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1. Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study

Author

Nori, Satoshi, Watanabe, Kota, Takeda, Kazuki, Yamane, Junichi, Kono, Hitoshi, Yokogawa, Noriaki, Sasagawa, Takeshi, Ando, Kei, Nakashima, Hiroaki, Segi, Naoki, Funayama, Toru, Eto, Fumihiko, Yamaji, Akihiro, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kiyasu, Katsuhito, Iizuka, Yoichi, Takasawa, Eiji, Funao, Haruki, Kaito, Takashi, Yoshii, Toshitaka, Ishihara, Masayuki, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Published
2024
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2. Muscle strength rather than appendicular skeletal muscle mass might affect spinal sagittal alignment, low back pain, and health-related quality of life

Author

Tanaka, Yoshihide, Miyagi, Masayuki, Inoue, Gen, Hori, Yusuke, Inage, Kazuhide, Murata, Kosuke, Fujimaki, Hisako, Kuroda, Akiyoshi, Yokozeki, Yuji, Inoue, Sho, Mimura, Yusuke, Takahashi, Shinji, Ohyama, Shoichiro, Terai, Hidetomi, Hoshino, Masatoshi, Suzuki, Akinobu, Tsujio, Tadao, Toyoda, Hiromitsu, Orita, Sumihisa, Eguchi, Yawara, Shiga, Yasuhiro, Furuya, Takeo, Maki, Satoshi, Ikeda, Shinsuke, Shirasawa, Eiki, Imura, Takayuki, Nakazawa, Toshiyuki, Uchida, Kentaro, Ohtori, Seiji, Nakamura, Hiroaki, and Takaso, Masashi

Published
2023
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3. Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament

Author

Okuwaki, Shun, Funayama, Toru, Koda, Masao, Eto, Fumihiko, Yamaji, Akihiro, Yokogawa, Noriaki, Sasagawa, Takeshi, Ando, Kei, Nakashima, Hiroaki, Segi, Naoki, Watanabe, Kota, Nori, Satoshi, Takeda, Kazuki, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kakutani, Kenichiro, Kakiuchi, Yuji, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Takegami, Norihiko, Funao, Haruki, Oshima, Yasushi, Kaito, Takashi, Sakai, Daisuke, Yoshii, Toshitaka, Ohba, Tetsuro, Otsuki, Bungo, Seki, Shoji, Miyazaki, Masashi, Ishihara, Masayuki, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Published
2023
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4. Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study

Author

Nori, Satoshi, Watanabe, Kota, Takeda, Kazuki, Yamane, Junichi, Kono, Hitoshi, Yokogawa, Noriaki, Sasagawa, Takeshi, Ando, Kei, Nakashima, Hiroaki, Segi, Naoki, Funayama, Toru, Eto, Fumihiko, Yamaji, Akihiro, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kiyasu, Katsuhito, Iizuka, Yoichi, Takasawa, Eiji, Funao, Haruki, Kaito, Takashi, Yoshii, Toshitaka, Ishihara, Masayuki, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Published
2022
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5. Factors Affecting the Waiting Time from Injury to Surgery in Elderly Patients with a Cervical Spine Injury: A Japanese Multicenter Survey

Author

Uehara, Masashi, Ikegami, Shota, Takizawa, Takashi, Oba, Hiroki, Yokogawa, Noriaki, Sasagawa, Takeshi, Ando, Kei, Nakashima, Hiroaki, Segi, Naoki, Funayama, Toru, Eto, Fumihiko, Yamaji, Akihiro, Watanabe, Kota, Nori, Satoshi, Takeda, Kazuki, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kakutani, Kenichiro, Kakiuchi, Yuji, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Takegami, Norihiko, Funao, Haruki, Oshima, Yasushi, Kaito, Takashi, Sakai, Daisuke, Yoshii, Toshitaka, Otsuki, Bungo, Seki, Shoji, Miyazaki, Masashi, Ishihara, Masayuki, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Published
2022
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6. Decreased muscle mass and strength affected spinal sagittal malalignment

Author

Miyagi, Masayuki, Inoue, Gen, Hori, Yusuke, Inage, Kazuhide, Murata, Kosuke, Kawakubo, Ayumu, Fujimaki, Hisako, Koyama, Tomohisa, Yokozeki, Yuji, Mimura, Yusuke, Takahashi, Shinji, Ohyama, Shoichiro, Terai, Hidetomi, Hoshino, Masatoshi, Suzuki, Akinobu, Tsujio, Tadao, Dohzono, Sho, Sasaoka, Ryuichi, Toyoda, Hiromitsu, Orita, Sumihisa, Eguchi, Yawara, Shiga, Yasuhiro, Furuya, Takeo, Maki, Satoshi, Shirasawa, Eiki, Saito, Wataru, Imura, Takayuki, Nakazawa, Toshiyuki, Uchida, Kentaro, Ohtori, Seiji, Nakamura, Hiroaki, and Takaso, Masashi

Published
2022
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7. Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases

Author

Yokogawa, Noriaki, Kato, Satoshi, Sasagawa, Takeshi, Hayashi, Hiroyuki, Tsuchiya, Hiroyuki, Ando, Kei, Nakashima, Hiroaki, Segi, Naoki, Funayama, Toru, Eto, Fumihiko, Yamaji, Akihiro, Nori, Satoshi, Yamane, Junichi, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kakutani, Kenichiro, Kakiuchi, Yuji, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Takegami, Norihiko, Funao, Haruki, Oshima, Yasushi, Kaito, Takashi, Sakai, Daisuke, Yoshii, Toshitaka, Ohba, Tetsuro, Otsuki, Bungo, Seki, Shoji, Miyazaki, Masashi, Ishihara, Masayuki, Okada, Seiji, Imagama, Shiro, and Watanabe, Kota

