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245 results on '"Shinoto, Makoto"'

8. [S-methyl-11C]-L-methionine positron emission tomography/computed tomography imaging parameters to evaluate early response for esophageal cancer with neoadjuvant carbon ion radiotherapy

Author

Narushima, Kazuo, Nishii, Ryuichi, Okazumi, Shinichi, Shimada, Hideaki, Akutsu, Yasunori, Maeda, Takamasa, Yasuda, Shigeo, Yamada, Shigeru, Shuto, Kiyohiko, Tamura, Kentaro, Yamazaki, Kana, Shinoto, Makoto, Ishikawa, Hitoshi, Mori, Mikito, and Matsubara, Hisahiro

Published
2022
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12. Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers

Author

Koto, Masashi, primary, Ikawa, Hiroaki, additional, Inaniwa, Taku, additional, Imai, Reiko, additional, Shinoto, Makoto, additional, Takiyama, Hirotoshi, additional, Isozaki, Tetsuro, additional, Mizuno, Hideyuki, additional, Kohno, Ryosuke, additional, Takahashi, Ikumi, additional, Yoshida, Naoki, additional, and Yamada, Shigeru, additional

Published
2024
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27. Carbon Ion Radiation Therapy With Concurrent Gemcitabine for Patients With Locally Advanced Pancreatic Cancer

Author

Asano, Takehide, Yamaguchi, Taketo, Amano, Hodaka, Ishihara, Takeshi, Otsuka, Masayuki, Matsuda, Masamichi, Kainuma, Osamu, Funakoshi, Akihiro, Furuse, Junji, Nakagori, Toshio, Okusaka, Takuji, Ishii, Hiroshi, Nagakawa, Tatsuya, Takahashi, Shinichiro, Hishinuma, Shoichi, Nakamura, Masafumi, Saito, Hirofumi, Ohara, Kiyoshi, Ohkawa, Shinichi, Hiraoka, Masahiro, Shinoto, Makoto, Yamada, Shigeru, Terashima, Kotaro, Yasuda, Shigeo, Shioyama, Yoshiyuki, Honda, Hiroshi, Kamada, Tadashi, Tsujii, Hirohiko, and Saisho, Hiromitsu

Published
2016
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29. Pancreatic Cancer

Author

Yamada, Shigeu, Terashima, Kohtaro, Shinoto, Makoto, Yasuda, Shigeo, Shiomi, Miho, Isozaki, Tetsuro, Tsujii, Hirohiko, editor, Kamada, Tadashi, editor, Shirai, Toshiyuki, editor, Noda, Koji, editor, Tsuji, Hiroshi, editor, and Karasawa, Kumiko, editor

Published
2014
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30. Postoperative Recurrence of Rectal Cancer

Author

Yamada, Shigeu, Endo, Satoshi, Terashima, Kohtaro, Shinoto, Makoto, Yasuda, Shigeo, Shiomi, Miho, Isozaki, Tetsuro, Tsujii, Hirohiko, editor, Kamada, Tadashi, editor, Shirai, Toshiyuki, editor, Noda, Koji, editor, Tsuji, Hiroshi, editor, and Karasawa, Kumiko, editor

Published
2014
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33. Stopping-power ratio of mouthpiece materials for charged-particle therapy in head and neck cancer

Author

Ikawa, Hiroaki, Inaniwa, Taku, Koto, Masashi, Bhattacharyya, Tapesh, Kaneko, Takashi, Takiyama, Hirotoshi, Shinoto, Makoto, Yamada, Shigeru, Tsuji, Hiroshi, Hiroaki, Ikawa, Taku, Inaniwa, Masashi, Koto, Takashi, Kaneko, Hirotoshi, Takiyama, Makoto, Shinoto, Shigeru, Yamada, and Hiroshi, Tsuji

Abstract

In this study, the stopping-power ratios (SPRs) of mouthpiece materials were measured and the errors in the predicted SPRs based on conversion table values were further investigated. The SPRs of the five mouthpiece materials were predicted from their computed tomography (CT) numbers using a calibrated conversion table. Independently, the SPRs of the materials were measured from the Bragg peak shift of a carbon-ion beam passing through the materials. The errors in the SPRs of the materials were determined as the difference between the predicted and measured values. The measured SPRs (errors) of the Nipoflex 710™ and Bioplast™ ethylene-vinyl acetate copolymers (EVAs) were 0.997 (0.023) and 0.982 (0.007), respectively. The SPRs of the vinyl silicon impression material, light-curable resin, and bis-acrylic resin were 1.517 (0.134), 1.161 (0.068), and 1.26 (0.101), respectively. Among the five tested materials, the EVAs had the lowest SPR errors, indicating the highest human-tissue equivalency.

