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Introduction: The effect of early initiation of gait training using hybrid assistive limb (HAL) remains unclear. This observational study aimed to investigate whether early initiation of gait training using HAL improves functional outcomes in patients with stroke. Methods: We retrospectively analyzed patients with acute stroke admitted to our facility. HAL was used for exoskeletal robotic gait training. Study participants were median split into an early group and a late group based on the days from stroke onset to initiation of gait training using HAL. The functional outcomes, defined by the Brunnstrom recovery stage (BRS), modified Rankin Scale (mRS), and Functional Independence Measure (FIM) at discharge, were compared using propensity score-matched analysis. Results: We performed a propensity score-matched analysis in 63 patients with stroke (31 from the early group and 32 from the late group), and 17 pairs were matched. There were no significant differences in discharge in the BRS of the upper limb and finger in the post-matched cohort. On the other hand, the BRS of the lower limb in the early group was significantly higher than that in the late group. In addition, the mRS, but not FIM scores, was significantly better in the early group than that in the late group. Conclusions: In conclusion, early initiation of gait training using HAL might improve the motor function of the paralyzed lower limb and disability in patients with stroke.

To determine how differences in frequency of the single-joint hybrid assistive limb (HAL-SJ) use affect the improvement of upper limb motor function and activities of daily living (ADL) in stroke patients.Subacute stroke patients were divided into the high or low frequency of HAL-SJ use groups. The two groups were matched by propensity score, and the degree of changes 30 days after initiating HAL-SJ use was compared. A logistic regression analysis was performed to examine whether frequent use would increase the number of subjects experiencing the efficacy of more than the minimal clinically important difference (MCID) of Fugl-Meyer assessment (FMA).Twenty-five stroke patients were matched by propensity score, and nine pairs were matched. The high-frequency group showed a significantly superior increase to total FMA shoulder, elbow, forearm, and Barthel index compared with the low-frequency group. Logistic regression analysis revealed no significant associations between frequent use and MCID.The frequency of HAL-SJ use may affect the improvement of motor function and ADL ability of the upper limb with exception of the fingers and wrist. However, the frequency of intervention was not effective enough to further increase the number of subjects with clinically meaningful changes in upper limb motor function.IMPLICATIONS FOR REHABILITATIONThe current study aimed to clarify how differences in the frequency of single-joint hybrid assistive limb (HAL-SJ) use can affect the improvement of upper-limb motor functions and ADL in subacute stroke patients.Our results implied that the frequency of HAL-SJ use may influence the recovery of upper limb function.However, even if HAL-SJ is used frequently, it does not mean that more patients will achieve clinically meaningful recovery.

The number of studies on the characteristics of patients with stroke who would benefit from robot-assisted upper limb rehabilitation is limited, and there are no clear criteria for determining which individuals should receive such treatment. The current study aimed to develop a clinical prediction rule using machine learning to identify the characteristics of patients with stroke who can the achieve minimal clinically important difference of the Fugl-Meyer Upper Extremity Evaluation (FMA-UE) after single-joint hybrid assistive limb (HAL-SJ) rehabilitation.This study included 71 patients with subacute stroke who received HAL-SJ rehabilitation. The chi-square automatic interaction detector (CHAID) model was applied to predict improvement in upper limb motor function. Based the analysis using CHAID, age, sex, days from stroke onset to the initiation of HAL-SJ rehabilitation, and upper limb motor and cognitive functions were used as independent variables. Improvement in upper limb motor function was determined based on the minimal clinically important difference of the FMA-UE, which was used as a dependent variable.According to the CHAID model, the FMA-UE score during the initiation of HAL-SJ rehabilitation was the most significant predictive factor for patients who are likely to respond to the intervention. Interestingly, this therapy was more effective in patients with moderate upper limb motor dysfunction and early initiation of HAL-SJ rehabilitation. The accuracy of the CHAID model was 0.89 (95% confidence interval: 0.81-0.96).We developed a clinical prediction rule for identifying the characteristics of patients with stroke whose upper limb motor function can improve with HAL-SJ rehabilitation.

