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9. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Author

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, Van Den Weyngaert D, Kaendler S, Krauseneck P, Vinolas N, Villa S, Wurm RE, Maillot MHB, Spagnolli F, Kantor G, Malhaire JP, Renard L, De Witte O, Scandolaro L, Vecht CJ, Maingon P, Lutterbach J, Kobierska A, Bolla M, Souchon R, Mitine C, Tzuk-Shina T, Kuten A, Haferkamp G, de Greve J, Priou F, Menten J, Rutten I, Clavere P, Malmstrom A, Jancar B, Newlands E, Pigott K, Twijnstra A, Chinot O, Reni M, Boiardi A, Fabbro M, Campone M, Bozzino J, Frenay M, Gijtenbeek J, Delattre JY, De Paula U, Hanzen C, Pavanato G, Schraub S, Pfeffer R, Soffietti R, Kortmann RD, Taphoorn M, Torrecilla JL, Grisold W, Huget P, Forsyth P, Fulton D, Kirby S, Wong R, Fenton D, Cairncross G, Whitlock P, Burdette-Radoux S, Gertler S, Saunders S, Laing K, Siddiqui J, Martin LA, Gulavita S, Perry J, Mason W, Thiessen B, Pai H, Alam ZY, Eisenstat D, Mingrone W, Hofer S, Pesce G, Dietrich PY, Thum P, Baumert B, Ryan G, Stupp, R, Mason, Wp, van den Bent, Mj, Weller, M, Fisher, B, Taphoorn, Mjb, Belanger, K, Brandes, Aa, Marosi, C, Bogdahn, U, Curschmann, J, Janzer, Rc, Ludwin, Sk, Gorlia, T, Allgeier, A, Lacombe, D, Cairncross, Jg, Eisenhauer, E, Mirimanoff, Ro, Van Den Weyngaert, D, Kaendler, S, Krauseneck, P, Vinolas, N, Villa, S, Wurm, Re, Maillot, Mhb, Spagnolli, F, Kantor, G, Malhaire, Jp, Renard, L, De Witte, O, Scandolaro, L, Vecht, Cj, Maingon, P, Lutterbach, J, Kobierska, A, Bolla, M, Souchon, R, Mitine, C, Tzuk-Shina, T, Kuten, A, Haferkamp, G, de Greve, J, Priou, F, Menten, J, Rutten, I, Clavere, P, Malmstrom, A, Jancar, B, Newlands, E, Pigott, K, Twijnstra, A, Chinot, O, Reni, M, Boiardi, A, Fabbro, M, Campone, M, Bozzino, J, Frenay, M, Gijtenbeek, J, Delattre, Jy, De Paula, U, Hanzen, C, Pavanato, G, Schraub, S, Pfeffer, R, Soffietti, R, Kortmann, Rd, Taphoorn, M, Torrecilla, Jl, Grisold, W, Huget, P, Forsyth, P, Fulton, D, Kirby, S, Wong, R, Fenton, D, Cairncross, G, Whitlock, P, Burdette-Radoux, S, Gertler, S, Saunders, S, Laing, K, Siddiqui, J, Martin, La, Gulavita, S, Perry, J, Mason, W, Thiessen, B, Pai, H, Alam, Zy, Eisenstat, D, Mingrone, W, Hofer, S, Pesce, G, Dietrich, Py, Thum, P, Baumert, B, Ryan, G, Neurology, and Plastic and Reconstructive Surgery and Hand Surgery

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Adrenal Cortex Hormones, Adrenal Cortex Hormones/therapeutic use Adult Aged Antineoplastic Agents, Alkylating/adverse effects/*therapeutic use Brain Neoplasms/*drug therapy/mortality/*radiotherapy Chemotherapy, Adjuvant Dacarbazine/adverse effects/*analogs & derivatives/*therapeutic use Disease Progression Female Glioblastoma/*drug therapy/mortality/*radiotherapy Humans Male Middle Aged Proportional Hazards Models Radiotherapy, Computer-Assisted/adverse effects Survival Analysis, medicine, Temozolomide, Humans, Survival rate, Pseudoprogression, Antineoplastic Agents, Alkylating, Aged, Proportional Hazards Models, business.industry, Brain Neoplasms, Hazard ratio, General Medicine, Middle Aged, Debulking, medicine.disease, Survival Analysis, Radiotherapy, Computer-Assisted, Surgery, Radiation therapy, Dacarbazine, Chemotherapy, Adjuvant, Concomitant, Disease Progression, Female, business, Glioblastoma, medicine.drug, Anaplastic astrocytoma
Abstract

BACKGROUND: Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety. METHODS: Patients with newly diagnosed, histologically confirmed glioblastoma were randomly assigned to receive radiotherapy alone (fractionated focal irradiation in daily fractions of 2 Gy given 5 days per week for 6 weeks, for a total of 60 Gy) or radiotherapy plus continuous daily temozolomide (75 mg per square meter of body-surface area per day, 7 days per week from the first to the last day of radiotherapy), followed by six cycles of adjuvant temozolomide (150 to 200 mg per square meter for 5 days during each 28-day cycle). The primary end point was overall survival. RESULTS: A total of 573 patients from 85 centers underwent randomization. The median age was 56 years, and 84 percent of patients had undergone debulking surgery. At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12.1 months with radiotherapy alone. The unadjusted hazard ratio for death in the radiotherapy-plus-temozolomide group was 0.63 (95 percent confidence interval, 0.52 to 0.75; P

Published
2005
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10. Measurement of charged jet production cross sections and nuclear modification in p–Pb collisions at sNN=5.02 TeV

