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What is known and objective Ifosfamide, an alkylating agent, is widely used in the treatment of malignant diseases. However, these treatments are often limited due to the incidence of neuropsychiatric symptoms such as delirium, seizures, hallucinations and agitation. In this study, we examined risk factors for neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy. Methods The study cases were patients with cancer receiving ifosfamide-based chemotherapy between April 2007 and March 2018. Risk analysis for ifosfamide-related neuropsychiatric symptoms was determined by time-dependent Cox proportional hazard regression analysis. Results and discussion Of 183 eligible patients, 32 patients (17.5%) experienced ifosfamide-related neuropsychiatric symptoms. Time-dependent Cox proportional hazard model showed that the albumin-bilirubin (ALBI) score was significantly correlated with the incidence of ifosfamide-related neuropsychiatric symptoms (hazard ratio [HR] =1.45, 95% confidence interval [CI] = 1.05-2.01, p = 0.025). Additionally, there were correlations between the predicted risk of neuropsychiatric symptoms and ifosfamide-dose per cycle (HR =0.51, 95% CI = 0.27-0.94, p = 0.030) and creatinine clearance (Ccr) (HR = 0.53, 95% CI = 0.28-1.00, p = 0.050). In contrast, neither serum albumin nor total bilirubin was a significant risk factor for neuropsychiatric symptoms. What is new and conclusion These findings indicate that ALBI score may be a useful biomarker for predicting neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy.

With respect to the biosynthesis of plant alkaloids, that of benzylisoquinoline alkaloids (BIAs) has been the most investigated at the molecular level. Previous investigations have shown that the biosynthesis of BIAs is comprehensively regulated by WRKY and bHLH transcription factors, while promoter analyses of biosynthesis enzyme-encoding genes have also implicated the involvement of members of the APETALA2/ethylene responsive factor (AP2/ERF) superfamily. To investigate the physiological roles of AP2/ERF transcription factors in BIA biosynthesis, 134 AP2/ERF genes were annotated using the draft genome sequence data of Eschscholzia californica (California poppy) together with transcriptomic data. Phylogenetic analysis revealed that these genes could be classified into 20 AP2, 5 RAV, 47 DREB, 60 ERF and 2 Soloist family members. Gene structure, conserved motif and orthologous analyses were also carried out. Gene expression profiling via RNA sequencing in response to methyl jasmonate (MeJA) indicated that approximately 20 EcAP2/ERF genes, including 10 group IX genes, were upregulated by MeJA, with an increase in the expression of the transcription factor-encoding gene EcbHLH1 and the biosynthesis enzyme-encoding genes Ec6OMT and EcCYP719A5. Further quantitative RT-PCR confirmed the MeJA responsiveness of the EcAP2/ERF genes, i.e., the increased expression of 9 group IX, 2 group X and 2 group III ERF subfamily genes. Transactivation activity of group IX EcAP2/ERFs was also confirmed by a luciferase reporter assay in conjunction with the promoters of the Ec6OMT and EcCYP719A5 genes. The physiological roles of AP2/ERF genes in BIA biosynthesis and their evolution in the regulation of alkaloid biosynthesis are discussed.

The Belle II experiment at the SuperKEKB aims at collecting 50 times more data than its predecessor Belle. One of the key components in the experiment is the particle identification (PID), especially the separation of kaons and pions. In the Belle II spectrometer, a proximity focusing ring imaging Cherenkov detector using aerogel as a radiator (ARICH) is equipped for the PID at the forward endcap. In this counter, a total of 420 of hybrid avalanche photo-detectors (HAPDs) with 144 channels are used as position-sensitive photon detectors that work inside a 1.5 T magnetic field. Belle II started the physics run with full detectors from 2019. We report on the operation of ARICH, including the fraction of dead channels, stability of HAPDs, and encountered problems. We also report the PID performance of ARICH estimated with using D * + → D 0 π slow + , D 0 → K − π + control sample with the initial data.