Published
2022
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8. Prospective Registration Study for Establishing Minimal Clinically Important Differences in Patients Undergoing Surgery for Spinal Metastases

Author

Hirota, Ryosuke, primary, Oshigiri, Tsutomu, additional, Iesato, Noriyuki, additional, Emori, Makoto, additional, Teramoto, Atsushi, additional, Shiratani, Yuki, additional, Suzuki, Akinobu, additional, Terai, Hidetomi, additional, Shimizu, Takaki, additional, Kakutani, Kenichiro, additional, Kanda, Yutaro, additional, Tominaga, Hiroyuki, additional, Kawamura, Ichiro, additional, Ishihara, Masayuki, additional, Paku, Masaaki, additional, Takahashi, Yohei, additional, Funayama, Toru, additional, Miura, Kousei, additional, Shirasawa, Eiki, additional, Inoue, Hirokazu, additional, Kimura, Atsushi, additional, Iimura, Takuya, additional, Moridaira, Hiroshi, additional, Nakajima, Hideaki, additional, Watanabe, Shuji, additional, Akeda, Koji, additional, Takegami, Norihiko, additional, Nakanishi, Kazuo, additional, Sawada, Hirokatsu, additional, Matsumoto, Koji, additional, Funaba, Masahiro, additional, Suzuki, Hidenori, additional, Funao, Haruki, additional, Hirai, Takashi, additional, Otsuki, Bungo, additional, Kobayakawa, Kazu, additional, Uotani, Koji, additional, Manabe, Hiroaki, additional, Tanishima, Shinji, additional, Hashimoto, Ko, additional, Iwai, Chizuo, additional, Yamabe, Daisuke, additional, Hiyama, Akihiko, additional, Seki, Shoji, additional, Goto, Yuta, additional, Miyazaki, Masashi, additional, Watanabe, Kazuyuki, additional, Nakamae, Toshio, additional, Kaito, Takashi, additional, Nakashima, Hiroaki, additional, Nagoshi, Narihito, additional, Kato, Satoshi, additional, Imagama, Shiro, additional, Watanabe, Kota, additional, Inoue, Gen, additional, and Furuya, Takeo, additional

Published
2024
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15. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan

Author

Segi, Naoki, Nakashima, Hiroaki, Machino, Masaaki, Ito, Sadayuki, Yokogawa, Noriaki, Sasagawa, Takeshi, Funayama, Toru, Eto, Fumihiko, Watanabe, Kota, Nori, Satoshi, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Hasegawa, Tomohiko, Yamada, Tomohiro, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Inoue, Gen, Shirasawa, Eiki, Kakutani, Kenichiro, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Funao, Haruki, Oshima, Yasushi, Yoshii, Toshitaka, Kaito, Takashi, Sakai, Daisuke, Ohba, Tetsuro, Seki, Shoji, Otsuki, Bungo, Ishihara, Masayuki, Miyazaki, Masashi, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Abstract

Study Design Retrospective multicenter studyObjectives To investigate changes over a 10-years period in the profile of cervical spine and spinal cord injuries among the elderly in Japan.Methods The current multicenter study was a retrospective analysis of inpatients aged ≥65 years, suffering cervical fracture (CF) and/or cervical spinal cord injury (CSCI). We analyzed 1413 patients’ epidemiology (from 2010 to 2019). Moreover, 727 patients who underwent surgical treatment were analyzed in 2 groups: the early (2010-2014) and late period (2015-2019).Results Both the number of patients and number of surgical patients showed a significant increasing trend (P< .001), while the mean age, the distribution of injury levels and paralysis severity, and the proportion of surgical indications remained the same. The number of surgical patients doubled from 228 to 499 from the early to late periods. Posterior surgery was the most common approach (90.4%), instrumentation surgery with screws increased significantly, and the range of fusion was significantly longer in the late period (2.1 vs 2.7 levels, P= .001). Significantly worsening neurological symptoms were recorded in the late period (1.3% vs 5.8%, P= .006), with C5 palsy being the major one. Otherwise, perioperative, major, and other complications, including mortality, did not differ significantly in incidence.Conclusions Both the number of elderly CF and/or CSCI patients and number of patients undergoing surgery increased dramatically over the decade without any change in profile. Instrumentation surgeries with screws increased, without an increase in systemic complications.

Published
2024
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18. Posterior Spinal Fusion Surgery for Neuromuscular Disease Patients with Severe Scoliosis Whose Cobb Angle Was over 100 Degrees

Author

Miyagi, Masayuki, primary, Saito, Wataru, additional, Mimura, Yusuke, additional, Nakazawa, Toshiyuki, additional, Imura, Takayuki, additional, Shirasawa, Eiki, additional, Uchida, Kentaro, additional, Ikeda, Shinsuke, additional, Kuroda, Akiyoshi, additional, Inoue, Sho, additional, Yokozeki, Yuji, additional, Tanaka, Yoshihide, additional, Akazawa, Tsutomu, additional, Takaso, Masashi, additional, and Inoue, Gen, additional

Published
2023
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19. Prognostic Factors for Respiratory Dysfunction for Cervical Spinal Cord Injury and/or Cervical Fractures in Elderly Patients: A Multicenter Survey

