Insight into the disease pathogenesis, host responses and plausible immunomodulatory effects of the antibacterials is important in choosing antibacterial agent and optimization of the treatment. Selected responses of broiler chickens experimentally infected with Escherichia coli (E. coli) and also those treated with florfenicol are evaluated in this study. Chickens (n = 70, 5 weeks old) were randomly assigned to four groups. The control groups included normal control (NC) and intratracheal infection control (ITC) (received sterile bacterial medium). The experimental groups consisted of intratracheal infection (IT) that received bacterial suspension and intratracheal infection with florfenicol administration (ITF) group. Results Florfenicol reversed the decreased albumin/globulin ratio to the level of control groups (p > 0.05). Serum interleukin 10 (IL-10) and interferon‐gamma (IFN-γ) concentrations decreased in IT birds as compared to NC group. Florfenicol decreased the serum interleukin 6 (IL-6) concentration as compared to IT group. Milder signs of inflammation, septicemia, and left shift were observed in the leukogram of the ITF group. Florfenicol decreased the severity of histopathological lesions in lungs and liver. Depletion of lymphoid tissue was detected in spleen, thymus and bursa of IT group but was absent in ITF birds. The number of colony forming units of E. coli in liver samples of ITF group was only slightly lower than IT birds. Conclusions Experimental E. coli infection of chickens by intratracheal route is associated with remarkable inflammatory responses as shown by changes in biochemical and hematological parameters. Histopathological lesions in lymphoid organs (especially in the spleen) were also prominent. Florfenicol has positive immunomodulatory effects and improves many of the lesions before the full manifestation of its antibacterial effects. These effects of florfenicol should be considered in pharmacotherapy decision-making process.

A major characteristic of cancer is dysregulated cell division, which results in aberrant growth of cells. Consequently, medicinal targets that prevent cell division would be useful in the fight against cancer. The primary regulator of proliferation is a complex consisting of cyclin and cyclin-dependent kinases (CDKs). The FDA has granted approval for CDK inhibitors (CDKIs) to treat metastatic hormone receptor-positive breast cancer. Specifically, CDK4/6 CDKIs block the enzyme activity of CDK4 and CDK6. Unfortunately, the majority of first-generation CDK inhibitors, also known as pan-CDK inhibitors because they target multiple CDKs, have not been authorized for clinical use owing to their serious side effects and lack of selection. In contrast to this, significant advancements have been created to permit the use of pan-CDK inhibitors in therapeutic settings. Notably, the toxicity and negative consequences of pan-CDK inhibitors have been lessened in recent years thanks to the emergence of combination therapy tactics. Therefore, pan-CDK inhibitors have renewed promise for clinical use when used in a combination regimen. The members of the CDK family have been reviewed and their primary roles in cell cycle regulation were covered in this review. Next, we provided an overview of the state of studies on CDK inhibitors.

Abstract Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution and accuracy. Here, we deploy digital telomere measurement (DTM) by nanopore sequencing to understand how distributions of human telomere length change with age and disease. We measure telomere attrition and de novo elongation with up to 30 bp resolution in genetically defined populations of human cells, in blood cells from healthy donors and in blood cells from patients with genetic defects in telomere maintenance. We find that human aging is accompanied by a progressive loss of long telomeres and an accumulation of shorter telomeres. In patients with defects in telomere maintenance, the accumulation of short telomeres is more pronounced and correlates with phenotypic severity. We apply machine learning to train a binary classification model that distinguishes healthy individuals from those with telomere biology disorders. This sequencing and bioinformatic pipeline will advance our understanding of telomere maintenance mechanisms and the use of telomere length as a clinical biomarker of aging and disease.

Background: Exam anxiety is a prevalent psychological and educational challenge among students, significantly impacting their academic performance, mood, and social behaviors. Gaining a deeper understanding of the psychological processes involved in exam anxiety can assist in developing effective strategies to enhance academic performance and improve students' overall quality of life. However, in the existing literature, the intricate interactions among maladaptive schemas, fear of negative evaluation, and exam anxiety have not been thoroughly examined. Aims: The purpose of this study was to modeling structural test anxiety based on early maladaptive schemas with mediating role fear of negative evaluation in students in Tehran city. Methods: This study was conducted in the presence of 500 people by convinience sampling method among high school students in Tehran city in year academic 2021-2022. To measure the variables, test anxiety inventory (TAI) of Abolghasemi and et al (1996), Young schema questionnaire – short form version 3 (YSQ-S3) of Young (2005) and brief fear of negative evaluation scale (BFNE) of Leary (1983). Data were analyzed using Pearson correlation and structural equation modelling with using SPSS-24 and AMOS software was investigated. Results: The results showed that there is a positive and significant relationship between early maladaptive schemas and fear of negative evaluation with test anxiety (P

