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4. Grundlagen der kinderärztlichen Betreuung

Author

Menzel, K., Fleischhacker, G., Wolff, J., Boehncke, H., Stemann, D., Brenner, W., Eichenwald, H. F., Shinefield, H. R., Lindner, G., Gleiss, J., Oberniedermayr, A., Biermann, G., Lassrich, M. A., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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14. Clinical effectiveness of seven-valent pneumococcal conjugate vaccine (Prevenar®) against invasive pneumococcal diseases: prospects for children in France

Author

Black, S., Shinefield, H., Cohen, R., Floret, D., Gaudelus, J., Olivier, C., and Reinert, P.

Abstract

A seven-valent pneumococcal polysaccharide—CRM197 carrier protein conjugate vaccine (PNC7V; Prevenar®, Wyeth, Paris) targets the serotypes (belonging to serogroups 14, 6, 19, 18, 23, 9, and 4) most often responsible for invasive pneumococcal disease (IPD) among children. A randomized, controlled, double-masked study among 37,868 children in northern California (Northern California Kaiser Permanente, USA) provided a per protocol vaccine efficacy value of 97.7% against invasive pediatric IPD due to the vaccine serotypes. The PNC7V vaccine was registered by the European Agency for the Evaluation of Medicinal Products (EMEA) in October 2000; a favorable “Community Marketing Decision” under the Centralized Procedure was granted in February 2001. PNC7V was recommended for most infants by the Conseil Supérieur d''Hygiène Publique de France in March 2002, on the advice of the Comité Technique des Vaccinations, as S. pneumoniae in children less than 2 years of age is the primary cause of bacterial meningitis and of mortality associated with community-acquired bacterial infections. The theoretical coverage of the vaccine towards pneumococcal invasive disease in France is about 80%, which represents one of the best serotype coverage estimates in Europe, and vaccines serotypes account for 90% of penicillin-nonsusceptible strains. Distinctive characteristics in France in terms of epidemiology, life style, and therapeutic attitudes justify a precise follow up of the consequences of the vaccination on a national level during the coming years. Hence, surveillance programs have been established: (i) to ascertain the future impact of large-scale PNC7V vaccination on invasive pneumococcal disease incidence, (ii) to follow the evolution of carriage and ecology of the pneumococcus, and (iii) to establish an active “vaccinovigilance”. [Copyright &y& Elsevier]

Published
2004
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17. Projected cost-effectiveness of pneumococcal conjugate vaccination of healthy infants and young children.

Author

Lieu, Tracy A., Ray, G. Thomas, Black, Steven B., Butler, Jay C., Klein, Jerome O., Breiman, Robert F., Miller, Mark A., Shinefield, Henry R., Lieu, T A, Ray, G T, Black, S B, Butler, J C, Klein, J O, Breiman, R F, Miller, M A, and Shinefield, H R

Subjects
PNEUMOCOCCAL vaccines, VACCINATION of infants, PUBLIC health, PREVENTIVE pediatrics
Abstract

