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361 results on '"Shim, Min Suk"'

14. 3D-Printed Chitosan Composites for Biomedical Applications

Author

Murugan, Sesha Subramanian, Anil, Sukumaran, Sivakumar, Padmanaban, Shim, Min Suk, Venkatesan, Jayachandran, Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, Jayakumar, R., editor, and Prabaharan, M., editor

Published
2021
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15. Oxygen‐Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH‐Responsive Multicompartmental Carriers with Sequential Drug Release Capability (Adv. Funct. Mater. 21/2024)

Author

Truong Hoang, Quan, primary, Kim, Do Yeon, additional, Park, Hyun Su, additional, Jang, Wookyoung, additional, Nguyen Cao, Thuy Giang, additional, Kang, Ji Hee, additional, Ko, Young Tag, additional, Mun, Seok Joon, additional, Bhang, Suk Ho, additional, Shim, Min Suk, additional, and Bong, Ki Wan, additional

Published
2024
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22. “Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Author

Kemp, Jessica A, Shim, Min Suk, Heo, Chan Yeong, and Kwon, Young Jik

Subjects
Bioengineering, Orphan Drug, Nanotechnology, Cancer, Genetics, Rare Diseases, Biotechnology, Gene Therapy, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Combined Modality Therapy, Drug Delivery Systems, Humans, Nanomedicine, Nanostructures, Neoplasms, Multi-modal therapy, Synergistic anti-cancer effects, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy
Abstract

The dynamic and versatile nature of diseases such as cancer has been a pivotal challenge for developing efficient and safe therapies. Cancer treatments using a single therapeutic agent often result in limited clinical outcomes due to tumor heterogeneity and drug resistance. Combination therapies using multiple therapeutic modalities can synergistically elevate anti-cancer activity while lowering doses of each agent, hence, reducing side effects. Co-administration of multiple therapeutic agents requires a delivery platform that can normalize pharmacokinetics and pharmacodynamics of the agents, prolong circulation, selectively accumulate, specifically bind to the target, and enable controlled release in target site. Nanomaterials, such as polymeric nanoparticles, gold nanoparticles/cages/shells, and carbon nanomaterials, have the desired properties, and they can mediate therapeutic effects different from those generated by small molecule drugs (e.g., gene therapy, photothermal therapy, photodynamic therapy, and radiotherapy). This review aims to provide an overview of developing multi-modal therapies using nanomaterials ("combo" nanomedicine) along with the rationale, up-to-date progress, further considerations, and the crucial roles of interdisciplinary approaches.

Published
2016

31. Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy

Author

Shim, Min Suk, Wang, Xi, Ragan, Regina, and Kwon, Young Jik

Subjects
Chemical Sciences, Physical Chemistry, Genetics, Biotechnology, Gene Therapy, Animals, Mice, Microscopy, Atomic Force, NIH 3T3 Cells, Plasmids, Polyethyleneimine, Polymers, RNA Interference, RNA, Small Interfering, Transfection, in situ AFM, mimicked intracellular trafficking, nonviral gene delivery, plasmid DNA and siRNA, polyethylenimine, Other Physical Sciences, Biochemistry and Cell Biology, Materials Engineering, Microscopy, Physical chemistry
Abstract

Elucidating dynamic morphological changes of gene-carrying vectors and their nucleic acid release under varying intracellular conditions has been a technical challenge. Atomic force microscopy (AFM) was used to observe nucleic acid/polymer polyplexes under endosomal and reducible cytosolic conditions. Both ketalized (acid-degradable) and unmodified (nondegradable) polyethylenimine (PEI) in linear and branched forms were used to prepare plasmid DNA- or siRNA-complexing polyplexes. Then, the polyplexes' complexation and disassembly were observed by in situ AFM in various differentially changing buffers that represent intracellular conditions. Results demonstrated obvious morphological destruction of DNA/ketalized linear PEI (KL-PEI) polyplexes under mildly acidic endosomal conditions, whereas no morphological changes were observed by DNA/ketalized branched PEI (KB-PEI) under the same conditions. In addition, siRNA was more efficiently dissociated from KL-PEI than KB-PEI under the same conditions. Nondegradable PEI did not show any evidence that DNA or siRNA was released. Anionic biomacromolecules (e.g., heparan sulfate), which was hypothesized to dissociate nucleic acids from cationic polymers, did not successfully disassemble polyplexes but appeared to be adsorbed on cationic polymers. The in situ AFM results combined with in vitro cellular transfection and gene silencing indicated that efficient endosomal escape of plasmid DNA in a compact polyplex form is required for efficient gene expression. On the contrary, rapid dissociation of siRNA from its cationic carrier is crucial for efficient gene silencing. The findings of this study may provide new insightful information for designing stimuli-responsive nonviral gene vectors as well as expanding tools for investigating nonviral vectors in nanoscales under biologically inspired conditions.

