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547 results on '"Shimura, Takaya"'

3. Unanticipated pathological clearance in two cases of clinical T4b dMMR/MSI-h advanced colorectal cancer: the potential of immune checkpoint inhibitors despite positive positron-emission tomography results

Author

Nakamura, Daigaku, Yanagita, Takeshi, Fujii, Yoshiaki, Watanabe, Kaori, Suzuki, Takuya, Ushigome, Hajime, Nishigaki, Ruriko, Sugimura, Naomi, Tanaka, Mamoru, Ogawa, Ryo, Takahashi, Hiroki, Shimura, Takaya, Hotta, Yuji, Matsuo, Yoichi, Kondo, Masahiro, Furukawa-Hibi, Yoko, and Takiguchi, Shuji

Published
2024
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9. A multicenter case–control study of self-expanding metallic stent versus trans-anal colorectal tube for stage II/III non-right-sided obstructive colon cancer

Author

Okuda, Yusuke, Shimura, Takaya, Uno, Konomu, Yamada, Tomonori, Nukui, Takayuki, Mizushima, Takashi, Takenaka, Yuya, Itoh, Keisuke, Inagaki, Yuki, Ozeki, Takanori, Nagao, Kazuhiro, Ebi, Masahide, Uchida, Erika, Nomura, Satoshi, Nojiri, Yu, Togawa, Shozo, Sugimura, Naomi, Fukusada, Shigeki, Iwasaki, Hiroyasu, Katano, Takahito, and Kataoka, Hiromi

Published
2023
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10. Phase II Prospective Study of Trastuzumab in Combination with S-1 and Oxaliplatin (SOX100) Therapy for HER2-Positive Advanced Gastric Cancer

Author

Mori, Yoshinori, Kataoka, Hiromi, Ebi, Masahide, Adachi, Kazunori, Yamaguchi, Yoshiharu, Hayashi, Noriyuki, Hirata, Yoshikazu, Sobue, Satoshi, Ishihara, Ryo, Suzuki, Yuta, Mizushima, Takashi, Inoue, Yusuke, Hasegawa, Izumi, Ono, Satoshi, Hirano, Atsuyuki, Kimura, Yoshihide, Seno, Kyoji, Ozeki, Keiji, Shimura, Takaya, and Kubota, Eiji

Published
2022
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13. Effectiveness of second-look endoscopy after gastric endoscopic submucosal dissection in patients taking antithrombotic agents: a multicenter propensity score matching analysis

Author

Iwatsubo, Taro, Takeuchi, Toshihisa, Hakoda, Akitoshi, Fujiwara, Yasuhiro, Nagami, Yasuaki, Naito, Yuji, Dohi, Osamu, Tatsuta, Tetsuya, Sawaya, Manabu, Jin, Xiaoyi, Koike, Tomoyuki, Sugimoto, Mitsushige, Murata, Masaki, Hamada, Kenta, Okada, Hiroyuki, Kobara, Hideki, Chiyo, Taiga, Yoshida, Norimasa, Tomatsuri, Naoya, Inaba, Tomoki, Ishikawa, Shigenao, Nagahara, Akihito, Ueyama, Hiroya, Koizumi, Eriko, Iwakiri, Katsuhiko, Mizukami, Kazuhiro, Murakami, Kazunari, Furuta, Takahisa, Suzuki, Takahiro, Ogasawara, Naotaka, Kasugai, Kunio, Isomoto, Hajime, Kawaguchi, Koichiro, Shibagaki, Kotaro, Kataoka, Hiromi, Shimura, Takaya, Suzuki, Hidekazu, Nishizawa, Toshihiro, and Higuchi, Kazuhide

Published
2022
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15. Real‐world data on efficacy/safety and economic impact of nivolumab administered every 2 and 4 weeks among Japanese patients

