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25 results on '"Shim, Inbo"'

1. Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques

Author

Pino, Maria, Pagliuzza, Amélie, Pampena, M. Betina, Deleage, Claire, Viox, Elise G., Nguyen, Kevin, Shim, Inbo, Zhang, Adam, Harper, Justin L., Samer, Sadia, King, Colin T., Cervasi, Barbara, Gill, Kiran P., Ehnert, Stephanie, Jean, Sherrie M., Freeman, Michael L., Lifson, Jeffrey D., Kulpa, Deanna, Betts, Michael R., Chomont, Nicolas, Lederman, Michael M., and Paiardini, Mirko

Published
2022
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3. Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2–positive dendritic cells in allergic asthma

Author

Cho, Minkyoung, Lee, Jeong-Eun, Lim, Hoyong, Shin, Hyun-Woo, Khalmuratova, Roza, Choi, Garam, Kim, Hyuk Soon, Choi, Wahn Soo, Park, Young-Jun, Shim, Inbo, Kim, Byung-Seok, Kang, Chang-Yuil, Kim, Jae-Ouk, Tanaka, Shinya, Kubo, Masato, Tung, Hui-Ying, Landers, Cameron T., Corry, David B., Kheradmand, Farrah, and Chung, Yeonseok

Published
2018
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9. Lanthanide(III)-doped magnetite nanoparticles

Author

De Silva, Channa R., Smith, Steve, Shim, Inbo, Pyun, Jeffrey, Gutu, Timothy, Jun Jiao, and Zhiping Zheng

Subjects
Rare earth metals -- Thermal properties, Rare earth metals -- Electric properties, Chemistry
Abstract

A thermally decomposed mixture of Fe[(acac).sub.3] and Ln[(acac).sub.3] (acac = acetylacetonate; Ln = Sm, Eu, Gd) in the presence of passivating surfactants is used to fabricate nearly monodisperse lanthanide-doped magnetite nanoparticles. The findings from magnetic studies provide insight into the room-temperature ferromagnetic properties of doped nanoparticles, which is distinctly different from those of the undoped parent magnetite or the doped nanoparticles prepared by a coprecipitation method.

Published
2009

19. Synthesis and Self-Assembly of Polymer-Coated Ferromagnetic Nanoparticles

Author

Yuin Keng, Pei, Shim, Inbo, D. Korth, Bryan, Pyun, Jeffrey, Shim, Inbo, and F. Douglas, Jack

Abstract

We describe the synthesis and characterization of polymer-coated ferromagnetic cobalt nanoparticles (CoNPs). The synthesis of end-functionalized polystyrene surfactants possessing amine, carboxylic acid, or phosphine oxide end-groups was accomplished using atom-transfer radical polymerization. This versatile synthetic method enabled the production of multigram quantities of these polymeric surfactants that stabilized ferromagnetic CoNPs when dispersed in organic media. An in-depth investigation into the synthesis of polystyrene-coated ferromagnetic CoNPs was also conducted using various combinations of these polymeric surfactants in the thermolysis of dicobaltoctacarbonyl (Co 2(CO) 8). Moreover, the application of a dual-stage thermolysis with Co 2(CO) 8allowed for the preparation of large samples (200–820 mg) per batch of well-defined and dispersable ferromagnetic nanoparticles. Characterization of these functionalized nanoparticle materials was then done using transmission electron microscopy, X-ray diffraction, vibrating sample magnetometry, and thermogravimetric analysis. Self-assembly of these dipolar nanoparticles was investigated in solutions cast onto supporting substrates, where local nematic-like ordering of nanoparticle chains was observed along with a tendency of adjacent chains to form “zippering” configurations, both phenomena having been predicted by recent simulations of dipolar fluids in conjunction with van der Waals interactions.

