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539 results on '"Shim, Young-Soo"'

18. Solid-organ malignancy as a risk factor for tuberculosis

Author

KIM, HYE-RYOUN, HWANG, SEUNG SIK, RO, YUN KWAN, JEON, CHANG HO, HA, DONG YEOB, PARK, SUNG JOON, LEE, CHANG-HOON, LEE, SANG-MIN, YOO, CHUL-GYU, KIM, YOUNG WHAN, HAN, SUNG KOO, SHIM, YOUNG-SOO, and YIM, JAE-JOON

Published
2008

26. Usefulness of whole-blood interferon-(gamma) assay and interferon-(gamma) enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis

Author

Kang, Young Ae, Lee, Hye Won, Hwang, Seung Sik, Um, Sang-Won, Han, Sung Koo, Shim, Young-Soo, and Yim, Jae-Joon

Subjects
Pulmonary tuberculosis -- Diagnosis, Pulmonary tuberculosis -- Demographic aspects, Pulmonary tuberculosis -- Research, Interferon gamma -- Analysis, Immunoenzyme technique -- Usage, Immunoenzyme technique -- Research, Health
Published
2007

46. Pulmonary lymphangioleiomyomatosis in Korea

Author

Oh, Yeon-Mok, Mo, Eun Kyung, Jang, Seung Hoon, Yoo, Chul Gyu, Kim, Young Whan, Seo, Jeong-Wook, Han, Sung Koo, Im, Jung-Gi, and Shim, Young-Soo

Published
1999

48. A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

Author

Chung Man, Park In, Choi Byoung, Park Jeong, Jeong Sung, Lee Kye, Jung Ki-Suck, Han Sung, Kim Young, Kim Yang-Ki, Uh Soo-Taek, Shin Hwa-Kyun, Park Jai-Soung, Jang An-Soo, Kim Do-Jin, Park Jong-Sook, Park Sung-Woo, Lee Shin-Hwa, Park Byung-Lae, Ahn Mi-Hyun, Shin Hyoung, Song Jin, Kim Dong, Park Choon-Sik, and Shim Young-Soo

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs) of the IL-8 gene on the risk of IPF. Methods One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and rs2227306C>T) of the IL-8 genes were genotyped in 237 subjects with IPF and 456 normal controls. Logistic regression analysis was applied to evaluate the association of these SNPs with IPF. IL-8 in BAL fluids was measured using a quantitative sandwich enzyme immunoassay, and promoter activity was assessed using the luciferase reporter assay. Results The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in the 162 subjects with surgical biopsy-proven IPF and 75 subjects with clinical IPF compared with normal controls in the recessive model (OR = 0.46 and 0.48, p = 0.006 and 0.007, respectively). The IL-8 protein concentration in BAL fluids significantly increased in 24 subjects with IPF compared with 14 controls (p = 0.009). Nine IPF subjects homozygous for the rs4073 T>A common allele exhibited higher levels of the IL-8 protein compared with six subjects homozygous for the minor allele (p = 0.024). The luciferase activity of the rs4073T>A common allele was significantly higher than that of the rs4073T>A minor allele (p = 0.002). Conclusion The common allele of a promoter SNP, rs4073T>A, may increase susceptibility to the development of IPF via up-regulation of IL-8.

Published
2011
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49. Translation and validation of the Korean confusion assessment method for the intensive care unit

Author

Han Sung, Kim Young, Yoo Chul-Gyu, Lee Han-A, Song Eun, Hahm Bong-Jin, Lee Byoung-Jo, Heo Eun, Shim Young-Soo, and Lee Sang-Min

Subjects
Psychiatry, RC435-571
Abstract

Abstract Background Delirium is a common problem and associated with poor outcomes in intensive care unit (ICU) patients. Diagnosis of delirium in ICU patients is limited and usually underdiagnosed by physicians. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) is one of the most widely used screening methods for detection of ICU delirium. Our goal was to translate and validate the CAM-ICU for use in the Korean ICU setting. Methods Translation of the CAM-ICU was done according to the guidelines suggested by the Translation and Cultural Adaptation Group. For validation and interrater reliability assessment of the Korean CAM-ICU, two nurses independently assessed delirium in ICU patients and the results were compared with the reference evaluation, which was done by a psychiatrist using the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV). Results Twenty-two patients were evaluated by two nurses and one psychiatrist expert independently. During the study period, we have continuously educated study nurses. Based on DSM-IV criteria, 16 out of 22 (72.7%) patients developed delirium. The sensitivities of the two nurses' evaluations using the Korean CAM-ICU were 89.80% for nurse 1 and 77.40% for nurse 2. Their specificities were 72.40% and 75.80% and their overall accuracy was 83.33% and 88.37% respectively. The Korean CAM-ICU was done with reasonable interrater reliability between nurse 1 and nurse 2 (κ = 0.81, p < 0.001). Conclusions The Korean CAM-ICU showed good validity and could be incorporated into clinical practice in Korean ICUs. Trial registration ISRCTN: ISRCTN50265663

Published
2011
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50. Detection of primary sites in unknown primary tumors using FDG-PET or FDG-PET/CT

Author

Shim Young-Soo, Han Sung, Kim Young, Chung June-Key, Yoo Chul-Gyu, Kang Won, Yim Jae-Joon, Park Jong, and Lee Sang-Min

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Carcinoma of unknown primary tumors (CUP) is present in 0.5%-9% of all patients with malignant neoplasms; only 20%-27% of primary sites are identified before the patients die. Currently, 18F-fluorodeoxy-glucose positron-emission tomography (18F-FDG PET) or PET combined with computed tomography (PET/CT) is widely used for the diagnosis of CUP. However, the diagnostic yield of the primary site varies. The aim of this study was to determine whether PET or PET/CT has additional advantages over the conventional diagnostic workup in detecting the primary origin of CUP. Findings Twenty patients with unknown primary tumors that underwent PET or PET/CT were included in this study. For all patients, the conventional diagnostic workup was unsuccessful in detecting the primary sites. Among 20 patients, 11 had PET scans. The remaining nine patients had PET/CT. In all 20 patients, neither the PET nor PET/CT identified the primary site of the tumor, including six cases with cervical lymph node metastases. The PET and PET/CT revealed sites of FDG uptake other than those associated with known metastases in seven patients, but these findings did not influence patient management or therapy. Two patients had unnecessary invasive diagnostic procedures due to false positive results on the PET or PET/CT. Conclusions Although it is inconclusive because of small sample size of the study, the additional value of PET or PET/CT for the detection of primary sites in patients with CUP might be less than expected; especially in patients that have already had extensive conventional diagnostic workups. Further study is needed to confirm this finding.

Published
2011
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