1. Using proton pump inhibitors correlates with an increased risk of chronic kidney disease: a nationwide database-derived case-controlled study
- Author
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Po-Chang Lee, Shih-Rong Hung, Shih-Chang Hung, Cheng-Li Lin, Kuan-Fu Liao, Shih-Wei Lai, and Hung-Chang Hung
- Subjects
Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Population ,Taiwan ,030232 urology & nephrology ,Logistic regression ,Risk Assessment ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Renal Insufficiency, Chronic ,Medical prescription ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Case-control study ,Proton Pump Inhibitors ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Logistic Models ,Case-Control Studies ,Female ,Family Practice ,Risk assessment ,business ,Kidney disease - Abstract
Background Those taking proton pump inhibitors (PPIs) might have a higher risk of acute kidney injury. The long-term safety, especially the PPI-associated chronic kidney disease (CKD) is the subsequent concern. Objective This study explores the potential relationship between using PPIs and CKD in Taiwan. Methods Using a database collated by the Taiwan National Health Insurance programme, we conducted a population-based case-controlled study to identify 16 704 cases of patients aged 20 years or older with newly diagnosed CKD between 2000 and 2013. 16 704 controls were randomly selected and were matched by sex, age and comorbidities. 'Use' of PPIs was defined as when subjects had received at least a prescription for PPIs before the index date. 'Non-use' was defined as subjects who had never received a prescription for PPIs before the index date. The odds ratio (OR) for CKD associated with the use of PPIs was estimated by a logistic regression model. Results The OR for CKD was 1.41 for subjects using PPIs [95% confidence interval (CI) 1.34, 1.48] compared with subjects who had never used PPIs. Almost all major types of PPIs present a weak association with increased odds of CKD in cumulative duration and dosage regression analysis. The OR in relation to cumulative duration (per month) of PPIs use was 1.02 (95% CI 1.01, 1.02) and the OR in relation to cumulative dosage (per microgram) of PPIs use was 1.23 (95% CI 1.18, 1.28). Conclusions Using PPIs presented 1.4-fold higher odds of CKD in Taiwan health insurance claims data analysis.
- Published
- 2017
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