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Your search keyword '"Shinomiya, H."' showing total 263 results
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263 results on '"Shinomiya, H."'

3. Corrigendum to ‘A phase II trial of paclitaxel plus biweekly cetuximab for patients with recurrent or metastatic head and neck cancer previously treated with both platinum-based chemotherapy and anti-PD-1 antibody’: [ESMO Open volume 9 issue 6 (2024) 103476]

Author

Koyama, T., Kiyota, N., Boku, S., Imamura, Y., Shibata, N., Satake, H., Tanaka, K., Hayashi, H., Onoe, T., Asada, Y., Yamazaki, T., Nose, T., Ohata, S., Nagatani, Y., Kimbara, S., Funakoshi, Y., Teshima, M., Shinomiya, H., and Minami, H.

Published
2024
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12. Prognostic value of the modified Glasgow Prognostic Score for head and neck cancer in the era of immunotherapy

Author

Imamura, Y., primary, Kiyota, N., additional, Suzuki, C., additional, Koyama, T., additional, Kimbara, S., additional, Shinomiya, H., additional, Otsuki, N., additional, Hasegawa, T., additional, Toyoda, M., additional, Funakoshi, Y., additional, Akashi, M., additional, Sasaki, R., additional, Nibu, K.I., additional, and Minami, H., additional

Published
2020
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19. Transfer of dendritic cells (DC)ex vivostimulated with interferon-gamma (IFN-γ) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice

Author

SHINOMIYA, M, FAZLE AKBAR, SM, SHINOMIYA, H, and ONJI, M

Subjects
Male, Adoptive cell transfer, endocrine system diseases, Immunology, Antigen presentation, Antigen-Presenting Cells, Nod, Autoimmune Diseases, Interferon-gamma, Islets of Langerhans, Mice, Mice, Inbred NOD, Animals, Humans, Immunology and Allergy, Medicine, Interferon gamma, Antigen-presenting cell, NOD mice, Mice, Inbred ICR, business.industry, Dendritic Cells, Dendritic cell, medicine.disease, Adoptive Transfer, Diabetes Mellitus, Type 1, Original Article, Female, business, Insulitis, medicine.drug
Abstract

SUMMARYThe NOD mouse has been used to explore the many features of insulin-dependent diabetes mellitus (IDDM) that is caused by the destruction of insulin-producing β cells in the islets of Langerhans of the pancreas. Self-reactive T cells have been considered to mediate IDDM in the NOD mouse, and antigen-presenting cells like DC and macrophages are expected to be involved in the processes from their role in generating regulatory or effector T cells. The present study shows that transfer of IFN-γ-stimulated DC of the NOD or ICR mouse into the NOD mouse did not accelerate IDDM onset but afforded long-lasting protection against clinical and histological signs of IDDM in the recipient mice. The anti-diabetogenic ability was unique to IFN-γ-stimulated DC when compared with unstimulated DC. A considerable proportion of the injected IFN-γ-stimulated DC was demonstrated to migrate into the pancreas and its associated lymphoid tissues, suggesting the DC exert their anti-diabetogenic effects there. These findings suggest that development of autoimmune diabetes in the NOD mouse is under the control of DC, and that IDDM onset could be controlled by appropriately manipulating DC systems in vivo, which may open the gate for the therapeutic application of ex vivo-conditioned DC to human IDDM.

Published
1999

20. A multi-institutional dose-finding and efficacy confirmation trial of superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for patients with locally advanced maxillary sinus cancer (JCOG1212, RADPLAT-MSC): Results of dose-finding phase

Author

Sakashita, T., primary, Homma, A., additional, Onimaru, R., additional, Matsuura, K., additional, Shinomiya, H., additional, Hayashi, R., additional, Shiga, K., additional, Tachibana, H., additional, Nakamura, K., additional, Mizusawa, J., additional, and Fujii, M., additional

Published
2016
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23. A 0.602 /spl mu/m/sup 2/ nestled 'Chain' cell structure formed by one mask etching process for 64 Mbit FeRAM

