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2. IgG heavy chain allotype (Gm), a genetic marker for human chromosome 14q32, and haematopoietic malignancies

Author

Nakao, Y., Matsumoto, H., Tsuji, K., Miyazaki, T., Masaoka, T., Nakayama, S., Kinoshita, K., Shingami, T., Toshimitsu Matsui, and Fujita, T.

Subjects
Adult, Genetic Markers, Leukemia, Adolescent, Lymphoma, Middle Aged, Phenotype, hemic and lymphatic diseases, Immunoglobulin G, Humans, Disease Susceptibility, Immunoglobulin Allotypes, Immunoglobulin Heavy Chains, Chromosomes, Human, 13-15, Research Article, Aged
Abstract

IgG heavy chain constant region allotypes, Gm, the genetic marker of human chromosome 14q32, are markers for susceptibility to certain diseases. We tested Gm allotypes in 365 patients with various types of haematological malignancies, 528 healthy controls and 35 healthy HTLV carriers. The frequency of specific Gm phenotypes was significantly increased in patients with adult onset null-ALL, AML, AMoL and CML in blastic crisis. Among these diseases, the frequency of Gm1,2,21 haplotype was significantly increased with adult onset null-ALL, AML and AMoL.

Published
1984

13. [A case with gastric cancer by OK-MF'C therapy (author's transl)].

Author

Tomomatsu H, Morita N, Nagai T, Shiwaku Y, Shingami T, Miura Y, Kihara K, Nakao Y, Shimokawahara H, Hashimoto S, and Yunoki K

Subjects
Cytarabine administration & dosage, Drug Therapy, Combination, Fluorouracil administration & dosage, Humans, Male, Middle Aged, Mitomycins administration & dosage, Myocardial Infarction drug therapy, Picibanil administration & dosage, Adenocarcinoma drug therapy, Antineoplastic Agents administration & dosage, Stomach Neoplasms drug therapy
Published
1979

16. IgG heavy chain allotype (Gm), a genetic marker for human chromosome 14q32, and haematopoietic malignancies.

Author

Nakao Y, Matsumoto H, Tsuji K, Miyazaki T, Masaoka T, Nakayama S, Kinoshita K, Shingami T, Matsui T, and Fujita T

Subjects
Adolescent, Adult, Aged, Disease Susceptibility, Genetic Markers, Humans, Middle Aged, Phenotype, Chromosomes, Human, 13-15, Immunoglobulin Allotypes analysis, Immunoglobulin G analysis, Immunoglobulin Heavy Chains analysis, Leukemia immunology, Lymphoma immunology
Abstract

IgG heavy chain constant region allotypes, Gm, the genetic marker of human chromosome 14q32, are markers for susceptibility to certain diseases. We tested Gm allotypes in 365 patients with various types of haematological malignancies, 528 healthy controls and 35 healthy HTLV carriers. The frequency of specific Gm phenotypes was significantly increased in patients with adult onset null-ALL, AML, AMoL and CML in blastic crisis. Among these diseases, the frequency of Gm1,2,21 haplotype was significantly increased with adult onset null-ALL, AML and AMoL.

Published
1984

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