Background: Academic dishonesty not only undermines the values of integrity and fairness but also impacts the learning environment, hindering the genuine development of knowledge and skills. A deeper understanding of the psychological and personality processes involved in academic dishonesty can offer solutions to enhance moral identity and the overall quality of students' educational experiences. Despite the significance of this issue, the interplay between personality traits, moral identity, and academic dishonesty has remained understudied in the existing literature. Aims: The purpose of this study was to structural equation modeling prediction of academic dishonesty based on personality characteristics with mediating role of moral identity in students in Tehran city. Methods: This study was conducted in the presence of 500 people by available sampling method among high school students in Tehran city in year academic 2021-2022. To measure the variables, academic dishonesty scale (ADS) of Witherspoon and et al (2010), neo personality inventory (NEO-PI-R) of McCrae and Costa (2008) and moral identity questionnaire (MIQ) of Black and Reynolds (2016) were used. Data were analyzed using Pearson correlation and structural equation modelling with using SPSS-24 and AMOS software was investigated. Results: The results showed that there is significant relationship between personality characteristics and moral identity with procrastination (P< 0.01). The results also showed that most of the direct paths of this study were significant and the indirect paths of personality characteristics were significant through the mediating role of moral identity on academic dishonesty. Also, proposed model had an acceptable fitness to the data (RMSEA= 0/052, P-value< 0/05) and evaluated model has a good fit and is an important step in identifying the factors that are effective in academic dishonesty in high school students in Tehran city. Conclusion: The findings of this research offer valuable insights towards reducing academic dishonesty among students by considering the roles of personality traits and moral identity. Several proactive measures can be implemented in this regard, such as organizing webinars aimed at improving personality traits and moral identity to diminish tendencies towards dishonesty and academic cheating among students.

Digital innovations provide novel opportunities to individualize a person’s care to best match their lifestyle needs and circumstances and to support them as they live their daily lives with diabetes. These innovations also serve to provide actionable data and insights for the care team giving them a “Webb telescope-like” view into their individual self-management journey, allowing them to see what cannot be seen during infrequent and limited office visits, thereby facilitating collaboration and communication to optimize the care plan on a timely basis. Technology advances are enabling diabetes care to transition from episodic, synchronous, primarily in-person care to include synchronous virtual care options and to continuous, on-demand, data-informed, asynchronous digital care better matching the demands of living with a relentless 24/7 chronic condition. In this paper we will discuss the critical elements and considerations in designing and implementing successful diabetes digital health tools in clinical practice.

Abstract Background Limited studies are available on vitamin D supplementation in dogs. This study evaluates the effect of a commercial vitamin D3 supplement on serum 25-hydroxy vitamin D as well as selected biochemical and hematological parameters in healthy dogs. Eight intact male adult dogs with a mean body weight of 20 kg from mixed breeds were included in the study. After adaptation period, dogs received vitamin D3 supplement at the dose of 50 IU/kg body weight per day. Blood samples were collected on days 0, 14, 28 and 42 of supplementation. Food was used for analysis of vitamin D3 content. Results Significant increase in serum level of 25-hydroxy vitamin D3 was detected since day 14 of supplementation. Changes in serum 25-hydroxy vitamin D3 concentration during time showed an upward significance (p

