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1. Validation of a phage-open reading frame typing kit for rapid identification of methicillin-resistant Staphylococcus aureus (MRSA) transmission in a tertiary hospital

Author

Takahashi H, Seki M, Yamamoto N, Hamaguchi S, Ojima M, Hirose T, Yoshiya K, Toyokawa M, Nishi I, Ogura H, Shimazu T, and Tomono K

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Hiroki Takahashi,1,* Masafumi Seki,2,4,* Norihisa Yamamoto,2 Shigeto Hamaguchi,2 Masahiro Ojima,1 Tomoya Hirose,1 Kazuhisa Yoshiya,1 Masahiro Toyokawa,3 Isao Nishi,3 Hiroshi Ogura,1 Takeshi Shimazu,1 Kazunori Tomono21Department of Traumatology and Acute Critical Medicine, Osaka University Hospital, Suita, Osaka, Japan; 2Division of Infection Control and Prevention, Osaka University Hospital, Suita, Osaka, Japan; 3Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 4Division of Infection Control and Prevention, Tohoku Pharmaceutical University Hospital, Sendai, Japan *These authors contributed equally to this work Abstract: Surveillance is very important to prevent the nosocomial spread of methicillin-resistant Staphylococcus aureus (MRSA), and infection sources and routes have historically been identified using molecular and epidemiological genotyping with pulsed-field gel electrophoresis. However, phage-open reading frame typing (POT) has recently been developed. Here, we investigated whether POT would be useful to survey MRSA outbreaks and transmission. We therefore applied POT to 91 MRSA isolates detected in cultures from inpatients at our hospital between May and October 2014. Among the 91 isolates, 12 POT types comprising 38 isolated MRSA strains were considered as overlapping. Five of them were detected in different wards, whereas the remaining seven were found in the same ward, including the emergency department. Three of seven POT number 93-155-111 strains were detected in the surgical ward, and all of four POT number 93-157-61 strains were detected in the cardiosurgical ward. These data suggested that transmission of the MRSA strains with the same POT-types from the same wards was nosocomial, and that POT accurately and rapidly identified MRSA strains, which allowed effective control of infection and transmission. Keywords: MRSA, active surveillance, POT, nosocomial transmission

Published
2015

2. Polymerase chain reaction-based active surveillance of MRSA in emergency department patients

Author

Seki M, Takahashi H, Yamamoto N, Hamaguchi S, Ojima M, Hirose T, Yoshiya K, Ogura H, Shimazu T, and Tomono K

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Masafumi Seki,1,2,* Hiroki Takahashi,3,* Norihisa Yamamoto,1 Shigeto Hamaguchi,1 Masahiro Ojima,3 Tomoya Hirose,3 Kazuhisa Yoshiya,3 Hiroshi Ogura,3 Takeshi Shimazu,3 Kazunori Tomono1 1Division of Infection Control and Prevention, Osaka University Hospital, Suita, Osaka, Japan; 2Division of Infection Control and Prevention, Tohoku Pharmaceutical University Hospital, Sendai, Japan; 3Department of Traumatology and Acute Critical Medicine, Osaka University Hospital, Suita, Osaka, Japan *These authors contributed equally to this work Abstract: Conventional culture methods to detect methicillin-resistant Staphylococcus aureus (MRSA) take a few days, and their sensitivity and usefulness also need to be improved. In this study, active screening was performed using the polymerase chain reaction (PCR) for colonization with MRSA on admission and follow-up surveillance after admission to an emergency department between June 2012 and August 2012, and the backgrounds of PCR and/or culture-method-positive patients were compared. Among 95 patients, 15 (15.8%) patients were positive for MRSA on PCR and/or culture; 6.3% (6/95) of patients were positive on admission, and 9.5% (9/95) became positive during the stay after admission. The major primary diagnoses in MRSA-positive patients were trauma and cerebrovascular diseases. Nine (60%) of 15 patients were MRSA-positive on both PCR and culture, compared with three (20%) of 15 who were PCR-positive but culture-negative. The other three (20%) of 15 patients were PCR-negative but culture-positive. Furthermore, there was a tendency for younger age and shorter stay to be associated with PCR-positive but culture-negative results. These findings suggest that active surveillance with PCR may be highly sensitive and useful for the early diagnosis of MRSA colonization to prevent nosocomial transmission from the emergency department to the regular inpatient wards of the hospital. Keywords: active surveillance, length of stay, nosocomial transmission, BD GeneOhm MRSA assay, sensitivity, specificity

