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10 results on '"Shiying Du"'

1. Synthesis of 3H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

Author

Xiao-Feng Wu, Jianhua Tang, Shiying Du, Zuguang Yang, and Zhengkai Chen

Subjects
Annulation, Nucleophilic addition, 010405 organic chemistry, Chemistry, Organic Chemistry, Intermolecular force, Angiotensin ii antagonist, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Nucleophile, Cascade, Intramolecular force, Sodium cyanate, Physical and Theoretical Chemistry
Abstract

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Published
2021

2. Palladium-Catalyzed Cascade Carbonylative Synthesis of 1,2,4-Triazol-3-ones from Hydrazonoyl Chlorides and NaN3

Author

Yufei Song, Shiying Du, Zhengkai Chen, Wei-Feng Wang, and Xiao-Feng Wu

Subjects
Nucleophilic addition, 010405 organic chemistry, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Catalysis, Acyl azide, chemistry.chemical_compound, chemistry, Cascade, Intramolecular force, Physical and Theoretical Chemistry, Carbonylation, Curtius rearrangement, Palladium
Abstract

A palladium-catalyzed three-component carbonylative reaction for the synthesis of 3H-1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3 has been achieved. The reaction presumably proceeds through a cascade carbonylation, acyl azide formation, Curtius rearrangement, and intramolecular nucleophilic addition sequence. A wide variety of structurally diverse 3H-1,2,4-triazol-3-ones were constructed in moderate to excellent yields. Benzene-1,3,5-triyl triformate (TFBen) was applied as a solid and convenient CO surrogate.

Published
2021

3. FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Isatins and Trifluoroacetimidoyl Chlorides

Author

Zhengkai Chen, Xiao-Feng Wu, Le-Cheng Wang, and Shiying Du

Subjects
Annulation, Trifluoromethyl, 010405 organic chemistry, Isatin, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Physical and Theoretical Chemistry, Derivative (chemistry)
Abstract

An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs rea...

Published
2020

5. The cascade coupling/iodoaminocyclization reaction of trifluoroacetimidoyl chlorides and allylamines: metal-free access to 2-trifluoromethyl-imidazolines

Author

Le-Cheng Wang, Xiao-Feng Wu, Yufei Song, Zhengkai Chen, and Shiying Du

Subjects
Coupling, chemistry.chemical_compound, Trifluoromethyl, chemistry, Metal free, Cascade, Yield (chemistry), Organic Chemistry, Imidazoline receptor, Imidazoline derivatives, Physical and Theoretical Chemistry, Biochemistry, Combinatorial chemistry
Abstract

A metal-free cascade coupling/iodoaminocyclization reaction for the rapid assembly of 2-trifluoromethyl-imidazolines has been disclosed. The transformation applies readily accessible trifluoroacetimidoyl chlorides, allylamines and N-iodosuccinimides as the starting substrates, achieving an efficient and straightforward pathway to construct diverse imidazoline derivatives. Excellent efficiency of the reaction is observed (higher than 90% isolated yield for half of the examples), and the obtained imidazoline products bearing a pendent iodomethyl group could be easily transformed into other synthetically valuable compounds.

Published
2021

7. Iodine-Mediated Multicomponent Synthesis of 3-Sulfenylimidazo[1,2-a]pyridines from 2-Aminopyridines, Ketones, and Sulfonyl Hydrazides

Author

Hu Sipei, Zhengkai Chen, Yunjie Yao, Shiying Du, Hongjun Ren, and Zuguang Yang

Subjects
Sulfonyl, chemistry.chemical_classification, chemistry, 010405 organic chemistry, Organic Chemistry, chemistry.chemical_element, Substrate (chemistry), 010402 general chemistry, Iodine, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Aminopyridines
Abstract

A one-pot multicomponent reaction for the synthesis of 3-sulfenylimidazo[1,2-a]pyridines from readily available 2-aminopyridines, ketones, and sulfonyl hydrazides, mediated by molecular iodine, has been developed. The transformations proceed smoothly with high efficiency and a broad substrate scope, affording the desired heterocyclic products in moderate to excellent yields.

Published
2019

8. Synthesis of 3

Author

Shiying, Du, Zuguang, Yang, Jianhua, Tang, Zhengkai, Chen, and Xiao-Feng, Wu

Abstract

A nickel-promoted cascade annulation reaction for the facile synthesis of 3

Published
2021

10. FeCl

Author

Le-Cheng, Wang, Shiying, Du, Zhengkai, Chen, and Xiao-Feng, Wu

Abstract

An FeCl

Published
2020

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