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6. Preliminary genome‐wide association study of bipolar disorder in the Japanese population

Author

Hattori, Eiji, primary, Toyota, Tomoko, additional, Ishitsuka, Yuichi, additional, Iwayama, Yoshimi, additional, Yamada, Kazuo, additional, Ujike, Hiroshi, additional, Morita, Yukitaka, additional, Kodama, Masafumi, additional, Nakata, Kenji, additional, Minabe, Yoshio, additional, Nakamura, Kazuhiko, additional, Iwata, Yasuhide, additional, Takei, Nori, additional, Mori, Norio, additional, Naitoh, Hiroshi, additional, Yamanouchi, Yoshio, additional, Iwata, Nakao, additional, Ozaki, Norio, additional, Kato, Tadafumi, additional, Nishikawa, Toru, additional, Kashiwa, Atsushi, additional, Suzuki, Mika, additional, Shioe, Kunihiko, additional, Shinohara, Manabu, additional, Hirano, Masami, additional, Nanko, Shinichiro, additional, Akahane, Akihisa, additional, Ueno, Mikako, additional, Kaneko, Naoshi, additional, Watanabe, Yuichiro, additional, Someya, Toshiyuki, additional, Hashimoto, Kenji, additional, Iyo, Masaomi, additional, Itokawa, Masanari, additional, Arai, Makoto, additional, Nankai, Masahiro, additional, Inada, Toshiya, additional, Yoshida, Sumiko, additional, Kunugi, Hiroshi, additional, Nakamura, Michiko, additional, Iijima, Yoshimi, additional, Okazaki, Yuji, additional, Higuchi, Teruhiko, additional, and Yoshikawa, Takeo, additional

Published
2009
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9. GRID Hamilton Rating Scale for Depression—Japanese Version

Author

Tabuse, Hideaki, primary, Kalali, Amir, additional, Azuma, Hideki, additional, Ozaki, Norio, additional, Iwata, Nakao, additional, Naitoh, Hiroshi, additional, Higuchi, Teruhiko, additional, Kanba, Shigenobu, additional, Shioe, Kunihiko, additional, Akechi, Tatsuo, additional, and Furukawa, Toshi A., additional

Published
2007
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13. Algorithms for the pharmacotherapy of major depression.

Author

Shioe, Kunihiko and Kanba, Shigenobu

Subjects
*DRUG therapy, *MENTAL depression, *PSYCHOTHERAPY, *PHOTOTHERAPY, *THERAPEUTICS
Abstract

We have shaped a practical and rational treatment algorithm for major depression. This algorithm is based on evidence obtained by collecting documents from overseas and within Japan, considering the actual state of drug selection in Japan. Because of the characteristics of the drug treatment algorithm, there are several items that are important but could not be discussed, such as psychotherapy, light therapy, and so-forth. Both mild and moderate depression are outlined on the same algorithm because these two cannot be distinguished from the perspectives of pharmacotherapy available in our country. [ABSTRACT FROM AUTHOR]

Published
1999

14. Preliminary genomewide association study of bipolar disorder in the Japanese populationHow to Cite this Article: Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T. 2009. Preliminary GenomeWide Association Study of Bipolar Disorder in the Japanese Population. Am J Med Genet Part B 150B:1110–1117.

Author

Hattori, Eiji, Toyota, Tomoko, Ishitsuka, Yuichi, Iwayama, Yoshimi, Yamada, Kazuo, Ujike, Hiroshi, Morita, Yukitaka, Kodama, Masafumi, Nakata, Kenji, Minabe, Yoshio, Nakamura, Kazuhiko, Iwata, Yasuhide, Takei, Nori, Mori, Norio, Naitoh, Hiroshi, Yamanouchi, Yoshio, Iwata, Nakao, Ozaki, Norio, Kato, Tadafumi, Nishikawa, Toru, Kashiwa, Atsushi, Suzuki, Mika, Shioe, Kunihiko, Shinohara, Manabu, Hirano, Masami, Nanko, Shinichiro, Akahane, Akihisa, Ueno, Mikako, Kaneko, Naoshi, Watanabe, Yuichiro, Someya, Toshiyuki, Hashimoto, Kenji, Iyo, Masaomi, Itokawa, Masanari, Arai, Makoto, Nankai, Masahiro, Inada, Toshiya, Yoshida, Sumiko, Kunugi, Hiroshi, Nakamura, Michiko, Iijima, Yoshimi, Okazaki, Yuji, Higuchi, Teruhiko, and Yoshikawa, Takeo

Abstract

Recent progress in genotyping technology and the development of public databases has enabled largescale genomewide association tests with diseases. We performed a twostage genomewide association study GWAS of bipolar disorder BD in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant P < 0.01 in at least one of the three models 1,577 markers in total. In the followup stage, we analyzed these markers using an Illumina platform 1,526 markers; 51 markers were not designable for the platform and an independent sample set, which consisted of 395 cases bipolar I  II and 409 controls. We also assessed the population stratification of current samples using principal components analysis. After the twostage analysis, 89 markers remained nominally significant allelic P < 0.05 with the same allele being consistently overrepresented in both the first and the followup stages. However, none of these were significant after correction for multipletesting by false discovery rates. Sample stratification was virtually negligible. Collectively, this is the first GWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary. © 2009 WileyLiss, Inc.

Published
2009
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15. [Bipolar I disorder].

Author

Kaneko N, Shioe K, and Kanba S

Subjects
Antimanic Agents therapeutic use, Biogenic Monoamines physiology, Diagnostic and Statistical Manual of Mental Disorders, Electroconvulsive Therapy, Environmental Exposure, Genetic Predisposition to Disease, Humans, Lithium therapeutic use, Psychotherapy methods, Recurrence, Reference Standards, Risk Factors, Bipolar Disorder classification, Bipolar Disorder diagnosis, Bipolar Disorder etiology, Bipolar Disorder therapy
Published
2003

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