Author

Tasaki, Yoshihiko, primary, Ito, Nanami, additional, Mimura, Yoshihisa, additional, Sugiyama, Yosuke, additional, Ogawa, Ryo, additional, Shimura, Takaya, additional, Nakamura, Motoki, additional, Kawakita, Daisuke, additional, Hamamoto, Shuzo, additional, Uemura, Takehiro, additional, Yokota, Keisuke, additional, Iida, Moeko, additional, Odagiri, Kunihiro, additional, Kimura, Yuka, additional, Hotta, Yuji, additional, Komatsu, Hirokazu, additional, Okuda, Katsuhiro, additional, Niimi, Akio, additional, Yasui, Takahiro, additional, Iwasaki, Shinichi, additional, Morita, Akimichi, additional, Kataoka, Hiromi, additional, Takiguchi, Shuji, additional, and Furukawa‐Hibi, Yoko, additional

Published
2024
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16. Krüppel-like Factor-4-Mediated Macrophage Polarization and Phenotypic Transitions Drive Intestinal Fibrosis in THP-1 Monocyte Models In Vitro

Author

Kanno, Takuya, primary, Katano, Takahito, additional, Shimura, Takaya, additional, Tanaka, Mamoru, additional, Nishie, Hirotada, additional, Fukusada, Shigeki, additional, Ozeki, Keiji, additional, Ogawa, Isamu, additional, Iwao, Takahiro, additional, Matsunaga, Tamihide, additional, and Kataoka, Hiromi, additional

Published
2024
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17. Data from Spatiotemporal Quantification of HER2-targeting Antibody–Drug Conjugate Bystander Activity and Enhancement of Solid Tumor Penetration

Author

Wei, Qing, primary, Yang, Teng, primary, Zhu, Jiayu, primary, Zhang, Ziwen, primary, Yang, Le, primary, Zhang, Yuchao, primary, Hu, Can, primary, Chen, Jiahui, primary, Wang, Jinchao, primary, Tian, Xuefei, primary, Shimura, Takaya, primary, Fang, Jianmin, primary, Ying, Jieer, primary, Fan, Mengyang, primary, Guo, Peng, primary, and Cheng, Xiangdong, primary

Published
2024
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18. Supplementary Data 1 from Spatiotemporal Quantification of HER2-targeting Antibody–Drug Conjugate Bystander Activity and Enhancement of Solid Tumor Penetration

Author

Wei, Qing, primary, Yang, Teng, primary, Zhu, Jiayu, primary, Zhang, Ziwen, primary, Yang, Le, primary, Zhang, Yuchao, primary, Hu, Can, primary, Chen, Jiahui, primary, Wang, Jinchao, primary, Tian, Xuefei, primary, Shimura, Takaya, primary, Fang, Jianmin, primary, Ying, Jieer, primary, Fan, Mengyang, primary, Guo, Peng, primary, and Cheng, Xiangdong, primary

Published
2024
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21. Correction to: Effectiveness of second-look endoscopy after gastric endoscopic submucosal dissection in patients taking antithrombotic agents: a multicenter propensity score matching analysis

Author

Iwatsubo, Taro, Takeuchi, Toshihisa, Hakoda, Akitoshi, Fujiwara, Yasuhiro, Nagami, Yasuaki, Naito, Yuji, Dohi, Osamu, Tatsuta, Tetsuya, Sawaya, Manabu, Jin, Xiaoyi, Koike, Tomoyuki, Sugimoto, Mitsushige, Murata, Masaki, Hamada, Kenta, Okada, Hiroyuki, Kobara, Hideki, Chiyo, Taiga, Yoshida, Norimasa, Tomatsuri, Naoya, Inaba, Tomoki, Ishikawa, Shigenao, Nagahara, Akihito, Ueyama, Hiroya, Koizumi, Eriko, Iwakiri, Katsuhiko, Mizukami, Kazuhiro, Murakami, Kazunari, Furuta, Takahisa, Suzuki, Takahiro, Ogasawara, Naotaka, Kasugai, Kunio, Isomoto, Hajime, Kawaguchi, Koichiro, Shibagaki, Kotaro, Kataoka, Hiromi, Shimura, Takaya, Suzuki, Hidekazu, Nishizawa, Toshihiro, and Higuchi, Kazuhide

Published
2022
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22. Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma.

