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814 results on '"Shimada, Jun"'

2. Online Learning and Distributed Control for Residential Demand Response

Author

Chen, Xin, Li, Yingying, Shimada, Jun, and Li, Na

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Machine Learning
Abstract

This paper studies the automated control method for regulating air conditioner (AC) loads in incentive-based residential demand response (DR). The critical challenge is that the customer responses to load adjustment are uncertain and unknown in practice. In this paper, we formulate the AC control problem in a DR event as a multi-period stochastic optimization that integrates the indoor thermal dynamics and customer opt-out status transition. Specifically, machine learning techniques including Gaussian process and logistic regression are employed to learn the unknown thermal dynamics model and customer opt-out behavior model, respectively. We consider two typical DR objectives for AC load control: 1) minimizing the total demand, 2) closely tracking a regulated power trajectory. Based on the Thompson sampling framework, we propose an online DR control algorithm to learn customer behaviors and make real-time AC control schemes. This algorithm considers the influence of various environmental factors on customer behaviors and is implemented in a distributed fashion to preserve the privacy of customers. Numerical simulations demonstrate the control optimality and learning efficiency of the proposed algorithm.

Published
2020

7. Genetic characteristics and antibiotic resistance of Haemophilus influenzae isolates from pediatric patients with acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine in Japan

Author

Inagaki, Mikiya, Kamakazu, Kiyoaki, Atago, Yoshihiro, Kakurai, Shinichi, Iwamoto, Junichi, Usui, Shinji, Ooyama, Seizou, Sugano, Sumio, Kuroda, Hisashi, Kamide, Yousuke, Kamide, Michihiro, Murakawa, Yasuko, Kaieda, Satoru, Kawaziri, Ippei, Kawai, Akimitsu, Kikuchi, Yasutake, Sawaki, Seiji, Kyou, Koujin, Kimura, Shigeru, Kimura, Yasuko, Kimura, Yutaka, Sashiyou, Hideyuki, Yoneya, Hirohide, Kosaka, Kazumi, Komeda, Mototane, Kobayashi, Katsuhiko, Sakaida, Yudzuru, Sawada, Shoichi, Satoh, Tatsuaki, Satoh, Masami, Shimizu, Toshiaki, Kimura, Osamu, Shimada, Jun, Hori, Yasutaka, Sugita, Rinya, Sugita, Yoshinobu, Uchizono, Akihiro, Soeda, Kazuhiro, Tabuchi, Tomizou, Matsuoka, Chiharu, Suzuki, Chiaki, Chiba, Hideki, Tsuboi, Yasuhiro, Tomiyama, Michio, Nakano, Kouji, Nakazawa, Tsutomu, Fukumoto, Akira, Fukumoto, Akiko, Nagura, Mitsuyoshi, Nagayama, Ikuo, Satoh, Mutsumi, Nakamura, Katsuhiko, Noguchi, Kenji, Shiiba, Kyoko, Nogami, Kenichirou, Matsuda, Hideki, Shiba, Emiko, Hirabayashi, Keishi, Hiyoshi, Masaaki, Yamagishi, Shigeo, Ozu, Chika, Maruyama, Jun, Matsubara, Shigenori, Suetake, Mitsuko, Miyashita, Motoaki, Mogami, Akira, Yamaguchi, Mikio, Yamaoka, Hideyuki, Yuta, Atsushi, Yoshikawa, Takuma, Toyofuku, Meiwa, Mori, Sachiko, Inagaki, Mitsuaki, Ubukata, Kimiko, Morozumi, Miyuki, Sakuma, Megumi, Adachi, Yoko, Mokuno, Eriko, Tajima, Takeshi, and Iwata, Satoshi

Published
2019
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9. Excluded Volume in Protein Sidechain Packing

Author

Kussell, Edo, Shimada, Jun, and Shakhnovich, Eugene I.