Context: Pneumococcal conjugate vaccine for infants has recently been found effective against meningitis, bacteremia, pneumonia, and otitis media.Objective: To evaluate the projected health and economic impact of pneumococcal conjugate vaccination of healthy US infants and young children.Design: Cost-effectiveness analysis based on data from the Northern California Kaiser Permanente randomized trial and other published and unpublished sources.Setting and Patients: A hypothetical US birth cohort of 3.8 million infants.Interventions: Hypothetical comparisons of routine vaccination of healthy infants, requiring 4 doses of pneumococcal conjugate vaccine (at 2, 4, 6, and 12-15 months), and catch-up vaccination of children aged 2 to 4.9 years requiring 1 dose, with children receiving no intervention.Main Outcome Measures: Cost per life-year saved and cost per episode of meningitis, bacteremia, pneumonia, and otitis media prevented.Results: Vaccination of healthy infants would prevent more than 12000 cases of meningitis and bacteremia, 53000 cases of pneumonia, 1 million episodes of otitis media, and 116 deaths due to pneumococcal infection. Before accounting for vaccine costs, the vaccination program would save $342 million in medical and $415 million in work-loss and other costs from averted pneumococcal disease. Vaccination of healthy infants would result in net savings for society if the vaccine cost less than $46 per dose, and net savings for the health care payer if the vaccine cost less than $18 per dose. At the manufacturer's list price of $58 per dose, infant vaccination would cost society $80000 per life-year saved or $160 per otitis media episode prevented (other estimated costs would be $3200 per pneumonia case prevented, $15000 for bacteremia, and $280000 for meningitis). The cost-effectiveness of an additional program to administer 1 dose of vaccine to children aged 2 to 4.9 years would vary depending on the children's ages, relative risks of pneumococcal disease, and vaccine cost.Conclusions: Pneumococcal conjugate vaccination of healthy US infants has the potential to be cost-effective. To achieve cost savings, its cost would need to be lower than the manufacturer's list price. In addition to tangible costs, the vaccine should be appraised based on the less tangible value of preventing mortality and morbidity from pneumococcal disease. [ABSTRACT FROM AUTHOR]

Published
2000
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18. Immunization levels among premature and low-birth-weight infants and risk factors for delayed up-to-date immunization status. Centers for Disease Control and Prevention Vaccine Safety Datalink Group.

Author

Davis RL, Rubanowice D, Shinefield HR, Lewis N, Gu D, Black SB, DeStefano F, Gargiullo P, Mullooly JP, Thompson RS, Chen RT, Centers for Disease Control and Prevention. Vaccine Safety Datalink Group, Davis, R L, Rubanowice, D, Shinefield, H R, Lewis, N, Gu, D, Black, S B, DeStefano, F, and Gargiullo, P

Abstract

Context: Studies have noted that health care professionals may not conform to proper immunization schedules for premature and low-birth-weight infants in the United States. Little is known about the success of current efforts to immunize these high-risk infants.Objective: To describe current immunization practices for premature and low-birth-weight infants and ascertain risk factors for poor immunization status, using large population-based data sources.Design and Setting: Cohort and case-control analyses of immunization data tracked from March 1991 through March 1997 for 3 large health maintenance organizations (HMOs) participating in the Centers for Disease Control and Prevention's Vaccine Safety Datalink project.Participants: A total of 11580 low-birth-weight and premature infants were enrolled from birth to age 2 months; 6832 of these were continuously enrolled from birth to age 24 months. At age 2 months, there were 173373 full-term, normal-birth-weight infants enrolled as controls; at age 24 months, there were 103 324.Main Outcome Measures: Age-specific immunization status by prematurity and birth weight (<1500 g, 1500-2500 g, born at <38 weeks' gestation with birth weight of >2500 g, or full-term with normal birth weight) and patient characteristics associated with up-to-date status.Results: At each age, infants weighing less than 1500 g at birth had lower up-to-date immunization levels than other infants. At age 6 months, 52% to 65% of infants weighing less than 1500 g were up-to-date at each of the 3 HMOs compared with 69% to 73% of those weighing 1500 to 2500 g, 66% to 80% of premature infants weighing more than 2500 g, and 65% to 76% of full-term, normal-birth-weight infants. By age 24 months, 78% to 86% of infants weighing less than 1500 g were up-to-date, significantly less than heavier infants, who had levels of 84% to 89%. Well-child preventive care strongly predicted immunization status, while concomitant pulmonary disease did not.Conclusions: Our data suggest that infants born prematurely are vaccinated at levels approaching that of the general population, but levels of vaccination for very low-birth-weight infants lag slightly behind. [ABSTRACT FROM AUTHOR]

Published
1999
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20. Topical sphingolipids in antisepsis and antifungal therapy.

Author

Bibel, D. J., Aly, R., and Shinefield, H. R.