We thanktheKEKBgroup for the excellentoperation of the accelerator; the KEK cryogenics group for the efficient operation of the solenoid; and the KEK computer group, and the Pacific Northwest National Laboratory (PNNL) EnvironmentalMolecular SciencesLaboratory (EMSL) computing group for strong computing support; and the National Institute of Informatics, and Science Information NETwork 5 (SINET5) for valuable network support. We acknowledge support from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, the Japan Society for the Promotion of Science (JSPS), and the TauLepton Physics Research Center of Nagoya University; the Australian Research Council including Grants No. DP180102629, No. DP170102389, No. DP170102204, No. DP150103061, No. FT130100303; AustrianFederalMinistry ofEducation, Science and Research (FWF) andFWFAustrian Science FundNo. P 31361-N36; theNationalNatural Science Foundation of China under Contracts No. 11435013, No. 11475187, No. 11521505, No. 11575017, No. 11675166, No. 11705209; No. 11761141009; No. 11975076; No. 12042509; No. 12005040; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS), Grant No. QYZDJSSW-SLH011; the CAS Center for Excellence in Particle Physics (CCEPP); theShanghaiPujiangProgramunderGrant No. 18PJ1401000; the Shanghai Science and Technology Committee (STCSM) under Grant No. 19ZR1403000; the Ministry of Education, Youth and Sports of the Czech Republic under Contract No. LTT17020; Horizon 2020 ERC Advanced Grant No. 884719 and ERC Starting Grant No. 947006 "InterLeptons" (EuropeanUnion); the Carl Zeiss Foundation, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Universe, and the VolkswagenStiftung; the Department of Atomic Energy (Project Identification No. RTI 4002) and the Department of Science and Technology of India; the Istituto Nazionale di Fisica Nucleare of Italy; National Research Foundation (NRF) of Korea Grants No. 2016R1D1A1B01010135, No. 2016R1D1A1B02012900, No. 2018R1A2B3003643, No. 2018R1A6A1A06024970, No. 2018R1D1A1B07047294, No. 2019K1A3A7A09 033840, No. 2019R1I1A3A01058933; Radiation Science Research Institute, Foreign Large-size Research Facility Application Supporting project, the Global Science Experimental Data Hub Center of the Korea Institute of Science and Technology Information and KREONET/GLORIAD; the Polish Ministry of Science and Higher Education and the National Science Center; the Ministry of Science and Higher Education of the Russian Federation, Agreement 14.W03.31.0026, and the HSE University Basic Research Program, Moscow; University of Tabuk research GrantsNo. S-1440-0321, No. S-0256-1438, andNo. S-02801439 (Saudi Arabia); the Slovenian Research Agency Grants No. J1-9124 and No. P1-0135; Ikerbasque, Basque Foundation for Science, Spain; the Swiss National Science Foundation; the Ministry of Education and the Ministry of Science and Technology of Taiwan; and the United States Department of Energy and the National Science Foundation. Document

Ifosfamide is extensively used to treat several malignant conditions. Administration of ifosfamide can cause encephalopathy and other neurotoxic effects. The aim of this study was to obtain novel information on the onset profiles of ifosfamide-induced encephalopathy (IIE) considering other associated clinical factors using the US Food and Drug Administration Adverse Event Reporting System (FAERS) and the Japanese Adverse Drug Event Report (JADER) databases. We analyzed the reports of encephalopathy between 2004 and 2018 from the FAERS and JADER databases. To define IIE, we used the Medical Dictionary for Regulatory Activities (MedDRA) preferred terms and standardized queries. The reporting odds ratios (ROR) at 95% confidence interval (CI) was used to detect the signal for IIE and adjusted for covariates using a multivariate logistic regression technique. We evaluated the time-to-onset profile of IIE and used the association rule mining technique to discover undetected associations, such as potential risk factors. In the FAERS database, the ROR (CI) for encephalopathy (preferred term, PT) and encephalopathy (standardized MedDRA queries, SMQ) was 56.58 (51.69–61.93) and 1.57 (1.48–1.67), respectively. In the JADER database, the ROR (95% CI) for encephalopathy (PT) and encephalopathy (SMQ) was 13.54 (9.91–18.50) and 1.24 (1.01–1.53), respectively. The multivariate logistic regression analysis showed a significant contribution in IIE signal in the ≥ 60 year group (p = 0.00094; vs.