Abstract Mutations in PINK1 and Parkin cause early-onset Parkinson’s Disease (PD). PINK1 is a kinase which functions as a mitochondrial damage sensor and initiates mitochondrial quality control by accumulating on the damaged organelle. There, it phosphorylates ubiquitin, which in turn recruits and activates Parkin, an E3 ubiquitin ligase. Ubiquitylation of mitochondrial proteins leads to the autophagic degradation of the damaged organelle. Pharmacological modulation of PINK1 constitutes an appealing avenue to study its physiological function and develop therapeutics. In this study, we used a thermal shift assay with insect PINK1 to identify small molecules that inhibit ATP hydrolysis and ubiquitin phosphorylation. PRT062607, an SYK inhibitor, is the most potent inhibitor in our screen and inhibits both insect and human PINK1, with an IC50 in the 0.5–3 µM range in HeLa cells and dopaminergic neurons. The crystal structures of insect PINK1 bound to PRT062607 or CYC116 reveal how the compounds interact with the ATP-binding pocket. PRT062607 notably engages with the catalytic aspartate and causes a destabilization of insert-2 at the autophosphorylation dimer interface. While PRT062607 is not selective for PINK1, it provides a scaffold for the development of more selective and potent inhibitors of PINK1 that could be used as chemical probes.

Coronary heart disease (CHD) continues to be the leading cause of morbidity and mortality. There are numerous therapeutic reperfusion methods, including thrombolytic therapy, primary percutaneous coronary intervention, and anti-remodeling drugs like angiotensin-converting enzyme inhibitors and beta-blockers. Despite this, there is no pharmacological treatment that can effectively stop cardiomyocyte death brought on by myocardial ischemia/reperfusion (I/R) injury. For the purpose of regenerating cardiac tissue, mesenchymal stem cell (MSC) therapy has recently gained more attention. The pleiotropic effects of MSCs are instead arbitrated by the secretion of soluble paracrine factors and are unrelated to their capacity for differentiation. One of these paracrine mediators is the extracellular vesicle known as an exosome. Exosomes deliver useful cargo to recipient cells from MSCs, including peptides, proteins, cytokines, lipids, miRNA, and mRNA molecules. Exosomes take part in intercellular communication processes and help tissues and organs that have been injured or are ill heal. Exosomes alone were found to be the cause of MSCs' therapeutic effects in a variety of animal models, according to studies. Here, we have focused on the recent development in the therapeutic capabilities of exosomal MSCs in cardiac diseases.

Abstract Colorectal cancer is one of the most common causes of mortality worldwide. There are several potential risk factors responsible for the initiation and progression of colorectal cancer, including age, family history, a history of inflammatory bowel disease, and lifestyle factors such as physical activity and diet. For decades, there has been a vast amount of study on treatment approaches for colorectal cancer, which has led to conventional therapies such as chemotherapy, surgery, etc. Considering the high prevalence and incidence rate, scholars believe there is an urgent need for an alternative, more efficacious treatment with fewer adverse effects than the abovementioned treatments. Immunotherapy has emerged as a potential treatment alternative in a few years and has become one of the fastest-evolving therapeutic methods. Immunotherapy works by activating or enhancing the immune system’s power to identify and attack cancerous cells. This review summarizes the most crucial new immunotherapy methods under investigation for colorectal cancer treatment, including Immune checkpoint inhibitors, CAR-T cell therapy, BiTEs, Tumor-infiltrating lymphocytes, and Oncolytic virus therapy. Furthermore, this study discusses the application of combination therapy, precision medicine, biomarker discovery, overcoming resistance, and immune-related adverse effects. Video Abstract

In the present work, thermal transport and the energy conversation in two thermoelectrically efficient candidates of Janus SnSSe and SnS2 are investigated within the non-equilibrium Monte Carlo simulation of the phonon Boltzmann equation. The phonon analysis has been performed to determine the contributed phonon in heat transport. The results present that the dominant participating phonons are the ones from the longitudinal acoustic (LA) branch while the least belongs to the transverse acoustic (TA) modes. Both materials reached the very high maximum temperature in response to the implied wasted heat. This is attributed to the low presence of the critical TA phonons which are on one hand fast enough to leave the hotspot but on the other hand have frequencies commensurable to ZA phonons’ frequency. Also, the temperature profile achieved during the heating and cooling of the materials is studied. It is obtained that the heat propagation through the SnS2 is, at first, swifter, which results in a temperature gradient through the whole material which is less than that of the SnSSe. As the time passes, the heat transfer that is directly related to the material thermal conductivity, slows down. So, the behavior of the SnS2 and SnSSe, in case of the heat propagation status, becomes similar. Moreover, the behavior of the thermoelectric figure of merit (zT), the efficiency (η), and the generated voltage have been figured out. It is stated that the higher zT and η do not guarantee a larger generated Seebeck voltage. This is true, while the generated Seebeck voltage is related to the temperature difference between the heated and the cold junction. Accordingly, how far the temperature of matter rises in response to the implied wasted heat is directly related to the obtained voltage. Mainly, it is presented that the maximum temperature that a material achieves, alongside the temperature gradient and the material property Seebeck coefficient, are essential in introducing thermoelectrically efficient materials with reasonable thermal to electrical energy conversion, useful for thermal engineering.