Author

Hirota, Ryosuke, Terashima, Yoshinori, Ohnishi, Hirofumi, Yamashita, Toshihiko, Yokogawa, Noriaki, Sasagawa, Takeshi, Ando, Kei, Nakashima, Hiroaki, Segi, Naoki, Funayama, Toru, Eto, Fumihiko, Yamaji, Akihiro, Watanabe, Kota, Yamane, Junichi, Takeda, Kazuki, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kakutani, Kenichiro, Kakiuchi, Yuji, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Takegami, Norihiko, Funao, Haruki, Oshima, Yasushi, Kaito, Takashi, Sakai, Daisuke, Yoshii, Toshitaka, Ohba, Tetsuro, Otsuki, Bungo, Seki, Shoji, Miyazaki, Masashi, Ishihara, Masayuki, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Abstract

Study design Retrospective Cohort StudyObjective The purpose of this study was to investigate the prognosis of respiratory function in elderly patients with cervical spinal cord injury (SCI) and to identify predictive factors.Methods We included 1353 cases of elderly cervical SCI patients collected from 78 institutions in Japan. Patients who required early tracheostomy and ventilator management and those who developed respiratory complications were defined as the respiratory disability group. Patients’ background characteristics, injury mechanism, injury form, neurological disability, complications, and treatment methods were compared between the disability and non-disability groups. Multiple logistic regression analysis was used to examine the independent factors. Patients who required respiratory management for 6 months or longer after injury and those who died of respiratory complications were classified into the severe disability group and were compared with minor cases who were weaned off the respirator.Results A total of 104 patients (7.8%) had impaired respiratory function. Comparisons between the disabled and non-disabled groups and between the severe and mild injury groups yielded distinct trends. In multiple logistic regression analysis, age, blood glucose level, presence of ossification of posterior longitudinal ligament (OPLL), anterior vertebral hematoma, and critical paralysis were selected as independent risk factors.Conclusion Age, OPLL, severe paralysis, anterior vertebral hematoma, hypoalbuminemia, and blood glucose level at the time of injury were independent factors for respiratory failure. Hyperglycemia may have a negative effect on respiratory function in this condition.

Published
2024
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21. Intraoperative Blood Loss at Different Surgical-Procedure Stages during Posterior Spinal Fusion for Idiopathic Scoliosis

Author

Shirasawa, Eiki, primary, Saito, Wataru, additional, Miyagi, Masayuki, additional, Imura, Takayuki, additional, Nakazawa, Toshiyuki, additional, Mimura, Yusuke, additional, Yokozeki, Yuji, additional, Kuroda, Akiyoshi, additional, Kawakubo, Ayumu, additional, Uchida, Kentaro, additional, Akazawa, Tsutomu, additional, Takaso, Masashi, additional, and Inoue, Gen, additional

Published
2023
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22. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan

Author

Segi, Naoki, primary, Nakashima, Hiroaki, additional, Machino, Masaaki, additional, Ito, Sadayuki, additional, Yokogawa, Noriaki, additional, Sasagawa, Takeshi, additional, Funayama, Toru, additional, Eto, Fumihiko, additional, Watanabe, Kota, additional, Nori, Satoshi, additional, Furuya, Takeo, additional, Yunde, Atsushi, additional, Nakajima, Hideaki, additional, Hasegawa, Tomohiko, additional, Yamada, Tomohiro, additional, Terashima, Yoshinori, additional, Hirota, Ryosuke, additional, Suzuki, Hidenori, additional, Imajo, Yasuaki, additional, Ikegami, Shota, additional, Uehara, Masashi, additional, Tonomura, Hitoshi, additional, Sakata, Munehiro, additional, Hashimoto, Ko, additional, Onoda, Yoshito, additional, Kawaguchi, Kenichi, additional, Haruta, Yohei, additional, Suzuki, Nobuyuki, additional, Kato, Kenji, additional, Uei, Hiroshi, additional, Sawada, Hirokatsu, additional, Nakanishi, Kazuo, additional, Misaki, Kosuke, additional, Terai, Hidetomi, additional, Tamai, Koji, additional, Inoue, Gen, additional, Shirasawa, Eiki, additional, Kakutani, Kenichiro, additional, Iizuka, Yoichi, additional, Takasawa, Eiji, additional, Akeda, Koji, additional, Kiyasu, Katsuhito, additional, Tominaga, Hiroyuki, additional, Tokumoto, Hiroto, additional, Funao, Haruki, additional, Oshima, Yasushi, additional, Yoshii, Toshitaka, additional, Kaito, Takashi, additional, Sakai, Daisuke, additional, Ohba, Tetsuro, additional, Seki, Shoji, additional, Otsuki, Bungo, additional, Ishihara, Masayuki, additional, Miyazaki, Masashi, additional, Okada, Seiji, additional, Imagama, Shiro, additional, and Kato, Satoshi, additional

Published
2023
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23. Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study