Subjects
SPHINGOLIPIDS, CANDIDA albicans, INFLAMMATION, ANTI-infective agents, SPHINGOSINE, LIPIDS, CANDIDA
Abstract

Sphingosine and sphinganinc, free sphingolipids of the stratum corneum, are, in vitro, strongly inhibitory for both bacteria and fungi. Whether or not they are suitable, indeed active, in vivo was examined: (i) on human volunteers, first as a preventative antiseptic against subsequently applied Staphylococcus aureas and Candida albicans, and second as a restorative antiseptic against the previously expanded normal skin flora, and (ii) on guinea-pigs as therapy for experimental C. albicans and Trichophyton mentagrophytes infections. In the antiseptic studies, which involved 200 μg/cm[SUP2] of sphinganine in ethanol (50 μl of a 1.6% solution), up to three-log reductions in the population of target micro-organisms were obtained, compared with vehicle and untreated controls (P < 0.001). The daily application of sphingosine as 1.5% ethanol petrolatum ointment was able to diminish inflammation slightly in dermatophyte-infected guinea-pigs (P=0.02 0.05), although the animals remained culture positive over the 3-week sampling period. The candida infections, treated daily with l.5%, sphinganine in ethanol, showed no improvement in inflammation compared with controls, except for 2 days of the 2-week observation period (P = 0.01-0.03), however, by the fourth day of therapy the yeast was eliminated in 75% of animals. No gross toxicity was observed among animals or human volunteers. These experiments further support simple sphingolipids as important antimicrobial agents of the cutaneous barrier and point toward a new biochemical approach in treating infectious disease. [ABSTRACT FROM AUTHOR]

Published
1995
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22. Bacterial adherence to nasal mucosal cells

Author

Aly, R, Shinefield, H I, Strauss, W G, and Maibach, H I

Abstract

The ability of several bacterial species to adhere to human nasal mucosal cells and their distribution on nasal mucosal surfaces was studied. Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Pseudomonas aeruginosa adhered to scraped nasal mucosal cells. In contrast, viridans streptococci and Klebsiella pneumoniae exhibited feeble or no adherence to nasal mucosal cells. S. aureus affinity for the nasal mucosal cells of carriers of S. aureus was greater than for those of the noncarriers (P less than 0.005). Heat treatment of S. aureus did not block, but slightly reduced, its binding to mucosal cells. The data suggest a high degree of specificity involved in the adherence of bacteria to nasal mucosal cells. The greater affinity of S. aureus for the nasal mucosal cells of carriers (than noncarriers) seems to be a property of mucosal cells rather than bacteria.

Published
1977
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30. Assessing the cost of pneumococcal disease and the cost-effectiveness of vaccination with PNCRM7.

Author

Black S and Shinefield H

Abstract

Streptococcus pneumoniae is the leading bacterial cause of sepsis, meningitis, pneumonia, and otitis media among children in the United States. In the Northern California Kaiser Permanente clinical trial with the pneumococcal saccharide conjugated vaccine, adsorbed* (PNCRM7), the pneumococcal conjugate vaccine was found to be highly effective against invasive disease and provided significant protection against otitis media and pneumonia. In addition to the efficacy component of the trial, an analysis of some of the costs associated with pneumococcal disease and the cost-effectiveness of vaccination was conducted. The cost-effectiveness of PNCRM7 was in the range of other routine preventive health measures. [ABSTRACT FROM AUTHOR]

Published
2002
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35. Soziale Betreuung des benachteiligten Kindes

Author

Krause-Lang, M., Göb, A., Straub, W., Aust, W., Loebell, E., Müller, M., Stollreiter, L., Rüdiger, E., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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36. Vor- und Fürsorge in den verschiedenen Altersstufen : Pränatale und perinatale Vor- und Fürsorge

Author

Pfeiffer, R. A., Döring, G. K., Schmid, F., Ehrengut-Lange, J., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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37. Vor- und Fürsorge für das Schul- und Jugendalter

Author

Rutenfranz, J., Schultze, W., Kühn, E., Maneke, M., Nitsch, K., Hellbrügge, Th., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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38. Säuglingsfürsorge und Säuglingsschutz

