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279 results on '"Shim, Joong Sup"'

3. Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

Author

Liu, Jianyong, primary, He, Qing-Li, additional, Zhou, Jianya, additional, Chikarmane, Roshan, additional, Hauk, Glenn, additional, Rachakonda, Archana, additional, Vaghasia, Ajay M., additional, Castagna, Nicole, additional, Steinberg, Ruchama C., additional, Pham, Minh-Tam, additional, Anders, Nicole M., additional, Wanjiku, Teresia M., additional, Nuhn, Philipp, additional, Shim, Joong Sup, additional, Giovinazzo, Hugh, additional, Esopi, David M., additional, Kim, Kunhwa, additional, Coulter, Jonathan, additional, Wang, Rulin, additional, Zhou, Jianying, additional, Rudek, Michelle A., additional, Berger, James M., additional, Liu, Jun O., additional, Nelson, William G., additional, and Yegnasubramanian, Srinivasan, additional

Published
2024
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5. Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression

Author

Wang, Xiaobo, Huang, Jing, Liu, Fenglin, Yu, Qian, Wang, Ruina, Wang, Jiaqi, Zhu, Zewen, Yu, Juan, Hou, Jun, Shim, Joong Sup, Jiang, Wei, Li, Zengxia, Zhang, Yuanyuan, and Dang, Yongjun

Subjects
Gene expression -- Health aspects, Phosphotransferases -- Health aspects, Enzyme inhibitors -- Patient outcomes, Cancer -- Care and treatment, Health care industry
Abstract

Aurora A plays a critical role in G2/M transition and mitosis, making it an attractive target for cancer treatment. Aurora A inhibitors showed remarkable antitumor effects in preclinical studies, but unsatisfactory outcomes in clinical trials have greatly limited their development. In this study, the Aurora A inhibitor alisertib upregulated programmed death ligand 1 (PD-L1) expression in a panel of tumor cells both in vitro and in vivo. Upregulation of the checkpoint protein PD- L1 reduced antitumor immunity in immune-competent mice, paradoxically inhibiting the antitumor effects of alisertib. Mechanistically, Aurora A directly bound to and phosphorylated cyclic GMP-AMP synthase (cGAS), suppressing PD-L1 expression in tumor cells. Aurora A inhibition by alisertib activated the cGAS/stimulator of IFN genes (STING)/NF-[kappa]B pathway and promoted PD-L1 expression. Combining alisertib with anti-PD-L1 antibody improved antitumor immunity and enhanced the antitumor effects of alisertib in immune-competent mice. Our results, which reveal the immunomodulatory functions of Aurora A inhibitors and provide a plausible explanation for the poor clinical outcomes with their use, offer a potential approach to improve the antitumor efficacy of these inhibitors., Introduction Aurora A, a member of the evolutionarily conserved Aurora serine/threonine kinase family, is an essential mediator for centrosome maturation and separation and for the ultimate formation of the mitotic [...]

Published
2023
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9. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

Author

Ding, Ren-Bo, Chen, Ping, Rajendran, Barani Kumar, Lyu, Xueying, Wang, Haitao, Bao, Jiaolin, Zeng, Jianming, Hao, Wenhui, Sun, Heng, Wong, Ada Hang-Heng, Valecha, Monica Vishnu, Yang, Eun Ju, Su, Sek Man, Choi, Tak Kan, Liu, Shuiming, Chan, Kin Iong, Yang, Ling-Lin, Wu, Jingbo, Miao, Kai, Chen, Qiang, Shim, Joong Sup, Xu, Xiaoling, and Deng, Chu-Xia

Published
2021
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12. Table S1-S9 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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13. Figure S6 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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14. Supplementary figure legends from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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15. Data from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, primary, Chan, Un In, primary, Su, Sek Man, primary, Shi, Changxiang, primary, Zhang, Xin, primary, An, Tingting, primary, Xu, Jun, primary, Mo, Lihua, primary, Liu, Jianlin, primary, Wang, Yuqing, primary, Li, Xiaoling, primary, Deng, Min, primary, Lei, Josh Haipeng, primary, Wang, Chunfei, primary, Tian, Hao, primary, Heng, Sun, primary, Shim, Joong Sup, primary, Zhang, Xuanjun, primary, Dai, Yunlu, primary, Yao, Zhicheng, primary, Kuang, Xiaying, primary, Lin, Ying, primary, Deng, Chu-Xia, primary, and Xu, Xiaoling, primary

Published
2023
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18. BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Author

Shu, Xiaodong, primary, Li, Jianjie, additional, Chan, Un In, additional, Su, Sek Man, additional, Shi, Changxiang, additional, Zhang, Xin, additional, An, Tingting, additional, Xu, Jun, additional, Mo, Lihua, additional, Liu, Jianlin, additional, Wang, Yuqing, additional, Li, Xiaoling, additional, Deng, Min, additional, Lei, Josh Haipeng, additional, Wang, Chunfei, additional, Tian, Hao, additional, Heng, Sun, additional, Shim, Joong Sup, additional, Zhang, Xuanjun, additional, Dai, Yunlu, additional, Yao, Zhicheng, additional, Kuang, Xiaying, additional, Lin, Ying, additional, Deng, Chu-Xia, additional, and Xu, Xiaoling, additional

