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34 results on '"Shimogawara, Rieko"'

4. Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan

Author

Yanagawa, Yasuaki, primary, Shimogawara, Rieko, additional, Takano, Misao, additional, Aoki, Takahiro, additional, Mizushima, Daisuke, additional, Gatanaga, Hiroyuki, additional, Kikuchi, Yoshimi, additional, Oka, Shinichi, additional, Yagita, Kenji, additional, and Watanabe, Koji, additional

Published
2022
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11. Utility of the Rapid Antigen Detection Test E. histolytica Quik Chek for the Diagnosis of Entamoeba histolytica Infection in Nonendemic Situations

Author

Yanagawa, Yasuaki, primary, Shimogawara, Rieko, additional, Endo, Tomoyuki, additional, Fukushima, Rika, additional, Gatanaga, Hiroyuki, additional, Hayasaka, Kasumi, additional, Kikuchi, Yoshimi, additional, Kobayashi, Taiichiro, additional, Koga, Michiko, additional, Koibuchi, Tomohiko, additional, Miyagawa, Toshikazu, additional, Nagata, Ayaka, additional, Nakata, Hirotomo, additional, Oka, Shinichi, additional, Otsuka, Risa, additional, Sakai, Kazumi, additional, Shibuya, Mami, additional, Shingyochi, Hiroyuki, additional, Tsuchihashi, Etsuko, additional, Watanabe, Koji, additional, and Yagita, Kenji, additional

Published
2020
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14. Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex

Author

Kwofie, Kofi Dadzie, primary, Sato, Kai, additional, Sanjoba, Chizu, additional, Hino, Akina, additional, Shimogawara, Rieko, additional, Amoa-Bosompem, Michael, additional, Ayi, Irene, additional, Boakye, Daniel A., additional, Anang, Abraham K., additional, Chang, Kyung-Soo, additional, Ohashi, Mitsuko, additional, Kim, Hye-Sook, additional, Ohta, Nobuo, additional, Matsumoto, Yoshitsugu, additional, and Iwanaga, Shiroh, additional

Published
2019
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18. Comparative analysis of knowledge on schistosomiasis japonica in the local people in the former endemic area in Yamanashi Prefecture, Japan: comparisons among the background of age and occupation

Author

HATA, Nobuhide, primary, YASUKAWA, Akio, additional, SEI, Eiichi, additional, KAWASUMI, Koh, additional, MIYA, Naoto, additional, YAMAGUCHI, Hironobu, additional, MINAI, Masaru, additional, SHIMOGAWARA, Rieko, additional, and OHTA, Nobuo, additional

Published
2017
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20. Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicuminfection using high-resolution ultrasound imaging

Author

Maezawa, Katsumi, Furushima-Shimogawara, Rieko, Yasukawa, Akio, Ohta, Nobuo, and Iwanaga, Shiro

Abstract

Hepatosplenic lesion formation is one of the typical clinical symptoms of schistosomiasis japonica. Although it is established that circum-oval granuloma formation mediated by T lymphocytes is the key event triggering the formation of hepatic lesions, the time-course kinetics of disease progression remains to be fully elucidated. The real-time process of the pathophysiology of schistosomiasis japonica from the early to late clinical phase was non-invasively observed in a murine experimental infection model using high-resolution ultrasonography. Together with clinical parameters, including body weight and the levels of serum markers of hepatic damage or fibrosis, ultrasonography was used to assess changes in the liver parenchyma and diameter of the portal vein and portal blood flow velocity. In parallel, parasitological parameters were observed, including egg number in the feces and maturation of parasites. Abnormal high-echo spot patterns in the liver parenchyma, reflecting hepatic fibrosis in ultrasonography, appeared in the liver at 4 weeks post-infection and the pattern became more enlarged and severe over time. This finding was concordant with parasite maturation and initial egg excretion. The serum M2BPGi level markedly increased from 8 weeks post-infection, suggesting sharp deterioration of hepatic fibrosis. At the same time, the diameter of the portal vein, reflecting portal hypertension, became enlarged and reached the peak level at 8 weeks post-infection. Ascites were apparent around the spleen at 9 weeks post-infection, and dilatation of the splenic vein was noted at 10 weeks post-infection. Live adult worms seemed to be detected in the portal vein at 4 weeks post-infection by ultrasonography. We obtained real-time imaging of the development of hepatosplenic lesions of schistosomiasis japonica in mice. The time-course kinetics of the onset, development, and modulation of each symptom was uncovered. These results are expected to provide new clues for understanding the pathophysiology of human schistosomiasis japonica.