Author

Nori, Satoshi, primary, Watanabe, Kota, additional, Takeda, Kazuki, additional, Yamane, Junichi, additional, Kono, Hitoshi, additional, Yokogawa, Noriaki, additional, Sasagawa, Takeshi, additional, Ando, Kei, additional, Nakashima, Hiroaki, additional, Segi, Naoki, additional, Funayama, Toru, additional, Eto, Fumihiko, additional, Yamaji, Akihiro, additional, Furuya, Takeo, additional, Yunde, Atsushi, additional, Nakajima, Hideaki, additional, Yamada, Tomohiro, additional, Hasegawa, Tomohiko, additional, Terashima, Yoshinori, additional, Hirota, Ryosuke, additional, Suzuki, Hidenori, additional, Imajo, Yasuaki, additional, Ikegami, Shota, additional, Uehara, Masashi, additional, Tonomura, Hitoshi, additional, Sakata, Munehiro, additional, Hashimoto, Ko, additional, Onoda, Yoshito, additional, Kawaguchi, Kenichi, additional, Haruta, Yohei, additional, Uei, Hiroshi, additional, Sawada, Hirokatsu, additional, Nakanishi, Kazuo, additional, Misaki, Kosuke, additional, Terai, Hidetomi, additional, Tamai, Koji, additional, Shirasawa, Eiki, additional, Inoue, Gen, additional, Kiyasu, Katsuhito, additional, Iizuka, Yoichi, additional, Takasawa, Eiji, additional, Funao, Haruki, additional, Kaito, Takashi, additional, Yoshii, Toshitaka, additional, Ishihara, Masayuki, additional, Okada, Seiji, additional, Imagama, Shiro, additional, and Kato, Satoshi, additional

Published
2023
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24. Supplemental Material - Epidemiology of Cervical Fracture/cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan

Author

Segi, Naoki, Nakashima, Hiroaki, Machino, Masaaki, Ito, Sadayuki, Yokogawa, Noriaki, Sasagawa, Takeshi, Funayama, Toru, Eto, Fumihiko, Watanabe, Kota, Nori, Satoshi, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Hasegawa, Tomohiko, Yamada, Tomohiro, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Inoue, Gen, Shirasawa, Eiki, Kakutani, Kenichiro, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Funao, Haruki, Oshima, Yasushi, Yoshii, Toshitaka, Kaito, Takashi, Sakai, Daisuke, Ohba, Tetsuro, Seki, Shoji, Otsuki, Bungo, Ishihara, Masayuki, Miyazaki, Masashi, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental Material for Epidemiology of Cervical Fracture/cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan by Philipp Pieroh, Ulrich J.A. Spiegl, Anna Völker, Sven Märdian, Nicolas H. von der Höh, Georg Osterhoff, Christoph-E. Heyde; Spine Section of the German Society for Orthopaedics and Trauma in Global Spine Journal

Published
2023
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25. Effect of low body mass index on clinical recovery after fusion surgery for osteoporotic vertebral fracture: A retrospective, multicenter study of 237 cases

Author

Inoue, Gen, primary, Miyagi, Masayuki, additional, Saito, Wataru, additional, Shirasawa, Eiki, additional, Uchida, Kentaro, additional, Hosogane, Naobumi, additional, Watanabe, Kei, additional, Katsumi, Keiichi, additional, Kaito, Takashi, additional, Yamashita, Tomoya, additional, Fujiwara, Hiroyasu, additional, Nagamoto, Yukitaka, additional, Nojiri, Kenya, additional, Suzuki, Satoshi, additional, Okada, Eijiro, additional, Ueda, Seiji, additional, Hikata, Tomohiro, additional, Shiono, Yuta, additional, Watanabe, Kota, additional, Terai, Hidetomi, additional, Tamai, Koji, additional, Matsuoka, Yuji, additional, Suzuki, Hidekazu, additional, Nishimura, Hirosuke, additional, Tagami, Atsushi, additional, Yamada, Shuta, additional, Adachi, Shinji, additional, Ohtori, Seiji, additional, Furuya, Takeo, additional, Orita, Sumihisa, additional, Inage, Kazuhide, additional, Yoshii, Toshitaka, additional, Ushio, Shuta, additional, Funao, Haruki, additional, Isogai, Norihiro, additional, Harimaya, Katsumi, additional, Okada, Seiji, additional, Kawaguchi, Kenichi, additional, Yokoyama, Nobuhiko, additional, Oishi, Hidekazu, additional, Doi, Toshio, additional, Kiyasu, Katsuhito, additional, Imagama, Shiro, additional, Ando, Kei, additional, Kobayashi, Kazuyoshi, additional, Sakai, Daisuke, additional, Tanaka, Masahiro, additional, Kimura, Atsushi, additional, Inoue, Hirokazu, additional, Nakano, Atsushi, additional, Ikegami, Shota, additional, Shimizu, Masayuki, additional, Futatsugi, Toshimasa, additional, Kakutani, Kenichiro, additional, Yurube, Takashi, additional, Nakanishi, Kazuyoshi, additional, Oshima, Masashi, additional, Uei, Hiroshi, additional, Aoki, Yasuchika, additional, Takahata, Masahiko, additional, Iwata, Akira, additional, Endo, Hirooki, additional, Seki, Shoji, additional, Murakami, Hideki, additional, Kato, Satoshi, additional, Yoshioka, Katsuhito, additional, Hongo, Michio, additional, Abe, Tetsuya, additional, Tsukanishi, Toshinori, additional, Takaso, Masashi, additional, and Ishii, Ken, additional

Published
2022
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26. Multicenter Retrospective Analysis of Intradiscal Condoliase Injection Therapy for Lumbar Disc Herniation

Author

Oshita, Yusuke, primary, Matsuyama, Daisuke, additional, Sakai, Daisuke, additional, Schol, Jordy, additional, Shirasawa, Eiki, additional, Emori, Haruka, additional, Segami, Kazuyuki, additional, Takahashi, Shu, additional, Yagura, Kazumichi, additional, Miyagi, Masayuki, additional, Saito, Wataru, additional, Imura, Takayuki, additional, Nakazawa, Toshiyuki, additional, Inoue, Gen, additional, Hiyama, Akihiko, additional, Katoh, Hiroyuki, additional, Akazawa, Tsutomu, additional, Kanzaki, Koji, additional, Sato, Masato, additional, Takaso, Masashi, additional, and Watanabe, Masahiko, additional