Author

Zhang, Peng, Tao, Changjuan, Lu, Ye, Li, Peijing, Wang, Xing, Dai, Yujie, Xi, Yun, Shimura, Takaya, Li, Xinfang, Fang, Jianmin, Yang, Liu, He, Dawei, and Guo, Peng

Subjects
DNA topoisomerase inhibitors, DNA antibodies, DNA methylation, TUMOR treatment, ANIMAL models in research, DNA topoisomerase I
Abstract

Therapeutic benefits and underlying biomechanism(s) of antibody drug conjugates (ADC) in combination with other targeted therapeutics are largely unknown. Here, the synergy between ADC and epigenetic drug decitabine (DAC), a clinically approved DNA methylation inhibitor, in multiple preclinical models of melanoma specifically investigated. Mechanistically, the underlying biomechanisms of how DAC cooperatively worked with ICAM1 antibody conjugated DNA topoisomerase I inhibitor DXd (I1‐DXd) is elucidated. DAC treatment significantly enhanced anti‐tumor efficacy of I1‐DXd by upregulating antigen expression, enhancing antibody internalization and potentiating tumor sensitivity by epigenetically reprogramming of melanoma. Meanwhile, I1‐DXd/DAC combination also exerted regulatory effects on tumor microenvironment (TME) by enhancing tumor infiltration of innate and adaptive immune cells and improving penetration of ADCs with a boosted antitumor immunity. This study provides a rational ADC combination strategy for solid tumor treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Implication of KLHL Gene Family Member KLHL5 in Colorectal Cancer Progression and Prognosis

Author

Uno, Konomu, primary, Nishie, Hirotada, additional, Hiyoshi, Hiromi, additional, Habu, Kyosuke, additional, Nakayama, Jun, additional, Tate, Sota, additional, Sakaue, Tomohisa, additional, Kubota, Eiji, additional, Tanaka, Mamoru, additional, Shimura, Takaya, additional, Kataoka, Hiromi, additional, Joh, Takashi, additional, and Higashiyama, Shigeki, additional

Published
2024
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27. Spatiotemporal quantification of HER2-targeting antibody-drug conjugate bystander activity and enhancement of solid tumor penetration

Author

Wei, Qing, primary, Yang, Teng, additional, Zhu, Jiayu, additional, Zhang, Ziwen, additional, Yang, Le, additional, Zhang, Yuchao, additional, Hu, Can, additional, Chen, Jiahui, additional, Wang, Jinchao, additional, Tian, Xuefei, additional, Shimura, Takaya, additional, Fang, Jianmin, additional, Ying, Jieer, additional, Fan, Mengyang, additional, Guo, Peng, additional, and Cheng, Xiangdong, additional

Published
2023
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31. The first management using intubation of a nasogastric tube with Gastrografin enterography or long tube for non-strangulated acute small bowel obstruction: a multicenter, randomized controlled trial

Author

Katano, Takahito, Shimura, Takaya, Nishie, Hirotada, Iwai, Tomohiro, Itoh, Keisuke, Ebi, Masahide, Mizuno, Yusuke, Togawa, Shozo, Shibata, Shunsuke, Yamada, Tomonori, Mizushima, Takashi, Inagaki, Yusuke, Kitagawa, Mika, Nojiri, Yu, Tanaka, Yoshito, Okamoto, Yasuyuki, Sugiura, Miyuki, Matoya, Sho, Nagura, Yoshihito, Inagaki, Yuki, Koguchi, Hiroki, Ono, Satoshi, Ozeki, Keiji, Hayashi, Noriyuki, Takiguchi, Shuji, and Kataoka, Hiromi

Published
2020
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35. Clinical Impact of Proton Pump Inhibitor and Potassium-Competitive Acid Blocker for Predicting the Curability of Endoscopic Resection in Ulcerative Early Gastric Cancer.