Author

Adam, J, Adamova, D, Aggarwal, Mm, Rinella, Ga, Agnello, M, Agrawal, N, Ahammed, Z, Ahn, Su, Aimo, I, Aiola, S, Ajaz, M, Akindinov, A, Alam, Sn, Aleksandrov, D, Alessandro, B, Alexandre, D, Molina, Ra, Alici, A, Alkin, A, Alme, J, Alt, T, Altinpinar, S, Altsybeev, I, Prado, Cag, Andrei, C, Andronic, A, Anguelov, V, Anielski, J, Anticic, T, Antinori, F, Antonioli, P, Aphecetche, L, Appelshauser, H, Arcelli, S, Armesto, N, Arnaldi, R, Aronsson, T, Arsene, Ic, Arslandok, M, Augustinus, A, Averbeck, R, Azmi, Md, Bach, M, Badala, A, Baek, Yw, Bagnasco, S, Bailhache, R, Bala, R, Baldisseri, A, Pedrosa, Fbds, Baral, Rc, Barbano, Am, Barbera, Roberto, Barile, F, Barnaoldi, Gg, Barnby, Ls, Barret, V, Bartalini, P, Bartke, J, Bartsch, E, Basile, M, Bastid, N, Basu, S, Bathen, B, Batigne, G, Batistacamejo, A, Batyunya, B, Batzing, Pc, Bearden, Ig, Beck, H, Bedda, C, Behera, Nk, Belikov, I, Bellini, F, Martinez, Hb, Bellwied, R, Belmont, R, Belmont Moreno, E, Belyaev, V, Bencedi, G, Beole, S, Berceanu, I, Bercuci, A, Berdnikov, Y, Berenyi, D, Bertens, Ra, Berzano, D, Betev, L, Bhasin, A, Bhat, Ir, Bhati, Ak, Bhattacharjee, B, Bhom, J, Bianchi, L, Bianchi, N, Bianchin, C, Bielcik, J, Bielcikova, J, Bilandzic, A, Biswas, S, Bjelogrlic, S, Blanco, F, Blau, D, Blume, C, Bock, F, Bogdanov, A, Boggild, H, Boldizsar, L, Bombara, M, Book, J, Borel, H, Borissov, A, Borri, M, Bossu, F, Botje, M, Botta, E, Bottger, S, Braun Munzinger, P, Bregant, M, Breitner, T, Broker, Ta, Browning, Ta, Broz, M, Brucken, Ej, Bruna, E, Bruno, Ge, Budnikov, D, Buesching, H, Bufalino, S, Buncic, P, Busch, O, Buthelezi, Z, Buxton, Jt, Caffarri, D, Cai, X, Caines, H, Diaz, Lc, Caliva, A, Villar, Ec, Camerini, P, Carena, F, Carena, W, Castellanos, Jc, Castro, Aj, Casula, Ear, Cavicchioli, C, Sanchez, Cc, Cepila, J, Cerello, P, Chang, B, Chapeland, S, Chartier, M, Charvet, Jl, Chattopadhyay, S, Chelnokov, V, Cherney, M, Cheshkov, C, Cheynis, B, Barroso, Vc, Chinellato, Dd, Chochula, P, Choi, K, Chojnacki, M, Choudhury, S, Christakoglou, P, Christensen, Ch, Christiansen, P, Chujo, T, Chung, Su, Chunhui, Z, Cicalo, C, Cifarelli, L, Cindolo, F, Cleymans, J, Colamaria, F, Colella, D, Collu, A, Colocci, M, Balbastre, Gc, del Valle ZC, Connors, Me, Contreras, Jg, Cormier, Tm, Morales, Yc, Maldonado, Ic, Cortese, P, Cosentino, Mr, Costa, F, Crochet, P, Albino, Rc, Cuautle, E, Cunqueiro, L, Dahms, T, Dainese, A, Danu, A, Das, D, Das, I, Das, S, Dash, A, Dash, S, De, S, De Caro, A, de Cataldo, G, de Cuveland, J, Falco A, D., De Gruttola, D, De Marco, N, De Pasquale, S, Deisting, A, Deloff, A, Denes, E, D'Erasmo, G, Di Bari, D, Di Mauro, A, Di Nezza, P, Diaz Corchero MA, Dietel, T, Dillenseger, P, Divia, R, Djuvsland, O, Dobrin, A, Dobrowolski, T, Domenicisgimenez, D, Donigus, B, Dordic, O, Dubey, Ak, Dubla, A, Ducroux, L, Dupieux, P, Ehlers, Rj, Elia, D, Engel, H, Erazmus, B, Erhardt, F, Eschweiler, D, Espagnon, B, Estienne, M, Esumi, S, Eum, J, Evans, D, Evdokimov, S, Eyyubova, G, Fabbietti, L, Fabris, D, Faivre, J, Fantoni, A, Fasel, M, Feldkamp, L, Felea, D, Feliciello, A, Feofilov, G, Ferencei, J, Tellez, Af, Ferreiro, Eg, Ferretti, A, Festanti, A, Figiel, J, Figueredo, Mas, Filchagin, S, Finogeev, D, Fionda, Fm, Fiore, Em, Fleck, Mg, Floris, M, Foertsch, S, Foka, P, Fokin, S, Fragiacomo, E, Francescon, A, Frankenfeld, U, Fuchs, U, Furget, C, Furs, A, Girard, Mf, Gaardhoje, Jj, Gagliardi, M, Gago, Am, Gallio, M, Gangadharan, Dr, Ganoti, P, Gao, C, Garabatos, C, Garcia Solis, E, Gargiulo, C, Gasik, P, Germain, M, Gheata, A, Gheata, M, Ghosh, P, Ghosh, Sk, Gianotti, P, Giubellino, P, Giubilato, P, Gladysz Dziadus, E, Glassel, P, Gomez Ramirez, A, Gonzalez Zamora, P, Gorbunov, S, Gorlich, L, Gotovac, S, Grabski, V, Graczykowski, Lk, Grelli, A, Grigoras, A, Grigoras, C, Grigoriev, V, Grigoryan, A, Grigoryan, S, Grinyov, B, Grion, N, Grosse Oetringhaus JF, Grossiord, Jy, Grosso, R, Guber, F, Guernane, R, Guerzoni, B, Gulbrandsen, K, Gulkanyan, H, Gunji, T, Gupta, A, Gupta, R, Haake, R, Haaland, O, Hadjidakis, C, Haiduc, M, Hamagaki, H, Hamar, G, Hanratty, Ld, Hansen, A, Harris, Jw, Hartmann, H, Harton, A, Hatzifotiadou, D, Hayashi, S, Heckel, St, Heide, M, Helstrup, H, Herghelegiu, A, Corral, Gh, Hess, Ba, Hetland, Kf, Hilden, Te, Hillemanns, H, Hippolyte, B, Hristov, P, Huang, M, Humanic, Tj, Hussain, N, Hussain, T, Hutter, D, Hwang, Ds, Ilkaev, R, Ilkiv, I, Inaba, M, Ionita, C, Ippolitov, M, Irfan, M, Ivanov, M, Ivanov, V, Izucheev, V, Jacobs, Pm, Jahnke, C, Jang, Hj, Janik, Ma, Jayarathna, Phsy, Jena, C, Jena, S, Bustamante, Rtj, Jones, Pg, Jung, H, Jusko, A, Kalinak, P, Kalweit, A, Kamin, J, Kang, Jh, Kaplin, V, Kar, S, Uysal, Ak, Karavichev, O, Karavicheva, T, Karpechev, E, Kebschull, U, Keidel, R, Keijdener, Dld, Keil, M, Khan, Kh, Khan, Mm, Khan, P, Khan, Sa, Khanzadeev, A, Kharlov, Y, Kileng, B, Kim, B, Kim, Dw, Kim, Dj, Kim, H, Kim, Js, Kim, M, Kim, S, Kim, T, Kirsch, S, Kisel, I, Kiselev, S, Kisiel, A, Kiss, G, Klay, Jl, Klein, C, Klein, J, Klein Boing, C, Kluge, A, Knichel, Ml, Knospe, Ag, Kobayashi, T, Kobdaj, C, Kofarago, M, Kohler, Mk, Kollegger, T, Kolojvari, A, Kondratiev, V, Kondratyeva, N, Kondratyuk, E, Konevskikh, A, Kouzinopoulos, C, Kovalenko, O, Kovalenko, V, Kowalski, M, Kox, S, Meethaleveedu, Gk, Kral, J, Kralik, I, Kravcakova, A, Krelina, M, Kretz, M, Krivda, M, Krizek, F, Kryshen, E, Krzewicki, M, Kubera, Am, Kucera, V, Kugathasan, T, Kuhn, C, Kuijer, Pg, Kulakov, I, Kumar, J, Kumar, L, Kurashvili, P, Kurepin, A, Kurepin, Ab, Kuryakin, A, Kushpil, S, Kweon, Mj, Kwon, Y, La Pointe SL, LA ROCCA, Paola, Lagana Fernandes, C, Lakomov, I, Langoy, R, Lara, C, Lardeux, A, Lattuca, A, Laudi, E, Lea, R, Leardini, L, Lee, Gr, Lee, S, Legrand, I, Lemmon, Rc, Lenti, V, Leogrande, E, Monozn, Il, Leoncino, M, Levai, P, Li, S, Li, X, Lien, J, Lietava, R, Lindal, S, Lindenstruth, V, Lippmann, C, Lisa, Ma, Ljunggren, Hm, Lodato, Df, Loenne, Pi, Loggins, Vr, Loginov, V, Loizides, C, Lopez, X, Lopez