We acknowledge support from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, the Japan Society for the Promotion of Science (JSPS), and the Tau-Lepton Physics Research Center of Nagoya University; the Australian Research Council including Grants No. DP180102629, No. DP170102389, No. DP170102204, No. DP150103061, No. FT130100303; Austrian Federal Ministry of Education, Science and Research (FWF) and FWF Austrian Science Fund No. P 31361-N36; the National Natural Science Foundation of China under Contracts No. 11435013, No. 11475187, No. 11521505, No. 11575017, No. 11675166, No. 11705209; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS), Grant No. QYZDJ-SSW-SLH011; the CAS Center for Excellence in Particle Physics (CCEPP); the Shanghai Pujiang Program under Grant No. 18PJ1401000; the Shanghai Science and Technology Committee (STCSM) under Grant No. 19ZR1403000; the Ministry of Education, Youth and Sports of the Czech Republic under Contract No. LTT17020; Horizon 2020 ERC Advanced Grant No. 884719 and ERC Starting Grant No. 947006 "InterLeptons" (European Union); the Carl Zeiss Foundation, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Universe, and the VolkswagenStiftung; the Department of Atomic Energy (Project Identification No. RTI 4002) and the Department of Science and Technology of India; the Istituto Nazionale di Fisica Nucleare of Italy; National Research Foundation (NRF) of Korea Grants No. 2016R1D1A1B01010135, No. 2016R1D1A1B02012900, No. 2018R1A2B3003643, No. 2018R1A6A1A06024970, No. 2018R1D1A1B07047294, No. 2019K1A3A7A09033840, No. 2019R1I1A3A01058933; Radiation Science Research Institute, Foreign Large-size Research Facility Application Supporting project, the Global Science Experimental Data Hub Center of the Korea Institute of Science and Technology Information and KREONET/GLORIAD; the Polish Ministry of Science and Higher Education and the National Science Center; the Ministry of Science and Higher Education of the Russian Federation, Agreement 14.W03.31.0026, and the HSE University Basic Research Program, Moscow; University of Tabuk research Grants No. S-1440-0321, No. S-0256-1438, and No. S-0280-1439 (Saudi Arabia); the Slovenian Research Agency Grant No. J1-9124 and No. P1-0135; Ikerbasque, Basque Foundation for Science, Spain; the Swiss National Science Foundation; the Ministry of Education and the Ministry of Science and Technology of Taiwan; and the United States Department of Energy and the National Science Foundation

International audience; In the forward end-cap of the Belle II spectrometer, an innovative proximity focusing Ring Imaging Cherenkov counter with a multilayer focusing aerogel radiator has been installed. The detector is designed to be operated in a magentic field of 1.5 T, and consists of a double layer aerogel radiator, an expansion volume and a photon detector. In total 420 Hamamatsu hybrid avalanche photo sensors with 144 channels each are used to read out single Cherenkov photons with high efficiency. We expect the device to provide better than 4s separation of pions from kaons in the full kinmatic region of the experiment, from 0.5 GeV/c to 4 GeV/c. The detector components have been successfully produced and installed in the spectrometer. After the commissioning phase in 2018, the detector is now included in the Belle II data taking, and is expected to contribute substantially to the performance of the spectrometer in looking for rare decays of B and D mesons, and of tau leptons. In this contribution we review the detector design and present results of the first detector performance studies.