The Hybrid Assistive Limb (HAL) is used in training to improve walking ability for stroke patients; however, the quality of the evidence for its effects has not been fully critiqued to date. This study conducted a systematic review of randomized controlled trials to investigate the effectiveness of post-stroke gait training with the HAL. PubMed, the Cochrane Library, the Physiotherapy Evidence Database (PEDro), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) were searched for randomized controlled clinical trials evaluating the effect of HAL on gait training in stroke patients, published from the inception of each database until March 2021. Two authors screened the titles and abstracts of articles returned in the initial search and reviewed the full text of articles that met the selection criteria. The risk of bias was assessed using the PEDro scale. Of 273 articles retrieved from the databases, three met all inclusion criteria. One study showed that gait training using HAL improves independence in walking; however, the quality of this study was rated as 4 (medium quality). Other studies did not show improvement with HAL in walking independence. This review did not provide strong evidence to support the effectiveness of HAL in improving walking ability.

In this paper we study non-symplectic automorphisms of order 6 on $K3$ surfaces which are not purely. In particular we shall describe their fixed loci.

During robot-assisted tasks, central nervous system may attend to external information-processing mode, termed as external attending. However, the neural mechanisms underlying this process remain unclear. The rostromedial prefrontal cortex (rmPFC) may be the core of an attentional control system that biases the allocation of attentional resources toward external information-processing when external attending is required for ongoing task performance. Here, we employed functional near-infrared spectroscopy to investigate hemodynamic responses in rmPFC subregions and additional frontal-parietal cortices during robot-assisted motor execution. Elbow flexion-extension movements, which require attention to kinematic consistency in range-of-motion, were employed as a motor task. Eighteen participants performed the task in three loading conditions requiring different degrees of external attending in ascending order: non-loading (NON), resistive loading (RES), and robotic assistive loading condition (ROB). Hemodynamic responses in the ventral and dorsal rmPFC were higher during ROB than during NON. Responses in the ventral rmPFC were significantly higher during ROB than during RES. Further, hemodynamic responses in the dorsal rmPFC during ROB were positively correlated with kinematic variability. These data suggest that robot-assisted motor execution involves rmPFC processes to bias the allocation of attentional resources toward external information-processing.

Purpose There is limited evidence of gait training using newly developed exoskeletal lower limb robot called Hybrid Assistive Limb (HAL) on the function and ability to perform ADL in stroke patients. In clinical settings, we frequently find it challenging to conduct a randomized controlled trial; thus, a large-scale observational study using propensity score analysis methods is a feasible alternative. The present study aimed to determine whether exoskeletal lower limb robot training improved the ability to perform ADL in stroke patients. Materials and methods Acute stroke patients who were admitted to our facility from April 2016 to March 2017 were evaluated in the conventional rehabilitation period (CRP) and those admitted from April 2017 to June 2019 were evaluated in the HAL rehabilitation period (HRP). We started a new gait rehabilitation program using HAL at the midpoint of these two periods. The functional outcomes or ADL ability outcomes of the patients in the CRP and the subsequent HRP were compared using propensity score matched analyses. Results Propensity score matching analysis was performed for 108 stroke patients (63 from the CRP and 45 from the HRP), and 36 pairs were matched. The ADL ability, defined by the FIM scores and FIM score change, was significantly higher in patients admitted during the HRP. In addition, more stroke patients obtained practical walking ability during hospitalization in the HRP. Conclusion Gait training using HAL affects the ADL ability and obtaining of practical walking ability of stroke patients.

Purpose: Previous studies have suggested that upper limb rehabilitation using therapeutic robots improves motor function of stroke patients. However, the effect of upper limb robotic rehabilitation on improving functioning in activities of daily living (ADL) remains unclear. The present study aimed to determine whether upper limb rehabilitation using single joint Hybrid Assistive Limb (HAL-SJ) affects ADL function and the use of a hemiparetic arm in ADLs of acute stroke patients. Materials and Methods: Twelve acute stroke patients participated in the study and were randomly divided into group A or group B. The patients in group A followed an A-B-A-B design and those in group B followed a B-A-B-A design. The patients received combination HAL-SJ and occupational therapy during A and conventional occupational therapy during B. Results: Upper limb motor function and ADLs, in particular, dressing the upper body, were improved during combination HAL-SJ and occupational therapy. Interestingly, the use of a hemiparetic arm in daily life evaluated using the motor activity log was also significantly improved during A in group A. Conclusions: Combination HAL-SJ and occupational therapy affects ADL function and real use of a hemiparetic arm in the daily life of acute stroke patients.