Torres, E, Lowe, A, Luettig, P, Lunardon, M, Luparello, G, Luz, Phfnd, Maevskaya, A, Mager, M, Mahajan, S, Mahmood, Sm, Maire, A, Majka, Rd, Malaev, M, Maldonadocervantes, I, Malinina, L, Mal'Kevich, D, Malzacher, P, Mamonov, A, Manceau, L, Manko, V, Manso, F, Manzari, V, Marchisone, M, Mares, J, Margagliotti, Gv, Margotti, A, Margutti, J, Marin, A, Markert, C, Marquard, M, Martin, Na, Martin Blanco, J, Martinengo, P, Martinez, Mi, Martinez Garcia, G, Pedreira, Mm, Martynov, Y, Mas, A, Masciocchi, S, Masera, M, Masoni, A, Massacrier, L, Mastroserio, A, Masui, H, Matyja, A, Mayer, C, Mazer, J, Mazzoni, Ma, Mcdonald, D, Meddi, F, Menchaca Rocha, A, Meninno, E, Mercado Perez, J, Meres, M, Miake, Y, Mieskolainen, Mm, Mikhaylov, K, Milano, L, Milosevic, J, Minervini, Lm, Mischke, A, Mishra, An, Miskowiec, D, Mitra, J, Mitu, Cm, Mohammadi, N, Mohanty, B, Molnar, L, Montano Zetina, L, Montes, E, Morando, M, De Godoy DAM, Moretto, S, Morreale, A, Morsch, A, Muccifora, V, Mudnic, E, Muhlheim, D, Muhuri, S, Mukherjee, M, Muller, H, Mulligan, Jd, Munhoz, Mg, Murray, S, Musa, L, Musinsky, J, Nandi, Bk, Nania, R, Nappi, E, Naru, Mu, Nattrass, C, Nayak, K, Nayak, Tk, Nazarenko, S, Nedosekin, A, Nellen, L, Ng, F, Nicassio, M, Niculescu, M, Niedziela, J, Nielsen, Bs, Nikolaev, S, Nikulin, S, Nikulin, V, Noferini, F, Nomokonov, P, Nooren, G, Norman, J, Nyanin, A, Nystrand, J, Oeschler, H, Oh, S, Oh, Sk, Ohlson, A, Okatan, A, Okubo, T, Olah, L, Oleniacz, J, Oliveira Da Silva AC, Oliver, Mh, Onderwaater, J, Oppedisano, C, Ortizvelasquez, A, Oskarsson, A, Otwinowski, J, Oyama, K, Ozdemir, M, Pachmayer, Y, Pagano, P, Paic, G, Pajares, C, Pal, Sk, Pan, J, Pandey, Ak, Pant, D, Papikyan, V, Pappalardo, Gs, Pareek, P, Park, Wj, Parmar, S, Passfeld, A, Paticchio, V, Paul, B, Peitzmann, T, Da Costa HP, De Oliveira EP, Peresunko, D, Perez Lara CE, Peskov, V, Pestov, Y, Petracek, V, Petrov, V, Petrovici, M, Petta, Catia Maria Annunziata, Piano, S, Pikna, M, Pillot, P, Pinazza, O, Pinsky, L, Piyarathna, Db, Ploskon, M, Planinic, M, Pluta, J, Pochybova, S, Podesta Lerma PLM, Poghosyan, Mg, Polichtchouk, B, Poljak, N, Poonsawat, W, Pop, A, Porteboeuf Houssais, S, Porter, J, Pospisil, J, Prasad, Sk, Preghenella, R, Prino, F, Pruneau, Ca, Pshenichnov, I, Puccio, M, Puddu, G, Pujahari, P, Punin, V, Putschke, J, Qvigstad, H, Rachevski, A, Raha, S, Rajput, S, Rak, J, Rakotozafindrabe, A, Ramello, L, Raniwala, R, Raniwala, S, Rasanen, Ss, Rascanu, Bt, Rathee, D, Read, Kf, Real, Js, Redlich, K, Reed, Rj, Rehman, A, Reichelt, P, Reicher, M, Reidt, F, Ren, X, Renfordt, R, Reolon, Ar, Reshetin, A, Rettig, F, Revol, Jp, Reygers, K, Riabov, V, Ricci, Ra, Richert, T, Richter, M, Riedler, P, Riegler, W, Riggi, Francesco, Ristea, C, Rivetti, A, Rocco, E, Rodriguez Cahuantzi, M, Rodriguez Manso, A, Roed, K, Rogochaya, E, Rohr, D, Rohrich, D, Romita, R, Ronchetti, F, Ronflette, L, Rosnet, P, Rossi, A, Roukoutakis, F, Roy, A, Roy, C, Roy, P, Rubio Montero AJ, Rui, R, Russo, R, Ryabinkin, E, Ryabov, Y, Rybicki, A, Sadovsky, S, Safarik, K, Sahlmuller, B, Sahoo, P, Sahoo, R, Sahoo, S, Sahu, Pk, Saini, J, Sakai, S, Saleh, Ma, Salgado, Ca, Salzwedel, J, Sambyal, S, Samsonov, V, Sanchez Castro, X, Sandor, L, Sandoval, A, Sano, M, Santagati, G, Sarkar, D, Scapparone, E, Scarlassara, F, Scharenberg, Rp, Schiaua, C, Schicker, R, Schmidt, C, Schmidt, Hr, Schuchmann, S, Schukraft, J, Schulc, M, Schuster, T, Schutz, Y, Schwarz, K, Schweda, K, Scioli, G, Scomparin, E, Scott, R, Seeder, Ks, Seger, Je, Sekiguchi, Y, Selyuzhenkov, I, Senosi, K, Seo, J, Serradilla, E, Sevcenco, A, Shabanov, A, Shabetai, A, Shadura, O, Shahoyan, R, Shangaraev, A, Sharma, A, Sharma, N, Shigaki, K, Shtejer, K, Sibiriak, Y, Siddhanta, S, Sielewicz, Km, Siemiarczuk, T, Silvermyr, D, Silvestre, C, Simatovic, G, Simonetti, G, Singaraju, R, Singh, R, Singha, S, Singhal, V, Sinha, Bc, Shina, T, Sitar, B, Sitta, M, Skaali, Tb, Slupecki, M, Smirnov, N, Snellings, Rjm, Snellman, Tw, Sogaard, C, Soltz, R, Song, J, Song, M, Song, Z, Soramel, F, Sorensen, S, Spacek, M, Spiriti, E, Sputowska, I, Spyropoulou Stassinaki, M, Srivastava, Bk, Stachel, J, Stan, I, Stefanek, G, Steinpreis, M, Stenlund, E, Steyn, G, Stiller, Jh, Stocco, D, Strmen, P, Suaide, Aap, Sugitate, T, Suire, C, Suleymanov, M, Sultanov, R, Sumbera, M, Symons, Tjm, Szabo, A, de Toledo AS, Szarka, I, Szczepankiewicz, A, Szymanski, M, Takahashi, J, Tanaka, N, Tangaro, Ma, Takaki, Jdt, Tarantola Peloni, A, Tariq, M, Tarzila, Mg, Tauro, A, Munoz, G, Telesca, A, Terasaki, K, Terrevoli, C, Teyssier, B, Thader, J, Thomas, D, Tieulent, R, Timmins, Ar, Toia, A, Trogolo, S, Trubnikov, V, Trzaska, Wh, Tsuji, T, Tumkin, A, Turrisi, R, Tveter, Ts, Ullaland, K, Uras, A, Usai, Gl, Utrobicic, A, Vajzer, M, Vala, M, Valencia Palomo, L, Vallero, S, Van Der Maarel, J, Van Hoorne JW, van leeuwen, M, Vanat, T, Vande Vyvre, P, Varga, D, Vargas, A, Vargyas, M, Varma, R, Vasileiou, M, Vasiliev, A, Vauthier, A, Vechernin, V, Veen, Am, Veldhoen, M, Velure, A, Venaruzzo, M, Vercellin, E, Vergara Limon, S, Vernet, R, Verweij, M, Vickovic, L, Viesti, G, Viinikainen, J, Vilakazi, Z, Villalobos Baillie, O, Vinogradov, A, Vinogradov, L, Vinogradov, Y, Virgili, T, Vislavicius, V, Viyogi, Yp, Vodopyanov, A, Volkl, Ma, Voloshin, K, Voloshin, Sa, Volpe, G, von Haller, B, Vorobyev, I, Vranic, D, Vrlakova, J, Vulpescu, B, Vyushin, A, Wagner, B, Wagner, J, Wang, H, Wang, M, Wang, Y, Watanabe, D, Weber, M, Weber, Sg, Wessels, Jp, Westerhoff, U, Wiechula, J, Wikne, J, Wilde, M, Wilk, G, Wilkinson, J, Williams, Mcs, Windelband, B, Winn, M, Yaldo, Cg, Yamaguchi, Y, Yang, H, Yang, P, Yano, S, Yin, Z, Yokoyama, H, Yoo, Ik, Yurchenko, V, Yushmanov, I, Zaborowska, A, Zaccolo, V, Zaman, A, Zampolli, C, Zanoli, Hjc, Zaporozhets, S, Zarochentsev, A, Zavada, P, Zaviyalov, N, Zbroszczyk, H, Zgura, Is, Zhalov, M, Zhang, H, Zhang, X, Zhang, Y, Zhao, C, Zhigareva, N, Zhou, D, Zhou, Y, Zhou, Z, Zhu, H, Zhu, J, Zhu, X, Zichichi, A, Zimmermann, A, Zimmermann, Mb, Zinovjev, G, and Zyzak, M.

