17 results on '"Shiona K Glass-Kaastra"'
Search Results
2. Variation in Outpatient Oral Antimicrobial Use Patterns among Canadian Provinces, 2000 to 2010
- Author
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Shiona K Glass-Kaastra, Rita Finley, Jim Hutchinson, David M Patrick, Karl Weiss, and John Conly
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
BACKGROUND: The volume and patterns of antimicrobial drug use are key variables to consider when developing guidelines for prescribing, and programs to address stewardship and combat the increasing prevalence of antimicrobial resistant pathogens. Because drug programs are regulated at the provincial level, there is an expectation that antibiotic use may vary among provinces.
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- 2014
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3. Longitudinal Surveillance of Outpatient Quinolone Antimicrobial Use in Canada
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Shiona K Glass-Kaastra, Rita Finley, Jim Hutchinson, David M Patrick, Karl Weiss, and John Conly
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
INTRODUCTION: Because antimicrobial use is commonly associated with the development of antimicrobial resistance, monitoring the volume and patterns of use of these agents is important.
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- 2014
- Full Text
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4. Provincial and Temporal Variation in Macrolide and Lincosamide Antimicrobial Use by Outpatients in Canada, 1995 to 2010
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Shiona K Glass-Kaastra, Rita Finley, Jim Hutchinson, David M Patrick, Karl Weiss, and John Conly
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
INTRODUCTION: Because antimicrobial use is commonly associated with the development of antimicrobial resistance, monitoring the volume and patterns of use of these agents is very important.
- Published
- 2014
- Full Text
- View/download PDF
5. Longitudinal Surveillance of Outpatient Tetracycline, Sulfonamide-Trimethoprim and ‘Other’ Antimicrobial Use in Canada, 1995 to 2010
- Author
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Shiona K Glass-Kaastra, Rita Finley, Jim Hutchinson, David M Patrick, Karl Weiss, and John Conly
- Subjects
Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
INTRODUCTION: Monitoring the volume and patterns of use of antimicrobial agents is important in light of antimicrobial resistance.
- Published
- 2014
- Full Text
- View/download PDF
6. Does variation among provincial drug formulary antimicrobial listings in Canada influence prescribing rates?
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Shiona K Glass-Kaastra, Rita Finley, Jim Hutchinson, David M Patrick, Karl Weiss, and John Conly
- Subjects
Medicine ,Science - Abstract
BACKGROUND: The financial accessibility of antimicrobial drugs to the outpatient community in Canada is governed at the provincial level through formularies. Each province may choose to list particular drugs or impose restriction criteria on products in order to guide prescribing and/or curtail costs. Although changes to formularies have been shown to change patterns in the use of individual products and alter costs, no comparison has been made among the provincial antimicrobial formularies with regards to flexibility/stringency, or an assessment of how these formularies impact overall antimicrobial use in the provinces. OBJECTIVES: To summarize provincial antimicrobial formularies and assess whether their relative flexibility/stringency had a statistical impact upon provincial prescription volume during a one year period. METHODS: Provincial drug plan formularies were accessed and summarized for all prescribed antimicrobials in Canada during 2010. The number of general and restricted benefits for each plan was compiled by antimicrobial classification. Population-adjusted prescription rates for all individual antimicrobials and by antimicrobial class were obtained from the Canadian Integrated Program for Antimicrobial Resistance Surveillance. Correlations between the number of general benefits, restricted benefits, and total benefits with the prescription rate in the provinces were assessed by Spearman rank correlation coefficients. RESULTS: Formularies varied considerably among the Canadian provinces. Quebec had the most flexible formulary, offering the greatest number of general benefits and fewest restrictions. In contrast, Saskatchewan's formulary displayed the lowest number of general benefits and most restrictions. Correlation analyses detected a single significant result; macrolide prescription rates decreased as the number of general macrolide benefits increased. All other rates of provincial antimicrobial prescribing and measures of flexibility/stringency revealed no significant correlations. CONCLUSIONS: Although antimicrobial formulary listings are used to guide prescribing rates within a province, our analysis of one year's data of the impact of the antimicrobial formulary structure did not correlate with antimicrobial prescribing rates, and other factors are likely to be at play.
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- 2014
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7. Declines in outpatient antimicrobial use in Canada (1995-2010).