Subjects
Condensed Matter - Soft Condensed Matter, Quantitative Biology
Abstract

To examine the relationship between sidechain geometry and sidechain packing, we use an all-atom Monte Carlo simulation to sample the large space of sidechain conformations. We study three models of excluded volume and use umbrella sampling to effectively explore the entire space. We find that while excluded volume constraints reduce the size of conformational space by many orders of magnitude, the number of allowed conformations is still large. An average repacked conformation has 20% of its chi angles in a non-native state. Interestingly, well-packed conformations, with up to 50% non-native chi's exist. Entropy is distributed non-uniformly over positions, and we partially explain the observed distribution using rotamer probabilities derived from the pdb database. In spite of our finding that 65% of the native rotamers and 85% of chi 1 angles can be correctly predicted on the basis of excluded volume only, 95% of positions can accomodate more than 1 rotamer in simulation. We estimate that in order to quench the sidechain entropy observed in the presence of excluded volume interactions, other interactions (hydrophobic, polar, electrostatic) must provide an additional stabilization of at least 0.6 kT per residue in order to single out the native state., Comment: 36 pages, 7 figures, submitted to Journal of Molecular Biology

Published
2001

10. Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media

Author

Shimada, Jun, Moon, Sung K, Lee, Haa-Yung, Takeshita, Tamotsu, Pan, Huiqi, Woo, Jeong-Im, Gellibolian, Robert, Yamanaka, Noboru, and Lim, David J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pneumonia & Influenza, Lung, Infectious Diseases, Otitis Media, Pneumonia, Pediatric, Infection, Animals, Disease Susceptibility, Eustachian Tube, Gene Expression Profiling, Gene Expression Regulation, Mice, Mice, Inbred C57BL, Microbial Sensitivity Tests, Muramidase, Pneumococcal Infections, RNA, Reverse Transcriptase Polymerase Chain Reaction, Streptococcus pneumoniae, Microbiology, Medical Microbiology, Clinical sciences, Medical microbiology, Public health
Abstract

BackgroundLysozyme is an antimicrobial innate immune molecule degrading peptidoglycan of the bacterial cell wall. Lysozyme shows the ubiquitous expression in wide varieties of species and tissues including the tubotympanum of mammals. We aim to investigate the effects of lysozyme depletion on pneumococcal clearance from the middle ear cavity.MethodsImmunohistochemistry was performed to localize lysozyme in the Eustachian tube. Lysozyme expression was compared between the wild type and the lysozyme M-/- mice using real time quantitative RT-PCR and western blotting. Muramidase activity and bactericidal activity of lysozyme was measured using a lysoplate radial diffusion assay and a liquid broth assay, respectively. To determine if depletion of lysozyme M increases a susceptibility to pneumococal otitis media, 50 CFU of S. pneumoniae 6B were transtympanically inoculated to the middle ear and viable bacteria were counted at day 3 and 7 with clinical grading of middle ear inflammation.ResultsImmunolabeling revealed that localization of lysozyme M and lysozyme P is specific to some/particular cell types of the Eustachian tube. Lysozyme P of lysozyme M-/- mice was mainly expressed in the submucosal gland but not in the tubal epithelium. Although lysozyme M-/- mice showed compensatory up-regulation of lysozyme P, lysozyme M depletion resulted in a decrease in both muramidase and antimicrobial activities. Deficiency in lysozyme M led to an increased susceptibility to middle ear infection with S. pneumoniae 6B and resulted in severe middle ear inflammation, compared to wild type mice.ConclusionThe results suggest that lysozyme M plays an important role in protecting the middle ear from invading pathogens, particularly in the early phase. We suggest a possibility of the exogenous lysozyme as an adjuvant therapeutic agent for otitis media, but further studies are necessary.

Published
2008

11. Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells

Author

Lee, Haa-Yung, Takeshita, Tamotsu, Shimada, Jun, Akopyan, Arsen, Woo, Jeong-Im, Pan, Huiqi, Moon, Sung K, Andalibi, Ali, Park, Rae-Kil, Kang, Sung-Ho, Kang, Shin-Seok, Gellibolian, Robert, and Lim, David J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Otitis Media, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Underpinning research, Inflammatory and immune system, Animals, Cell Line, Ear, Middle, Epithelial Cells, Haemophilus influenzae, Humans, Interleukin-1 Receptor-Associated Kinases, Male, Mice, Mice, Inbred C57BL, Myeloid Differentiation Factor 88, Signal Transduction, TNF Receptor-Associated Factor 6, Toll-Like Receptor 2, Up-Regulation, beta-Defensins, p38 Mitogen-Activated Protein Kinases, Microbiology, Clinical sciences, Medical microbiology, Public health
Abstract