Published
2022
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27. Is Blood Loss Greater in Elderly Patients under Antiplatelet or Anticoagulant Medication for Cervical Spine Injury Surgery? A Japanese Multicenter Survey

Author

Uehara, Masashi, primary, Ikegami, Shota, additional, Takizawa, Takashi, additional, Oba, Hiroki, additional, Yokogawa, Noriaki, additional, Sasagawa, Takeshi, additional, Ando, Kei, additional, Nakashima, Hiroaki, additional, Segi, Naoki, additional, Funayama, Toru, additional, Eto, Fumihiko, additional, Yamaji, Akihiro, additional, Watanabe, Kota, additional, Nori, Satoshi, additional, Takeda, Kazuki, additional, Furuya, Takeo, additional, Orita, Sumihisa, additional, Nakajima, Hideaki, additional, Yamada, Tomohiro, additional, Hasegawa, Tomohiko, additional, Terashima, Yoshinori, additional, Hirota, Ryosuke, additional, Suzuki, Hidenori, additional, Imajo, Yasuaki, additional, Tonomura, Hitoshi, additional, Sakata, Munehiro, additional, Hashimoto, Ko, additional, Onoda, Yoshito, additional, Kawaguchi, Kenichi, additional, Haruta, Yohei, additional, Suzuki, Nobuyuki, additional, Kato, Kenji, additional, Uei, Hiroshi, additional, Sawada, Hirokatsu, additional, Nakanishi, Kazuo, additional, Misaki, Kosuke, additional, Terai, Hidetomi, additional, Tamai, Koji, additional, Shirasawa, Eiki, additional, Inoue, Gen, additional, Kakutani, Kenichiro, additional, Kakiuchi, Yuji, additional, Kiyasu, Katsuhito, additional, Tominaga, Hiroyuki, additional, Tokumoto, Hiroto, additional, Iizuka, Yoichi, additional, Takasawa, Eiji, additional, Akeda, Koji, additional, Takegami, Norihiko, additional, Funao, Haruki, additional, Oshima, Yasushi, additional, Kaito, Takashi, additional, Sakai, Daisuke, additional, Yoshii, Toshitaka, additional, Ohba, Tetsuro, additional, Otsuki, Bungo, additional, Seki, Shoji, additional, Miyazaki, Masashi, additional, Ishihara, Masayuki, additional, Okada, Seiji, additional, Aoki, Yasuchika, additional, Harimaya, Katsumi, additional, Murakami, Hideki, additional, Ishii, Ken, additional, Ohtori, Seiji, additional, Imagama, Shiro, additional, and Kato, Satoshi, additional

Published
2022
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28. Characteristics of the cervical spine and cervical cord injuries in the elderly with cervical ossification of the posterior longitudinal ligament

Author

Okuwaki, Shun, primary, Funayama, Toru, additional, Koda, Masao, additional, Eto, Fumihiko, additional, Yamaji, Akihiro, additional, Yokogawa, Noriaki, additional, Sasagawa, Takeshi, additional, Ando, Kei, additional, Nakashima, Hiroaki, additional, Segi, Naoki, additional, Watanabe, Kota, additional, Nori, Satoshi, additional, Takeda, Kazuki, additional, Furuya, Takeo, additional, Yunde, Atsushi, additional, Nakajima, Hideaki, additional, Yamada, Tomohiro, additional, Hasegawa, Tomohiko, additional, Terashima, Yoshinori, additional, Hirota, Ryosuke, additional, Suzuki, Hidenori, additional, Imajo, Yasuaki, additional, Ikegami, Shota, additional, Uehara, Masashi, additional, Tonomura, Hitoshi, additional, Sakata, Munehiro, additional, Hashimoto, Ko, additional, Onoda, Yoshito, additional, Kawaguchi, Kenichi, additional, Haruta, Yohei, additional, Suzuki, Nobuyuki, additional, Kato, Kenji, additional, Uei, Hiroshi, additional, Sawada, Hirokatsu, additional, Nakanishi, Kazuo, additional, Misaki, Kosuke, additional, Terai, Hidetomi, additional, Tamai, Koji, additional, Shirasawa, Eiki, additional, Inoue, Gen, additional, Kakutani, Kenichiro, additional, Kakiuchi, Yuji, additional, Kiyasu, Katsuhito, additional, Tominaga, Hiroyuki, additional, Tokumoto, Hiroto, additional, Iizuka, Yoichi, additional, Takasawa, Eiji, additional, Akeda, Koji, additional, Takegami, Norihiko, additional, Funao, Haruki, additional, Oshima, Yasushi, additional, Kaito, Takashi, additional, Sakai, Daisuke, additional, Yoshii, Toshitaka, additional, Ohba, Tetsuro, additional, Otsuki, Bungo, additional, Seki, Shoji, additional, Miyazaki, Masashi, additional, Ishihara, Masayuki, additional, Okada, Seiji, additional, Imagama, Shiro, additional, and Kato, Satoshi, additional

Published
2022
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29. Prognostic Factors for Respiratory Dysfunction for Cervical Spinal Cord Injury and/or Cervical Fractures in Elderly Patients: A Multicenter Survey

