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Your search keyword '"Shlomi-Loubaton, Shir"' showing total 9 results
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9 results on '"Shlomi-Loubaton, Shir"'

1. Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

Author

Barboy, Oren, Bercovich, Akhiad, Li, Hanjie, Eyal-Lubling, Yaniv, Yalin, Adam, Shapir Itai, Yuval, Abadie, Kathleen, Zada, Mor, David, Eyal, Shlomi-Loubaton, Shir, Katzenelenbogen, Yonatan, Jaitin, Diego Adhemar, Gur, Chamutal, Yofe, Ido, Feferman, Tali, Cohen, Merav, Dahan, Rony, Newell, Evan W., Lifshitz, Aviezer, Tanay, Amos, and Amit, Ido

Published
2024
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2. The transcriptional and regulatory identity of erythropoietin producing cells

Author

Kragesteen, Bjørt K., Giladi, Amir, David, Eyal, Halevi, Shahar, Geirsdóttir, Laufey, Lempke, Olga M., Li, Baoguo, Bapst, Andreas M., Xie, Ken, Katzenelenbogen, Yonatan, Dahl, Sophie L., Sheban, Fadi, Gurevich-Shapiro, Anna, Zada, Mor, Phan, Truong San, Avellino, Roberto, Wang, Shuang-Yin, Barboy, Oren, Shlomi-Loubaton, Shir, Winning, Sandra, Markwerth, Philipp P., Dekalo, Snir, Keren-Shaul, Hadas, Kedmi, Merav, Sikora, Martin, Fandrey, Joachim, Korneliussen, Thorfinn S., Prchal, Josef T., Rosenzweig, Barak, Yutkin, Vladimir, Racimo, Fernando, Willerslev, Eske, Gur, Chamutal, Wenger, Roland H., and Amit, Ido

Published
2023
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3. XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author

Deczkowska, Aleksandra, David, Eyal, Ramadori, Pierluigi, Pfister, Dominik, Safran, Michal, Li, Baoguo, Giladi, Amir, Jaitin, Diego Adhemar, Barboy, Oren, Cohen, Merav, Yofe, Ido, Gur, Chamutal, Shlomi-Loubaton, Shir, Henri, Sandrine, Suhail, Yousuf, Qiu, Mengjie, Kam, Shing, Hermon, Hila, Lahat, Eylon, Ben Yakov, Gil, Cohen-Ezra, Oranit, Davidov, Yana, Likhter, Mariya, Goitein, David, Roth, Susanne, Weber, Achim, Malissen, Bernard, Weiner, Assaf, Ben-Ari, Ziv, Heikenwälder, Mathias, Elinav, Eran, and Amit, Ido

Published
2021
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4. Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

Author

Cohen, Yael C., Zada, Mor, Wang, Shuang-Yin, Bornstein, Chamutal, David, Eyal, Moshe, Adi, Li, Baoguo, Shlomi-Loubaton, Shir, Gatt, Moshe E., Gur, Chamutal, Lavi, Noa, Ganzel, Chezi, Luttwak, Efrat, Chubar, Evgeni, Rouvio, Ory, Vaxman, Iuliana, and Pasvolsky, Oren

Subjects
Oncology, Experimental, Molecular dynamics -- Research, Drug resistance -- Research, Multiple myeloma -- Drug therapy -- Patient outcomes, Cancer -- Relapse -- Research, Biological sciences, Health
Abstract