BackgroundAll mucosal epithelia, including those of the tubotympanium, are secreting a variety of antimicrobial innate immune molecules (AIIMs). In our previous study, we showed the bactericidal/bacteriostatic functions of AIIMs against various otitis media pathogens. Among the AIIMs, human beta-defensin 2 is the most potent molecule and is inducible by exposure to inflammatory stimuli such as bacterial components or proinflammatory cytokines. Even though the beta-defensin 2 is an important AIIM, the induction mechanism of this molecule has not been clearly established. We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear.MethodsMonoclonal antibody blocking method was employed in monitoring the TLR-dependent NTHi response. Two gene knock down methods - dominant negative (DN) plasmid and small interfering RNA (siRNA) - were employed to detect and confirm the involvement of several key genes in the signaling cascade resulting from the NTHi stimulated beta-defensin 2 expression in human middle ear epithelial cell (HMEEC-1). The student's t-test was used for the statistical analysis of the data.ResultsThe experimental results showed that the major NTHi-specific receptor in HMEEC-1 is the Toll-like receptor 2 (TLR2). Furthermore, recognition of NTHi component(s)/ligand(s) by TLR2, activated the Toll/IL-1 receptor (TIR)-MyD88-IRAK1-TRAF6-MKK3/6-p38 MAPK signal transduction pathway, ultimately leading to the induction of beta-defensin 2.ConclusionThis study found that the induction of beta-defensin 2 is highest in whole cell lysate (WCL) preparations of NTHi, suggesting that the ligand(s) responsible for this up-regulation may be soluble macromolecule(s). We also found that this induction takes place through the TLR2 dependent MyD88-IRAK1-TRAF6-p38 MAPK pathway, with the primary response occurring within the first hour of stimulation. In combination with our previous studies showing that IL-1alpha-induced beta-defensin 2 expression takes place through a MyD88-independent Raf-MEK1/2-ERK MAPK pathway, we found that both signaling cascades act synergistically to up-regulate beta-defensin 2 levels. We propose that this confers an essential evolutionary advantage to the cells in coping with infections and may serve to amplify the innate immune response through paracrine signaling.

Published
2008

31. Sidechain Dynamics and Protein Folding

Author

Kussell, Edo, Shimada, Jun, Shakhnovich, Eugene I., Beig, R., editor, Englert, B. -G., editor, Frisch, U., editor, Hänggi, P., editor, Hepp, K., editor, Hillebrandt, W., editor, Imboden, D., editor, Jaffe, R. L., editor, Lipowsky, R., editor, v. Löhneysen, H., editor, Ojima, I., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Wess, J., editor, Zittartz, J., editor, Nielaba, Peter, editor, Mareschal, Michel, editor, and Ciccotti, Giovanni, editor

Published
2002
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41. Advances in Multifunctional Materials and Systems

Author

Jun Akedo, Hitoshi Ohsato, Takeshi Shimada, Jun Akedo, Hitoshi Ohsato, Takeshi Shimada and Jun Akedo, Hitoshi Ohsato, Takeshi Shimada, Jun Akedo, Hitoshi Ohsato, Takeshi Shimada

Published
2010

46. List of Contributors

Author

Aihara, Nobuhide, primary, Arai, Sachiho, additional, Ban, Takuya, additional, Chitose, Atsushi, additional, Chosa, Tadashi, additional, Funada, Ryo, additional, Hasumi, Keiji, additional, Hirasawa, Tadashi, additional, Ishizaki, Haruki, additional, Iwaoka, Masahiro, additional, Kajita, Shinya, additional, Kameyama, Hideo, additional, Kanda, Shuhei, additional, Kato, Hitoshi, additional, Kawai, Shinya, additional, Kobayashi, Yuichi, additional, Matsumoto, Takeshi, additional, Matsumura, Shoji, additional, Motobayashi, Takashi, additional, Nomiyama, Toshio, additional, Ohno, Hiroyuki, additional, Ookawa, Taiichiro, additional, Qian, Eika W., additional, Shimada, Jun, additional, Takeuchi, Michio, additional, Tanaka, Haruo, additional, Toda, Hiroto, additional, Tojo, Seishu, additional, Tonozuka, Takashi, additional, Toyota, Koki, additional, Yakushido, Kenichi, additional, Yamada, Masaaki, additional, Yamazaki, Ryoichi, additional, Yokoyama, Tadashi, additional, Yoshida, Hiroshi, additional, and Yoshida, Makoto, additional

Published
2014
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