Author

Hirota, Ryosuke, primary, Terashima, Yoshinori, additional, Ohnishi, Hirofumi, additional, Yamashita, Toshihiko, additional, Yokogawa, Noriaki, additional, Sasagawa, Takeshi, additional, Ando, Kei, additional, Nakashima, Hiroaki, additional, Segi, Naoki, additional, Funayama, Toru, additional, Eto, Fumihiko, additional, Yamaji, Akihiro, additional, Watanabe, Kota, additional, Yamane, Junichi, additional, Takeda, Kazuki, additional, Furuya, Takeo, additional, Yunde, Atsushi, additional, Nakajima, Hideaki, additional, Yamada, Tomohiro, additional, Hasegawa, Tomohiko, additional, Suzuki, Hidenori, additional, Imajo, Yasuaki, additional, Ikegami, Shota, additional, Uehara, Masashi, additional, Tonomura, Hitoshi, additional, Sakata, Munehiro, additional, Hashimoto, Ko, additional, Onoda, Yoshito, additional, Kawaguchi, Kenichi, additional, Haruta, Yohei, additional, Suzuki, Nobuyuki, additional, Kato, Kenji, additional, Uei, Hiroshi, additional, Sawada, Hirokatsu, additional, Nakanishi, Kazuo, additional, Misaki, Kosuke, additional, Terai, Hidetomi, additional, Tamai, Koji, additional, Shirasawa, Eiki, additional, Inoue, Gen, additional, Kakutani, Kenichiro, additional, Kakiuchi, Yuji, additional, Kiyasu, Katsuhito, additional, Tominaga, Hiroyuki, additional, Tokumoto, Hiroto, additional, Iizuka, Yoichi, additional, Takasawa, Eiji, additional, Akeda, Koji, additional, Takegami, Norihiko, additional, Funao, Haruki, additional, Oshima, Yasushi, additional, Kaito, Takashi, additional, Sakai, Daisuke, additional, Yoshii, Toshitaka, additional, Ohba, Tetsuro, additional, Otsuki, Bungo, additional, Seki, Shoji, additional, Miyazaki, Masashi, additional, Ishihara, Masayuki, additional, Okada, Seiji, additional, Imagama, Shiro, additional, and Kato, Satoshi, additional

Published
2022
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30. A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs

Author

Miyagi, Masayuki, primary, Uchida, Kentaro, additional, Inoue, Sho, additional, Takano, Shotaro, additional, Nakawaki, Mitsufumi, additional, Kawakubo, Ayumu, additional, Sekiguchi, Hiroyuki, additional, Nakazawa, Toshiyuki, additional, Imura, Takayuki, additional, Saito, Wataru, additional, Shirasawa, Eiki, additional, Kuroda, Akiyoshi, additional, Ikeda, Shinsuke, additional, Yokozeki, Yuji, additional, Mimura, Yusuke, additional, Akazawa, Tsutomu, additional, Takaso, Masashi, additional, and Inoue, Gen, additional

Published
2022
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31. Prevalence and Characteristics of Spinal Sagittal Malalignment in Patients with Osteoporosis

Author

Matsunaga, Takayuki, primary, Miyagi, Masayuki, additional, Nakazawa, Toshiyuki, additional, Murata, Kosuke, additional, Kawakubo, Ayumu, additional, Fujimaki, Hisako, additional, Koyama, Tomohisa, additional, Kuroda, Akiyoshi, additional, Yokozeki, Yuji, additional, Mimura, Yusuke, additional, Shirasawa, Eiki, additional, Saito, Wataru, additional, Imura, Takayuki, additional, Uchida, Kentaro, additional, Nanri, Yuta, additional, Inage, Kazuhide, additional, Akazawa, Tsutomu, additional, Ohtori, Seiji, additional, Takaso, Masashi, additional, and Inoue, Gen, additional

Published
2021
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32. Incidence of Unintentional Intraoperative Hypothermia in Pediatric Scoliosis Surgery and Associated Preoperative Risk Factors

Author

Okamura, Maho, primary, Saito, Wataru, additional, Miyagi, Masayuki, additional, Shirasawa, Eiki, additional, Imura, Takayuki, additional, Nakazawa, Toshiyuki, additional, Mimura, Yusuke, additional, Yokozeki, Yuji, additional, Kuroda, Akiyoshi, additional, Kawakubo, Ayumu, additional, Uchida, Kentaro, additional, Akazawa, Tsutomu, additional, Takaso, Masashi, additional, and Inoue, Gen, additional

Published
2021
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33. Prevalence and Location of Endplate Fracture and Subsidence after Oblique Lumbar Interbody Fusion for Adult Spinal Deformity

Author

Inoue, Gen, primary, Saito, Wataru, additional, Miyagi, Masayuki, additional, Imura, Takayuki, additional, Shirasawa, Eiki, additional, Mimura, Yusuke, additional, Kuroda, Akiyoshi, additional, Yokozeki, Yuji, additional, Akazawa, Tsutomu, additional, Nakazawa, Toshiyuki, additional, Uchida, Kentaro, additional, and Takaso, Masashi, additional

Published
2021
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34. Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned

Author

Machida, Shuhei, primary, Miyagi, Masayuki, additional, Saito, Wataru, additional, Matsui, Ayano, additional, Imura, Takayuki, additional, Inoue, Gen, additional, Nakazawa, Toshiyuki, additional, Shirasawa, Eiki, additional, Ikeda, Shinsuke, additional, Kawakubo, Ayumu, additional, Kuroda, Akiyoshi, additional, Yokozeki, Yuji, additional, Mimura, Yusuke, additional, Uchida, Kentaro, additional, Akazawa, Tsutomu, additional, and Takaso, Masashi, additional

Published
2021
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35. Body Composition in Japanese Girls with Adolescent Idiopathic Scoliosis