Objective: Consequences of imprisonment include negative psychological effects, social stigma, and challenges for reintegrating into society. In this regard, this study aimed to investigate the effectiveness of Rational Emotive Behavior Therapy (REBT) on self-control and impulsivity among male prisoners. Method: A randomized controlled clinical trial (RCT) utilizing a design the included pretest, post-test, and follow-up assessment as well as a waiting-list control group was conducted. A total of 30 male prisoners were selected using convenience sampling and randomly assigned to experimental and waiting list control groups (the intervention group (n = 15) and the control group (n = 15)). The participants in the experimental group underwent the 12-session REBT intervention over a period of six weeks. (For six weeks). All participants responded to the Self- Control Scale (SCS) and Dysfunctional Impulsivity Questionnaire (DFIQ) as dependent variables at three time points (pretest, post-test, and one-month follow-up). A repeated measures analysis of variance was used to analyze the data. Results: The results revealed that after the implementation of the REBT intervention, the mean scores of self-control increased (P < 0.05), while the mean scores of impulsivity diminished significantly (P < 0.05). Furthermore, these changes remained relatively stable during the follow-up period (P < 0.05). Conclusion: Based on the findings of this study, it can be inferred that REBT intervention plays a significant role in diminishing self-control deficits and mitigating impulsivity among incarcerated individuals. These results present promising implications for the utilization of REBT in lowering recidivism rates.

Abstract Background Effect of antibacterials on mucociliary system and clinical outcome of chickens with mixed viral respiratory conditions is not properly addressed. Objective We evaluated enrofloxacin effects on clinical parameters and mucociliary system of broilers challenged with H9N2/IB viruses. Methods Broilers (105), at the age of 25 days, were randomly allocated into three groups: Group 1 (negative control), no treatment; Group 2 (positive control [PC]) challenged by intranasal and intraocular route. Group 3 (antibiotic [AB]‐treated) challenged and also received enrofloxacin started after manifestation of clinical signs (day 2 post‐challenge [pc]) and continued for 5 days. Results Administration of AB was not associated with appreciable changes in body weight, feed conversion ratio (FCR) or the severity of clinical signs although it slightly reduced mortality rate as compared to PC group (p > 0.05). Virus shedding period and number of virus positive tracheal and caecal tonsil samples were also statistically similar between PC and AB groups. In necropsy, the most profound effect of AB was decreased pleuropneumonia severity score on day 12 pc. Histopathological lesion scores were statistically the same between PC and AB groups. However, the administration of AB increased the number of tracheal goblet cells, with no effect on ciliostasis. Conclusions We found a weak positive effect of enrofloxacin administration in H9N2/IB‐infected chickens. Considering the risks of AB treatment in broiler chickens, the results of this small‐scale study do not encourage the benefit of enrofloxacin use in these viral diseases.

The study of heat transport in micro/nanoscale structures due to their application, especially in Nanoelectronics, is a matter of interest. In other words, the precise simulation of the temperature distribution inside the transistors is consequential in designing and building more reliable devices reaching lower maximum temperatures during the operation. The present study constitutes a framework for micro/nanoscale heat transport study, which leads to calculating accurate temperature/heat flux profiles with low computational cost. The newly non-dimensional parameter γ, presenting the strength of the nonlocality, is utilized through the nonlocal DPL modeling (NDPL). Alongside calculating the nonlocality coefficient, the factors appearing in DPL, including the temperature jump and phase lagging ratio, are revisited. The factor γ is found to have a linear relationship with Knudsen (Kn) number, being 3.5 for Kn=10 and 0.035 for Kn=0.1. Although the nonlocality is bold for the large Knudsen numbers, it also plays a vital role for low Knudsen number structures, especially at earlier times. Further, It is obtained that intruding γ is critical for obtaining accurate temperature and heat flux distributions that are very close to the practical results of the Phonon Boltzmann equation.