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7 results on '"Shimotsu, Kyoko"'

1. Physiology of Simple Photoreceptors in the Abdominal Ganglion of Onchidium

Author

Nishi, Takako, Shimotsu, Kyoko, Gotow, Tsukasa, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Mele, Francesco, editor, Ramella, Giuliana, editor, Santillo, Silvia, editor, and Ventriglia, Francesco, editor

Published
2007
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2. Non-image Forming Function of the Extraocular Photoreceptors in the Ganglion of the Sea Slug Onchidium

Author

Gotow, Tsukasa, Shimotsu, Kyoko, Nishi, Takako, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, De Gregorio, Massimo, editor, Di Maio, Vito, editor, Frucci, Maria, editor, and Musio, Carlo, editor

Published
2005
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5. Reduced N-Acetylaspartate Levels in Mice Lacking Aralar, a Brain- and Muscle-type Mitochondrial Aspartate-glutamate Carrier

Author

Jalil, Md. Abdul, primary, Begum, Laila, additional, Contreras, Laura, additional, Pardo, Beatriz, additional, Iijima, Mikio, additional, Li, Meng Xian, additional, Ramos, Milagros, additional, Marmol, Patricia, additional, Horiuchi, Masahisa, additional, Shimotsu, Kyoko, additional, Nakagawa, Shiro, additional, Okubo, Akiko, additional, Sameshima, Munefumi, additional, Isashiki, Yasushi, additional, del Arco, Araceli, additional, Kobayashi, Keiko, additional, Satrústegui, Jorgina, additional, and Saheki, Takeyori, additional

Published
2005
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6. Non-image Forming Function of the Extraocular Photoreceptors in the Ganglion of the Sea Slug Onchidium.

Author

Gregorio, Massimo, Maio, Vito, Frucci, Maria, Musio, Carlo, Gotow, Tsukasa, Shimotsu, Kyoko, and Nishi, Takako

Abstract

Several identified photoresponsive neurons (or extraocular photoreceptors) exist in the ganglion (CNS) of the sea slug Onchidium. The named A-P-1/Es-1 of these neurons responded to light with a depolarization, caused by closing of the cGMP-gated K+ channels, as in vertebrate phototransduction. The hyperpolarizing photoresponse of the others Ip-2/Ip-1 was produced by opening of the same cGMP-gated K+ channels as above following activation of a G-protein, Go coupled with guanylate cyclase. The amount of light required to stimulate these neurons covered in situ could be easily provided by the transmission of living daylight through the animal's body wall. The first order photosensory cells, A-P-1/Es-1 and Ip-2/Ip-1 were not only the second order interneurons relaying several kinds of sensory inputs, but also motoneurons innervating the mantle and the pneumostome. Thus, it is suggested that the depolarizing photoresponse of A-P-1/Es-1 plays a role in facilitating the synaptic transmission of sensory inputs and the following outputs, i.e. the mantle movements and that the hyperpolarizing one of Ip-2/Ip-1 in depressing a transmission similar to above and the following pneumostome ones. Similarly, it is possible that the photoresponse of photoresponsive neurons, ipRGCs in mammalian retina operates also in the general regulation of synaptic transmission and behavioral activities. [ABSTRACT FROM AUTHOR]

Published
2005
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7. Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study

Author

MATSUMOTO, Yasuhide, SHIMOTSU, Kyoko, IIJIMA, Mikio, SAHEKI, Takeyori, and NAKAGAWA, Shiro

Subjects
elevated plus-maze test, aralar, light-dark exploration test, tryptophan hydroxylase, serotonin
Abstract

Aralar, an isoform of the calcium-binding aspartate-glutamate mitochondrial carrier, is distributed specifically in the brainand skeletal muscles. The aim of the present study was to investigate behaviors induced by the decreased expression ofaralar in the brain and to assess whether expression of brain tryptophan hydroxylase, a key enzyme in serotonin synthesis,is correlative with behavioral changes in aralar-deficient mice. In the elevated plus-maze test, heterozygous mice (Aralar^{＋/－})spent more time in the open arms and showed a significant increase in the number of entries to the open arms comparedto wild-type littermates (Aralar^{＋/＋}). In addition, Aralar^{＋/－} mice spent more time in the light compartment in a light-darkexploration test compared to Aralar^{＋/＋} mice. Western blot analysis showed a decreased expression of brain tryptophanhydroxylase in Aralar^{＋/－} mice compared to Aralar^{＋/＋} mice. These results suggested that Aralar^{＋/－} mice exhibit a lowerlevel of anxiety-like behaviors compared to Aralar^{＋/＋} littermates. This might be correlative with the reduced serotoninsynthesis.

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