Published
2007
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21. Tuning the SUPRA CAR to differentiate high/low Her2 levels

Author

Shim, Inbo

Subjects
Biomedical engineering
Abstract

On-target, off-tumor toxicity has been a major challenge for chimeric antigen receptor (CAR) T cells to clinically treat solid tumors. This is due to conventional CAR T cells poorly discriminating between high and low tumor associated antigen densities, causing them to attack both cancer and healthy cells. Her2 is a tumor associated antigen where it is minimally expressed in healthy cells and overexpressed in cancer cells of Her2 positive cancer patients. Previous case reports demonstrate that targeting Her2 with conventional ɑ-Her2-CAR could be fatal. To reduce the risk of on-target, off-tumor toxicity, an ultrasensitive CAR T cell platform that highly activates against high antigen density and minimally activates against low antigen density is in need. The Wong lab has developed the split, universal and programmable (SUPRA) CAR system for a safer and more effective CAR. Composed of a universal receptor and an exogenous scFv protein, this split CAR allows safe, effective, and flexible control over T cell activity due to its various tunable components. This thesis aims to demonstrate that the SUPRA CAR can differentiate high and low Her2 densities more than that of a conventional ɑ-Her2-CAR.

Published
2022

24. Nucleophilic substitution reaction based layer-by-layer growth of superparamagnetic nanocomposite films with high nonvolatile memory performance

Author

Dayang Wang, Inbo Shim, Younghoon Kim, Chan Woo Lee, Jinhan Cho, Kim, Younghoon, Lee, Chanwoo, Shim, Inbo, Wang, Dayang, and Cho, Jinhan

Subjects
magnetic nanoparticles, Dendrimer, Nanocomposite, Materials science, nanocomposite, Mechanical Engineering, Layer by layer, Nanotechnology, self assembly, equipment and supplies, Nanocomposites, Non-volatile memory, Bromine Compounds, nonvolatile resistive switching memory, Magnetics, Isobutyrates, Mechanics of Materials, Nucleophilic substitution, Nanoparticles, General Materials Science, nucleophilic substitution, Amines, human activities, Superparamagnetism
Abstract

Magnetic nanocomposite multilayers including magnetic nanoparticles are prepared using a nucleophilic substitution reaction between 2-bromo-2-methylpropionic acid (-BMPA) and amino (-NH2) groups. The assembly of magnetic nanoparticles in a nonpolar solvent induces densely packed adsorption, which significantly enhances the magnetic and nonvolatile memory properties of nanocomposite films. Refereed/Peer-reviewed

Published
2010

25. Clonal Expansion of Allergen-specific CD4 + T Cell in the Lung in the Absence of Lymph Nodes.

Author

Choi G, Kim BS, Park YJ, Shim I, and Chung Y

Abstract

The expansion of allergen-specific CD4 + T cells is a critical step in inducing airway inflammation during allergic asthma. Such clonal expansion of T cells is initiated through the interaction between allergen-bearing dendritic cells and allergen-specific naïve T cells in the draining lymph nodes. Whether such T cell clonal expansion also occurs in the lung, the primary organ encountering inhaled allergens, remains unclear. Compared with wild-type mice, we found similar frequencies of CD4 + T cells in the lung of lymph node-deficient Rorgt gfp/gfp mice after repeated exposure to inhaled allergens. In addition, we observed an evident population of CD4 + T cells that underwent clonal expansion in the lung of allergen-challenged mice treated with an S1P antagonist FTY720 in an in vivo proliferation study with CFSE-labeled OT-II T cells. Moreover, the expansion of allergen-specific CD4 + T cells was significantly enhanced in the lungs of Rorgt gfp/gfp mice in comparison to that of wild-type mice. These results together demonstrate that the clonal expansion of allergen-specific CD4 + T cells occurs in the absence of the lymph nodes, indicating that the lung can act as a primary site of the clonal expansion of CD4 + T cells in response to inhaled allergens., Competing Interests: CONFLICTS OF INTEREST: The authors have no financial conflict of interest.

Published
2017
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