AIMS: A number of epidemiologic surveys have demonstrated that improving lifestyle habits, providing patient education, and regular screening of patients for early diabetic symptoms and complications through multidisciplinary collaboration are crucial for the management of diabetes. METHODS: To evaluate the Diabetes Coordination Notebook and the Diabetes Regional Coordination Path in management of diabetes, 217 community pharmacies conducted a survey by questionnaire in Gifu Prefecture, Japan. RESULTS: A reply to the questionnaire was obtained from 27,016 individuals, of whom 5,572 claimed to have diabetes or prediabetes. The rate of usage of the Diabetes Coordination Notebook and the Diabetes Regional Coordination Path was 40% and 7%, respectively. Interestingly, patients using the Diabetes Regional Coordination Path more frequently visited an ophthalmic clinic (p

AIM Older patients are considered to be at high risk for developing adverse drug reactions (ADR), because they commonly receive multidrug therapy despite changes in pharmacokinetic function with age. In the present study, we assessed the relationship between the number of prescribed drugs and the incidence of ADR or the time to discharge in older patients with neuromuscular disease. METHODS A retrospective study was carried out among 135 older patients (aged ≥65 years) who were admitted to the neurology ward from October 2007 through December 2011. Drugs that possess a high risk for initiation of grade ≥2 ADR were determined using logistic regression analysis. RESULTS A total of 38 patients (28.1%) experienced grade ≥2 ADR. Multivariate logistic regression analysis showed that corticosteroids, antibiotics, enteric nutrients and insulin were significant risks for grade ≥2 ADR. Notably, the time to discharge extended as the grade of ADR increased, with mean values of 24.4 days for grade 0, 38.3 days for grade 1, 47.5 days for grade 2 and 73.1 days for grade 3-4 events. Furthermore, the number of high-risk drugs for grade ≥2 ADR correlated well with the incidence of grade ≥2 events (R = 0.964, P = 0.008), as well as with the time to discharge (R = 0.473, P

A 71-year-old woman with a 9-year history of Parkinson's disease was admitted to our hospital emergently because of consciousness disturbance. Her consciousness level was 200 on the Japan coma scale (JCS), and she presented with tenderness and distension of the lower abdomen. Brain computed tomography showed normal findings. Blood tests showed an increased ammonia level (209 μg/dl) with normal AST and ALT levels. We catheterized the bladder for urinary retention. Five hours after admission, the blood ammonia level decreased to 38 μg/dl, and her consciousness level improved dramatically. Corynebacterium urearyticum, a bacterial species that produces urease, was detected by urine culture. Therefore, she was diagnosed with hyperammonemic encephalopathy resulting from urinary tract infection caused by urease-producing bacteria. In this case, urologic active agents had been administered to treat neurogenic bladder. We suspect that these drugs caused urinary obstruction and urinary tract infection. It is important to recognize that obstructive urinary tract infection caused by urease-producing bacteria can cause hyperammonemia. Neurological disorders, such as Parkinson's disease, tend to complicate neurogenic bladder. This disease should be considered in elderly patients with Parkinson's disease who are receiving urologic active drugs.

Study of CP violation and the precise measurements of the Cabibbo-Kobayashi-Maskawa (CKM) provide test of the Standard Model. Recent measurements on angles and sides of the unitarity triangle such as phi_1, phi_3, phi_s, |V_{cb}| from ATLAS, BaBar, Belle and LHCb experiments are summarized. LHCb has performed amplitude analyses on 3 body B decays and has studied the source of local CP asymmetry. This study is also mentioned in this proceedings.