Subjects
Nuclear and High Energy Physics, Astrophysics::High Energy Astrophysical Phenomena, nuclear modification factor, Nuclear and High Energy Physics, charged jet production cross section, nuclear modification factor, p-Pb collisions, PPB COLLISIONS, lcsh:QC1-999, p-Pb collisions, DEPENDENCE, SIDE, High Energy Physics::Experiment, TRANSVERSE-MOMENTUM DISTRIBUTIONS, RANGE ANGULAR-CORRELATIONS, LONG-RANGE, PARTICLE PRODUCTION, PPB COLLISIONS, SUPPRESSION, DEPENDENCE, SIDE, PARTICLE PRODUCTION, charged jet production cross section, LONG-RANGE, Nuclear Experiment, TRANSVERSE-MOMENTUM DISTRIBUTIONS, lcsh:Physics, RANGE ANGULAR-CORRELATIONS, SUPPRESSION
Abstract

Charged jet production cross sections in p–Pb collisions at sNN=5.02 TeV measured with the ALICE detector at the LHC are presented. Using the anti-kT algorithm, jets have been reconstructed in the central rapidity region from charged particles with resolution parameters R=0.2 and R=0.4. The reconstructed jets have been corrected for detector effects and the underlying event background. To calculate the nuclear modification factor, RpPb, of charged jets in p–Pb collisions, a pp reference was constructed by scaling previously measured charged jet spectra at s=7 TeV. In the transverse momentum range 20≤pT,chjet≤120 GeV/c, RpPb is found to be consistent with unity, indicating the absence of strong nuclear matter effects on jet production. Major modifications to the radial jet structure are probed via the ratio of jet production cross sections reconstructed with the two different resolution parameters. This ratio is found to be similar to the measurement in pp collisions at s=7 TeV and to the expectations from PYTHIA pp simulations and NLO pQCD calculations at sNN=5.02 TeV.

Published
2015

11. Measurement of charged jet production cross sections and nuclear modification in p-Pb collisions at root s(NN)=5.02 TeV

