1. Infants' diminished response to DTaP vaccine is associated with exposure to organophosphate esters
- Author
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Stephanie C. Hammel, Shila Nordone, Sharon Zhang, Amelia M. Lorenzo, Brian Eichner, M. Anthony Moody, Lynn Harrington, Joyce Gandee, Liz Schmidt, Stephanie Smith, Heather M. Stapleton, and Kate Hoffman
- Subjects
Adult ,Environmental Engineering ,Tetanus ,Adolescent ,Infant ,Diphtheria ,Esters ,Environmental Exposure ,Middle Aged ,Diphtheria-Tetanus-acellular Pertussis Vaccines ,Pollution ,Organophosphates ,Plasticizers ,Environmental Chemistry ,Humans ,Child ,Waste Management and Disposal ,Diphtheria-Tetanus-Pertussis Vaccine ,Flame Retardants - Abstract
Organophosphate esters (OPEs) are commonly applied as flame retardants and plasticizers. Toxicological studies suggest exposure effects on immune endpoints, raising concerns as infants' OPE exposures are elevated compared to older children and adults due to hand-to-mouth behavior and breastfeeding. Here, we sought to evaluate the immune responsiveness of infants to a neoantigen (e.g., a newly encountered antigen) in the presence of OPE exposures. As a proxy for immune responsiveness, children were given three doses of the Diphtheria, Tetanus, and Pertussis (DTaP) vaccine as recommended, and diphtheria and tetanus antibodies were evaluated in serum samples collected when children were 12 months old (n = 84). Titers were compared, based on maximum sample overlap, to measurements of OPE metabolites in spot urine samples collected before vaccination (age 2 months, n = 73) and at the time of antibody assessment (12 months of age, n = 46). Metabolites of two chlorinated OPEs were significantly associated with diminished antibodies for diphtheria and tetanus. A metabolite of tris (1,3-dichloroisopropyl)phosphate (TDCIPP) measured at 2 months was associated with decreased diphtheria antibodies (-0.07 IU/mL per log
- Published
- 2022