Published
2015

3. Case of invasive nontypable Haemophilus influenzae respiratory tract infection with a large quantity of neutrophil extracellular traps in sputum

Author

Hamaguchi S, Seki M, Yamamoto N, Hirose T, Matsumoto N, Irisawa T, Takegawa R, Shimazu T, and Tomono K

Subjects
Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Shigeto Hamaguchi,1,* Masafumi Seki,1,* Norihisa Yamamoto,1 Tomoya Hirose,2 Naoya Matsumoto,2 Taro Irisawa,2 Ryosuke Takegawa,2 Takeshi Shimazu,2 Kazunori Tomono11Division of Infection Control and Prevention, 2Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka, Japan *These authors contributed equally to this workAbstract: Haemophilus influenzae type b was once the most common cause of invasive H. influenzae infection, but the incidence of this disease has decreased markedly with introduction of conjugate vaccines to prevent the disease. In contrast, the incidence of invasive infection caused by nontypable H. influenzae has increased in the US and in European countries. Neutrophil extracellular traps (NETs) are fibrous structures released extracellularly from activated neutrophils during inflammation, including in pneumonia, and rapidly trap and kill pathogens as a first line of immunological defense. However, their function and pathological role have not been fully investigated. Here, we report a case of fatal nontypable H. influenzae infection with severe pneumonia and bacteremia in an adult found to have a vast amount of NETs in his sputum. The patient had a two-day history of common cold-like symptoms and was taken to the emergency room as a cardiopulmonary arrest. He recovered temporarily, but died soon afterwards, although appropriate antibiotic therapy and general management had been instituted. Massive lobular pneumonia and sepsis due to nontypable H. influenzae was found, in spite of H. influenzae type b vaccine being available. His sputum showed numerous bacteria phagocytosed by neutrophils, and immunohistological staining indicated a number of NETs containing DNA, histone H3, and neutrophil elastase. This case highlights an association between formation of NETs and severe respiratory and septic infection. An increase in severe nontypable H. influenzae disease can be expected as a result of “athogen shift”due to increased use of the H. influenzae type b vaccine in Japan.Keywords: neutrophil extracellular traps, sepsis, pneumonia, Haemophilus influenzae, type b, nontypable

Published
2012

5. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

Author

Author et al, Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, and Tridente, A

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Good Health and Well Being, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

[This corrects the article DOI: 10.1186/s13054-016-1208-6.].

Published
2016

6. 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.

Author

Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, Tridente, A, and Nee, P

Subjects
Emergency & Critical Care Medicine, Medical and Health Sciences
Published
2016

7. Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., Sato, Y., Shin, Sangah, Saito, Eiko, Sawada, Norie, Ishihara, Junko, Takachi, Ribeka, Nanri, Akiko, Shimazu, Taichi, Yamaji, Taiki, Iwasaki, Motoki, Sasazuki, Shizuka, Inoue, Manami, and Tsugane, Shoichiro

Published
2018
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8. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Goto, A., Hidaka, A., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Doi, M., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Sou, Y., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., Sato, Y., Hamazaki, Kei, Iso, Hiroyasu, Eshak, Ehab S., Ikehara, Satoyo, Ikeda, Ai, Iwasaki, Motoki, Hamazaki, Tomohito, and Tsugane, Shoichiro

Published
2018
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9. Association of green tea consumption with mortality due to all causes and major causes of death in a Japanese population: the Japan Public Health Center-based Prospective Study (JPHC Study)

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Saito, Eiko, Inoue, Manami, Sawada, Norie, Shimazu, Taichi, Yamaji, Taiki, Iwasaki, Motoki, Sasazuki, Shizuka, Noda, Mitsuhiko, Iso, Hiroyasu, and Tsugane, Shoichiro

Published
2015
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11. Plasma 25-hydroxy vitamin D and subsequent prostate cancer risk in a nested Case-Control study in Japan: The JPHC study

Author

Sawada, N, Inoue, M, Iwasaki, M, Yamaji, T, Shimazu, T, Sasazuki, S, and Tsugane, S