Author

Adam, J, Adamova, D, Aggarwal, Mm, Rinella, Ga, Agnello, M, Agrawal, N, Ahammed, Z, Ahn, Su, Aimo, I, Aiola, S, Ajaz, M, Akindinov, A, Alam, Sn, Aleksandrov, D, Alessandro, B, Alexandre, D, Molina, Ra, Alici, A, Alkin, A, Alme, J, Alt, T, Altinpinar, S, Altsybeev, I, Prado, Cag, Andrei, C, Andronic, A, Anguelov, V, Anielski, J, Anticic, T, Antinori, F, Antonioli, P, Aphecetche, L, Appelshauser, H, Arcelli, S, Armesto, N, Arnaldi, R, Aronsson, T, Arsene, Ic, Arslandok, M, Augustinus, A, Averbeck, R, Azmi, Md, Bach, M, Badala, A, Baek, Yw, Bagnasco, S, Bailhache, R, Bala, R, Baldisseri, A, Pedrosa, Fbds, Baral, Rc, Barbano, Am, Barbera, R, Barile, F, Barnaoldi, Gg, Barnby, Ls, Barret, V, Bartalini, P, Bartke, J, Bartsch, E, Basile, M, Bastid, N, Basu, S, Bathen, B, Batigne, G, Batistacamejo, A, Batyunya, B, Batzing, Pc, Bearden, Ig, Beck, H, Bedda, C, Behera, Nk, Belikov, I, Bellini, F, Martinez, Hb, Bellwied, R, Belmont, R, Belmont-Moreno, E, Belyaev, V, Bencedi, G, Beole, S, Berceanu, I, Bercuci, A, Berdnikov, Y, Berenyi, D, Bertens, Ra, Berzano, D, Betev, L, Bhasin, A, Bhat, Ir, Bhati, Ak, Bhattacharjee, B, Bhom, J, Bianchi, L, Bianchi, N, Bianchin, C, Bielcik, J, Bielcikova, J, Bilandzic, A, Biswas, S, Bjelogrlic, S, Blanco, F, Blau, D, Blume, C, Bock, F, Bogdanov, A, Boggild, H, Boldizsar, L, Bombara, M, Book, J, Borel, H, Borissov, A, Borri, M, Bossu, F, Botje, M, Botta, E, Bottger, S, Braun-Munzinger, P, Bregant, M, Breitner, T, Broker, Ta, Browning, Ta, Broz, M, Brucken, Ej, Bruna, E, Bruno, Ge, Budnikov, D, Buesching, H, Bufalino, S, Buncic, P, Busch, O, Buthelezi, Z, Buxton, Jt, Caffarri, D, Cai, X, Caines, H, Diaz, Lc, Calivà, A, Villar, Ec, Camerini, P, Carena, F, Carena, W, Castellanos, Jc, Castro, Aj, Casula, Ear, Cavicchioli, C, Sanchez, Cc, Cepila, J, Cerello, P, Chang, B, Chapeland, S, Chartier, M, Charvet, Jl, Chattopadhyay, S, Chelnokov, V, Cherney, M, Cheshkov, C, Cheynis, B, Barroso, Vc, Chinellato, Dd, Chochula, P, Choi, K, Chojnacki, M, Choudhury, S, Christakoglou, P, Christensen, Ch, Christiansen, P, Chujo, T, Chung, Su, Chunhui, Z, Cicalo, C, Cifarelli, L, Cindolo, F, Cleymans, J, Colamaria, F, Colella, D, Collu, A, Colocci, M, Balbastre, Gc, del Valle ZC, Connors, Me, Contreras, Jg, Cormier, Tm, Morales, Yc, Maldonado, Ic, Cortese, P, Cosentino, Mr, Costa, F, Crochet, P, Albino, Rc, Cuautle, E, Cunqueiro, L, Dahms, T, Dainese, A, Danu, A, Das, D, Das, I, Das, S, Dash, A, Dash, S, De, S, De Caro, A, de Cataldo, G, de Cuveland, J, D Falco A, De Gruttola, D, De Marco, N, De Pasquale, S, Deisting, A, Deloff, A, Denes, E, D'Erasmo, G, Di Bari, D, Di Mauro, A, Di Nezza, P, Diaz Corchero MA, Dietel, T, Dillenseger, P, Divia, R, Djuvsland, O, Dobrin, A, Dobrowolski, T, Domenicisgimenez, D, Donigus, B, Dordic, O, Dubey, Ak, Dubla, A, Ducroux, L, Dupieux, P, Ehlers, Rj, Elia, D, Engel, H, Erazmus, B, Erhardt, F, Eschweiler, D, Espagnon, B, Estienne, M, Esumi, S, Eum, J, Evans, D, Evdokimov, S, Eyyubova, G, Fabbietti, L, Fabris, D, Faivre, J, Fantoni, A, Fasel, M, Feldkamp, L, Felea, D, Feliciello, A, Feofilov, G, Ferencei, J, Tellez, Af, Ferreiro, Eg, Ferretti, A, Festanti, A, Figiel, J, Figueredo, Mas, Filchagin, S, Finogeev, D, Fionda, Fm, Fiore, Em, Fleck, Mg, Floris, M, Foertsch, S, Foka, P, Fokin, S, Fragiacomo, E, Francescon, A, Frankenfeld, U, Fuchs, U, Furget, C, Furs, A, Girard, Mf, Gaardhoje, Jj, Gagliardi, M, Gago, Am, Gallio, M, Gangadharan, Dr, Ganoti, P, Gao, C, Garabatos, C, Garcia-Solis, E, Gargiulo, C, Gasik, P, Germain, M, Gheata, A, Gheata, M, Ghosh, P, Ghosh, Sk, Gianotti, P, Giubellino, P, Giubilato, P, Gladysz-Dziadus, E, Glassel, P, Gomez Ramirez, A, Gonzalez-Zamora, P, Gorbunov, S, Gorlich, L, Gotovac, S, Grabski, V, Graczykowski, Lk, Grelli, A, Grigoras, A, Grigoras, C, Grigoriev, V, Grigoryan, A, Grigoryan, S, Grinyov, B, Grion, N, Grosse-Oetringhaus, Jf, Grossiord, Jy, Grosso, R, Guber, F, Guernane, R, Guerzoni, B, Gulbrandsen, K, Gulkanyan, H, Gunji, T, Gupta, A, Gupta, R, Haake, R, Haaland, O, Hadjidakis, C, Haiduc, M, Hamagaki, H, Hamar, G, Hanratty, Ld, Hansen, A, Harris, Jw, Hartmann, H, Harton, A, Hatzifotiadou, D, Hayashi, S, Heckel, St, Heide, M, Helstrup, H, Herghelegiu, A, Corral, Gh, Hess, Ba, Hetland, Kf, Hilden, Te, Hillemanns, H, Hippolyte, B, Hristov, P, Huang, M, Humanic, Tj, Hussain, N, Hussain, T, Hutter, D, Hwang, Ds, Ilkaev, R, Ilkiv, I, Inaba, M, Ionita, C, Ippolitov, M, Irfan, M, Ivanov, M, Ivanov, V, Izucheev, V, Jacobs, Pm, Jahnke, C, Jang, Hj, Janik, Ma, Jayarathna, Phsy, Jena, C, Jena, S, Bustamante, Rtj, Jones, Pg, Jung, H, Jusko, A, Kalinak, P, Kalweit, A, Kamin, J, Kang, Jh, Kaplin, V, Kar, S, Uysal, Ak, Karavichev, O, Karavicheva, T, Karpechev, E, Kebschull, U, Keidel, R, Keijdener, Dld, Keil, M, Khan, Kh, Khan, Mm, Khan, P, Khan, Sa, Khanzadeev, A, Kharlov, Y, Kileng, B, Kim, B, Kim, Dw, Kim, Dj, Kim, H, Kim, Js, Kim, M, Kim, S, Kim, T, Kirsch, S, Kisel, I, Kiselev, S, Kisiel, A, Kiss, G, Klay, Jl, Klein, C, Klein, J, Klein-Boing, C, Kluge, A, Knichel, Ml, Knospe, Ag, Kobayashi, T, Kobdaj, C, Kofarago, M, Kohler, Mk, Kollegger, T, Kolojvari, A, Kondratiev, V, Kondratyeva, N, Kondratyuk, E, Konevskikh, A, Kouzinopoulos, C, Kovalenko, O, Kovalenko, V, Kowalski, M, Kox, S, Meethaleveedu, Gk, Kral, J, Kralik, I, Kravcakova, A, Krelina, M, Kretz, M, Krivda, M, Krizek, F, Kryshen, E, Krzewicki, M, Kubera, Am, Kucera, V, Kugathasan, T, Kuhn, C, Kuijer, Pg, Kulakov, I, Kumar, J, Kumar, L, Kurashvili, P, Kurepin, A, Kurepin, Ab, Kuryakin, A, Kushpil, S, Kweon, Mj, Kwon, Y, La Pointe SL, La Rocca, P, Lagana Fernandes, C, Lakomov, I, Langoy, R, Lara, C, Lardeux, A, Lattuca, A, Laudi, E, Lea, R, Leardini, L, Lee, Gr, Lee, S, Legrand, I, Lemmon, Rc, Lenti, V, Leogrande, E, Monozn, Il, Leoncino, M, Levai, P, Li, S, Li, X, Lien, J, Lietava, R, Lindal, S, Lindenstruth, V, Lippmann, C, Lisa, Ma, Ljunggren, Hm, Lodato, Df, Loenne, Pi, Loggins, Vr, Loginov, V, Loizides, C, Lopez, X, Lopez Torres, E, Lowe, A, Luettig, P, Lunardon, M, Luparello, G, Luz, Phfnd, Maevskaya, A, Mager, M, Mahajan, S, Mahmood, Sm, Maire, A, Majka, Rd, Malaev, M, Maldonadocervantes, I, Malinina, L, Mal'Kevich, D, Malzacher, P, Mamonov, A, Manceau, L, Manko, V, Manso, F, Manzari, V, Marchisone, M, Mares, J, Margagliotti, Gv, Margotti, A, Margutti, J, Marin, A, Markert, C, Marquard, M, Martin, Na, Martin Blanco, J, Martinengo, P, Martinez, Mi, Martinez Garcia, G, Pedreira, Mm, Martynov, Y, Mas, A, Masciocchi, S, Masera, M, Masoni, A, Massacrier, L, Mastroserio, A, Masui, H, Matyja, A, Mayer, C, Mazer, J, Mazzoni, Ma, Mcdonald, D, Meddi, F, Menchaca-Rocha, A, Meninno, E, Mercado Perez, J, Meres, M, Miake, Y, Mieskolainen, Mm, Mikhaylov, K, Milano, L, Milosevic, J, Minervini, Lm, Mischke, A, Mishra, An, Miskowiec, D, Mitra, J, Mitu, Cm, Mohammadi, N, Mohanty, B, Molnar, L, Montano Zetina, L, Montes, E, Morando, M, De Godoy DAM, Moretto, S, Morreale, A, Morsch, A, Muccifora, V, Mudnic, E, Muhlheim, D, Muhuri, S, Mukherjee, M, Muller, H, Mulligan, Jd, Munhoz, Mg, Murray, S, Musa, L, Musinsky, J, Nandi, Bk, Nania, R, Nappi, E, Naru, Mu, Nattrass, C, Nayak, K, Nayak, Tk, Nazarenko, S, Nedosekin, A, Nellen, L, Ng, F, Nicassio, M, Niculescu, M, Niedziela, J, Nielsen, Bs, Nikolaev, S, Nikulin, S, Nikulin, V, Noferini, F, Nomokonov, P, Nooren, G, Norman, J, Nyanin, A, Nystrand, J, Oeschler, H, Oh, S, Oh, Sk, Ohlson, A, Okatan, A, Okubo, T, Olah, L, Oleniacz, J, Oliveira Da Silva AC, Oliver, Mh, Onderwaater, J, Oppedisano, C, Ortizvelasquez, A, Oskarsson, A, Otwinowski, J, Oyama, K, Ozdemir, M, Pachmayer, Y, Pagano, P, Paic, G, Pajares, C, Pal, Sk, Pan, J, Pandey, Ak, Pant, D, Papikyan, V, Pappalardo, Gs, Pareek, P, Park, Wj, Parmar, S, Passfeld, A, Paticchio, V, Paul, B, Peitzmann, T, Da Costa HP, De Oliveira EP, Peresunko, D, Perez Lara CE, Peskov, V, Pestov, Y, Petracek, V, Petrov, V, Petrovici, M, Petta, C, Piano, S, Pikna, M, Pillot, P, Pinazza, O, Pinsky, L, Piyarathna, Db, Ploskon, M, Planinic, M, Pluta, J, Pochybova, S, Podesta-Lerma, Plm, Poghosyan, Mg, Polichtchouk, B, Poljak, N, Poonsawat, W, Pop, A, Porteboeuf-Houssais, S, Porter, J, Pospisil, J, Prasad, Sk, Preghenella, R, Prino, F, Pruneau, Ca, Pshenichnov, I, Puccio, M, Puddu, G, Pujahari, P, Punin, V, Putschke, J, Qvigstad, H, Rachevski, A, Raha, S, Rajput, S, Rak, J, Rakotozafindrabe, A, Ramello, L, Raniwala, R, Raniwala, S, Rasanen, Ss, Rascanu, Bt, Rathee, D, Read, Kf, Real, Js, Redlich, K, Reed, Rj, Rehman, A, Reichelt, P, Reicher, M, Reidt, F, Ren, X, Renfordt, R, Reolon, Ar, Reshetin, A, Rettig, F, Revol, Jp, Reygers, K, Riabov, V, Ricci, Ra, Richert, T, Richter, M, Riedler, P, Riegler, W, Riggi, F, Ristea, C, Rivetti, A, Rocco, E, Rodriguez Cahuantzi, M, Rodriguez Manso, A, Roed, K, Rogochaya, E, Rohr, D, Rohrich, D, Romita, R, Ronchetti, F, Ronflette, L, Rosnet, P, Rossi, A, Roukoutakis, F, Roy, A, Roy, C, Roy, P, Rubio Montero AJ, Rui, R, Russo, R, Ryabinkin, E, Ryabov, Y, Rybicki, A, Sadovsky, S, Safarik, K, Sahlmuller, B, Sahoo, P, Sahoo, R, Sahoo, S, Sahu, Pk, Saini, J, Sakai, S, Saleh, Ma, Salgado, Ca, Salzwedel, J, Sambyal, S, Samsonov, V, Sanchez Castro, X, Sandor, L, Sandoval, A, Sano, M, Santagati, G, Sarkar, D, Scapparone, E, Scarlassara, F, Scharenberg, Rp, Schiaua, C, Schicker, R, Schmidt, C, Schmidt, Hr, Schuchmann, S, Schukraft, J, Schulc, M, Schuster, T, Schutz, Y, Schwarz, K, Schweda, K, Scioli, G, Scomparin, E, Scott, R, Seeder, Ks, Seger, Je, Sekiguchi, Y, Selyuzhenkov, I, Senosi, K, Seo, J, Serradilla, E, Sevcenco, A, Shabanov, A, Shabetai, A, Shadura, O, Shahoyan, R, Shangaraev, A, Sharma, A, Sharma, N, Shigaki, K, Shtejer, K, Sibiriak, Y, Siddhanta, S, Sielewicz, Km, Siemiarczuk, T, Silvermyr, D, Silvestre, C, Simatovic, G, Simonetti, G, Singaraju, R, Singh, R, Singha, S, Singhal, V, Sinha, Bc, Shina, T, Sitar, B, Sitta, M, Skaali, Tb, Slupecki, M, Smirnov, N, Snellings, Rjm, Snellman, Tw, Sogaard, C, Soltz, R, Song, J, Song, M, Song, Z, Soramel, F, Sorensen, S, Spacek, M, Spiriti, E, Sputowska, I, Spyropoulou-Stassinaki, M, Srivastava, Bk, Stachel, J, Stan, I, Stefanek, G, Steinpreis, M, Stenlund, E, Steyn, G, Stiller, Jh, Stocco, D, Strmen, P, Suaide, Aap, Sugitate, T, Suire, C, Suleymanov, M, Sultanov, R, Sumbera, M, Symons, Tjm, Szabo, A, de Toledo AS, Szarka, I, Szczepankiewicz, A, Szymanski, M, Takahashi, J, Tanaka, N, Tangaro, Ma, Takaki, Jdt, Tarantola Peloni, A, Tariq, M, Tarzila, Mg, Tauro, A, Munoz, G, Telesca, A, Terasaki, K, Terrevoli, C, Teyssier, B, Thader, J, Thomas, D, Tieulent, R, Timmins, Ar, Toia, A, Trogolo, S, Trubnikov, V, Trzaska, Wh, Tsuji, T, Tumkin, A, Turrisi, R, Tveter, Ts, Ullaland, K, Uras, A, Usai, Gl, Utrobicic, A, Vajzer, M, Vala, M, Valencia Palomo, L, Vallero, S, Van Der Maarel, J, Van Hoorne JW, van leeuwen, M, Vanat, T, Vande Vyvre, P, Varga, D, Vargas, A, Vargyas, M, Varma, R, Vasileiou, M, Vasiliev, A, Vauthier, A, Vechernin, V, Veen, Am, Veldhoen, M, Velure, A, Venaruzzo, M, Vercellin, E, Vergara Limon, S, Vernet, R, Verweij, M, Vickovic, L, Viesti, G, Viinikainen, J, Vilakazi, Z, Villalobos Baillie, O, Vinogradov, A, Vinogradov, L, Vinogradov, Y, Virgili, T, Vislavicius, V, Viyogi, Yp, Vodopyanov, A, Volkl, Ma, Voloshin, K, Voloshin, Sa, Volpe, G, von Haller, B, Vorobyev, I, Vranic, D, Vrlakova, J, Vulpescu, B, Vyushin, A, Wagner, B, Wagner, J, Wang, H, Wang, M, Wang, Y, Watanabe, D, Weber, M, Weber, Sg, Wessels, Jp, Westerhoff, U, Wiechula, J, Wikne, J, Wilde, M, Wilk, G, Wilkinson, J, Williams, Mcs, Windelband, B, Winn, M, Yaldo, Cg, Yamaguchi, Y, Yang, H, Yang, P, Yano, S, Yin, Z, Yokoyama, H, Yoo, Ik, Yurchenko, V, Yushmanov, I, Zaborowska, A, Zaccolo, V, Zaman, A, Zampolli, C, Zanoli, Hjc, Zaporozhets, S, Zarochentsev, A, Zavada, P, Zaviyalov, N, Zbroszczyk, H, Zgura, Is, Zhalov, M, Zhang, H, Zhang, X, Zhang, Y, Zhao, C, Zhigareva, N, Zhou, D, Zhou, Y, Zhou, Z, Zhu, H, Zhu, J, Zhu, X, Zichichi, A, Zimmermann, A, Zimmermann, Mb, Zinovjev, G, and Zyzak, M