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Rita Finley, Shiona K Glass-Kaastra, Jim Hutchinson, David M Patrick, Karl Weiss, and John Conly
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Medicine ,Science - Abstract
With rising reports of antimicrobial resistance in outpatient communities, surveillance of antimicrobial use is imperative for supporting stewardship programs. The primary objective of this article is to assess the levels of antimicrobial use in Canada over time.Canadian antimicrobial use data from 1995 to 2010 were acquired and assessed by four metrics: population-adjusted prescriptions, Defined Daily Doses, spending on antimicrobials (inflation-adjusted), and average Defined Daily Doses per prescription. Linear mixed models were built to assess significant differences among years and antimicrobial groups, and to account for repeated measurements over time. Measures were also compared to published reports from European countries.Temporal trends in antimicrobial use in Canada vary by metric and antimicrobial grouping. Overall reductions were seen for inflation-adjusted spending, population-adjusted prescription rates and Defined Daily Doses, and increases were observed for the average number of Defined Daily Doses per prescription. The population-adjusted prescription and Defined Daily Doses values for 2009 were comparable to those reported by many European countries, while the average Defined Daily Dose per prescription for Canada ranked high. A significant reduction in the use of broad spectrum penicillins occurred between 1995 and 2004, coupled with increases in macrolide and quinolone use, suggesting that replacement of antimicrobial drugs may occur as new products arrive on the market.There have been modest decreases of antimicrobial use in Canada over the past 15 years. However, continued surveillance of antimicrobial use coupled with data detailing antimicrobial resistance within bacterial pathogens affecting human populations is critical for targeting interventions and maintaining the effectiveness of these products for future generations.
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- 2013
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8. Country food consumption in Yukon, Northwest Territories and Nunavut, Foodbook study 2014–2015
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Matt Hurst, Jennifer Cutler, Angie Mullen, Anna Manore, Nadia Ciampa, Shiona K Glass-Kaastra, and Vanessa Morton
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Response rate (survey) ,Consumption (economics) ,northwest territories ,Food consumption ,General Medicine ,yukon ,lcsh:Infectious and parasitic diseases ,nunavut ,Geography ,country food ,Food products ,food consumption ,lcsh:RC109-216 ,Survey ,Socioeconomics - Abstract
Background: This article presents a descriptive summary of the consumption of various country food (i.e. locally harvested plant and animal foods) products by residents of Yukon (YT), Northwest Territories (NT) and Nunavut (NU). Data were collected as part of the Foodbook study in 2014–2015. Methods: The Foodbook study was conducted by telephone over a one-year period. Respondents were asked about consumption of a wide range of food products over the previous seven days. Residents of the territories were also asked about consumption of regionally-specific country food. Data were weighted to develop territorial estimates of consumption. Data on age, gender, location, income and education were also collected. Results: The national response rate for the Foodbook survey was 19.9%. In total, 1,235 residents of the territories participated in the study (YT, n=402; NT, n=458; NU, n=375). Consumption of any country food during the previous seven days was reported by 77.5%, 60.7%, and 66.4% of participants in NU, NT and YT, respectively. Conclusion: Responses to country food questions asked alongside the main Foodbook questionnaire provide insight on country food consumption in YT, NT and NU.
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- 2021
9. La consommation d’aliments traditionnels au Yukon, aux Territoires du Nord-Ouest et au Nunavut, étude Foodbook en 2014–2015
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Jennifer Cutler, Anna Manore, Angie Mullen, Matt Hurst, Shiona K Glass-Kaastra, Vanessa Morton, and Nadia Ciampa
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nunavut ,aliments traditionnels ,consommation alimentaire ,General Medicine ,Infectious and parasitic diseases ,RC109-216 ,yukon ,territoires du nord-ouest - Abstract
Contexte : Cet article présente un résumé descriptif de la consommation de divers aliments traditionnels (i.e. des aliments d’origine végétale et animale procurés localement dans la nature) par les résidents du Yukon (Yn), des Territoires du Nord-Ouest (T. N.-O.) et du Nunavut (Nt). Les données ont été collectées dans le cadre de l’étude Foodbook en 2014 et 2015. Méthodes : L’étude Foodbook a été réalisée par téléphone sur une période d’un an. Les répondants ont été interrogés sur la consommation d’un large éventail de produits alimentaires au cours des sept jours précédents. Les habitants des territoires ont également été interrogés sur la consommation d’aliments traditionnels spécifiques à la région. Les données ont été pondérées afin d’élaborer des estimations territoriales de la consommation. Des données sur l’âge, le sexe, le lieu, le revenu et le niveau de scolarité ont également été recueillies. Résultats : Le taux de réponse national pour le sondage Foodbook a été de 19,9 %. Au total, 1 235 résidents des territoires ont participé à l’étude (Yn, n = 402, T. N.-O., n = 458, Nt, n = 375). La consommation d’aliments traditionnels au cours des sept jours précédents a été signalée par 77,5 %, 60,7 % et 66,4 % des participants au Yukon, aux Territoires du Nord-Ouest et au Nunavut, respectivement. Conclusion : Les réponses aux questions sur les aliments traditionnels posées en parallèle au questionnaire principal de l’étude Foodbook donnent un aperçu de la consommation d’aliments traditionnels au Yukon, aux Territoires du Nord-Ouest et au Nunavut.