Subjects
Prostate cancer -- Risk factors, Alfacalcidol -- Health aspects, Calcifediol -- Health aspects, Vitamin D -- Health aspects, Food/cooking/nutrition, Health
Abstract

Background/Objectives: Although vitamin D has been experimentally reported to inhibit tumorigenesis, cell growth and prostate cancer invasion, epidemiologic data regarding prostate cancer risk are inconsistent, and some studies have suggested positive but nonsignificant associations. Further, the impact of vitamin D on prostate cancer between Western and Japanese populations may differ due to different plasma vitamin D levels. Subjects/Methods: We performed a nested case-control study within the Japan Public Health Center-based Prospective (JPHC) Study in 14,203 men (40-69 years) who answered a self-administered questionnaire at baseline (1990-1994) and gave blood samples, and were followed until 2005. We identified 201 prostate cancers which are newly diagnosed during follow-up (mean 12.8 years). We selected two matched controls for each case from the cohort. We used a conditional logistic regression model to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for prostate cancer with respect to levels of 25-hydroxy vitamin D (25(OH)D) in plasma. Results: We did not observe statistically significant association between 25(OH)D level and total prostate cancer (multivariate OR=1.13 (95%CI=0.66-1.94, P.sub.trend=0.94) for the highest versus lowest tertile) However, 25(OH) levels were slightly positively associated with advanced cancer. The results remained substantially unchanged after stratification by intake of fish or calcium intake. Conclusions: 25(OH)D level showed no association with overall prostate cancer among Japanese men in this large cohort., Author(s): N Sawada [sup.1] , M Inoue [sup.1] [sup.2] , M Iwasaki [sup.1] , T Yamaji [sup.1] , T Shimazu [sup.1] , S Sasazuki [sup.1] , S Tsugane [sup.1] , [...]

Published
2017
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12. Shared Decision-Making Support Program for Elderly Patients with Advanced Cancer Using Question Prompts and Geriatric Assessments: Phase II Randomized Controlled Trial

Author

Obama, K., primary, Fujimori, M., additional, Boku, N., additional, Matsuoka, A., additional, Mori, K., additional, Okizaki, A., additional, Miyaji, T., additional, Kadowaki, M., additional, Okamura, M., additional, Majima, Y., additional, Shimazu, T., additional, and Uchitomi, Y., additional

Published
2022
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13. Association of vegetable and fruit intake with gastric cancer risk among Japanese: a pooled analysis of four cohort studies

Author

Sasazuki, Shizuka, Tsugane, Shoichiro, Inoue, Manami, Iwasaki, Motoki, Otani, Tetsuya, Sawada, Norie, Shimazu, Taichi, Yamaji, Taiki, Tsuji, Ichiro, Tsubono, Yoshitaka, Nishino, Yoshikazu, Tamakoshi, Akiko, Matsuo, Keitaro, Ito, Hidemi, Wakai, Kenji, Nagata, Chisato, Mizoue, Tetsuya, Tanaka, Keitaro, Shimazu, T., Wakai, K., Tamakoshi, A., Tsuji, I., Tanaka, K., Matsuo, K., Nagata, C., Mizoue, T., Inoue, M., Tsugane, S., and Sasazuki, S.

Published
2014
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14. Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center‐based Prospective Study

Author

Masaoka, Hiroyuki, Matsuo, Keitaro, Sawada, Norie, Yamaji, Taiki, Goto, Atsushi, Shimazu, Taichi, Iwasaki, Motoki, Inoue, Manami, Eto, Masatoshi, Tsugane, Shoichiro, Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R, Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., and Sato, Y.

Published
2017
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15. Sugar intake and colorectal cancer risk: A prospective Japanese cohort study.

Author

Kanehara, Rieko, Katagiri, Ryoko, Goto, Atsushi, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Inoue, Manami, Tsugane, Shoichiro, Miyamoto, Y., Ihira, H., Abe, S. K., Tanaka, S., Hanaoka, T., Hidaka, A., Sasazuki, S., Charvat, H., Shimazu, T., Budhathoki, S., Muto, M., and Imatoh, T.