Published
2018
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21. A new surveillance and response tool: Risk map of infected Oncomelania hupensis detected by Loop-mediated isothermal amplification (LAMP) from pooled samples

Author

Tong, Qun-Bo, primary, Chen, Rui, additional, Zhang, Yi, additional, Yang, Guo-Jing, additional, Kumagai, Takashi, additional, Furushima-Shimogawara, Rieko, additional, Lou, Di, additional, Yang, Kun, additional, Wen, Li-Yong, additional, Lu, Shao-Hong, additional, Ohta, Nobuo, additional, and Zhou, Xiao-Nong, additional

Published
2015
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22. Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation

Author

Anyan, William K., primary, Seki, Takenori, additional, Kumagai, Takashi, additional, Obata-Ninomiya, Kazushige, additional, Furushima-Shimogawara, Rieko, additional, Kwansa-Bentum, Bethel, additional, Akao, Nobuaki, additional, Bosompem, Kwabena M., additional, Boakye, Daniel A., additional, Wilson, Michael D., additional, Karasuyama, Hajime, additional, and Ohta, Nobuo, additional

Published
2013
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27. Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production: Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo

Author

Anyan, William K., primary, Kumagai, Takashi, additional, Shimogawara, Rieko F., additional, Seki, Takenori, additional, Akao, Nobuaki, additional, Obata, Kazushige, additional, Kwansa-Bentum, Bethel, additional, Bosompem, Kwabena Mante, additional, Boakye, Daniel A, additional, Wilson, Michael D., additional, Karasuyama, Hajime, additional, and Ohta, Nobuo, additional

Published
2010
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30. Interleukin-4 (IL-4) and IL-13 Suppress Excessive Neutrophil Infiltration and Hepatocyte Damage during Acute Murine Schistosomiasis Japonica

Author

Seki, Takenori, Kumagai, Takashi, Kwansa-Bentum, Bethel, Furushima-Shimogawara, Rieko, Anyan, William K., Miyazawa, Yuuki, Iwakura, Yoichiro, and Ohta, Nobuo

Abstract

ABSTRACTDue to the importance of neutrophils and proinflammatory cytokines in schistosomal liver damage, we analyzed the mechanisms underlying neutrophil and proinflammatory responses in murine schistosomiasis japonica. We found that granulomatous inflammation around parasite eggs in the liver was greater in Schistosoma japonicum-infected IL-4−/−IL-13−/−(double-knockout [DKO]) mice than in infected wild-type (WT) mice at 6 weeks, but not at 8 weeks, postinfection, suggesting the importance of Th2 responses in these typical hepatic lesions. Infected DKO mice also showed increased neutrophil infiltration accompanying more severe pathology, as shown by the enhanced necrosis of hepatocytes. This was not likely due to a Th1/Th2 imbalance, because there was no detectable increase in gamma interferon (IFN-γ) production in these DKO mice. mRNA expression of interleukin-17A (IL-17A), proinflammatory cytokines, and the neutrophil chemoattractant CXCL2 in liver was higher in infected DKO mice than in WT mice. However, in IL-4−/−IL-13−/−IL-17A−/−(triple-knockout [TKO]) mice, the absence of IL-17A was associated with only marginal differences in schistosomal liver damage, suggesting that IL-17A is only partially responsible for neutrophil-driven hepatic damage. Furthermore, the expression of mRNAs encoding proinflammatory cytokines was not under the control of IL-17A in TKO mice. These findings indicate that IL-4 and IL-13 suppress excessive neutrophil recruitment, proinflammatory cytokine production, and hepatic damage during the acute stage of S. japonicuminfection, suggesting that neutrophils and proinflammatory cytokines are mainly responsible for hepatocyte damage during acute murine schistosomiasis japonica. However, neutrophil induction and the production of proinflammatory cytokines were not due solely to IL-17A.

Published
2011
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31. Utility of the Rapid Antigen Detection Test E. histolyticaQuik Chek for the Diagnosis of Entamoeba histolyticaInfection in Nonendemic Situations

Author

Yanagawa, Yasuaki, Shimogawara, Rieko, Endo, Tomoyuki, Fukushima, Rika, Gatanaga, Hiroyuki, Hayasaka, Kasumi, Kikuchi, Yoshimi, Kobayashi, Taiichiro, Koga, Michiko, Koibuchi, Tomohiko, Miyagawa, Toshikazu, Nagata, Ayaka, Nakata, Hirotomo, Oka, Shinichi, Otsuka, Risa, Sakai, Kazumi, Shibuya, Mami, Shingyochi, Hiroyuki, Tsuchihashi, Etsuko, Watanabe, Koji, and Yagita, Kenji

Abstract

Entamoeba histolyticainfection is an increasingly common sexually transmitted infection in Japan. Currently, stool ova and parasite examination (O&P) is the only approved diagnostic method. Here, we assessed the utility of the commercially available rapid antigen detection test (Quik Chek) for E. histolytica. A multicenter cross-sectional study was conducted. Stool samples that had been submitted for O&P were included. The samples were subjected to both Quik Chek and PCR, and the Quik Chek results were assessed in comparison with PCR as the reference standard.

Published
2020
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32. Immunogenicity and anti-fecundity effect of nanoparticle coated glutathione S-transferase (SjGST) DNA vaccine against murine Schistosoma japonicum infection.