Published
2023
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19. Supplementary Table 1 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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20. Supplementary Figure 5 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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21. Supplementary Figure 6 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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22. Supplementary Figure 4 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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24. Supplementary Figure 8 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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25. Supplementary Figure 3 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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26. Supplementary Figure 2 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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27. Supplementary Figure 1 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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28. Supplementary Table 2 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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29. Supplementary Figure 9 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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30. Supplementary Figure 7 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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31. Supplementary Methods from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice

Author

Kamiyama, Hirohiko, primary, Rauenzahn, Sherri, primary, Shim, Joong Sup, primary, Karikari, Collins A., primary, Feldmann, Georg, primary, Hua, Li, primary, Kamiyama, Mihoko, primary, Schuler, F. William, primary, Lin, Ming-Tseh, primary, Beaty, Robert M., primary, Karanam, Balasubramanyam, primary, Liang, Hong, primary, Mullendore, Michael E., primary, Mo, Guanglan, primary, Hidalgo, Manuel, primary, Jaffee, Elizabeth, primary, Hruban, Ralph H., primary, Jinnah, H.A., primary, Roden, Richard B.S., primary, Jimeno, Antonio, primary, Liu, Jun O., primary, Maitra, Anirban, primary, and Eshleman, James R., primary

Published
2023
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34. ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones

Author

Tao, Shishi, primary, Yang, Eun Ju, additional, Zong, Guanghui, additional, Mou, Pui Kei, additional, Ren, Guowen, additional, Pu, Yue, additional, Chen, Liang, additional, Kwon, Ho Jeong, additional, Zhou, Jianhong, additional, Hu, Zhijian, additional, Khosravi, Arman, additional, Zhang, Qingyang, additional, Du, Yuchun, additional, Shi, Wei Q., additional, and Shim, Joong Sup, additional

Published
2023
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37. Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment (Adv. Sci. 26/2022)

Author

Xiong, Yunfang, primary, Ke, Ran, additional, Zhang, Qingyu, additional, Lan, Wenjun, additional, Yuan, Wanjun, additional, Chan, Karol Nga Ieng, additional, Roussel, Tom, additional, Jiang, Yifan, additional, Wu, Jing, additional, Liu, Shuai, additional, Wong, Alice Sze Tsai, additional, Shim, Joong Sup, additional, Zhang, Xuanjun, additional, Xie, Ruiyu, additional, Dusetti, Nelson, additional, Iovanna, Juan, additional, Habib, Nagy, additional, Peng, Ling, additional, and Lee, Leo Tsz On, additional

Published
2022
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43. Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

Author

Zhang, Liyun, primary, Chen, Conan, additional, Fu, Jie, additional, Lilley, Brendan, additional, Berlinicke, Cynthia, additional, Hansen, Baranda, additional, Ding, Ding, additional, Wang, Guohua, additional, Wang, Tao, additional, Shou, Daniel, additional, Ye, Ying, additional, Mulligan, Timothy, additional, Emmerich, Kevin, additional, Saxena, Meera T, additional, Hall, Kelsi R, additional, Sharrock, Abigail V, additional, Brandon, Carlene, additional, Park, Hyejin, additional, Kam, Tae-In, additional, Dawson, Valina L, additional, Dawson, Ted M, additional, Shim, Joong Sup, additional, Hanes, Justin, additional, Ji, Hongkai, additional, Liu, Jun O, additional, Qian, Jiang, additional, Ackerley, David F, additional, Rohrer, Baerbel, additional, Zack, Donald J, additional, and Mumm, Jeff S, additional

Published
2021
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44. Author response: Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

Author

Zhang, Liyun, primary, Chen, Conan, additional, Fu, Jie, additional, Lilley, Brendan, additional, Berlinicke, Cynthia, additional, Hansen, Baranda, additional, Ding, Ding, additional, Wang, Guohua, additional, Wang, Tao, additional, Shou, Daniel, additional, Ye, Ying, additional, Mulligan, Timothy, additional, Emmerich, Kevin, additional, Saxena, Meera T, additional, Hall, Kelsi R, additional, Sharrock, Abigail V, additional, Brandon, Carlene, additional, Park, Hyejin, additional, Kam, Tae-In, additional, Dawson, Valina L, additional, Dawson, Ted M, additional, Shim, Joong Sup, additional, Hanes, Justin, additional, Ji, Hongkai, additional, Liu, Jun O, additional, Qian, Jiang, additional, Ackerley, David F, additional, Rohrer, Baerbel, additional, Zack, Donald J, additional, and Mumm, Jeff S, additional

Published
2021
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48. Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

Author

Zong, Guanghui, primary, Hu, Zhijian, additional, Duah, Kwabena Baffour, additional, Andrews, Lauren E., additional, Zhou, Jianhong, additional, O’Keefe, Sarah, additional, Whisenhunt, Lucas, additional, Shim, Joong Sup, additional, Du, Yuchun, additional, High, Stephen, additional, and Shi, Wei Q., additional

Published
2020
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