The authors thank Pablo G. Roig and Gabriel L. Castro from CINVESTAV for the extensive help and fruitful discussions. We thank the KEKB group for the excellent operation of the accelerator; the KEK cryogenics group for the efficient operation of the solenoid; the KEK computer group, and the Pacific Northwest National Laboratory (PNNL) Environmental Molecular Sciences Laboratory (EMSL) computing group for strong computing support; and the National Institute of Informatics, and Science Information NETwork 5 (SINET5) for valuable network support. We acknowledge support from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, the Japan Society for the Promotion of Science (JSPS), and the Tau-Lepton Physics Research Center of Nagoya University; the Australian Research Council including Grants No. DP180102629, No. DP170102389, No. DP170102204, No. DP150103061, and No. FT130100303; Austrian Science Fund (FWF); the National Natural Science Foundation of China under Contracts No. 11435013, No. 11475187, No. 11521505, No. 11575017, No. 11675166, and No. 11705209; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS), Grant No. QYZDJ-SSW-SLH011; the CAS Center for Excellence in Particle Physics (CCEPP); the Shanghai Pujiang Program under Grant No. 18PJ1401000; the Ministry of Education, Youth and Sports of the Czech Republic under Contract No. LTT17020; the Carl Zeiss Foundation, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Universe, and the VolkswagenStiftung; the Department of Science and Technology of India; the Istituto Nazionale di Fisica Nucleare of Italy; National Research Foundation (NRF) of Korea Grants No. 2015H1A2A1033649, No. 2016R1D1A1B01010135, No. 2016K1A3A7A09005 603, No. 2016R1D1A1B02012900, No. 2018R1A2B3003 643, No. 2018R1A6A1A06024970, and No. 2018R1D1 A1B07047294; Radiation Science Research Institute, Foreign Large-size Research Facility Application Supporting project, the Global Science Experimental Data Hub Center of theKorea Institute of Science and Technology Information and KREONET/GLORIAD; the Polish Ministry of Science and Higher Education and the National Science Center; the Grant of the Russian Federation Government, Grant No. 14.W03.31.0026; the Slovenian Research Agency; Ikerbasque, Basque Foundation for Science, Spain; the Swiss National Science Foundation; the Ministry of Education and the Ministry of Science and Technology of Taiwan; and the United States Department of Energy and the National Science Foundation.

Aims A questionnaire survey of the prevalence of diabetic retinopathy was recently conducted in Japan. A subgroup analysis to examine the association of periodontal disease with diabetic retinopathy in subjects with diabetes and prediabetes was conducted. Methods The association of the presence of periodontal disease with the occurrence of diabetic retinopathy was examined using multivariate logistic regression analysis. Results Of 27 016 subjects who completed a survey at 217 community pharmacies, 5 572 had diabetes or prediabetes, among whom 522 and 1 421 had retinopathy or periodontal disease, respectively. Therapy duration≥10 years (OR: 2.73, 95% CI: 2.17–3.43, P Conclusions These findings indicate that the target HbA1c level for diabetes patients with periodontal disease may be set lower than for those without it, and that regular dental visits should be prescribed for the management of periodontal disease and the prevention of diabetic retinopathy.

Large data samples accumulated by BaBar, Belle, BESIII and LHCb experiments provide opportunities to perform studies of charmed baryons. The observation of excited \(\Omega _c\) charm baryons by LHCb, and confirmation by Belle is reported. Another charmed-strange baryon \(\Xi _c(2930)^0\) is observed by Belle. The decays of \(\Omega _c\) and \(\Lambda _c\) into various final states are studied by the experiments, and the branching fractions are measured. In this proceedings, recent measurements related to charmed baryons are summarized.

Insulin is frequently used for glycemic control. Medication errors related to insulin are a common problem for medical institutions. Here, we prepared a standardized sliding scale insulin (SSI) order sheet and assessed the effect of its introduction. Observations before and after the introduction of the standardized SSI template were conducted at Gifu University Hospital. The incidence of medication errors, hyperglycemia, and hypoglycemia related to SSI were obtained from the electronic medical records. The introduction of the standardized SSI order sheet significantly reduced the incidence of medication errors related to SSI compared with that prior to its introduction (12/165 [7.3%] vs 4/159 [2.1%], P = .048). However, the incidence of hyperglycemia (≥250 mg/dL) and hypoglycemia (≤50 mg/dL) in patients who received SSI was not significantly different between the 2 groups. The introduction of the standardized SSI order sheet reduced the incidence of medication errors related to SSI.