Author

Hellbrügge, Th., Pechstein, J., Ehrengut-Lange, J., Sager, C.-A., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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39. Vor- und Fürsorge im Kleinkindesalter

Author

Hellbrügge, Th., Pechstein, J., Ehrengut-Lange, J., Hetzer, H., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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40. Allgemeine Grundlagen

Author

Hellbrügge, Th., Pechstein, J., Hallermann, W., Maneke, M., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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41. Allgemeine Biostatistik des Kindesalters

Author

Hellbrügge, Th., Pechstein, J., Vogt, D., Müller, H., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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42. Anhang zu Vor- und Fürsorge für das Schul- und Jugendalter

Author

Hellbrügge, Th., Rutenfranz, J., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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43. Spezielle Probleme der pädiatrischen Biostatistik

Author

Pache, H.-D., Gleiss, J., van Randenborgh, H., Pechstein, J., Gädeke, R., Moll, H., Krause-Lang, M., Hallermann, W., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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44. Impfungen

Author

Windorfer, A., Ehrengut, W., Niggemeyer, H., Hansen, F., Wiesener, H., Spiess, H., Vivell, O., Sauthoff, R., Schmid, F., Hufnagl, D., Eyer, H., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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45. Spezielle Prophylaxe

Author

Droese, W., Stolley, H., Hellbrügge, Th., Pechstein, J., Gedicke, K., Held, A. J., Colombo, J. P., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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46. Der rheumatische Formenkreis

Author

Köttgen, U., Küster, F., Stoeber, E., Lincke, T., Schmid, F., Ewald, R., Wissler, H., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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47. Klinische Immunologie

Author

Damerow, R., Erdmann, G., Groër, Fr., Schmid, F., Schneider, W., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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48. Immunologische Grundlagen

Author

Schmid, F., Rapp, W., Opitz, H., editor, Schmid, F., editor, Hellbrügge, Th., editor, Aust, W., editor, Biermann, G., editor, Boehncke, H., editor, Brenner, W., editor, Colombo, J. P., editor, Damerow, R., editor, Döring, G. K., editor, Droese, W., editor, Ehrengut, W., editor, Ehrengut-Lange, J., editor, Eichenwald, H. F., editor, Erdmann, G., editor, Ewald, R., editor, Eyer, H., editor, Fleischhacker, G., editor, Gädeke, R., editor, Gedicke, K., editor, Gleiss, J., editor, Göb, A., editor, Groër, Fr., editor, Hallermann, W., editor, Hansen, F., editor, Held, A.-J., editor, Hetzer, H., editor, Hufnagl, D., editor, Köttgen, U., editor, Krause-Lang, M., editor, Kühn, E., editor, Küster, F., editor, Lassrich, M. A., editor, Lincke, T., editor, Lindner, G., editor, Loebell, E., editor, Maneke, M., editor, Menzel, K., editor, Moll, H., editor, Müller, H., editor, Müller, M., editor, Niggemeyer, H., editor, Nitsch, K., editor, Oberniedermayr, A., editor, Pache, H.-D., editor, Pechstein, J., editor, Pfeiffer, R. A., editor, van Randenborgh, H., editor, Rapp, W., editor, Rüdiger, E., editor, Rutenfranz, J., editor, Sager, C.-A., editor, Sauthoff, R., editor, Schneider, W., editor, Schultze, W., editor, Shinefield, H. R., editor, Spiess, H., editor, Stemann, D., editor, Stoeber, E., editor, Stolley, H., editor, Stollreiter, L., editor, Straub, W., editor, Vivell, O., editor, Vogt, D., editor, Wiesener, H., editor, Windorfer, A., editor, Wissler, H., editor, and Wolff, J., editor

Published
1966
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49. Risk of rheumatoid arthritis following vaccination with tetanus, influenza and hepatitis B vaccines among persons 15-59 years of age.