Published
2010

34. Three-year follow-up of patients with acetylcholine-induced coronary artery spasm combined with insignificant coronary stenosis

Author

Choi, Byoung Geol, Park, Sung Hun, Rha, Seung-Woon, Ahn, Jihun, Choi, Se Yeon, Byun, Jae Kyeong, Li, Hu, Mashaly, Ahmed, Shim, Min Suk, Kang, Jun Hyuk, Kim, Woohyeun, Choi, Jah Yeon, Park, Eun Jin, Lee, Sunki, Na, Jin Oh, Choi, Cheol Ung, Lim, Hong Euy, Kim, Eung Ju, Park, Chang Gyu, Seo, Hong Seog, and Oh, Dong Joo

Published
2017
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38. Piezocatalytic 2D WS 2 Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy (Adv. Mater. 18/2023)

Author

Truong Hoang, Quan, primary, Huynh, Kim Anh, additional, Nguyen Cao, Thuy Giang, additional, Kang, Ji Hee, additional, Dang, Xuan Nghia, additional, Ravichandran, Vasanthan, additional, Kang, Han Chang, additional, Lee, Minjong, additional, Kim, Jong‐Eun, additional, Ko, Young Tag, additional, Lee, Tae Il, additional, and Shim, Min Suk, additional

Published
2023
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42. Impact of Statin Use on Development of New-Onset Diabetes Mellitus in Asian Population

Author

Rha, Seung-Woon, Choi, Byoung Geol, Seo, Hong Seog, Park, Sang-Ho, Park, Ji Young, Chen, Kang-Yin, Park, Yoonjee, Choi, Se Yeon, Shim, Min-Suk, Kim, Ji Bak, Park, Taeshik, Park, Joonhyung, Lee, Jae Joong, Park, Eun Jin, Park, Sung Hun, Choi, Jah Yeon, Lee, Sunki, Na, Jin Oh, Choi, Cheol Ung, Lim, Hong Euy, Kim, Jin Won, Kim, Eung Ju, Park, Chang Gyu, and Oh, Dong Joo

Published
2016
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43. Piezocatalytic 2D WS2 Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy

Author

Hoang, Quan Truong, primary, Huynh, Kim Anh, additional, Cao, Thuy Giang Nguyen, additional, Kang, Ji Hee, additional, Nghia, Dang Xuan, additional, Ravichandran, Vasanthan, additional, Kang, Han Chang, additional, Lee, Minjong, additional, Kim, Jong‐Eun, additional, Ko, Young Tag, additional, Lee, Tae Il, additional, and Shim, Min Suk, additional

Published
2023
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47. Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targetingElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4bm00313f

Author

Cho, Hana, Huh, Kang Moo, Cho, Hyun Ji, Kim, Bogeon, Shim, Min Suk, Cho, Yong-Yeon, Lee, Joo Young, Lee, Hye Suk, Kwon, Young Jik, and Kang, Han Chang

Abstract

Various strategies at the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many benefits, such as improved water solubility, improved chemical/physical stability, improved oral absorption, and improved targetability of their payloads. Their therapeutic potential in disease animal models (e.g., solid tumors, virus-infected lungs, metastasis, diabetes, and so on) has been investigated, and could be expanded to disease targeting after systemic/lymphatic circulation, although the detailed paths and mechanisms of endocytosis, endosomal escape, intracellular trafficking, and exocytosis through the epithelial cell lining in the GI tract are still unclear. Thus, this review summarizes and discusses potential GI transporters/receptors, their absorption and distribution, in vivostudies, and potential sequential targeting (e.g., oral absorption and disease targeting in organs/tissues).

Published
2024
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48. Selective ß1-Blockers Are Not Associated With New-onset Diabetes Mellitus in Hypertensive Patients

Author

Park, Yoonjee, Choi, Byoung Geol, Rha, Seung-Woon, Baek, Man Jong, Ryu, Yang Gi, Choi, Se Yeon, Byun, Jae Kyeong, Shim, Min Suk, Mashaly, Ahmed, Li, Hu, Jang, Won Young, Kim, Woohyeun, Kang, Jun Hyuk, Choi, Jah Yeon, Park, Eun Jin, Park, Sung Hun, Lee, Sunki, Na, Jin Oh, Choi, Cheol Ung, Lim, Hong Euy, Kim, Eung Ju, Park, Chang Gyu, Seo, Hong Seog, and Oh, Dong Joo

Published
2018
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