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- 2021
10. Discharge Destination from a Rehabilitation Unit After Acute Ischemic Stroke
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Gordon Bryan Young, Shiona K Glass-Kaastra, and Amalie Saab
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Bowel incontinence ,Logistic regression ,Rehabilitation Centers ,Brain Ischemia ,medicine ,Humans ,Stroke ,Retrospective Studies ,Balance (ability) ,Rehabilitation ,business.industry ,Stroke Rehabilitation ,Montreal Cognitive Assessment ,General Medicine ,medicine.disease ,Long-Term Care ,Functional Independence Measure ,Patient Discharge ,Neurology ,Heart failure ,Emergency medicine ,Female ,Neurology (clinical) ,business - Abstract
Background: We reviewed numerous variables for ischemic stroke patients admitted to a rehabilitation unit to determine those that were statistically associated with discharge destination. Methods: A retrospective chart review of patients with ischemic stroke discharged from the rehabilitation unit between January 1, 2005 and December 31, 2015. Variables were examined for their association with discharge destination (home versus long-term care (LTC)). Univariable relationships with discharge destination were assessed, and a multivariable logistic regression model was built. Results: Univariate predictors of discharge to LTC: advanced age, decreasing admission and discharge functional independence measure (FIM) scores, increasing change in FIM score from admission to discharge, dependency, residence outside of home before the stroke, absence of a caregiver, urinary and bowel incontinence, low Berg balance score at admission and discharge, low Montreal Cognitive Assessment scores, smoking, chronic heart failure, and an inability to transfer. Multivariable logistic regression: five factors remained significant predictors with LTC disposition: advanced age, bowel incontinence, residence outside of the home prior to stroke, right hemisphere site of the stroke, and absence of a caregiver. Conclusions: Several easily measured variables were significantly associated with discharge to LTC versus home following stroke rehabilitation.
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- 2019
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11. Canadian Consumer Food Safety Practices and Knowledge: Foodbook Study
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Matt Hurst, Nadia Ciampa, Christine Gardhouse, Shiona K Glass-Kaastra, Kristyn Franklin, Regan Murray, M. Kate Thomas, Andrea Nesbitt, and Barbara Marshall
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0301 basic medicine ,Male ,Consumer Product Safety ,Canada ,Health Knowledge, Attitudes, Practice ,Food Safety ,Food Handling ,030106 microbiology ,Population ,Psychological intervention ,Pasteurization ,Food Contamination ,Microbiology ,law.invention ,Foodborne Diseases ,03 medical and health sciences ,0404 agricultural biotechnology ,law ,Environmental health ,Medicine ,Food microbiology ,Animals ,Humans ,Food science ,Cooking ,Raw meat ,education ,education.field_of_study ,business.industry ,04 agricultural and veterinary sciences ,Food safety ,040401 food science ,Food Microbiology ,Female ,business ,Food Science ,Food contaminant - Abstract
Understanding consumers' food safety practices and knowledge supports food safety education for the prevention of foodborne illness. The objective of this study was to describe Canadian consumer food safety practices and knowledge. This study identifies demographic groups for targeted food safety education messaging and establishes a baseline measurement to assess the effectiveness of food safety interventions over time. Questions regarding consumer food safety practices and knowledge were included in a population-based telephone survey, Foodbook, conducted from November 2014 to March 2015. The results were analyzed nationally by age group and by gender. The results showed that approximately 90% of Canadians reported taking the recommended cleaning and separating precautions when handling raw meat to prevent foodborne illness. Only 29% of respondents reported using a food thermometer when cooking any meat, and even fewer (12%) reported using a food thermometer for small cuts of meat such as chicken pieces. The majority (>80%) of Canadians were aware of the foodborne illness risks related to chicken and hamburger, but fewer (
- Published
- 2017
12. Multiple-class antimicrobial resistance surveillance in swine Escherichia coli F4, Pasteurella multocida and Streptococcus suis isolates from Ontario and the impact of the 2004–2006 Porcine Circovirus type-2 Associated Disease outbreak
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David L. Pearl, Shiona K Glass-Kaastra, Jim Fairles, Scott A. McEwen, Durda Slavic, Richard J. Reid-Smith, and Beverly McEwen