Author

Uno, Konomu, Shimura, Takaya, Inaguma, Shingo, Kuroyanagi, Keita, Nishigaki, Ruriko, Kanno, Takuya, Sasaki, Makiko, Fukusada, Shigeki, Sugimura, Naomi, Mizuno, Yusuke, Nukui, Takayuki, Kojima, Yuki, Tanaka, Mamoru, Ozeki, Keiji, Kubota, Eiji, Takahashi, Satoru, and Kataoka, Hiromi

Subjects
*ENDOSCOPIC surgery, *PROTON pump inhibitors, *STOMACH cancer, *H2 receptor antagonists, *HYPERKALEMIA
Abstract

Introduction: Endoscopic diagnosis is essential for predicting the curability of early gastric cancer (EGC; R0 resection) before treatment, but the relationship between ulcerative lesions and clinical outcomes remains unclear. We aimed to investigate the effect of proton pump inhibitor (PPI) or potassium-competitive acid blocker (P-CAB) on the morphological changes of ulcerative EGCs and its relevance to the clinical outcomes. Methods: Altogether, 143 patients with differentiated ulcerative EGC that were resected by endoscopic submucosal dissection were retrospectively identified and divided into the following two cohorts depending on their PPI/P-CAB administration status: PPI/P-CAB (n = 76) and non-PPI/P-CAB (n = 67) cohorts. Furthermore, in each cohort, the patients were further divided into the improved and unimproved subgroups based on the ulcerative changes. Results: In the PPI/P-CAB cohort, the deep submucosal invasion and lymphovascular invasion rates were significantly higher in the unimproved subgroup than in the improved subgroup, resulting in a significantly lower R0 resection rate. Contrarily, no significant differences were found between the two subgroups in the non-PPI/P-CAB cohort. The significance of PPI/P-CAB administration was observed only in the ulcerative EGCs with open-type atrophy (R0 resection rate; improved vs. unimproved, 90.9% vs. 48.0%, p = 0.001). When the finding of improved ulcer with PPI/P-CAB administration was used as the indication of endoscopic resection in ulcerative EGCs with open-type atrophy, high sensitivity (78.9%) and accuracy (76.3%) rates for the curability were observed, which were higher than those of conventional endoscopic diagnosis alone (p = 0.021). Conclusion: PPI or P-CAB administration might contribute to the potential selection of ulcerative EGCs, enabling endoscopic curative resection. [ABSTRACT FROM AUTHOR]

Published
2024
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37. A prospective cohort study of a new electrosurgical unit for preventing colorectal post‐endoscopic submucosal dissection coagulation syndrome.

Author

Shimura, Takaya, Iwasaki, Hiroyasu, Ozeki, Takanori, Katano, Takahito, Okuda, Yusuke, Mizuno, Yusuke, Fukusada, Shigeki, Sugimura, Naomi, Kitagawa, Mika, Nishie, Hirotada, and Kataoka, Hiromi

Subjects
*LONGITUDINAL method, *LEUKOCYTE count, *COHORT analysis
Abstract

Background and Aim: Post‐endoscopic submucosal dissection coagulation syndrome (PECS) is a recognized complication of colorectal endoscopic submucosal dissection (ESD); however, there is a lack of interventions for preventing PECS. We therefore conducted a prospective study to evaluate the utility of maXium, a novel electrosurgical unit, for preventing PECS. Methods: This single‐center, prospective cohort study prospectively enrolled patients undergoing colorectal ESD. The voltage and power of the electrosurgical units were measured. PECS was defined as a visual analog scale (VAS) ≥ 30 mm, an increase of VAS ≥ 20 mm from baseline, body temperature ≥ 37.5°C, or white blood cell count ≥ 10 000/μL after ESD. PECS was classified into type I (without extra‐luminal air) and type II (with peri‐luminal air). The primary endpoint was the incidence of PECS. A sample size of 92 patients was required to ensure the upper limit of the 90% CI for the incidence of PECS was less than 15%. Results: At resistances greater than 400 Ω, the maXium unit allowed submucosal dissection with lower power than with the VIO300D unit. Ninety‐one patients meeting the inclusion criteria were included in the final study analysis. The incidence of PECS was 16% (90% CI, 10–23%), comprising type I (11%) and type II (5%) PECS. Simple extra‐luminal air without PECS was observed in 7% of patients. Conclusion: Use of the maXium electrosurgical unit did not reduce the incidence of PECS after colorectal ESD; however, the maXium unit had equivalent performance to a conventional electrosurgical unit used for colorectal ESD. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Eosinophil may be a predictor of immune‐related adverse events induced by different immune checkpoint inhibitor types: A retrospective multidisciplinary study