Author

Miyagi, Masayuki, primary, Saito, Wataru, additional, Imura, Takayuki, additional, Nakazawa, Toshiyuki, additional, Shirasawa, Eiki, additional, Kawakubo, Ayumu, additional, Uchida, Kentaro, additional, Akazawa, Tsutomu, additional, Inage, Kazuhide, additional, Ohtori, Seiji, additional, Inoue, Gen, additional, and Takaso, Masashi, additional

Published
2021
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37. Role of CD14‐positive cells in inflammatory cytokine and pain‐related molecule expression in human degenerated intervertebral discs

Author

Miyagi, Masayuki, primary, Uchida, Kentaro, additional, Takano, Shotaro, additional, Nakawaki, Mitsufumi, additional, Sekiguchi, Hiroyuki, additional, Nakazawa, Toshiyuki, additional, Imura, Takayuki, additional, Saito, Wataru, additional, Shirasawa, Eiki, additional, Kawakubo, Ayumu, additional, Akazawa, Tsutomu, additional, Inoue, Gen, additional, and Takaso, Masashi, additional

Published
2020
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39. Role of CD14‐positive cells in inflammatory cytokine and pain‐related molecule expression in human degenerated intervertebral discs.

Author

Miyagi, Masayuki, Uchida, Kentaro, Takano, Shotaro, Nakawaki, Mitsufumi, Sekiguchi, Hiroyuki, Nakazawa, Toshiyuki, Imura, Takayuki, Saito, Wataru, Shirasawa, Eiki, Kawakubo, Ayumu, Akazawa, Tsutomu, Inoue, Gen, and Takaso, Masashi

Subjects
NEUROTROPHINS, INTERVERTEBRAL disk, CYTOKINES, TUMOR necrosis factors, CALCITONIN gene-related peptide, NERVE growth factor, LEG pain
Abstract

Multiple human and animal studies suggest that the upregulation of inflammatory cytokines and other pain‐related molecules in degenerated or injured intervertebral discs (IVDs) may cause discogenic low back pain (LBP). We previously reported that macrophages in injured IVD in mice produced inflammatory cytokines, but not other pain‐related molecules. CD14 is a monocyte marker expressed mainly by macrophages. The aim of the current study was to evaluate the role of CD14‐positive cells in inflammatory cytokine and pain‐related molecule expression in human degenerated IVD. IVD samples were harvested from 14 patients, including 10 with lumbar spinal stenosis, four with adult spinal deformity, and one with lumbar disc herniation during spinal interbody fusion surgery. Harvested IVD‐derived mononuclear cells were obtained and CD14‐positive (+) and CD14‐negative (−) cells were separated using CD14 antibody and streptavidin‐labeled magnetic beads. Inflammatory cytokines messenger RNA (mRNA) in the CD14(+) and CD14(−) cells, including tumor necrosis factor ɑ (TNFA), in, terleukin‐1β (IL1B) and IL6, were determined using quantitative polymerase chain reaction (qPCR) and their expression levels were compared. To evaluate factors controlling the regulation of pain‐related molecules mRNA expression, cultured CD14(−) and CD14(+) cells from IVDs were stimulated with recombinant human TNF‐ɑ and IL‐1β and levels of pain‐related molecules, including calcitonin gene‐related peptide (CGRP) and nerve growth factor (NGF) were determined using qPCR. Levels of TNFA, IL1B, IL6, and NGF in CD14(+) cells were significantly increased compared with those in CD14(−) cells (TNFA, p = 0.006; IL1B, p =.017; IL6, p =.010; NGF, p =.027). Following TNFA stimulation, NGF levels were significantly increased in CD14(−) and CD14(+) cells (CD14(−), p =.003; CD14(+), p <.001) and CGRP was significantly increased in CD14(−) IVD cells (p =.040). Following IL1B stimulation, NGF levels were significantly increased in CD14(−) cells (p =.004). CD14(+) cells had higher TNFA, IL1B, IL6, and NGF expressions than CD14(−) cells in human degenerated IVDs. Additionally, TNFA stimulation promoted the upregulation of NGF and CGRP in CD14(−) cells. These findings suggested that CD14(+) cells directly and indirectly contributed to inflammatory cytokine and pain‐related molecule expression in human degenerated IVD. CD14(+) cells might be important in the pathological mechanism of chronic discogenic LBP in humans. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Occupational Characteristics of Low Back Pain Among Standing Workers in a Japanese Manufacturing Company

Author

Inoue, Gen, primary, Uchida, Kentaro, additional, Miyagi, Masayuki, additional, Saito, Wataru, additional, Nakazawa, Toshiyuki, additional, Imura, Takayuki, additional, Shirasawa, Eiki, additional, Akazawa, Tsutomu, additional, Orita, Sumihisa, additional, Inage, Kazuhide, additional, Takaso, Masashi, additional, and Ohtori, Seiji, additional

Published
2019
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41. Occupational Characteristics of Low Back Pain Among Standing Workers in a Japanese Manufacturing Company.