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Circovirus ,Pasteurella multocida ,Streptococcus suis ,Swine ,animal diseases ,Pasteurella Infections ,Microbial Sensitivity Tests ,medicine.disease_cause ,Disease Outbreaks ,Microbiology ,Antibiotic resistance ,Food Animals ,Drug Resistance, Multiple, Bacterial ,Streptococcal Infections ,Escherichia coli ,medicine ,Animals ,Cluster Analysis ,Poisson Distribution ,Prospective Studies ,Porcine circovirus associated disease ,Circoviridae Infections ,Escherichia coli Infections ,Ontario ,Swine Diseases ,biology ,Outbreak ,biology.organism_classification ,Antimicrobial ,Virology ,Anti-Bacterial Agents ,Porcine circovirus ,Animal Science and Zoology ,Seasons - Abstract
The objective of this work was to describe trends in multiple-class antimicrobial resistance present in clinical isolates of Escherichia coli F4, Pasteurella multocida and Streptococcus suis from Ontario swine 1998–2010. Temporal changes in multiple-class resistance varied by the pathogens examined; significant yearly changes were apparent for the E. coli and P. multocida data. Although not present in the E. coli data, significant increases in multiple-class resistance within P. multocida isolates occurred from 2003 to 2005, coinciding with the expected increase in antimicrobials used to treat clinical signs of Porcine Circovirus Associated Disease (PCVAD) before it was confirmed. Prospective temporal scan statistics for multiple-class resistance suggest that significant clusters of increased resistance may have been found in the spring of 2004; months before the identification of the PCVAD outbreak in the fall of 2004.
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- 2014
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13. Longitudinal Surveillance of Outpatient Tetracycline, Sulfonamide-Trimethoprim and ‘Other’ Antimicrobial Use in Canada, 1995 to 2010
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David M. Patrick, Shiona K Glass-Kaastra, John Conly, Karl Weiss, Jim Hutchinson, and Rita Finley
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Tetracycline ,business.industry ,Sulfonamide (medicine) ,Infectious and parasitic diseases ,RC109-216 ,Original Articles ,Antimicrobial ,Microbiology ,Trimethoprim ,QR1-502 ,Metronidazole ,Infectious Diseases ,Antibiotic resistance ,Antimicrobial use ,Internal medicine ,medicine ,business ,medicine.drug - Abstract
Monitoring the volume and patterns of use of antimicrobial agents is important in light of antimicrobial resistance.To assess the use of three antimicrobial groups - tetracycline, sulfonamide-trimethoprim and 'other' antimicrobials - within Canadian provinces over time.Prescription counts from 1995 to 2010 were acquired for the tetracycline and sulfonamide-trimethoprim groups of antimicrobials, and from 2001 to 2010 for the 'other' antimicrobial group. Linear mixed models were produced to assess differences among provinces and over time while accounting for repeated measurements. Prescription rate, defined daily dose per 1000 inhabitant-days and defined daily doses per prescription measures for the year 2009 were also compared with those reported by participating European Union countries to determine where Canadian provinces rank in terms of antimicrobial use among these countries.Prescribing of all three groups varied according to province and over time. Tetracycline and sulfonamide-trimethoprim group prescribing were significantly reduced over the study period, by 36% and 61%, respectively. Prescribing of the 'other' antimicrobial group increased in all provinces from 2001 to 2010 with the exception of Prince Edward Island, although by varying amounts (10% to 61% increases).The overall use of antimicrobials in Canada has dropped from 1995 to 2010, and the tetracycline and sulfonamide-trimethoprim groups have contributed to this decline. The use of the 'other' antimicrobials has increased, however. These results may suggest that switches are being made among these groups, particularly among the antimicrobials used to treat urinary tract infections.Il est important de surveiller le volume et le mode d’utilisation des antimicrobiens compte tenu de la résistance antimicrobienne.