1. [Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide].
- Author
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Kurbatova GT, Fedorenko OM, Sokhov ST, Verkholomova IA, and Shklovskaia NI
- Subjects
- Anesthetics administration & dosage, Animals, Drug Carriers, Lidocaine administration & dosage, Lidocaine pharmacokinetics, Microspheres, Particle Size, Powders, Procaine administration & dosage, Procaine pharmacokinetics, Rabbits, Tissue Distribution, Trimecaine administration & dosage, Trimecaine pharmacokinetics, Acrylic Resins, Anesthetics pharmacokinetics, Drug Delivery Systems, Iron, Magnetics
- Abstract
The effect of external magnetic field (direct and alternating) on the targeted delivery and distribution in body tissues of experimental animals of anesthetics (novocain, lidocaine, and trimecaine) immobilized on highly dispersed ferromagnetics with biocompatible coating was studied by the method of emission spectral analysis. The results are compared with the results obtained earlier on highly dispersed iron powders with dextran coating. The parameters for the powders with dextran coating are considerably lower than those for the magnetic carriers with the polyacrylamide coating.
- Published
- 2002