Extracellular-superoxide dismutase (genetic name SOD3) is a secreted anti-oxidative enzyme, and its presence in vascular walls may play an important role in protecting the vascular system against oxidative stress. Oxidative stress has been implicated in the pathogenesis of diabetic retinopathy; therefore, increases in extracellular-superoxide dismutase have been suggested to inhibit the progression of diabetic retinopathy. Incretin-based drugs such as glucagon-like peptide-1 receptor agonists are used in the treatment of type 2 diabetes. Glucagon-like peptide-1 receptor agonists are expected to function as extrapancreatic agents because the glucagon-like peptide-1 receptor is expressed not only in pancreatic tissues, but also in many other tissue types. We herein demonstrated that exendin-4, a glucagon-like peptide-1 receptor agonist, induced the expression of extracellular-superoxide dismutase in human retinal microvascular endothelial cells through epigenetic regulation. The results of the present study demonstrated that exendin-4 induced the expression of extracellular-superoxide dismutase through histone H3 acetylation at the SOD3 proximal promoter region. Moreover, plasma extracellular-superoxide dismutase concentrations in diabetic patients were elevated by incretin-based therapies. Therefore, incretin-based therapies may exert direct extrapancreatic effects in order to protect blood vessels by enhancing anti-oxidative activity.

International audience; The aerogel Ring Imaging CHerenkov counter (ARICH) is the particle identification device installed in the forward region of the Belle II detector at the SuperKEKB accelerator facility in Japan. The first electron–positron collisions at SuperKEKB took place on April 26, 2018, during the so called phase 2 run. The measured performance of the detector based on recorded Bhabha events during phase 2 is presented. We measure a 14 mrad average angular resolution per photon and 10 photons per Bhabha electron in the [6–8] GeV/c momentum range.

International audience; The Belle II experiment at the SuperKEKB facility started the beam collision in 2018, aiming search for the New Physics beyond the Standard Model. The Aerogel Ring Imaging Cherenkov (ARICH) counter is a particle identification (PID) device in the forward endcap of the Belle II detector to provide 4\(\sigma \) separation of charged kaons and pions of momenta up to 3.5 GeV. The ARICH counter is a proximity-focusing RICH counter to identify particle species based on the angular distribution of Cherenkov photons located in 30 cm depth of narrow space and 1.5 T of high magnetic field. Two layers of the silica aerogel with different refractive indices emits photons as Cherenkov ring image. A total of 420 of Hybrid Avalanche Photo Detectors (HAPDs) are used to measure the 2-dimensional distribution of photons. We have collected ring images in the first beam collision data during the Phase II commissioning run and studies for the PID performance estimation are being carried out toward the Phase III physics data taking starting in 2019.

International audience; The Hybrid Avalanche Photo Detector (HAPD) is used as a photon detector for Aerogel Ring Imaging Cherenkov counter (ARICH), a particle identification device at Belle II. ARICH measures Cherenkov angles of photons emitted in silica aerogel radiators, hence a high photon detection efficiency is required by the HAPD module, a combination of HAPD and front-end electronics board. We evaluate the performance of the HAPD modules by measuring the noise level, the offset value, the pulse height, temperature dependency and the variation of performance in the beam commissioning period. This article describes the results of performance evaluation of the HAPD and shows that it fulfills the requirements of ARICH.

International audience; The Belle II Aerogel Ring Imaging Cherenkov (ARICH) counter uses the angular distribution of Cherenkov photons emitted in silica aerogel to discriminate between charged pions and kaons. The Hybrid Avalanche Photo Detector (HAPD) is used as the photo-sensor, and is clearly the most critical component of the detector. HAPDs were installed into ARICH in July 2017, and ARICH was installed in the Belle II spectrometer in the end of 2017. During the Belle II beam commissioning in spring 2018, the performance of HAPDs was evaluated through measurements of the offset value, noise level and pulse height. Long term stability of the signal-to-noise ratio and the fraction of dead channel was also monitored. The signal-to-noise ratio exceeded 6, and the fraction of dead channels was less than 1%. The results of the performance evaluation and of the commissioning showed that the ARICH counter fulfills the requirements.

International audience; A proximity focusing RICH detector with an aerogel radiator is used for charged particle identification in the forward end-cap of the Belle II spectrometer. The detector, consisting of a 4 cm aerogel radiator, a 16 cm expansion volume and a photon detector with 420 Hybrid Avalanche Photo Detectors, is mounted in a very confined space between Central Drift Chamber and Electromagnetic Calorimeter, allowing only 5 cm of space for the readout electronics. In our solution, low power front-end read-out boards are mounted at the back side of each of the HAPD photosensors. These boards have each been tested individually before their installation onto the photosensors and into the spectrometer. Most important design issues and first experiences with the aforementioned front-end read-out boards are presented in this contribution.