Évaluer l’utilisation de trois groupes d’antimicrobiens, soit la tétracycline, la sulfonamide-triméthoprime et d’« autres » antimicrobiens dans les provinces canadiennes au fil du temps.Les chercheurs ont obtenu le nombre de prescriptions des groupes de tétracycline et de sulfonamide-triméthoprime entre 1995 et 2010 et du groupe d’« autres » antimicrobiens entre 2001 et 2010. Ils ont produit des modèles linéaires mixtes pour évaluer les différences entre les provinces et dans le temps tout en tenant compte des mesures répétées. Ils ont également comparé le taux de prescriptions, les doses quotidiennes définies par 1 000 habitants-jours et les doses quotidiennes définies par mesures de prescription à ceux des pays participants de l’Union européenne en 2009 pour déterminer le classement des provinces canadiennes en matière d’utilisation d’antimicrobiens au sein de ces pays.Les prescriptions des trois groupes de médicaments variaient selon la province et dans le temps. La prescription des groupes de tétracycline et de sulfonamide-triméthoprime a diminué considérablement pendant la période de l’étude, soit de 36 % et de 61 %, respectivement. La prescription du groupe d’« autres » antimicrobiens a augmenté dans toutes les provinces entre 2001 et 2010, à l’exception de l’Île-du-Prince-Édouard, mais selon des taux différents (augmentations de 10 % à 61 %).L’utilisation globale d’antimicrobiens a diminué au Canada entre 1995 et 2010, et les groupes de tétracycline et de sulfonamide-triméthoprime y ont contribué. L’utilisation d’« autres » antimicrobiens a toutefois augmenté. Ces résultats laissent peut-être supposer des substitutions entre ces groupes, notamment entre les antimicrobiens utilisés pour soigner les infections urinaires.
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- 2014
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14. Longitudinal Surveillance of Outpatient Quinolone Antimicrobial Use in Canada
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Karl Weiss, Rita Finley, Shiona K Glass-Kaastra, John Conly, Jim Hutchinson, and David M. Patrick
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Microbiology (medical) ,Drug Utilization ,medicine.medical_specialty ,medicine.drug_class ,business.industry ,Original Articles ,Infectious and parasitic diseases ,RC109-216 ,Quinolone ,Microbiology ,QR1-502 ,Infectious Diseases ,Antimicrobial use ,Antibiotic resistance ,medicine ,Intensive care medicine ,business - Abstract
Because antimicrobial use is commonly associated with the development of antimicrobial resistance, monitoring the volume and patterns of use of these agents is important.To assess the use of quinolone antimicrobials within Canadian provinces over time.ANTIMICROBIAL PRESCRIBING DATA COLLECTED BY IMS HEALTH CANADA WERE ACQUIRED FROM THE CANADIAN INTEGRATED PROGRAM FOR ANTIMICROBIAL RESISTANCE SURVEILLANCE AND THE CANADIAN COMMITTEE FOR ANTIMICROBIAL RESISTANCE, AND WERE USED TO CALCULATE TWO YEARLY METRICS: prescriptions per 1000 inhabitant-days and the mean defined daily doses (DDDs) per prescription. These measures were used to produce linear mixed models to assess differences among provinces and over time, while accounting for repeated measurements.The quinolone class of antimicrobials is used similarly among Canadian provinces. Year-to-year increases in quinolone prescribing occurred from 1995 to 2010, with a levelling off in the latter years. Year-to-year decreases in the DDDs per prescription were found to be significant from 2000 to 2010.Although the overall use of antimicrobials differs significantly among Canadian provinces, the use of the quinolone class does not vary at the provincial level. Results suggest that prescribing of ciprofloxacin may be a potential target for antimicrobial stewardship programs; however, decreases in the average DDDs per prescription suggest continued uptake of appropriate treatment guidelines.Puisque l’utilisation d’antimicrobiens s’associe souvent à l’apparition d’une résistance antimicrobienne, il est important d’en surveiller le volume et le mode d’utilisation.Évaluer l’utilisation d’antimicrobiens de la classe des quinolones au sein des provinces canadiennes au fil du temps.Les chercheurs ont acquis les données de prescription d’antimicrobiens colligées par IMS Health Canada auprès du Programme intégré canadien de surveillance de la résistance aux antimicrobiens et du Comité canadien sur la résistance aux antibiotiques et les ont utilisées pour calculer deux mesures annuelles : les prescriptions par 1 000 habitants-jours et les doses quotidiennes définies (DTD) moyennes par prescription. Ils les ont utilisées pour produire des modèles linéaires mixtes afin d’évaluer les différences entre les provinces et au fil du temps, tout en tenant compte des mesures répétées.Les antimicrobiens de la classe des quinolones sont utilisés de manière similaire dans les provinces canadiennes. Les prescriptions annuelles de quinolone ont augmenté de 1995 à 2010, mais ont plafonné au cours des dernières années. Les DTD par prescription ont diminué annuellement de manière significative entre 2000 et 2010.Même si l’utilisation globale d’antimicrobiens diffère de manière significative entre les provinces canadiennes, l’utilisation de la classe des quinolones ne varie pas sur la scène provinciale. D’après les résultats, la prescription de ciprofloxacine peut être une cible potentielle des programmes de gestion des antimicrobiens. Cependant, les diminutions des DTD moyennes par prescription sont indicatrices d’une assimilation continue des directives thérapeutiques pertinentes.