Subjects
Suppression, Particle Production, Long-Range, Range Angular-Correlations, Side, Transverse-Momentum Distributions, Root-S-Nn=5.02 Tev, Ppb Collisions, Dependence, Atlas Detector
Abstract

Charged jet production cross sections in p-Pb collisions at root s(NN) = 5.02 TeV measured with the ALICE detector at the LHC are presented. Using the anti-k(T) algorithm, jets have been reconstructed in the central rapidity region from charged particles with resolution parameters R = 0.2 and R = 0.4. The reconstructed jets have been corrected for detector effects and the underlying event background. To calculate the nuclear modification factor, R-pPb, of charged jets in p-Pb collisions, a pp reference was constructed by scaling previously measured charged jet spectra at root s = 7 TeV. In the transverse momentum range 20

Published
2015

12. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Author

Baumert, B.G., Hegi, M.E., Bent, M.J. van den, Deimling, A. von, Gorlia, T., Hoang-Xuan, K., Brandes, A.A., Kantor, G., Taphoorn, M.J., Hassel, M.B., Hartmann, C., Ryan, G., Capper, D., Kros, J.M., Kurscheid, S., Wick, W., Enting, R., Reni, M., Thiessen, B., Dhermain, F., Bromberg, J.E., Feuvret, L., Reijneveld, J.C., Chinot, O., Gijtenbeek, J.M.M., Rossiter, J.P., Dif, N., Balana, C., Bravo-Marques, J., Clement, P.M., Marosi, C., Tzuk-Shina, T., Nordal, R.A., Rees, J., Lacombe, D., Mason, W.P., Stupp, R., Baumert, B.G., Hegi, M.E., Bent, M.J. van den, Deimling, A. von, Gorlia, T., Hoang-Xuan, K., Brandes, A.A., Kantor, G., Taphoorn, M.J., Hassel, M.B., Hartmann, C., Ryan, G., Capper, D., Kros, J.M., Kurscheid, S., Wick, W., Enting, R., Reni, M., Thiessen, B., Dhermain, F., Bromberg, J.E., Feuvret, L., Reijneveld, J.C., Chinot, O., Gijtenbeek, J.M.M., Rossiter, J.P., Dif, N., Balana, C., Bravo-Marques, J., Clement, P.M., Marosi, C., Tzuk-Shina, T., Nordal, R.A., Rees, J., Lacombe, D., Mason, W.P., and Stupp, R.

Abstract

Item does not contain fulltext, BACKGROUND: Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors. METHODS: For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration. Eligible patients were randomly assigned (1:1) to receive either conformal radiotherapy (up to 50.4 Gy; 28 doses of 1.8 Gy once daily, 5 days per week for up to 6.5 weeks) or dose-dense oral temozolomide (75 mg/m2 once daily for 21 days, repeated every 28 days [one cycle], for a maximum of 12 cycles). Random treatment allocation was done online by a minimisation technique with prospective stratification by institution, 1p deletion (absent vs present vs undetermined), contrast enhancement (yes vs no), age (<40 vs >/=40 years), and WHO performance status (0 vs >/=1). Patients, treating physicians, and researchers were aware of the assigned intervention. A planned analysis was done after 216 progression events occurred. Our primary clinical endpoint was progression-free survival, analysed by intention-to-treat; secondary outcomes were overall survival, adverse events, neurocognitive function (will be reported separately), health-related quality of life and neurological function (reported separately), and correlative analyses of pro

Published
2016

13. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Author

Baumert, B.G. (Brigitta), Hegi, M.E. (Monika), Bent, M.J. (Martin) van den, Deimling, A. (Andreas) von, Gorlia, T.S. (Thierry), Hoang-Xuan, K. (Khê), Brandes, A. (Alba), Kantor, R. (Rami), Taphoorn, M.J. (Martin), Hassel, M.B. (Mohamed Ben), Hartmann, C. (Christian), Ryan, G. (Gail), Capper, D. (David), Kros, J.M. (Johan), Kurscheid, S. (Sebastian), Wick, W. (Wolfgang), Enting, R. (Roelien), Reni, M. (Michele), Thiessen, B. (Brian), Dhermain, F.G. (Frederic), Bromberg, J.E.C. (Jacoline), Feuvret, L. (Loic), Reijneveld, J.C., Chinot, O., Gijtenbeek, J. (Johanna), Rossiter, J.P. (John P), Dif, N. (Nicolas), Balana, C. (Carmen), Bravo-Marques, J. (Jose), Clement, P.M.J. (Paul), Marosi, C. (Christine), Tzuk-Shina, T. (Tzahala), Nordal, R.A. (Robert A), Rees, J. (Jeremy), Lacombe, D. (Denis), Mason, W.P. (Warren), Stupp, R. (Roger), Baumert, B.G. (Brigitta), Hegi, M.E. (Monika), Bent, M.J. (Martin) van den, Deimling, A. (Andreas) von, Gorlia, T.S. (Thierry), Hoang-Xuan, K. (Khê), Brandes, A. (Alba), Kantor, R. (Rami), Taphoorn, M.J. (Martin), Hassel, M.B. (Mohamed Ben), Hartmann, C. (Christian), Ryan, G. (Gail), Capper, D. (David), Kros, J.M. (Johan), Kurscheid, S. (Sebastian), Wick, W. (Wolfgang), Enting, R. (Roelien), Reni, M. (Michele), Thiessen, B. (Brian), Dhermain, F.G. (Frederic), Bromberg, J.E.C. (Jacoline), Feuvret, L. (Loic), Reijneveld, J.C., Chinot, O., Gijtenbeek, J. (Johanna), Rossiter, J.P. (John P), Dif, N. (Nicolas), Balana, C. (Carmen), Bravo-Marques, J. (Jose), Clement, P.M.J. (Paul), Marosi, C. (Christine), Tzuk-Shina, T. (Tzahala), Nordal, R.A. (Robert A), Rees, J. (Jeremy), Lacombe, D. (Denis), Mason, W.P. (Warren), and Stupp, R. (Roger)

Abstract

Background Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors. Methods For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration. Eligible patients were randomly assigned (1:1) to receive either conformal radiotherapy (up to 50·4 Gy; 28 doses of 1·8 Gy once daily, 5 days per week for up to 6·5 weeks) or dose-dense oral temozolomide (75 mg/m2 once daily for 21 days, repeated every 28 days [one cycle], for a maximum of 12 cycles). Random treatment allocation was done online by a minimisation technique with prospective stratification by institution, 1p deletion (absent vs present vs undetermined), contrast enhancement (yes vs no), age (<40 vs ≥40 years), and WHO performance status (0 vs ≥1). Patients, treating physicians, and researchers were aware of the assigned intervention. A planned analysis was done after 216 progression events occurred. Our primary clinical endpoint was progression-free survival, analysed by intention-to-treat; secondary outcomes were overall survival, adverse events, neurocognitive function (will be reported separately), health-related quality of life and neurological function (reported separately), and correlative analyses of progressi

Published
2016
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14. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Author

Baumert, BG, Hegi, ME, van den Bent, MJ, von Deimling, A, Gorlia, T, Hoang-Xuan, K, Brandes, AA, Kantor, G, Taphoorn, MJB, Ben Hassel, M, Hartmann, C, Ryan, G, Capper, D, Kros, JM, Kurscheid, S, Wick, W, Enting, R, Reni, M, Thiessen, B, Dhermain, F, Bromberg, JE, Feuvret, L, Reijneveld, JC, Chinot, O, Gijtenbeek, JMM, Rossiter, JP, Dif, N, Balana, C, Bravo-Marques, J, Clement, PM, Marosi, C, Tzuk-Shina, T, Nordal, RA, Rees, J, Lacombe, D, Mason, WP, Stupp, R, Baumert, BG, Hegi, ME, van den Bent, MJ, von Deimling, A, Gorlia, T, Hoang-Xuan, K, Brandes, AA, Kantor, G, Taphoorn, MJB, Ben Hassel, M, Hartmann, C, Ryan, G, Capper, D, Kros, JM, Kurscheid, S, Wick, W, Enting, R, Reni, M, Thiessen, B, Dhermain, F, Bromberg, JE, Feuvret, L, Reijneveld, JC, Chinot, O, Gijtenbeek, JMM, Rossiter, JP, Dif, N, Balana, C, Bravo-Marques, J, Clement, PM, Marosi, C, Tzuk-Shina, T, Nordal, RA, Rees, J, Lacombe, D, Mason, WP, and Stupp, R

Abstract

BACKGROUND: Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors. METHODS: For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration. Eligible patients were randomly assigned (1:1) to receive either conformal radiotherapy (up to 50·4 Gy; 28 doses of 1·8 Gy once daily, 5 days per week for up to 6·5 weeks) or dose-dense oral temozolomide (75 mg/m2 once daily for 21 days, repeated every 28 days [one cycle], for a maximum of 12 cycles). Random treatment allocation was done online by a minimisation technique with prospective stratification by institution, 1p deletion (absent vs present vs undetermined), contrast enhancement (yes vs no), age (<40 vs ≥40 years), and WHO performance status (0 vs ≥1). Patients, treating physicians, and researchers were aware of the assigned intervention. A planned analysis was done after 216 progression events occurred. Our primary clinical endpoint was progression-free survival, analysed by intention-to-treat; secondary outcomes were overall survival, adverse events, neurocognitive function (will be reported separately), health-related quality of life and neurological function (reported separately), and correlative analyses of progres