For efficient separation of hadrons in the forward end-cap of the Belle II spectrometer , an aerogel proximity focusing Ring Imaging Detector is installed in the high magnetic field between the central drift chamber and electromagnetic calorimeter . Cherenkov photons , emitted in the double layer aerogel radiator are expanded through the empty space and detected on the photon detector consisting of Hybrid Avalanche Photo diodes . The readout electronics working in a threshold mode records hit patterns registered during beam collisions. A particle identification algorithm based on the two dimensional extended maximum likelihood technique is used to assign probabilities for different particle hypotheses of tracks traversing the aerogel RICH detector. For efficient discrimination, the Aerogel RICH detector has to be calibrated. We present the key calibration steps used to optimize the detector performance.

The Belle II experiment is a new generation B factory experiment at the SuperKEKB electron–positron collider. The main purpose of the experiment is to search for new physics with a large sample of B meson decays. The proximity-focusing Aerogel Ring-Imaging Cherenkov detector (ARICH) has been designed to identify kaons and pions in the forward end-cap of the Belle II spectrometer. Using aerogel as radiator with specialized photon sensors called HAPD, the K/ π separation is expected to reach more than 4 σ in the momentum range from 0.5 GeV/c to 4.0 GeV/c. ARICH detector was constructed in summer 2017 and was installed in the Belle II spectrometer in the beam line of the SuperKEKB collider. The test of the ARICH detector is performed using both cosmic rays and the beam collisions during the accelerator commissioning. We observe Cherenkov rings in the ARICH detector associated with charged tracks detected by the tracking system. The reconstructed Cherenkov angle distribution has a clear and reasonable peak. The ARICH K ∕ π separation performance is evaluated using Bhabha events in beam runs; the separation power achieve the design value.

The Aerogel Ring-Imaging Cherenkov (ARICH) detector provides particle identification information in the forward endcap part of Belle II. It efficiently separates charged kaons from pions for momenta between 0.5 GeV/c and 4.0 GeV/c. Optical photons are emitted in a double layer aerogel radiator and detected by Hybrid Avalanche Photo Detectors. ARICH was installed in Belle II at the end of 2017, the first phase of a complex detector calibration of electronic signals and preparation for physics signals calibration has been successfully concluded. Cherenkov rings, created by cosmic rays as well as by charged particles from beam collisions, have been observed. The kaon identification efficiency using D ± ∗ decays has been studied and its calibration is expected by the end of the commissioning phase when sufficient data is available.

Drug-induced pressure ulcer (DIPU), which is a newly recognized adverse drug reaction, is associated with the administration of psychiatric drugs in geriatric patients with dementia. The notification of the causative drugs is crucial to the treatment of DIPU. We herein report the case of a 56-year-old woman with early-stage Parkinson's disease who developed DIPUs after starting olanzapine treatment for depressive symptoms. Our findings illustrate that if an akinetic patient with pressure ulcers is encountered, the patient's medication should be reviewed by a multidisciplinary team, to evaluate whether the development of the pressure ulcer is drug-related, regardless of the patient's age.

Older patients are considered to be at high risk for developing adverse drug reactions (ADR), because they commonly receive multidrug therapy despite changes in pharmacokinetic function with age. In the present study, we assessed the relationship between the number of prescribed drugs and the incidence of ADR or the time to discharge in older patients with neuromuscular disease.A retrospective study was carried out among 135 older patients (aged ≥65 years) who were admitted to the neurology ward from October 2007 through December 2011. Drugs that possess a high risk for initiation of grade ≥2 ADR were determined using logistic regression analysis.A total of 38 patients (28.1%) experienced grade ≥2 ADR. Multivariate logistic regression analysis showed that corticosteroids, antibiotics, enteric nutrients and insulin were significant risks for grade ≥2 ADR. Notably, the time to discharge extended as the grade of ADR increased, with mean values of 24.4 days for grade 0, 38.3 days for grade 1, 47.5 days for grade 2 and 73.1 days for grade 3-4 events. Furthermore, the number of high-risk drugs for grade ≥2 ADR correlated well with the incidence of grade ≥2 events (R = 0.964, P = 0.008), as well as with the time to discharge (R = 0.473, P 0.001).Older patients receiving multidrug therapy using corticosteroids, antibiotics, enteric nutrients, or insulin were at high risk for grade ≥2 ADR and prolongation of hospital stay. Geriatr Gerontol Int 2018; 18: 1018-1024.

