324 results on '"Shirahase, Hiroaki"'
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2. The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis
3. CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway
4. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice
5. Osteogenic Effects of KY-054, a Novel Coumarin Derivative on Femur Cortical Bone in Ovariectomized Female Rats
6. Insulin Sensitization by a Novel Partial Peroxisome Proliferator-Activated Receptor γ Agonist With Protein Tyrosine Phosphatase 1B Inhibitory Activity in Experimental Osteoporotic Rats
7. Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: Peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition
8. Endothelium-Dependent Contraction of Cerebral Arteries
9. Therapeutic effects of CDK8 kinase inhibitor on abnormal bone development in achondroplasia model mice
10. Osteogenetic effects of KY-273, a diphenylether derivative, in mesenchymal stem cells and ovariectomized rats.
11. NK 1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries
12. Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities
13. Regional heterogeneity of substance P-induced endothelium-dependent contraction, relaxation, and -independent contraction in rabbit pulmonary arteries
14. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells
15. Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice—possible dysfunction of receptor and/or receptor–G protein coupling
16. Effects of KY-903, a Novel Tetrazole-Based Peroxisome Proliferator-Activated Receptor γ Modulator, in Male Diabetic Mice and Female Ovariectomized Rats
17. Synthesis and Evaluation of a Novel Series of 2,7-Substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonists
18. Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats
19. Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice
20. Role of intracellular Ca2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries
21. Role of intracellular Ca 2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries
22. (S)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist
23. Effect of Topically Applied Iganidipine Dihydrochloride, a Novel Calcium Antagonist, on Optic Nerve Head Circulation in Rabbits
24. Inhibitory effects of PGD2, PGJ2 and 15-deoxy-Δ 12,14-PGJ2 on iNOS induction in rat mesenteric artery
25. A Novel Oral Anti-osteoporosis Drug with Osteogenesis-promoting Effects via Osteoblast Differentiation
26. 2-Acyl-3-carboxyl-tetrahydroisoquinoline Derivatives: Mixed-Type PTP1B Inhibitors without PPARγ Activation
27. Anti-diabetic and anti-obesity effects of the allosteric PTP1B inhibitor KY-226 via insulin and leptin signal enhancement
28. Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitors with Non-competitive Actions
29. Novel 2,7-Substituted (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: Peroxisome Proliferator-Activated Receptor γ Partial Agonists with Protein–Tyrosine Phosphatase 1B Inhibition
30. Endothelium-dependent relaxation followed by contraction mediated by NK1 receptors in precontracted rabbit intrapulmonary arteries
31. Endothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+channel antagonist., in canine mesenteric arteries
32. P–202 - Biphasic endothelium-dependent response mediated by tachykinin NK1 receptors in rabbit intrapulmonary arteries.
33. P–172 - Possible involvement of reactive oxygen species and arachidonic acid metabolites in nicotine-induced contraction of rat coronary artery
34. ChemInform Abstract: A Novel Series of (S)‐2,7‐Substituted‐1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylic Acids: Peroxisome Proliferator‐Activated Receptor α/γ Dual Agonists with Protein‐Tyrosine Phosphatase 1B Inhibitory Activity.
35. Active Conformation of Seven‐Membered‐Ring Benzolactams as New ACAT Inhibitors: Latent Chirality at N5 in the 1,5‐Benzodiazepin‐2‐one Nucleus
36. Hypolipidemic and Antioxidant Activity of the Novel Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitor KY-455 in Rabbits and Hamsters
37. Synergistic Effect of Nitric Oxide Synthase and Cyclooxygenase Inhibitors on Carrageenan-induced Paw Edema in Rats
38. Relationships between Lipophilicity and Biological Activities in a Series of Indoline-based Anti-oxidative Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors
39. ChemInform Abstract: 2‐Acyl‐tetrahydroisoquinoline‐3‐carboxylic Acids: Lead Compounds with Triple Actions, Peroxisome Proliferator‐Activated Receptor α/γ Agonist and Protein‐Tyrosine Phosphatase 1B Inhibitory Activities.
40. Lipopolysaccharide-induced impairment of nitric oxide-mediated vasorelaxation and protective effects of nitric oxide synthesis inhibitors in isolated rat mesenteric arteries
41. ChemInform Abstract: Novel Prodrugs of Meropenem with Two Lipophilic Promoieties: Synthesis and Pharmacokinetics.
42. Novel prodrugs of meropenem with two lipophilic promoieties: synthesis and pharmacokinetics
43. 2-Acyl-tetrahydroisoquinoline-3-carboxylic Acids: Lead Compounds with Triple Actions, Peroxisome Proliferator-Activated Receptor .ALPHA./.GAMMA. Agonist and Protein-Tyrosine Phosphatase 1B Inhibitory Activities
44. A Novel Series of (S)-2,7-Substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acids: Peroxisome Proliferator-Activated Receptor .ALPHA./.GAMMA. Dual Agonists with Protein-Tyrosine Phosphatase 1B Inhibitory Activity
45. ChemInform Abstract: Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: Indoline-Based Sulfamide Derivatives with Low Lipophilicity and Protein Binding Ratio.
46. ChemInform Abstract: Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities Against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation.
47. ChemInform Abstract: AS-924, a Novel Bifunctional Prodrug of Ceftizoxime.
48. ChemInform Abstract: A Novel Series of Thromboxane A2 Synthetase Inhibitors with Free Radical Scavenging and Antiperoxidative Activities.
49. Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: Indoline-Based Sulfamide Derivatives with Low Lipophilicity and Protein Binding Ratio
50. Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation
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