Published
2016

15. Measurement of charged jet production cross sections and nuclear modification in p-Pb collisions at root s(NN)=5.02 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahn, S. U., Aimo, I., Aiola, S., Ajaz, M., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Prado, C. Alves Garcia, Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshauser, H., Arcelli, S., Armesto, N., Arnaldi, R., Aronsson, T., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M. D., Bach, M., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Pedrosa, F. Baltasar Dos Santos, Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoeldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Batista Camejo, A., Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, S., Bjelogrlic, S., Blanco, F., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botje, M., Botta, E., Boettger, S., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Buxton, J. T., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Villar, E. Calvo, Camerini, P., Carena, F., Carena, W., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Cavicchioli, C., Ceballos Sanchez, C., Cepila, J., Cerello, P., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Chochula, P., Choi, K., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Chunhui, Z., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, del Valle, Z. Conesa, Connors, M. E., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Maldonado, I. Cortes, Cortese, P., Cosentino, M. R., Costa, F., Crochet, P., Cruz Albino, R., Cuautle, E., Cunqueiro, L., Dahms, T., Dainese, A., Danu, A., Das, D., Das, I., Das, S., Dash, A., Dash, S., De, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., Deisting, A., Deloff, A., Denes, E., D'Erasmo, G., Di Bari, D., Di Mauro, A., Di Nezza, P., Diaz Corchero, M. A., Dietel, T., Dillenseger, P., Divia, R., Djuvsland, O., Dobrin, A., Dobrowolski, T., Domenicis Gimenez, D., Doenigus, B., Dordic, O., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Ehlers, R. J., Elia, D., Engel, H., Erazmus, B., Erhardt, F., Eschweiler, D., Espagnon, B., Estienne, M., Esumi, S., Eum, J., Evans, D., Evdokimov, S., Eyyubova, G., Fabbietti, L., Fabris, D., Faivre, J., Fantoni, A., Fasel, M., Feldkamp, L., Felea, D., Feliciello, A., Feofilov, G., Ferencei, J., Fernandez Tellez, A., Ferreiro, E. G., Ferretti, A., Festanti, A., Figiel, J., Figueredo, M. A. 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D., Hansen, A., Harris, J. W., Hartmann, H., Harton, A., Hatzifotiadou, D., Hayashi, S., Heckel, S. T., Heide, M., Helstrup, H., Herghelegiu, A., Herrera Corral, G., Hess, B. A., Hetland, K. F., Hilden, T. E., Hillemanns, H., Hippolyte, B., Hristov, P., Huang, M., Humanic, T. J., Hussain, N., Hussain, T., Hutter, D., Hwang, D. S., Ilkaev, R., Ilkiv, I., Inaba, M., Ionita, C., Ippolitov, M., Irfan, M., Ivanov, M., Ivanov, V., Izucheev, V., Jacobs, P. M., Jahnke, C., Jang, H. J., Janik, M. A., Jayarathna, P. H. S. Y., Jena, C., Jena, S., Bustamante, R. T. Jimenez, Jones, P. G., Jung, H., Jusko, A., Kalinak, P., Kalweit, A., Kamin, J., Kang, J. H., Kaplin, V., Kar, S., Uysal, A. Karasu, Karavichev, O., Karavicheva, T., Karpechev, E., Kebschull, U., Keidel, R., Keijdener, D. L. D., Keil, M., Khan, K. H., Khan, M. M., Khan, P., Khan, S. A., Khanzadeev, A., Kharlov, Y., Kileng, B., Kim, B., Kim, D. W., Kim, D. J., Kim, H., Kim, J. 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A., Mcdonald, D., Meddi, F., Menchaca-Rocha, A., Meninno, E., Mercado Perez, J., Meres, M., Miake, Y., Mieskolainen, M. M., Mikhaylov, K., Milano, L., Milosevic, J., Minervini, L. M., Mischke, A., Mishra, A. N., Miskowiec, D., Mitra, J., Mitu, C. M., Mohammadi, N., Mohanty, B., Molnar, L., Montano Zetina, L., Montes, E., Morando, M., De Godoy, D. A. Moreira, Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muehlheim, D., Muhuri, S., Mukherjee, M., Mueller, H., Mulligan, J. D., Munhoz, M. G., Murray, S., Musa, L., Musinsky, J., Nandi, B. K., Nania, R., Nappi, E., Naru, M. U., Nattrass, C., Nayak, K., Nayak, T. K., Nazarenko, S., Nedosekin, A., Nellen, L., Ng, F., Nicassio, M., Niculescu, M., Niedziela, J., Nielsen, B. S., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Nomokonov, P., Nooren, G., Norman, J., Nyanin, A., Nystrand, J., Oeschler, H., Oh, S., Oh, S. K., Ohlson, A., Okatan, A., Okubo, T., Olah, L., Oleniacz, J., Oliveira Da Silva, A. C., Oliver, M. 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K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, S., Bjelogrlic, S., Blanco, F., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botje, M., Botta, E., Boettger, S., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Buxton, J. T., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Villar, E. Calvo, Camerini, P., Carena, F., Carena, W., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Cavicchioli, C., Ceballos Sanchez, C., Cepila, J., Cerello, P., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. 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M., Mohammadi, N., Mohanty, B., Molnar, L., Montano Zetina, L., Montes, E., Morando, M., De Godoy, D. A. Moreira, Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muehlheim, D., Muhuri, S., Mukherjee, M., Mueller, H., Mulligan, J. D., Munhoz, M. G., Murray, S., Musa, L., Musinsky, J., Nandi, B. K., Nania, R., Nappi, E., Naru, M. U., Nattrass, C., Nayak, K., Nayak, T. K., Nazarenko, S., Nedosekin, A., Nellen, L., Ng, F., Nicassio, M., Niculescu, M., Niedziela, J., Nielsen, B. S., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Nomokonov, P., Nooren, G., Norman, J., Nyanin, A., Nystrand, J., Oeschler, H., Oh, S., Oh, S. K., Ohlson, A., Okatan, A., Okubo, T., Olah, L., Oleniacz, J., Oliveira Da Silva, A. C., Oliver, M. H., Onderwaater, J., Oppedisano, C., Ortiz Velasquez, A., Oskarsson, A., Otwinowski, J., Oyama, K., Ozdemir, M., Pachmayer, Y., Pagano, P., Paic, G., Pajares, C., Pal, S. K., Pan, J., Pandey, A. K., Pant, D., Papikyan, V., Pappalardo, G. 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Abstract

Charged jet production cross sections in p-Pb collisions at root s(NN) = 5.02 TeV measured with the ALICE detector at the LHC are presented. Using the anti-k(T) algorithm, jets have been reconstructed in the central rapidity region from charged particles with resolution parameters R = 0.2 and R = 0.4. The reconstructed jets have been corrected for detector effects and the underlying event background. To calculate the nuclear modification factor, R-pPb, of charged jets in p-Pb collisions, a pp reference was constructed by scaling previously measured charged jet spectra at root s = 7 TeV. In the transverse momentum range 20

Published
2015

20. A rare event of 5-fluorouracil-associated peripheral neuropathy: a report of two patients

Author

Yarnitsky D, Tzuk-Shina T, Moshe Stein, Drumea K, and Benny A

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, medicine.medical_treatment, Rectum, Adenocarcinoma, Medicine, Humans, Aged, Chemotherapy, business.industry, Rectal Neoplasms, Middle Aged, medicine.disease, Combined Modality Therapy, Surgery, medicine.anatomical_structure, Peripheral neuropathy, Oncology, Fluorouracil, Colonic Neoplasms, Female, business, medicine.drug, Demyelinating Diseases
Abstract

5-Fluorouracil (5-FU) is known to cause multifocal cerebral demyelination, which is pathologically related to a central inflammatory demyelinating process. To date, no case of peripheral neuropathy has been described after the administration of 5-FU alone. The authors describe two patients who had peripheral neuropathy that developed while they were receiving 5-FU-based chemotherapy.

Published
1998

45. Higher-order local and non-local correlations for 1D strongly interacting Bose gas

Author

EJKP Nandani, Rudolf A Römer, Shina Tan, and Xi-Wen Guan

Subjects
high order correlation functions, generalized exclusion statistics, Fermi distribution, Bethe ansatz weave functions, Science, Physics, QC1-999
Abstract

The correlation function is an important quantity in the physics of ultracold quantum gases because it provides information about the quantum many-body wave function beyond the simple density profile. In this paper we first study the M -body local correlation functions, g _M , of the one-dimensional (1D) strongly repulsive Bose gas within the Lieb–Liniger model using the analytical method proposed by Gangardt and Shlyapnikov (2003 Phys. Rev. Lett. http://dx.doi.org/10.1103/PhysRevLett.90.010401 90 http://dx.doi.org/10.1103/PhysRevLett.90.010401 ; 2003 New J. Phys. http://dx.doi.org/10.1088/1367-2630/5/1/379 5 http://dx.doi.org/10.1088/1367-2630/5/1/379 ). In the strong repulsion regime the 1D Bose gas at low temperatures is equivalent to a gas of ideal particles obeying the non-mutual generalized exclusion statistics with a statistical parameter $\alpha =1-2/\gamma $ , i.e. the quasimomenta of N strongly interacting bosons map to the momenta of N free fermions via ${k}_{i}\approx \alpha {k}_{i}^{F}$ with $i=1,\ldots ,N$ . Here γ is the dimensionless interaction strength within the Lieb–Liniger model. We rigorously prove that such a statistical parameter α solely determines the sub-leading order contribution to the M -body local correlation function of the gas at strong but finite interaction strengths. We explicitly calculate the correlation functions g _M in terms of γ and α at zero, low, and intermediate temperatures. For M = 2 and 3 our results reproduce the known expressions for g _2 and g _3 with sub-leading terms (see for instance (Vadim et al 2006 Phys. Rev. A http://dx.doi.org/10.1103/PhysRevA.73.051604 73 http://dx.doi.org/10.1103/PhysRevA.73.051604 ; Kormos et al 2009 Phys. Rev. Lett. http://dx.doi.org/10.1103/PhysRevLett.103.210404 103 http://dx.doi.org/10.1103/PhysRevLett.103.210404 ; Wang et al 2013 Phys. Rev. A http://dx.doi.org/10.1103/PhysRevA.87.043634 87 http://dx.doi.org/10.1103/PhysRevA.87.043634 ). We also express the leading order of the short distance non-local correlation functions $\langle {{\rm{\Psi }}}^{\dagger }({x}_{1})\cdots {{\rm{\Psi }}}^{\dagger }({x}_{M}){\rm{\Psi }}({y}_{M})\cdots {\rm{\Psi }}({y}_{1})\rangle $ of the strongly repulsive Bose gas in terms of the wave function of M bosons at zero collision energy and zero total momentum. Here ${\rm{\Psi }}(x)$ is the boson annihilation operator. These general formulas of the higher-order local and non-local correlation functions of the 1D Bose gas provide new insights into the many-body physics.