Published
2021

37. Long-term outcomes of high dose carbon-ion radiation therapy for unresectable upper cervical (C1-2) chordoma

Author

Aoki, Shuri, Koto, Masashi, Ikawa, Hiroaki, Imai, Reiko, Tokuhiko, Omatsu, Shinoto, Makoto, Takiyama, Hirotoshi, Yamada, Shigeru, Tsuji, Hiroshi, Shuri, Aoki, Masashi, Koto, Hiroaki, Ikawa, Reiko, Imai, Makoto, Shinoto, Hirotoshi, Takiyama, Shigeru, Yamada, and Hiroshi, Tsuji

Abstract

Background: Chordoma is a rare, locally invasive neoplasm of the axial skeleton. Complete resection is often difficult, especially for the upper-cervical (C1-2) spine. We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) for unresectable C1-2 chordoma. Methods: Patients with C1-2 chordoma treated with definitive CIRT (60.8 Gy [RBE] in 16 fractions) were retrospectively analyzed. We evaluated OS, LC, PFS, and toxicity. Results: Nineteen eligible patients all completed the planned course of CIRT. With the median follow-up 68 months (range: 29-144), median OS was 126 months (range: 36-NA). Five-year OS, LC, and PFS were 68.4% (95% CI, 42.8%-84.4%), 75.2% (46.1%-90.0%), and 64.1% (36.3%-82.3%), respectively. Regarding acute toxicity of grade ≥3, there was only one grade 3 mucositis. Late toxicity included radiation-induced myelitis (grade 3 in 1 patient; 5.3%), and compression fractures (n = 5; 26.3%). Conclusions: High-dose CIRT is a promising treatment option for unresectable upper cervical chordoma.

Published
2022

43. Comparison of dosimetries of carbon-ion pencil beam scanning, proton pencil beam scanning and volumetric modulated arc therapy for locally recurrent rectal cancer.

Author

Mori, Shinichiro, Bhattacharyya, Tapesh, Furuichi, Wataru, Tohyama, Naoki, Nomoto, Akihiro, Shinoto, Makoto, Takiyama, Hirotoshi, and Yamada, Shigeru

Subjects
VOLUMETRIC-modulated arc therapy, RECTAL cancer, PROTON beams, RECTUM, WILCOXON signed-rank test, URODYNAMICS, RADIATION dosimetry
Abstract

We compared the dose distributions of carbon-ion pencil beam scanning (C-PBS), proton pencil beam scanning (P-PBS) and Volumetric Modulated Arc Therapy (VMAT) for locally recurrent rectal cancer. The C-PBS treatment planning computed tomography (CT) data sets of 10 locally recurrent rectal cancer cases were randomly selected. Three treatment plans were created using identical prescribed doses. The beam angles for C-PBS and P-PBS were identical. Dosimetry, including the dose received by 95% of the planning target volume (PTV) (D95%), dose to the 2 cc receiving the maximum dose (D2cc), organ at risk (OAR) volume receiving > 15Gy (V15) and > 30Gy (V30), was evaluated. Statistical significance was assessed using the Wilcoxon signed-rank test. Mean PTV-D95% values were > 95% of the volume for P-PBS and C-PBS, whereas that for VMAT was 94.3%. However, PTV-D95% values in P-PBS and VMAT were < 95% in five and two cases, respectively, due to the OAR dose reduction. V30 and V15 to the rectum/intestine for C-PBS (V30 = 4.2 ± 3.2 cc, V15 = 13.8 ± 10.6 cc) and P-PBS (V30 = 7.3 ± 5.6 cc, V15 = 21.3 ± 13.5 cc) were significantly lower than those for VMAT (V30 = 17.1 ± 10.6 cc, V15 = 55.2 ± 28.6 cc). Bladder-V30 values with P-PBS/C-PBS (3.9 ± 4.8 Gy(RBE)/3.0 ± 4.0 Gy(RBE)) were significantly lower than those with VMAT (7.9 ± 8.1 Gy). C-PBS provided superior dose conformation and lower OAR doses compared with P-PBS and VMAT. C-PBS may be the best choice for cases in which VMAT and P-PBS cannot satisfy dose constraints. C-PBS could be another choice for cases in which VMAT and P-PBS cannot satisfy dose constraints, thereby avoiding surgical resection. [ABSTRACT FROM AUTHOR]

Published
2023
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46. [S-methyl-11C]-L-methionine positron emission tomography/computed tomography imaging parameters to evaluate early response for esophageal cancer with neoadjuvant carbon ion radiotherapy.