Author

Mbanefo, Evaristus Chibunna, Kumagai, Takashi, Kodama, Yukinobu, Kurosaki, Tomoaki, Furushima-Shimogawara, Rieko, Cherif, Mahamoud Sama, Mizukami, Shusaku, Kikuchi, Mihoko, Huy, Nguyen Tien, Ohta, Nobuo, Sasaki, Hitoshi, and Hirayama, Kenji

Subjects
*SCHISTOSOMA japonicum, *NANOMEDICINE, *DNA vaccines, *IMMUNOGENETICS, *GLUTATHIONE transferase, *ZOONOSES
Abstract

There is still urgent need for a vaccine against schistosomiasis, especially in Schistosoma japonicum endemic areas where even a vaccine that will interrupt zoonotic transmission will be potentially effective as an intervention tool. We had developed a novel nanoparticle gene delivery system, which has proven efficacious in gene transfection to target immune cells with complementary adjuvant effect and high protective efficacy in several diseases. Here, we applied this nanoparticle system in combination with S . japonicum glutathione S-transferase ( Sj GST) DNA vaccine to show the immunogenicity and anti-fecundity effect of the nanoparticle coated vaccine formulation against murine schistosomiasis. The nanoparticle-coated DNA vaccine formulation induced desired immune responses. In comparison with the nanoparticle coated empty vector, it produced significantly increased antigen-specific humoral response, T-helper 1 polarized cytokine environment, higher proportion of IFN-γ producing CD4 + T-cells and the concomitant decrease in IL-4 producing CD4 + T-cells. Although there was no effect on worm burden, we recorded a marked reduction in tissue egg burden. There was up to 71.3% decrease in tissue egg burden and 55% reduction in the fecundity of female adult worms. Our data showed that Sj GST DNA vaccine, delivered using the nanoparticle gene delivery system, produced anti-fecundity effect on female adult schistosomes as previously described by using conventional subunit vaccine with adjuvant, proving this DNA vaccine formulation as a promising candidate for anti-pathology and transmission blocking application. [ABSTRACT FROM AUTHOR]

Published
2015
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33. Amebiasis as a sexually transmitted infection: A re-emerging health problem in developed countries.

Author

Kawashima A, Yanagawa Y, Shimogawara R, Yagita K, Gatanaga H, and Watanabe K

Abstract

Amebiasis, which is caused by Entamoeba histolytica ( E. histolytica ), is the second leading cause of parasite-related death worldwide. It manifests from asymptomatic carriers to severe clinical conditions, like colitis and liver abscesses. Amebiasis is commonly seen in developing countries, where water and food are easily contaminated by feces because of the poor sanitation. However, a recently challenge in many developed countries is the increase in domestic cases of invasive amebiasis as a sexually transmitted infection (STI amebiasis). In contrast to food-/ waterborne transmission of E. histolytica in developing countries, transmission of STI amebiasis occurs directly through human-to-human sexual contact ( e.g. , men who have sex with men and people who engage in oral-anal sex); in this setting, asymptomatic infected individuals are the main reservoir of E. histolytica . The Development of screening methods for the early diagnosis of asymptomatic E. histolytica infection is the key to epidemiologic control. Moreover, delay in diagnosis of severe cases ( e.g. , fulminant amebiasis) leads to death even in developed countries. It is also important to increase clinical awareness of domestically transmitted STI amebiasis in the clinical settings. This review considers the changing epidemiology and clinical manifestations of STI amebiasis, and finally discusses the future strategies for the better practice., Competing Interests: The authors have no conflicts of interest to disclose., (2023, National Center for Global Health and Medicine.)

Published
2023
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34. How Did the Dengue Fever Outbreak Progress in Yoyogi Park, Tokyo, in 2014?-Evaluation Based on a Mathematical Model.

Author

Ishikawa H, Shimogawara R, and Fueda K

Subjects
Animals, Dengue virology, Humans, Time Factors, Tokyo epidemiology, Virus Latency, Aedes virology, Dengue epidemiology, Dengue transmission, Dengue Virus physiology, Disease Outbreaks, Models, Theoretical
Abstract

Objectives: In the summer of 2014, an outbreak of autochthonous dengue fever occurred in Yoyogi Park and its vicinity, Tokyo, Japan. In this study, we investigated how the dengue fever outbreak progressed in Yoyogi Park using a mathematical model., Methods: This study was limited to the transmission of the dengue virus in Yoyogi Park and its vicinity. We estimated the distributions of the intrinsic incubation period and infection dates on the basis of epidemiological information on the dengue outbreak in 2014. We searched for an assumption that satisfactorily explains the outbreak in 2014 using rough estimates of secondary and tertiary infection cases. We constructed a mathematical model for the transmission of the dengue virus between humans and Aedes albopictus., Results: We carried out 1,000-trial stochastic simulations for all combinations of three kinds of assumption about Ae. albopictus and asymptomatic infection with each of three levels. Simulation results showed that the scale of the outbreak was markedly affected by the daily survival rate of Ae. albopictus. The outbreak involved a small number of secondary infection cases, reached a peak at tertiary infection, and transformed to termination at the fourth infection. Under some assumptions, the daily progress of onset cases was within a range between the 1st-3rd quartiles of 1,000 trials for 87% of dates and within a range between the minimum and maximum for all dates., Conclusions: It is important to execute plans to detect asymptomatic cases and reduce the survival rate of Ae. albopictus to prevent the spread of tertiary infections unless an outbreak is suppressed at the secondary infection stage.

Published
2017
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