Published
2016
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46. Diagnostic value of reduced left atrial compliance during ergometry exercise in heart failure with preserved ejection fraction.

Author

Harada T, Kagami K, Shina T, Sorimachi H, Yuasa N, Saito Y, Naito A, Yoshida K, Kato T, Wada N, Ishii H, and Obokata M

Subjects
Humans, Stroke Volume, Ergometry, Dyspnea diagnosis, Dyspnea etiology, Ventricular Function, Left, Heart Failure diagnosis, Atrial Fibrillation diagnosis, Noncommunicable Diseases
Abstract

Aims: Diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging in patients presenting with chronic dyspnoea. We sought to determine the diagnostic value of reduced left atrial (LA) compliance during exercise to diagnose HFpEF., Methods and Results: Ergometry exercise stress echocardiography was performed in 225 patients with HFpEF and 262 non-heart failure controls (non-cardiac dyspnoea [NCD]) in Protocol 1, where the diagnosis of HFpEF was defined by the HFA-PEFF algorithm. In Protocol 2, the diagnosis of HFpEF was ascertained by exercise right heart catheterization in 67 participants (49 HFpEF and 18 NCD). Speckle-tracking echocardiography was performed at rest and during exercise to determine LA compliance (ratio of LA reservoir strain to E/e'). As compared with NCD, patients with HFpEF demonstrated decreased LA reservoir strain and compliance at rest, and these differences further increased during exercise in Protocol 1. Exercise LA compliance discriminated HFpEF from NCD (area under the curve 0.87, p < 0.0001), with a superior diagnostic ability to exercise E/e' ratio (DeLong p = 0.005). Exercise LA compliance demonstrated incremental diagnostic value over clinical factors (age, systemic hypertension, and atrial fibrillation) and resting LA compliance (χ 2 212.4 vs. 166.2, p < 0.0001). These findings were confirmed in Protocol 2., Conclusion: Left atrial compliance during exercise demonstrated superior diagnostic ability to exercise E/e' ratio, with incremental diagnostic value over the resting LA compliance. Exercise LA compliance may enhance the diagnosis of HFpEF among patients with dyspnoea., (© 2023 European Society of Cardiology.)

Published
2023
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47. The perception and attitudes of Israeli cancer patients regarding advance care planning.

Author

Bar-Sela G, Bagon S, Mitnik I, Adi S, Baziliansky S, Bar-Sella A, Vornicova O, and Tzuk-Shina T

Subjects
Aged, Attitude, Humans, Perception, Advance Care Planning, Neoplasms therapy, Terminal Care
Abstract

Objectives: Advance care planning (ACP) allows patients to acknowledge and document their preferences regarding end-of-life care and to ensure their fulfilment. Several factors were found to be related to patients' motivation regarding this process, such as their fear of being a burden on family members; however, the completion rate of the ACP forms is partial. The current study aimed to evaluate the barriers and motives among Israeli cancer patients regarding ACP, including many older adults., Setting and Measurements: Advanced cancer patients participated in the study. All completed an initial questionnaire to evaluate their basic knowledge regarding the issue. Participants who agreed to talk with a social worker completed a semi open-ended questionnaire which investigated their main motives and barriers regarding the issue., Results: Most of the patients who completed the ACP forms were older and had lung cancer. They mentioned information and open communication with family and staff members as the main enabling factors. Their main motives were to ensure that the best medical decisions would be made and to avoid unnecessary medical procedures. The main reasons for not completing the forms was no close relative who would agree to take the responsibility as well as timing. Most of the participants did not hear about the issue from sources outside the oncology division., Conclusions: Despite several limitations, the current findings may have important implications regarding ways to establish a more suitable ACP process, adjusted to older patients' needs. This may assist in promoting patients' cooperation with ACP and its implementation in the medical system, including older adults., Competing Interests: Declaration of Competing Interest No author has any conflict of interest to declare., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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48. Memory in low-grade glioma patients treated with radiotherapy or temozolomide: a correlative analysis of EORTC study 22033-26033.

Author

Klein M, Drijver AJ, van den Bent MJ, Bromberg JC, Hoang-Xuan K, Taphoorn MJB, Reijneveld JC, Ben Hassel M, Vauleon E, Eekers DBP, Tzuk-Shina T, Lucas A, Freixa SV, Golfinopoulos V, Gorlia T, Hottinger AF, Stupp R, and Baumert BG

Subjects
Antineoplastic Agents, Alkylating therapeutic use, Humans, Progression-Free Survival, Temozolomide therapeutic use, Brain Neoplasms drug therapy, Brain Neoplasms radiotherapy, Glioma drug therapy, Glioma radiotherapy
Abstract

Background: EORTC study 22033-26033 showed no difference in progression-free survival between high-risk low-grade glioma receiving either radiotherapy (RT) or temozolomide (TMZ) chemotherapy alone as primary treatment. Considering the potential long-term deleterious impact of RT on memory functioning, this study aims to determine whether TMZ is associated with less impaired memory functioning., Methods: Using the Visual Verbal Learning Test (VVLT), memory functioning was evaluated at baseline and subsequently every 6 months. Minimal compliance for statistical analyses was set at 60%. Conventional indices of memory performance (VVLT Immediate Recall, Total Recall, Learning Capacity, and Delayed Recall) were used as outcome measures. Using a mixed linear model, memory functioning was compared between treatment arms and over time., Results: Neuropsychological assessment was performed in 98 patients (53 RT, 46 TMZ). At 12 months, compliance had dropped to 66%, restricting analyses to baseline, 6 months, and 12 months. At baseline, patients in either treatment arm did not differ in memory functioning, sex, age, or educational level. Over time, patients in both arms showed improvement in Immediate Recall (P = 0.017) and total number of words recalled (Total Recall; P < 0.001, albeit with delayed improvement in RT patients (group by time; P = 0.011). Memory functioning was not associated with RT gross, clinical, or planned target volumes., Conclusion: In patients with high-risk low-grade glioma there is no indication that in the first year after treatment, RT has a deleterious effect on memory function compared with TMZ chemotherapy., (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.)

Published
2021
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49. The perception of Israeli oncology staff members regarding advance care planning.

Author

Bar-Sela G, Bagon S, Mitnik I, Baziliansky S, Bar-Sella A, Vornicova O, and Tzuk-Shina T

Subjects
Adult, Communication, Female, Humans, Israel, Male, Medical Oncology methods, Middle Aged, Neoplasms psychology, Nurses psychology, Physicians psychology, Surveys and Questionnaires, Terminal Care methods, Advance Care Planning, Attitude of Health Personnel, Neoplasms therapy, Patient Preference psychology, Terminal Care psychology
Abstract

Background: Advance care planning (ACP) defines end-of-life care in accordance with the patients' preferences. It is highly important during mental and/or physical deterioration, which prevents patients from expressing their wishes. Despite various attempts worldwide to promote the issue, it is not well established, suggesting various challenges in the implementation of the process in the medical system. The current study aimed to evaluate the perception of Israeli oncology staff members regarding the process., Methods: Physicians and nurses from a division of oncology participated in the study. They completed the study's questionnaires, which included quantitative items regarding staff and patients' motives and barriers, as well as qualitative questions to better evaluate their understanding regarding the process., Results: According to staff members, the optimal time to complete the forms is during the final stages of the disease. Making the right medical decisions and avoiding unnecessary medical procedures were rated as the main motives for patients in the process. The communication factor was perceived as the main barrier for patients, as well as the main motive and barrier for staff. The central role of communication was demonstrated in the qualitative section as well. Various differences were demonstrated between staff members who talked with patients about ACP and those who did not., Conclusion: The study demonstrated the central role of communication in the process of ACP from the staff's perception. This highlights the need to further promote training programs for staff members to establish better interactions and communication skills when dealing with end-of-life issues.

Published
2020
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50. Tumor Board Report: The value of tissue diagnosis.

Author

Hijab A, Eran A, Tzuk-Shina T, and Kaidar-Person O

Subjects
Aged, Brain Neoplasms secondary, Carcinoma, Non-Small-Cell Lung pathology, Humans, Interdisciplinary Communication, Lung Neoplasms pathology, Male, Prognosis, Brain Neoplasms therapy, Carcinoma, Non-Small-Cell Lung therapy, Chemoradiotherapy methods, Lung Neoplasms therapy
Abstract

Intracranial lesions in the presence of a known cancer are highly suspicious for brain metastases. Lung cancer is the most common solid tumor responsible for brain metastases. This case emphasizes the importance of multidisciplinary tumor boards including a dedicated neuroradiologist in the management of patients with cancer., (Copyright © 2019. Published by Elsevier Inc.)

Published
2020
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