K 3 K3 surfaces with non-symplectic symmetry of order 3 3 are classified by open sets of twenty-four complex ball quotients associated to Eisenstein lattices. We show that twenty-two of those moduli spaces are rational.

It is known that a non-symplectic automorphism of order 32 on a K 3 surface does not act trivially on the Neron–Severi lattice. Oguiso gave an example of a K 3 surface with a non-symplectic automorphism of order 32 which acts on the Neron–Severi lattice as an involution. In this paper, we prove that a pair of a K 3 surface and its non-symplectic automorphism of order 32 is isomorphic to Oguiso’s example.

We treat non-symplectic automorphisms on $K3$ surfaces which act trivially on the N\'{e}ron-Severi lattice. In this paper, we classify non-symplectic automorphisms of prime-power order, especially 2-power order on $K3$ surfaces, i.e., we describe their fixed locus., Comment: 15 pages

We use classification of non-symplectic automorphisms of K3 surfaces to obtain a partial classification of log del Pezzo surfaces of index three. We can classify those with "Multiple Smooth Divisor Property", whose definition we will give. Our methods include the definition of right resolutions of quotient singularities of index three and some analysis of automorphism-stable elliptic fibrations on K3 surfaces. In particular we find several log del Pezzo surfaces of Picard number one with non-toric singularities of index three., 32 pages, to appear in Manuscripta Math

In this paper, we study non-symplectic automorphisms of order 3 on algebraic $K3$ surface over $\mathbb{C}$ which act trivially on the Neron-Severi lattice. In particular we shall characterize their fixed locus in terms of the invariants of 3-elementary lattices.

We classify K3 surfaces with non-symplectic automorphism of order 16 in full generality. We show that the fixed locus contains only rational curves and points and we completely classify the seven possible configurations. If the N\'eron-Severi group has rank 6, there are two possibilities and if its rank is 14, there are five possibilities. In particular if the action of the automorphism is trivial on the N\'eron-Severi group, then we show that its rank is six., Comment: 15 pages

We classify non-symplectic automorphisms of 3-power order on algebraic $K3$ surfaces which act trivially on the Neron-Severi lattice, i.e., we describe their fixed locus. Moreover we give Weierstrass equations of $K3$ surfaces with a non-symplectic automorphism of 3-power order.

In this note we present the classification of non-symplectic automorphisms of prime order on K3 surfaces, i.e.we describe the topological structure of their fixed locus and determine the invariant lattice in cohomology. We provide new results for automorphisms of order 5 and 7 and alternative proofs for higher orders. Moreover, for any prime p, we identify the irreducible components of the moduli space of K3 surfaces with a non-symplectic automorphism of order p., Comment: 28 pages; With an appendix by Shigeyuki Kondo. We add Smith exact sequences in the study of the fixed locus. To appear in Math. Z

We investigated the formation of a high-viscosity wormlike-micelle solution consisting of a mixed aqueous solution containing the cationic surfactant cetyltrimethylammonium bromide (CTAB) and sodiu...

Since liquid crystals have found wide use in liquid crystal displays, we try to apply liquid crystals to biotechnology. The purpose of this study is to describe the physical properties of the biopolymer DNA in regard to electrooptics. Synthetic oligonucleotide molecules were dispersed in a nematic liquid crystal (NLC). The ICP analyses showed that all of the oligonuleotide molecules added dispersed in the NLC. This sample was injected into the twisted nematic liquid crystal display cells, and then we measured its dielectric properties. The NLC doped with oligonucleotide molecules exhibited dielectric relaxation characteristics, depending on the concentration of oligonucleotide molecules. After analyzing this effect by using the equivalent circuit model, we found a difference in electrical conductivity between Watson–Crick base pairs (AT and GC). This result suggests that the difference might have contributed to the existence of a functional group involved in the hydrogen-bond interaction.