Author

Tasaki, Yoshihiko, primary, Sugiyama, Yosuke, additional, Hamamoto, Shuzo, additional, Naiki, Taku, additional, Uemura, Takehiro, additional, Yokota, Keisuke, additional, Kawakita, Daisuke, additional, Nakamura, Motoki, additional, Ogawa, Ryo, additional, Shimura, Takaya, additional, Mimura, Yoshihisa, additional, Hotta, Yuji, additional, Odagiri, Kunihiro, additional, Ito, Nanami, additional, Iida, Moeko, additional, Kimura, Yuka, additional, Komatsu, Hirokazu, additional, Kataoka, Hiromi, additional, Takiguchi, Shuji, additional, Morita, Akimichi, additional, Iwasaki, Shinichi, additional, Okuda, Katsuhiro, additional, Niimi, Akio, additional, Yasui, Takahiro, additional, and Furukawa‐Hibi, Yoko, additional

Published
2023
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39. Laparoscopic pancreas‐preserving duodenectomy: Minimally invasive surgery for superficial nonampullary duodenal epithelial tumors

Author

Ito, Sunao, primary, Sagawa, Hiroyuki, additional, Iwasaki, Hiroyasu, additional, Shimura, Takaya, additional, Nakano, Satsuki, additional, Kusudo, Natsuki, additional, Fujita, Kohei, additional, Saito, Masaki, additional, Harata, Shinnosuke, additional, Hayakawa, Shunsuke, additional, Okubo, Tomotaka, additional, Tanaka, Tatsuya, additional, Ogawa, Ryo, additional, Takahashi, Hiroki, additional, Matsuo, Yoichi, additional, Kataoka, Hiromi, additional, and Takiguchi, Shuji, additional

Published
2023
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44. Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesity

Author

Fukusada, Shigeki, primary, Shimura, Takaya, additional, Natsume, Makoto, additional, Nishigaki, Ruriko, additional, Okuda, Yusuke, additional, Iwasaki, Hiroyasu, additional, Sugimura, Naomi, additional, Kitagawa, Mika, additional, Katano, Takahito, additional, Tanaka, Mamoru, additional, Ozeki, Keiji, additional, Kubota, Eiji, additional, Hayashi, Kazuki, additional, and Kataoka, Hiromi, additional

Published
2023
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45. A MULTICENTER CASE-CONTROL STUDY ON LONG-TERM OUTCOMES OF SELF-EXPANDING METALLIC STENT VERSUS TRANS-ANAL COLORECTAL TUBE FOR STAGE II/III NON-RIGHT-SIDED OBSTRUCTIVE COLON CANCER

Author

Okuda, Yusuke, primary, Shimura, Takaya, additional, Uno, Konomu, additional, Yamada, Tomonori, additional, Nukui, Takayuki, additional, Mizushima, Takashi, additional, Takenaka, Yuya, additional, Ito, Keisuke, additional, Inagaki, Yuki, additional, Ozeki, Takanori, additional, Nagao, Kazuhiro, additional, Ebi, Masahide, additional, Uchida, Erika, additional, Nomura, Satoshi, additional, Nojiri, Yu, additional, Togawa, Shozo, additional, and Kataoka, Hiromi, additional

Published
2023
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46. Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers.