Abstract

The influence of sugar consumption on the risk of colorectal cancer (CRC) remains controversial. Prospective cohort studies focusing on total and specific types of sugar intake among the Asian population who have different patterns of sugar intake sources than American and European populations are scarce. We intended to examine the association of sugar intake with CRC risk among middle‐aged adults in a Japanese large‐scale population‐based cohort study. The participants (42,405 men and 48,600 women) who were 45–74 years old and answered the questionnaire in 1995–1999 in the Japan Public Health Center‐based Prospective Study were followed up until December 2013. Total sugars, total fructose, and specific types of sugar intake were estimated using a validated 147‐item food frequency questionnaire and divided into quintiles (Q1–Q5). We used Cox proportional hazard regression models adjusted for potential confounders to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During the follow‐up, 2118 CRC cases (1226 men and 892 women) were identified. We did not observe any clear association between all types of sugar intake and an increased risk of CRC. Analyses by tumor sites yielded a positive association of total sugar consumption with rectal cancer in women (1.75 [1.07–2.87] for Q1 vs. Q5; plinear trend = 0.03), but no statistically significant trend was detected among men. Sugar intake was not associated with CRC risk in middle‐aged Japanese adults. However, for rectal cancer, the probability of an increased risk among women with a higher total sugar intake cannot be excluded. [ABSTRACT FROM AUTHOR]

Published
2023
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16. High serum total cholesterol is associated with suicide mortality in Japanese women

Author

Svensson, T., Inoue, M., Sawada, N., Charvat, H., Mimura, M., Tsugane, S., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R, Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F, Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M, Ichii, M, Takano, M., Tsubono, Y., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., and Sato, Y.

Published
2017
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19. Soymilk-fermented with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L improves immune-health in pigs

Author

Suda, Y., primary, Kagawa, K., additional, Fukuyama, K., additional, Elean, M., additional, Zhou, B., additional, Tomokiyo, M., additional, Islam, M. Aminul, additional, Rajoka, M.S.R., additional, Kober, A.K.M. Humayun, additional, Shimazu, T., additional, Egusa, S., additional, Terashima, Y., additional, Aso, H., additional, Ikeda-Ohtsubo, W., additional, Villena, J., additional, and Kitazawa, H., additional

Published
2022
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21. Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study

Author

Svensson, Thomas, Inoue, Manami, Sawada, Norie, Yamagishi, Kazumasa, Charvat, Hadrien, Saito, Isao, Kokubo, Yoshihiro, Iso, Hiroyasu, Kawamura, Noriyuki, Shibuya, Kenji, Mimura, Masaru, Tsugane, Shoichiro, Tsugane, S., Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Shimazu, T., Yamaji, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., and Akiba, S.

Published
2016
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27. Dietary patterns and type 2 diabetes in Japanese men and women: the Japan public health center-based prospective study

Author

Nanri, A., Shimazu, T., Takachi, R., Ishihara, J., Mizoue, T., Noda, M., Inoue, M., and Tsugane, S.

Subjects
Japan -- Health aspects, Public health -- Research, Type 2 diabetes -- Diagnosis -- Care and treatment -- Demographic aspects, Diet -- Health aspects, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVE: Dietary patterns in Western populations have been linked to type 2 diabetes, but the association Of distinctive dietary patterns of Japanese population remains unclear. We prospectively investigated the association between dietary patterns and risk of developing type 2 diabetes among Japanese adults. SUBJECTS/METHODS: Participants were 27 816 men and 36 889 women aged 45-74 years who participated in the second survey of the Japan Public Health Center-based prospective study and had no history of diabetes. Dietary patterns were derived by using principal component analysis of the consumption of 134 food and beverage items ascertained by a food frequency questionnaire. Odds ratios of self-reported physician-diagnosed type 2 diabetes over 5 year were estimated using logistic regression analysis. RESULTS: A total of 1194 new cases (692 men and 502 women) of type 2 diabetes were self-reported. We identified three dietary patterns: prudent, westernized and traditional Japanese patterns. Any dietary pattern was not significantly associated with type 2 diabetes risk after adjustment for covariates in both men and women. The multivariate-adjusted odds ratios (95% confidence interval) for type 2 diabetes for the highest versus lowest quartile of each dietary pattern score in men and women, respectively, were 0.93 (0.74-1.16) and 0.90 (0.69-1.16) for the prudent pattern, 1.15 (0.90-1.46) and 0.81 (0.61-1.08) for the westernized pattern, and 0.97 (0.74-1.27) and 0.87 (0.66-1.15) for the traditional pattern. CONCLUSIONS: Although a small protective effect of the prudent dietary pattern cannot be excluded, dietary patterns may not be appreciably associated with type 2 diabetes risk in Japanese. European Journal of Clinical Nutrition (2013) 67, 18-24; doi:10.1038/ejcn.2012.171; published online 24 October 2012 Keywords: cohort studies; dietary patterns; Japanese; type 2 diabetes, INTRODUCTION Type 2 diabetes has been increasing worldwide. (1) In Japan, in particular, the prevalence of diabetes has increased from 6.9 to 8.9 million between 1997 and 2007. (2) Although [...]