Author

Ray P, Black S, Shinefield H, Dillon A, Carpenter D, Lewis E, Ross P, Chen RT, Klein NP, and Baxter R

Subjects
Adolescent, Adult, California epidemiology, Case-Control Studies, Female, Hepatitis B Vaccines administration & dosage, Humans, Influenza Vaccines administration & dosage, Male, Middle Aged, Retrospective Studies, Risk Assessment, Tetanus Toxoid administration & dosage, Young Adult, Arthritis, Rheumatoid chemically induced, Arthritis, Rheumatoid epidemiology, Hepatitis B Vaccines adverse effects, Influenza Vaccines adverse effects, Tetanus Toxoid adverse effects, Vaccination adverse effects
Abstract

Background: Associations between vaccinations, particularly hepatitis B, and onset of rheumatoid arthritis (RA) have been reported, but examined in few large-scale studies., Method: Onset of RA cases and dates of vaccination against hepatitis B, tetanus, and influenza were identified in a retrospective chart review of approximately 1 million Kaiser Permanente Northern California members ages 15-59 years from 1997 through 1999. In a cohort analysis, rates of new-onset RA were compared between vaccinated and unvaccinated within 90, 180, and 365 days. In a case-control analysis, rates of vaccination during exposure intervals (90, 180, 365, and 730 days) were compared between cases and controls using conditional logistic regression., Results: 378 RA cases were included in the cohort analysis; 37 additional cases were included in the case-control analysis. In the cohort analysis the relative risks of RA onset within 90, 180, or 365 days of hepatitis B vaccination were not significant (R.R.=1.44, p=0.53; R.R.=1.67, p=0.22; R.R.=1.23, p=0.59 respectively). We found a possible association between RA and influenza vaccine in the previous 180 and 365 days in the cohort analysis (R.R=1.36, p=0.03; R.R.=1.34, p=0.01 respectively), but in the case-control analysis, cases were no more likely than controls to have received any of the three vaccines., Conclusions: In this large retrospective study we found no statistically significant association between exposure to hepatitis B vaccine and onset of RA. A possible association between RA and influenza vaccination in the cohort study was not borne out in the larger case-control analysis., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Published
2011
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50. The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children.

Author

Zhang T, Black S, Hao C, Ding Y, Ji W, Chen R, Lin Y, Eskola J, Shinefield H, Knoll MD, and Zhao G

Subjects
Child, Child, Preschool, False Positive Reactions, Female, Hospitals, Humans, Male, Nasopharynx microbiology, Pulmonary Medicine methods, Respiration, Suction adverse effects, Pneumonia diagnosis, Pneumonia microbiology, Pneumonia, Bacterial diagnosis, Pneumonia, Bacterial microbiology, Respiratory Tract Infections diagnosis, Respiratory Tract Infections microbiology
Abstract

Background: Acute lower respiratory infection (ALRI) is a major cause of hospitalization for children in China, while the etiological diagnosis of ALRI remains a challenge. This study was performed to evaluate the utility of the blind Nasotracheal aspiration (NTA) in the pathogen detection in ALRI through an evaluation of the test's specificity., Methodology/principal Findings: A hospital-based study of children ≤3 years was carried out from March 2006 through March 2007 in Suzhou University Affiliated Children's Hospital, including 379 cases with ALRI from the respiratory wards, and 394 controls receiving elective surgery. Nasopharyngeal swabs (NPS) and NTA specimens were taken on admission. S. pneumoniae was isolated from 10.3% of NTA samples from ALRI children, H. influenzae from 15.3%, and M. catarrhalis from 4.7%. The false positive rate--the strains from NTA in control group children--was 8.4% (95% CI: 5.8%-11.4%) for S. pneumoniae, 27.2% (95% CI: 22.7-31.5%) for H. influenzae, and 22.1% (95% CI: 18.0%-26.2%) for M. catarrhalis. The agreement between NPS and NTA in the control group was over 70%., Conclusion/significance: The blind NTA test is not a useful test for etiologic diagnosis of ALRI.

Published
2010
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