Author

Kanaya, H., primary, Tomioka, K., additional, Matsushita, T., additional, Omura, M., additional, Ozaki, T., additional, Kumura, Y., additional, Shimojo, Y., additional, Morimoto, T., additional, Hidaka, O., additional, Shuto, S., additional, Koyama, H., additional, Yamada, Y., additional, Osari, K., additional, Tokoh, N., additional, Fujisaki, F., additional, Iwabuchi, N., additional, Yamaguchi, N., additional, Watanabe, T., additional, Yabuki, M., additional, Shinomiya, H., additional, Watanabe, N., additional, Itoh, E., additional, Tsuchiya, T., additional, Yamakawa, K., additional, Natori, K., additional, Yamazaki, S., additional, Nakazawa, K., additional, Takashima, D., additional, Shiratake, S., additional, Ohtsuki, S., additional, Oowaki, Y., additional, Kunishima, I., additional, and Nitayama, A., additional

Published
2004
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35. Parallelism between regulatory effects of erythrocyte glycoproteins on phagocytosis and on the alternative complement pathway.

Author

Shinomiya, H., Sukegawa, T., Hatanaka, Mieko, and Utsumi, S.

Subjects
*GLYCOPROTEINS, *ERYTHROCYTES, *BLOOD cells, *LIPOSOMES, *PHAGOCYTOSIS, *IMMUNE response
Abstract

Major membrane glycoprotein fractions from erythrocytes of humans, rats, sheep and rabbits were isolated and reconstituted into dinitrophenyl (DNP)-haptenated liposomes, in an attempt to compare their effects on the phagocytic response of human polymorphonuclear leucocytes (PMN) and on the alternative pathway of human complement. These glycoproteins on liposomes, by themselves, barely induced the nitroblue tetrazolium blue (NBT)-reducing reaction in PMN cells, but exhibited a suppressive effect to a variable extent on the Fc receptor-mediated uptake of haptenated liposomes opsonized with IgG, as judged by NBT reaction. The rank order in the suppressive activity was human > rat, sheep > rabbit. In parallel to their effect on phagocytosis, these glycoproteins were also found to suppress the alternative pathway of human complement which was initiated by IgG molecules attached to the same liposome surface. The results are taken to suggest that a molecular mechanism analogous to that in the complement cascade might also be involved in the phagocytic recognition system. [ABSTRACT FROM AUTHOR]

Published
1983

36. Inhibition of phagocytosis by erythrocyte membrane sialoglycoprotein on target liposomes.

Author

Utsumi, S., Shinomiya, H., Minami, J., and Sonoda, S.

Subjects
*PHAGOCYTOSIS, *ERYTHROCYTES, *GLYCOPROTEINS, *LIPOSOMES, *ERYTHROCYTE membranes, *BLOOD cells
Abstract

Sialoglycoprotein (GP) of human erythrocytes was incorporated into liposomes and its effect on the Fe receptor-mediated phagocytic reaction of human PMN cells was examined. Whereas liposomes carrying 2,4-dinitrophenylated lipid were, upon opsonization with rabbit anti-DNP, readily ingested by PMN cells and induced the NBT-reducing reaction, these reactions were markedly suppressed when GP was incorporated into the target liposomes. The inhibitory activity was found in the glycophorin A and B fractions, but the latter was more active than the former on a weight basis. It was estimated that incorporation of only a single molecule of GP per vesicle of 6000 lipid molecules may be sufficient to protect the particle from phagocytosis, hut there was an apparent antagonism between the suppressive GP and opsonizing antibody as, with more antibody, more GP became necessary to inhibit phagocytosis. The effect of GP was largely abolished by trypsin treatment of GP-bearing liposomes or by the addition of F(ab′)2 of anti-GP. [ABSTRACT FROM AUTHOR]

Published
1983

37. Understanding Japanese sardine migrations using acoustic and other aids.

Author

Tameishi, H., Shinomiya, H., Aoki, I., and Sugimoto, T.

Subjects
SARDINOPS sagax, KUROSHIO, OYASHIO Current, UNDERWATER acoustics, PHYTOPLANKTON, ZOOPLANKTON
Abstract

The migration routes of the Japanese sardine in the Kuroshio and Oyashio transition area were investigated using acoustic aids, satellite images, aerial observations, and commercial catch data. Japanese sardine schools were distributed in warm streamers, especially at their heads, where phytoplankton and zooplankton biomass were most heavily concentrated. These observations suggest that warm streamers play an important role in the northward migration of Japanese sardines. [ABSTRACT FROM PUBLISHER]

Published
1996
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