- Published
- 2014
15. Antibiotic prescriptions for outpatient acute rhinosinusitis in Canada, 2007-2013
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Scott Weese, Rita Finley, Shiona K Glass-Kaastra, Prateek Sharma, and Warren J. McIsaac
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0301 basic medicine ,Medical Doctors ,Health Care Providers ,Antibiotics ,lcsh:Medicine ,Disease ,Pediatrics ,Geographical locations ,0302 clinical medicine ,Outpatients ,Medicine and Health Sciences ,Antimicrobial stewardship ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Young adult ,Child ,lcsh:Science ,Rhinitis ,Multidisciplinary ,Antimicrobials ,Drugs ,Middle Aged ,Anti-Bacterial Agents ,Professions ,Child, Preschool ,Acute Disease ,Research Article ,medicine.drug ,Adult ,Canada ,medicine.medical_specialty ,Adolescent ,Patients ,medicine.drug_class ,030106 microbiology ,Drug Prescriptions ,Microbiology ,Young Adult ,03 medical and health sciences ,Antibiotic resistance ,Physicians ,Microbial Control ,Internal medicine ,medicine ,Humans ,Sinusitis ,Medical prescription ,Intensive care medicine ,Aged ,Pharmacology ,business.industry ,lcsh:R ,Infant, Newborn ,Infant ,Biology and Life Sciences ,Penicillin ,Health Care ,Age Groups ,Antibiotic Resistance ,People and Places ,North America ,Etiology ,Population Groupings ,lcsh:Q ,Antimicrobial Resistance ,business - Abstract
Introduction Acute rhinosinusitis (ARS) is a respiratory disease commonly caused by viral infections. Physicians regularly prescribe antibiotics despite bacterial etiologies being uncommon. This is of concern, as this use adds to the selection pressure for resistance. Here we present the descriptive epidemiology of acute rhinosinusitis and corresponding antibiotic prescribing practices by Canadian outpatient physicians from 2007–2013. Materials/Methods Diagnosis and antibiotic prescription data for ARS were extracted from the Canadian Disease and Therapeutic Index for 2007 to 2013, and population data were acquired from Statistics Canada. ARS diagnosis and antibiotic prescription rates and frequencies of antibiotic classes were calculated. Results Eighty-eight percent of patients diagnosed with ARS in 2013 were adults, with a greater rate of antibiotic prescriptions observed among the adults relative to the pediatric patients (1632.9 and 468.6 antibiotic prescriptions per 10,000 inhabitants). Between 2007 and 2013, the ARS diagnosis rate decreased from 596 to 464 diagnoses per 10,000 inhabitants, while the percentage of diagnoses with antibiotic prescriptions at the national level remained stable (87% to 84%). From 2007 to 2013, prescription rates for macrolides decreased from 203.5 to 105.4 prescriptions per 10,000 inhabitants. In 2013, penicillins with extended spectrum were more commonly prescribed compared to macrolides among adult patients (153.5 and 105.4 prescriptions per 10,000 inhabitants, respectively). Conclusion This study is the first to describe physician antibiotic prescribing practices for treatment of ARS in Canada. Results show that antibiotic treatment for ARS represents an area for implementing antimicrobial stewardship, and through it, managing antibiotic resistance. Further work is required to better understand diagnosing practices and treatment criteria for ARS, and use this information to further assist physicians to limit unnecessary antibiotic prescribing practices.