Published
2013
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30. Association of vegetable and fruit intake with gastric cancer risk among Japanese: a pooled analysis of four cohort studies

Author

Shimazu, T., Wakai, K., Tamakoshi, A., Tsuji, I., Tanaka, K., Matsuo, K., Nagata, C., Mizoue, T., Inoue, M., Tsugane, S., Sasazuki, S., Sasazuki, Shizuka, Tsugane, Shoichiro, Inoue, Manami, Iwasaki, Motoki, Otani, Tetsuya, Sawada, Norie, Shimazu, Taichi, Yamaji, Taiki, Tsuji, Ichiro, Tsubono, Yoshitaka, Nishino, Yoshikazu, Tamakoshi, Akiko, Matsuo, Keitaro, Ito, Hidemi, Wakai, Kenji, Nagata, Chisato, Mizoue, Tetsuya, and Tanaka, Keitaro

Published
2014
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33. Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies

Author

Inoue, M., Sasazuki, S., Wakai, K., Suzuki, T., Matsuo, K., Shimazu, T., Tsuji, I., Tanaka, K., Mizoue, T., Nagata, C., Tamakoshi, A., Sawada, N., and Tsugane, S.

Subjects
Green tea -- Health aspects, Green tea -- Research, Stomach cancer -- Risk factors, Stomach cancer -- Demographic aspects, Stomach cancer -- Research, Cohort analysis -- Usage, Health
Published
2009

35. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, J.Y.Y., Hsiung, C.A., Matsuo, K., Wong, M.P., Seow, W.J., Song, M., Chang, I.-S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J.H., Seow, A., Caporaso, N.E., Shin, M.-H., Chung, L.P., An, S.-J., Zheng, H., Yatabe, Y., Kim, Y.T., Cai, Q., Kim, Y.-C., Bassig, B.A., Ho, J.C.M., Ji, B.-T., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Hosgood, H.D., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S.-I., Kubo, M., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Song, L., Hua, X., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wei, F., Matsuda, F., Kim, Y.H., Oh, I.-J., Song, F., Su, W.-C., Chang, G.-C., Chen, K.-Y., Chien, L.-H., Xiang, Y.-B., Kweon, S.-S., Lee, K.-M., Blechter, B., Qian, B., Lu, D., Jeon, H.-S., Hsiao, C.-F., Sung, J.S., Tsai, Y.-H., Jung, Y.J., Chung, C.C., Burdett, L., Yeager, M., Hutchinson, A., Berndt, S.I., Pang, H., Choi, J.E., Park, K.H., Sung, S.W., Zhu, M., Guan, P., Tan, W., Hsin, M., Sit, K.-Y., Ho, J., Choi, Y.Y., Kim, J.S., Yoon, H.I., Park, I.K., Xu, P., He, Q., Perng, R.-P., Vermeulen, R., Lim, W.-Y., Chen, K.-C., Jin, L., Jiang, S.-S., Yamaji, T., Hicks, B., Wyatt, K., Dai, J., Jin, G., Song, B., Cheng, S., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Fei, K., Wu, G., Lin, H.-C., Fang, Y.-H., Tsai, F.-Y., Hsieh, W.-S., Yu, J., Stevens, V.L., Laird-Offringa, I.A., Marconett, C.N., Rieswijk, L., Chao, A., Shu, X.-O., Lin, D., Chen, K., Zhou, B., Kohno, T., Shen, H., Chanock, S.J., Rothman, N., Lan, Q., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
Lung adenocarcinoma, Pathway analysis, Mendelian randomization, Tuberculosis, Lung cancer
Abstract