Multiple myeloma (MM) is a neoplastic plasma-cell disorder characterized by clonal proliferation of malignant plasma cells. Despite extensive research, disease heterogeneity within and between treatment-resistant patients is poorly characterized. In the present study, we conduct a prospective, multicenter, single-arm clinical trial (NCT04065789), combined with longitudinal single-cell RNA-sequencing (scRNA-seq) to study the molecular dynamics of MM resistance mechanisms. Newly diagnosed MM patients (41), who either failed to respond or experienced early relapse after a bortezomib-containing induction regimen, were enrolled to evaluate the safety and efficacy of a daratumumab, carfilzomib, lenalidomide and dexamethasone combination. The primary clinical endpoint was safety and tolerability. Secondary endpoints included overall response rate, progression-free survival and overall survival. Treatment was safe and well tolerated; deep and durable responses were achieved. In prespecified exploratory analyses, comparison of 41 primary refractory and early relapsed patients, with 11 healthy subjects and 15 newly diagnosed MM patients, revealed new MM molecular pathways of resistance, including hypoxia tolerance, protein folding and mitochondria respiration, which generalized to larger clinical cohorts (CoMMpass). We found peptidylprolyl isomerase A (PPIA), a central enzyme in the protein-folding response pathway, as a potential new target for resistant MM. CRISPR-Cas9 deletion of PPIA or inhibition of PPIA with a small molecule inhibitor (ciclosporin) significantly sensitizes MM tumor cells to proteasome inhibitors. Together, our study defines a roadmap for integrating scRNA-seq in clinical trials, identifies a signature of highly resistant MM patients and discovers PPIA as a potent therapeutic target for these tumors. Integration of longitudinal single-cell analysis of relapsed and refractory multiple myeloma patients in a prospective clinical trial uncovers new pathways of drug resistance and identifies potential actionable targets., Author(s): Yael C. Cohen [sup.1] [sup.2] , Mor Zada [sup.1] [sup.3] , Shuang-Yin Wang [sup.3] , Chamutal Bornstein [sup.3] , Eyal David [sup.3] , Adi Moshe [sup.3] , Baoguo Li [...]

Published
2021
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5. Publisher Correction: XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author

Deczkowska, Aleksandra, David, Eyal, Ramadori, Pierluigi, Pfister, Dominik, Safran, Michal, Li, Baoguo, Giladi, Amir, Jaitin, Diego Adhemar, Barboy, Oren, Cohen, Merav, Yofe, Ido, Gur, Chamutal, Shlomi-Loubaton, Shir, Henri, Sandrine, Suhail, Yousuf, Qiu, Mengjie, Kam, Shing, Hermon, Hila, Lahat, Eylon, Ben Yakov, Gil, Cohen-Ezra, Oranit, Davidov, Yana, Likhter, Mariya, Goitein, David, Roth, Susanne, Weber, Achim, Malissen, Bernard, Weiner, Assaf, Ben-Ari, Ziv, Heikenwälder, Mathias, Elinav, Eran, and Amit, Ido

Published
2022
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6. The transcriptional and regulatory identity of erythropoietin producing cells

Author

Kragesteen, Bjørt K, Giladi, Amir, David, Eyal, Halevi, Shahar, Geirsdóttir, Laufey, Lempke, Olga M, Li, Baoguo, Bapst, Andreas M, Xie, Ken, Katzenelenbogen, Yonatan, Dahl, Sophie L, Sheban, Fadi, Gurevich-Shapiro, Anna, Zada, Mor, Phan, Truong San, Avellino, Roberto, Wang, Shuang-Yin, Barboy, Oren, Shlomi-Loubaton, Shir, Winning, Sandra, Markwerth, Philipp P, Dekalo, Snir, Keren-Shaul, Hadas, Kedmi, Merav, Sikora, Martin, Fandrey, Joachim, Korneliussen, Thorfinn S, Prchal, Josef T, Rosenzweig, Barak, Yutkin, Vladimir, et al, University of Zurich, and Kragesteen, Bjørt K

Subjects
1300 General Biochemistry, Genetics and Molecular Biology, General Biochemistry, 570 Life sciences, biology, 610 Medicine & health, Genetics and Molecular Biology, General Medicine, 10052 Institute of Physiology
Published
2023

7. LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma

Author

Gur, Chamutal, primary, Wang, Shuang-Yin, additional, Sheban, Fadi, additional, Zada, Mor, additional, Li, Baoguo, additional, Kharouf, Fadi, additional, Peleg, Hagit, additional, Aamar, Suhail, additional, Yalin, Adam, additional, Kirschenbaum, Daniel, additional, Braun-Moscovici, Yolanda, additional, Jaitin, Diego Adhemar, additional, meir-salame, Tomer, additional, Hagai, Efrat, additional, Kragesteen, Bjørt K., additional, Avni, Batia, additional, Grisariu, Sigal, additional, Bornstein, Chamutal, additional, Shlomi-Loubaton, Shir, additional, David, Eyal, additional, Shreberk-Hassidim, Rony, additional, Molho-Pessach, Vered, additional, Amar, Dalit, additional, Tzur, Tomer, additional, Kuint, Rottem, additional, Gross, Moshe, additional, Barboy, Oren, additional, Moshe, Adi, additional, Fellus-Alyagor, Liat, additional, Hirsch, Dana, additional, Addadi, Yoseph, additional, Erenfeld, Shlomit, additional, Biton, Moshe, additional, Tzemach, Tehila, additional, Elazary, Anat, additional, Naparstek, Yaakov, additional, Tzemach, Reut, additional, Weiner, Assaf, additional, Giladi, Amir, additional, Balbir-Gurman, Alexandra, additional, and Amit, Ido, additional

Published
2022
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8. XCR1+type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author

Deczkowska, Aleksandra, David, Eyal, Ramadori, Pierluigi, Pfister, Dominik, Safran, Michael, At the, Baoguo, Giladi, Amir, Jaitin, Diego Adhemar, Barboy, Oren, Cohen, Merav, Yofe, Ido, Gur, Chamutal, Shlomi-Loubaton, Shir, Henri, Sandrine, Suhail, Yousuf, Qiu, Mengjie, Kam, Shing, Hermon, Hila, Lahat, Eylon, Ben Yakov, Gil, Cohen-Ezra, Oranit, Davidov, Yana, Likhter, Mariya, Goitein, David, Roth, Susanne, Weber, Achim, Malissen, Bernard, Weiner, Assaf, Ben-Ari, Ziv, Heikenwälder, Mathias, Elinav, Eran, and Amit, Ido

Abstract

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this disease are poorly understood. Here, using single-cell transcriptomic analysis, we comprehensively profiled the immune composition of the mouse liver during NASH. We identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDCs) and further defined their source as NASH-induced boost in cycling of cDC progenitors in the bone marrow. Analysis of blood and liver from patients on the NAFLD/NASH spectrum showed that type 1 cDCs (cDC1) were more abundant and activated in disease. Sequencing of physically interacting cDC-T cell pairs from liver-draining lymph nodes revealed that cDCs in NASH promote inflammatory T cell reprogramming, previously associated with NASH worsening. Finally, depletion of cDC1 in XCR1DTAmice or using anti-XCL1-blocking antibody attenuated liver pathology in NASH mouse models. Overall, our study provides a comprehensive characterization of cDC biology in NASH and identifies XCR1+cDC1 as an important driver of liver pathology.

Published
2021
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9. Publisher Correction: XCR1+type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author

Deczkowska, Aleksandra, David, Eyal, Ramadori, Pierluigi, Pfister, Dominik, Safran, Michal, Li, Baoguo, Giladi, Amir, Jaitin, Diego Adhemar, Barboy, Oren, Cohen, Merav, Yofe, Ido, Gur, Chamutal, Shlomi-Loubaton, Shir, Henri, Sandrine, Suhail, Yousuf, Qiu, Mengjie, Kam, Shing, Hermon, Hila, Lahat, Eylon, Ben Yakov, Gil, Cohen-Ezra, Oranit, Davidov, Yana, Likhter, Mariya, Goitein, David, Roth, Susanne, Weber, Achim, Malissen, Bernard, Weiner, Assaf, Ben-Ari, Ziv, Heikenwälder, Mathias, Elinav, Eran, and Amit, Ido

Published
2022
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