Author

Inoue, Gen, Uchida, Kentaro, Miyagi, Masayuki, Saito, Wataru, Nakazawa, Toshiyuki, Imura, Takayuki, Shirasawa, Eiki, Akazawa, Tsutomu, Orita, Sumihisa, Inage, Kazuhide, Takaso, Masashi, and Ohtori, Seiji

Subjects
CHI-squared test, CHRONIC diseases, CONFIDENCE intervals, EXERCISE, HEALTH promotion, INDUSTRIAL hygiene, MULTIVARIATE analysis, OCCUPATIONAL diseases, QUESTIONNAIRES, REGRESSION analysis, RISK assessment, SMOKING, STANDING position, STATISTICS, T-test (Statistics), MANUFACTURING industries, LOGISTIC regression analysis, SOCIOECONOMIC factors, PAIN measurement, DISEASE prevalence, CROSS-sectional method, SEVERITY of illness index, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, LUMBAR pain
Abstract

Low back pain (LBP) is a major public health problem that adversely affects the quality of life (QOL) of workers. The etiology of LBP is considered to be multi-factorial with individual, physical, and psychosocial factors contributing to its development and persistence. Although prevention of LBP in workers in the workplace is very important, only a small number of studies have assessed the risk factors and epidemiology of LBP among Japanese factory workers who stand as part of their job. This cross-sectional study investigated the prevalence of LBP in 691 factory employees who conducted their work while standing. Health-related QOL was evaluated using the Roland-Morris Disability Questionnaire (RDQ) to quantify the severity of LBP with the aim of identifying risk factors for LBP among workers who stand as part of their work in an electronics manufacturing company. We observed that the prevalence of LBP lasting for at least 48 hours within a week was 20.0% among participants, with female employees and those with a prior history of LBP having a significantly increased risk of developing LBP. The distribution of the RDQ score showed a negative regression curve among the employees, which was different from the normal distribution pattern reported previously in Japanese patients with LBP. These findings suggest that prolonged standing among factory workers poses an increased risk for LBP. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Common iliac vein injury during L5–S1 posterior lumbar interbody fusion in a patient with systemic lupus erythematosus receiving steroid treatment: A case report

Author

Saito, Wataru, primary, Inoue, Gen, additional, Nakazawa, Toshiyuki, additional, Imura, Takayuki, additional, Miyagi, Masayuki, additional, Uchida, Kentaro, additional, Namba, Takanori, additional, Shirasawa, Eiki, additional, Takahira, Naonobu, additional, and Takaso, Masashi, additional

Published
2017
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49. Surgical treatment for suicidal jumper's fracture (unstable sacral fracture) with thoracolumbar burst fracture: a report of three cases

Author

Fujino, Shotaro, primary, Miyagi, Masayuki, additional, Tajima, Shuichiro, additional, Imura, Takayuki, additional, Tazawa, Ryo, additional, Inoue, Gen, additional, Nakazawa, Toshiyuki, additional, Saito, Wataru, additional, Shirasawa, Eiki, additional, Minehara, Hiroaki, additional, Matsuura, Terumasa, additional, Kawamura, Tadashi, additional, Uchida, Kentaro, additional, Takahira, Naonobu, additional, and Takaso, Masashi, additional

Published
2017
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50. Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture

Author

Segi, Naoki, Nakashima, Hiroaki, Machino, Masaaki, Ito, Sadayuki, Yokogawa, Noriaki, Sasagawa, Takeshi, Funayama, Toru, Eto, Fumihiko, Yamaji, Akihiro, Watanabe, Kota, Nori, Satoshi, Takeda, Kazuki, Furuya, Takeo, Yunde, Atsushi, Nakajima, Hideaki, Yamada, Tomohiro, Hasegawa, Tomohiko, Terashima, Yoshinori, Hirota, Ryosuke, Suzuki, Hidenori, Imajo, Yasuaki, Ikegami, Shota, Uehara, Masashi, Tonomura, Hitoshi, Sakata, Munehiro, Hashimoto, Ko, Onoda, Yoshito, Kawaguchi, Kenichi, Haruta, Yohei, Suzuki, Nobuyuki, Kato, Kenji, Uei, Hiroshi, Sawada, Hirokatsu, Nakanishi, Kazuo, Misaki, Kosuke, Terai, Hidetomi, Tamai, Koji, Shirasawa, Eiki, Inoue, Gen, Kakutani, Kenichiro, Kakiuchi, Yuji, Iizuka, Yoichi, Takasawa, Eiji, Akeda, Koji, Takegami, Norihiko, Kiyasu, Katsuhito, Tominaga, Hiroyuki, Tokumoto, Hiroto, Funao, Haruki, Oshima, Yasushi, Yoshii, Toshitaka, Kaito, Takashi, Sakai, Daisuke, Ohba, Tetsuro, Seki, Shoji, Otsuki, Bungo, Ishihara, Masayuki, Miyazaki, Masashi, Okada, Seiji, Imagama, Shiro, and Kato, Satoshi

Abstract

Study Design Retrospective multicenter study.Objective The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, with and without fractures.Methods The current multicenter study was a retrospective analysis of 140 patients aged 65 years or older with cDISH-related cervical spine injuries; 106 fractures and 34 spinal cord injuries without fracture were identified. Propensity score–matched cohorts from 1363 patients without cDISH were generated and compared. Logistic regression analysis was performed to determine the risk of early mortality for patients with cDISH-related injury.Results Patients with cDISH-related injuries with fracture did not differ significantly in the incidence of each complication and ambulation or severity of paralysis compared to matched controls. In patients with cDISH-related injury without fracture, those who were nonambulatory at discharge comprised 55% vs 34% of controls, indicating significantly poorer ambulation in those with cDISH-related injuries (P= .023). There was no significant difference in the incidence of complications and ambulation or paralysis severity at 6 months as compared with controls. Fourteen patients died within 3 months. Logistic regression analysis identified complete paralysis (odds ratio [OR] 36.99) and age (OR 1.24) as significant risk factors for mortality.Conclusions The current study showed no significant differences in the incidence of complications, ambulation outcomes between patients with cDISH-related injury with fracture and matched controls, and that the ambulation at discharge for patients with cDISH-related injury without fractures were significantly inferior to those of matched controls.

Published
2024
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