Author

Narushima, Kazuo, Nishii, Ryuichi, Okazumi, Shinichi, Shimada, Hideaki, Akutsu, Yasunori, Maeda, Takamasa, Yasuda, Shigeo, Yamada, Shigeru, Shuto, Kiyohiko, Tamura, Kentaro, Yamazaki, Kana, Shinoto, Makoto, Ishikawa, Hitoshi, Mori, Mikito, and Matsubara, Hisahiro

Subjects
POSITRON emission tomography, ESOPHAGEAL cancer, COMPUTED tomography, METHIONINE, TUMOR grading
Abstract

This study aimed to evaluate the uptake of the clinical effectiveness of [S-methyl-11C]-L-methionine positron emission tomography/computed tomography (MET PET/CT) in patients with esophageal cancer and to investigate MET PET/CT imaging parameters to assess early response for esophageal cancer with neoadjuvant carbon ion radiotherapy (CIRT). MET PET/CT scans were performed in nineteen patients before and 3 weeks after completion of CIRT. After Surgery, the effect of neoadjuvant CIRT was investigated by examining the relationship between each parameter of MET uptake and the histological assessment (grade and tumor residual ratio). Four parameters of MET uptake were the maximum and minimum standardized uptake values of pre and post CIRT (pre-SUVmax, pre-SUVmean, post-SUVmax, and post-SUVmean). MET PET/CT imaging of esophageal cancer was clearly demonstrated. The post-SUVmax was the most suitable parameter. When the cutoff value was set as post-SUVmax = 6.21, the sensitivity, the specificity, and the accuracy of Grades 3 were 100.0%, 63.6%, and 78.9%, respectively. And there was a positive relationship between the tumor residual ratio and post-SUVmax (R2 = 0.38, p < 0.005). MET PET/CT is clinically useful for the assessment of early response to neoadjuvant CIRT in esophageal cancer. Particularly, post-SUVmax is considered a promising PET imaging parameter. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Carbon-ion Radiotherapy for Colorectal Cancer

Author

Yamada, Shigeru, primary, Takiyama, Hirotoshi, additional, Isozaki, Yuka, additional, Shinoto, Makoto, additional, Makishima, Hirokazu, additional, Yamamoto, Naoyoshi, additional, and Tsuji, Hiroshi, additional

Published
2021
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48. Pancreatic Cancer

Author

Yamada, Shigeu, primary, Terashima, Kohtaro, additional, Shinoto, Makoto, additional, Yasuda, Shigeo, additional, Shiomi, Miho, additional, and Isozaki, Tetsuro, additional

Published
2013
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49. Postoperative Recurrence of Rectal Cancer

Author

Yamada, Shigeu, primary, Endo, Satoshi, additional, Terashima, Kohtaro, additional, Shinoto, Makoto, additional, Yasuda, Shigeo, additional, Shiomi, Miho, additional, and Isozaki, Tetsuro, additional

Published
2013
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50. Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1404 Rectum

Author

Shinoto, Makoto, Yamada, Shigeru, Okamoto, Masahiko, Shioyama, Yoshiyuki, Ohno, Tatsuya, Nakano, Takashi, Nemoto, Kenji, Isozaki, Yuka, Kawashiro, Shohei, Tsuji, Hiroshi, and Kamada, Tadashi

Abstract

Purpose: We investigated the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally recurrent rectal cancer (LRRC). Patients and methods: Data from patients with LRRC treated with C-ion RT from November 2003 to December 2014 at three institutions were retrospectively analyzed. The endpoints of this clinical trial were overall survival (OS), local control (LC), and acute/late toxicity. Results: A total of 224 patients’ data were collected. The prescribed dose was 70.4 Gy (relative biological effectiveness [RBE]-weighted absorbed dose) or 73.6 Gy (RBE) in 16 fractions. The median follow-up period from the initiation of C-ion RT was 62 months (range 6–169 months). The OS rates were 73% (95% confidence interval [CI], 67%–79%) at 3 years and 51% (95%CI 44%–58%) at 5 years. The LC rates were 93% (95%CI 88%–96%) at 3 years, and 88% (95%CI 82%–93%) at 5 years. Grade 3 acute toxicity was observed in three patients: gastrointestinal toxicity (n = 1) and pelvic infection (n = 2). Grade 3 late toxicity was observed in 12 patients: skin reaction (n = 2), gastrointestinal toxicity (n = 2), neuropathy (n = 1), and pelvic infection (n = 7). There was no grade 4 or 5 acute or late toxicity. Conclusions: This first multi-institutional analysis of C-ion RT for LRRC indicated relatively favorable outcomes with limited toxicities.

Published
2018

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