- Published
- 2017
16. Declines in Outpatient Antimicrobial Use in Canada (1995–2010)
- Author
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Shiona K Glass-Kaastra, Jim Hutchinson, John Conly, Rita Finley, David M. Patrick, and Karl Weiss
- Subjects
Canada ,Veterinary medicine ,Broad spectrum penicillins ,Psychological intervention ,Administration, Oral ,lcsh:Medicine ,Pharmacy ,World Health Organization ,Drug Prescriptions ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,Anti-Infective Agents ,Environmental health ,Outpatients ,Confidence Intervals ,Humans ,Medicine ,030212 general & internal medicine ,Medical prescription ,lcsh:Science ,0303 health sciences ,Multidisciplinary ,030306 microbiology ,business.industry ,lcsh:R ,Antimicrobial ,3. Good health ,Antimicrobial use ,Defined daily dose ,Linear Models ,lcsh:Q ,business ,Research Article - Abstract
Background With rising reports of antimicrobial resistance in outpatient communities, surveillance of antimicrobial use is imperative for supporting stewardship programs. The primary objective of this article is to assess the levels of antimicrobial use in Canada over time. Methods Canadian antimicrobial use data from 1995 to 2010 were acquired and assessed by four metrics: population-adjusted prescriptions, Defined Daily Doses, spending on antimicrobials (inflation-adjusted), and average Defined Daily Doses per prescription. Linear mixed models were built to assess significant differences among years and antimicrobial groups, and to account for repeated measurements over time. Measures were also compared to published reports from European countries. Results Temporal trends in antimicrobial use in Canada vary by metric and antimicrobial grouping. Overall reductions were seen for inflation-adjusted spending, population-adjusted prescription rates and Defined Daily Doses, and increases were observed for the average number of Defined Daily Doses per prescription. The population-adjusted prescription and Defined Daily Doses values for 2009 were comparable to those reported by many European countries, while the average Defined Daily Dose per prescription for Canada ranked high. A significant reduction in the use of broad spectrum penicillins occurred between 1995 and 2004, coupled with increases in macrolide and quinolone use, suggesting that replacement of antimicrobial drugs may occur as new products arrive on the market. Conclusions There have been modest decreases of antimicrobial use in Canada over the past 15 years. However, continued surveillance of antimicrobial use coupled with data detailing antimicrobial resistance within bacterial pathogens affecting human populations is critical for targeting interventions and maintaining the effectiveness of these products for future generations.
- Published
- 2013
- Full Text
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17. Describing antimicrobial use and reported treatment efficacy in Ontario swine using the Ontario swine veterinary-based Surveillance program
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Scott A. McEwen, Rocio Amezcua, Beverly McEwen, Richard J. Reid-Smith, Shiona K Glass-Kaastra, Robert M. Friendship, and David L. Pearl
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Veterinary Medicine ,Veterinary medicine ,Swine ,medicine.drug_class ,Cephalosporin ,Biosecurity ,Penicillins ,Anti-Infective Agents ,medicine ,Animals ,Antimicrobial stewardship ,Retrospective Studies ,Ontario ,Swine Diseases ,General Veterinary ,business.industry ,Retrospective cohort study ,General Medicine ,Tetracycline ,Antimicrobial ,veterinary(all) ,Cephalosporins ,Penicillin ,Vaccination ,Antimicrobial use ,Treatment Outcome ,Treatment failure ,Treatment efficacy ,Population Surveillance ,business ,Ceftiofur ,Research Article ,medicine.drug - Abstract
Background The objective of this work was to retrospectively assess records received through the Ontario Swine Veterinary-based Surveillance program July 2007 – July 2009 to describe and assess relationships between reported treatment failure, antimicrobial use, diagnosis and body system affected. Results Antimicrobial use occurred in 676 records, 80.4% of all records recording treatment (840). The most commonly used antimicrobials were penicillin (34.9%), tetracyclines (10.7%) and ceftiofur (7.8%), and the use of multiple antimicrobials occurred in 141/676 records (20.9%). A multi-level logistic regression model was built to describe the probability of reported treatment failure. The odds of reported treatment failure were significantly reduced if the record indicated that the gastro-intestinal (GI) system was affected, as compared to all other body systems (p
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