Medical data are often maintained by different organizations. However, detailed analyses sometimes require these datasets to be integrated without violating patient or commercial privacy. Multiparty Private Set Intersection (MPSI), which is an important privacy-preserving protocol, computes an intersection of multiple private datasets. This approach ensures that only designated parties can identify the intersection. In this paper, we propose a practical MPSI that satisfies the following requirements: The size of the datasets maintained by the different parties is independent of the others, and the computational complexity of the dataset held by each party is independent of the number of parties. Our MPSI is based on the use of an outsourcing provider, who has no knowledge of the data inputs or outputs. This reduces the computational complexity. The performance of the proposed MPSI is evaluated by implementing a prototype on a virtual private network to enable parallel computation in multiple threads. Our protocol is confirmed to be more efficient than comparable existing approaches.

Insulin is frequently used for glycemic control. Medication errors related to insulin are a common problem for medical institutions. Here, we prepared a standardized sliding scale insulin (SSI) order sheet and assessed the effect of its introduction. Observations before and after the introduction of the standardized SSI template were conducted at Gifu University Hospital. The incidence of medication errors, hyperglycemia, and hypoglycemia related to SSI were obtained from the electronic medical records. The introduction of the standardized SSI order sheet significantly reduced the incidence of medication errors related to SSI compared with that prior to its introduction (12/165 [7.3%] vs 4/159 [2.1%], P = .048). However, the incidence of hyperglycemia (≥250 mg/dL) and hypoglycemia (≤50 mg/dL) in patients who received SSI was not significantly different between the 2 groups. The introduction of the standardized SSI order sheet reduced the incidence of medication errors related to SSI.

Lithium carbonate is considered to be a first-line treatment for bipolar disorder; however, this drug has a narrow therapeutic window, and lithium intoxication is commonly induced by various drugs interaction and situations. We herein report a case of lithium intoxication induced by the administration of an antihypertensive agent targeting the angiotensin 1 (AT1) subtype of the angiotensin II receptor in a 65-year-old woman with a 40-year history of bipolar disorder type 1, and 1-year history of essential hypertension. Her bipolar disorder had been well-controlled with 600 mg/day of lithium carbonate for more than 10 years. She was later diagnosed with hypertension and the AT1 receptor blocker, azilsartan was thereafter administrated on a daily basis. After 3 weeks of azilsartan administration, she presented with progressive action tremor and showed a gradual deterioration of her physical state. Four months after the start of azilsartan administration, she presented with alternating episodes of diarrhea and constipation. Two weeks before admission to our hospital, she presented with mild consciousness disturbances, myoclonus, truncal ataxia, and appetite loss. She was diagnosed to have lithium intoxication based on an elevated serum lithium concentration of 3.28 mEq/l.It is therefore important to evaluate the serum lithium concentration after the administration of antihypertensive agents, and consider lithium-antihypertensive agent interactions when selecting antihypertensive agents in elderly patients receiving long-term lithium carbonate treatment.

Microstructures in the weld heat affected zone (HAZ) can cause a decrease in fracture toughness, and evaluating the effect of microstructures on fracture toughness is helpful in understanding the cause of the fracture toughness decrease. In this study, micro-sized tensile specimens were sampled from base metal and HAZ, and the mechanical properties and fracture behaviours of different steel microstructures were directly investigated by micro-sized mechanical testing.

Primary amine thiourea organocatalyst 8 was used to promote Michael additions of bulky α,α-disubstituted aldehydes, such as isobutyraldehyde with maleimides to afford the corresponding adducts in high to excellent yields and with up to 91% ee.