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In this work, a Ni/KIT-6 catalyst with the highly uniform Ni dispersion was synthesized by a facile methanol-assisted co-impregnation technique and its activity towards to CO2 reforming of renewable ethanol was depicted for syngas production and CO2 elimination. Herein, its physicochemical features were determined in detail by various characterization technique including XRD, TPR, Raman, SEM and TEM etc. The results revealed the presence of the smaller Ni particles and the stronger Ni-support interaction in the Ni/KIT-6 catalyst compared to the reference Ni/SiO2 sample. More importantly, Ni/KIT-6 catalyst showed the satisfactory activity and stability while a rapid deactivation was noted for Ni/SiO2. Typically, full ethanol conversion was obtained at 550 °C for Ni/KIT-6 and no obvious deactivation was observed after 40 h tests. Indeed, this superior behavior was related to the confinement effect of KIT-6 channels which could stabilize Ni particles under the severe reaction conditions. On the other hand, the smaller Ni species greatly inhibited the coke deposition, especially for the encapsulated carbon. Moreover, the existence of strong Ni-support interaction was also responsible for the anti-sintering of active metal and carbon accumulation. This attractive results might be helpful to design high efficient Ni-based catalysts for chemical conversion of the undesirable CO2.

White matter injury (WMI), which reflects myelin loss, contributes to cognitive decline or dementia caused by cerebral vascular diseases. However, because pharmacological agents specifically for WMI are lacking, novel therapeutic strategies need to be explored. It is recently found that adaptive myelination is required for homeostatic control of brain functions. In this study, adaptive myelination-related strategies are applied to explore the treatment for ischemic WMI-related cognitive dysfunction. Here, bilateral carotid artery stenosis (BCAS) is used to model ischemic WMI-related cognitive impairment and uncover that optogenetic and chemogenetic activation of glutamatergic neurons in the medial prefrontal cortex (mPFC) promote the differentiation of oligodendrocyte precursor cells (OPCs) in the corpus callosum, leading to improvements in myelin repair and working memory. Mechanistically, these neuromodulatory techniques exert a therapeutic effect by inducing the secretion of Wnt2 from activated neuronal axons, which acts on oligodendrocyte precursor cells and drives oligodendrogenesis and myelination. Thus, this study suggests that neuromodulation is a promising strategy for directing myelin repair and cognitive recovery through adaptive myelination in the context of ischemic WMI.

Purpose: The aim of this study was to investigate the relationship between stressful life events and sleep quality and to probe the role of rumination and resilience in the relationship. Method: The Adolescent Self-Rating Life Events Checklist, Ruminative Responses Scale, Connor-Davidson Resilience Scale, and Pittsburgh Sleep Quality Index were used among 1,065 college students. Statistical Product and Service Solutions (SPSS) 20.0 and the SPSS macro Process, which were specifically developed for assessing complex models including both mediators and moderators, were used to analyze the data. Results: High scores of stressful life events predicted worse sleep quality. Rumination partially mediated the relations between stressful life events and sleep quality. Resilience moderated the direct and indirect paths leading from stressful life events to sleep quality. Conclusions: The results demonstrate that stressful life events can directly affect the sleep quality of college students and indirectly through rumination. Additionally, increasing psychological resilience could decrease both the direct effect and the indirect effect of stressful life events affecting sleep quality. The results of this study may contribute to a better understanding of the effects, as well as the paths and conditions, of stressful life events on sleep quality in college students. Moreover, these findings can provide constructive suggestions for improving college students' sleep quality.