1. Effects of Camel Milk on Glucolipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease
- Author
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Shiqi HAO, Yafei LI, Xiaoyun WU, Qin NA, Liang MING, Xiurong ZHANG, and Rimutu JI
- Subjects
non-alcoholic fatty liver disease ,camel milk ,high fat, high sugar and high cholesterol diet ,glucose and lipid metabolism ,c57bl/6j mice ,Food processing and manufacture ,TP368-456 - Abstract
Objective: This study was designed to explore the effect of camel milk on glucose and lipid metabolism metabolism in mice with nonalcoholic fatty liver disease induced by high fat, high sugar and high cholesterol diet. Methods: 50 C57BL6/J male mice were randomly divided into control group (NC), model group (Mod), control camel milk group (NCM, 3g·kg−1 bw), camel milk group (CaM, 3 g·kg−1 bw) and silymarin group (PC, 200 mg·kg−1 bw). The model of nonalcoholic fatty liver was established for 12 weeks. The mice in the camel milk group and the silymarin group were gavaged with the corresponding doses of camel milk and silymarin at a fixed time every day, respectively. Body weight, fasting blood glucose, serum biochemical, insulin resistance and insulin sensitivity, oral glucose tolerance and insulin tolerance were measured to investigate the effect of camel milk on glucolipid metabolism in mice with non-alcoholic fatty liver disease induced by high fat, high sugar, and high cholesterol diet. Results: Camel milk significantly inhibited the increase of body weight and blood sugar of NAFLD mice and notably reduced the levels of total triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), tumor necrosis factor (TNF-α), leptin (LEP) and insulin (INS) (P
- Published
- 2023
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