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

Published
2020

39. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, J.Y.Y., Hsiung, C.A., Matsuo, K., Wong, M.P., Seow, W.J., Song, M., Chang, I.-S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J.H., Seow, A., Caporaso, N.E., Shin, M.-H., Chung, L.P., An, S.-J., Zheng, H., Yatabe, Y., Kim, Y.T., Cai, Q., Kim, Y.-C., Bassig, B.A., Ho, J.C.M., Ji, B.-T., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Hosgood, H.D., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S.-I., Kubo, M., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Song, L., Hua, X., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wei, F., Matsuda, F., Kim, Y.H., Oh, I.-J., Song, F., Su, W.-C., Chang, G.-C., Chen, K.-Y., Chien, L.-H., Xiang, Y.-B., Kweon, S.-S., Lee, K.-M., Blechter, B., Qian, B., Lu, D., Jeon, H.-S., Hsiao, C.-F., Sung, J.S., Tsai, Y.-H., Jung, Y.J., Chung, C.C., Burdett, L., Yeager, M., Hutchinson, A., Berndt, S.I., Pang, H., Choi, J.E., Park, K.H., Sung, S.W., Zhu, M., Guan, P., Tan, W., Hsin, M., Sit, K.-Y., Ho, J., Choi, Y.Y., Kim, J.S., Yoon, H.I., Park, I.K., Xu, P., He, Q., Perng, R.-P., Vermeulen, R., Lim, W.-Y., Chen, K.-C., Jin, L., Jiang, S.-S., Yamaji, T., Hicks, B., Wyatt, K., Dai, J., Jin, G., Song, B., Cheng, S., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Fei, K., Wu, G., Lin, H.-C., Fang, Y.-H., Tsai, F.-Y., Hsieh, W.-S., Yu, J., Stevens, V.L., Laird-Offringa, I.A., Marconett, C.N., Rieswijk, L., Chao, A., Shu, X.-O., Lin, D., Chen, K., Zhou, B., Kohno, T., Shen, H., Chanock, S.J., Rothman, N., Lan, Q., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, J.Y.Y., Hsiung, C.A., Matsuo, K., Wong, M.P., Seow, W.J., Song, M., Chang, I.-S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J.H., Seow, A., Caporaso, N.E., Shin, M.-H., Chung, L.P., An, S.-J., Zheng, H., Yatabe, Y., Kim, Y.T., Cai, Q., Kim, Y.-C., Bassig, B.A., Ho, J.C.M., Ji, B.-T., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Hosgood, H.D., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S.-I., Kubo, M., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Song, L., Hua, X., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wei, F., Matsuda, F., Kim, Y.H., Oh, I.-J., Song, F., Su, W.-C., Chang, G.-C., Chen, K.-Y., Chien, L.-H., Xiang, Y.-B., Kweon, S.-S., Lee, K.-M., Blechter, B., Qian, B., Lu, D., Jeon, H.-S., Hsiao, C.-F., Sung, J.S., Tsai, Y.-H., Jung, Y.J., Chung, C.C., Burdett, L., Yeager, M., Hutchinson, A., Berndt, S.I., Pang, H., Choi, J.E., Park, K.H., Sung, S.W., Zhu, M., Guan, P., Tan, W., Hsin, M., Sit, K.-Y., Ho, J., Choi, Y.Y., Kim, J.S., Yoon, H.I., Park, I.K., Xu, P., He, Q., Perng, R.-P., Vermeulen, R., Lim, W.-Y., Chen, K.-C., Jin, L., Jiang, S.-S., Yamaji, T., Hicks, B., Wyatt, K., Dai, J., Jin, G., Song, B., Cheng, S., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Fei, K., Wu, G., Lin, H.-C., Fang, Y.-H., Tsai, F.-Y., Hsieh, W.-S., Yu, J., Stevens, V.L., Laird-Offringa, I.A., Marconett, C.N., Rieswijk, L., Chao, A., Shu, X.-O., Lin, D., Chen, K., Zhou, B., Kohno, T., Shen, H., Chanock, S.J., Rothman, N., and Lan, Q.

Published
2020

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