Author

Kojima, Yuki, Tanaka, Mamoru, Sasaki, Makiko, Ozeki, Keiji, Shimura, Takaya, Kubota, Eiji, and Kataoka, Hiromi

Subjects
PHOTODYNAMIC therapy, SORAFENIB, REACTIVE oxygen species, GLUTATHIONE peroxidase, IMIDAZOLES, KETONES, TUMOR treatment
Abstract

Background: Photodynamic therapy (PDT) is an effective tumor treatment that involves the administration of a photosensitizer to generate cytotoxic 1O2 [reactive oxygen species (ROS)] from molecular oxygen that is produced from energy absorption following tumor irradiation at specific wavelengths. Ferroptosis is induced by the disruption of the glutathione peroxidase 4 (GPX4) antioxidant system, leading to lipid peroxidation. We hypothesized that talaporfin sodium-photodynamic therapy (TS-PDT)-generated ROS would lead to ferroptosis via accumulation of lipid peroxidation. Methods: Cell viability assay in TS-PDT-treated cells in combination with a ferroptosis inhibitor (ferrostatin-1: Fer-1) or ferroptosis inducers (imidazole ketone erastin: IKE, Ras-selective lethal 3: RSL3) was performed. Accumulation of lipid peroxidation, GPX4 antioxidant system and cystine/glutamate antiporter (system xc−) activity in TS-PDT-treated cells was investigated. In xenograft mice, the antitumor effect of TS-PDT in combination with ferroptosis inducers (IKE or sorafenib) was examined. Results: TS-PDT-induced cell death was partly suppressed by Fer-1 and accompanied by lipid peroxidation. TS-PDT combined with IKE or RSL3 enhanced the induction of cell death. TS-PDT inhibited cystine uptake activity via system xc−. In vivo, the combination of TS-PDT and ferroptosis inducers (IKE or sorafenib) reduced tumor volume. Conclusion: This study found that the mechanism underlying TS-PDT-induced ferroptosis constitutes direct lipid peroxidation by the generated ROS, and the inhibition of system xc−, and that the combination of a ferroptosis inducer with TS-PDT enhances the antitumor effect of TS-PDT. Our findings suggest that ferroptosis-inducing therapies combined with PDT may benefit cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Laparoscopic pancreas‐preserving duodenectomy: Minimally invasive surgery for superficial nonampullary duodenal epithelial tumors.

Author

Ito, Sunao, Sagawa, Hiroyuki, Iwasaki, Hiroyasu, Shimura, Takaya, Nakano, Satsuki, Kusudo, Natsuki, Fujita, Kohei, Saito, Masaki, Harata, Shinnosuke, Hayakawa, Shunsuke, Okubo, Tomotaka, Tanaka, Tatsuya, Ogawa, Ryo, Takahashi, Hiroki, Matsuo, Yoichi, Kataoka, Hiromi, and Takiguchi, Shuji

Subjects
MINIMALLY invasive procedures, EPITHELIAL tumors, DUODENAL tumors, LAPAROSCOPIC surgery, ENDOSCOPIC surgery, DUODENAL obstructions
Abstract

No consensus exists regarding the optimal treatment for superficial nonampullary duodenal epithelial tumors. Herein, we describe a laparoscopic pancreas‐preserving duodenectomy for the treatment of a 30‐mm adenoma located in the third portion of the duodenum. The adenoma was located on the pancreatic side, further hindering safe endoscopic resection. Via laparoscopy, the jejunum was transected first. After releasing the third portion of the duodenum from the retroperitoneal space, the jejunum was pulled to the right side of the superior mesenteric artery and separated from the pancreas. Under endoscopic guidance, the duodenum was then transected and duodenojejunostomy performed intracorporeally. Laparoscopic pancreas‐preserving duodenectomy can be considered minimally invasive, achieving tumor radicality while preserving organs and causing minimal destruction to the abdominal wall. In conclusion, although technically demanding, laparoscopic pancreas‐preserving duodenectomy is a valuable treatment option for superficial nonampullary duodenal epithelial tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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