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180 results on '"Shih, Chi-Jen"'

6. Insights into the Various Cellular Antimicrobial Responses, Biocompatibility, Osteogenesis, Wound Healing, and Angiogenesis of Copper-Doped Nano-Hydroxyapatite Composite Calcium Phosphate Bone Cement In Vitro.

Author

Huang, Ssu-Meng, Chen, Wen-Cheng, Liu, Shih-Ming, Ko, Chia-Ling, Chen, Jian-Chih, and Shih, Chi-Jen

Subjects
VASCULAR endothelial cells, ESCHERICHIA coli, BONE remodeling, BONE cements, CALCIUM phosphate, BONE regeneration, NEOVASCULARIZATION
Abstract

Calcium phosphate bone cement (CPC) is a popular material for bone remodeling, and nanohydroxyapatite (nHA) represents a breakthrough that has a wide range of clinical applications. During the early stages of bone repair, antibacterial and angiogenesis effects are essential to remodel new bone tissues. In this study, an antibacterial effect was achieved by incorporating Cu2+-doped nano-hydroxyapatite (Cu–nHA) synthesized through hydrothermal methods into CPC, and the impact of various amounts of Cu–nHA addition on the antibacterial and mechanical properties of CPC hybridization was evaluated. Moreover, the effects of Cu–nHA/CPC composites on the proliferation and mineralization of mouse progenitor osteoblastic cells (D1 cells) were characterized; the cell migration and angiogenesis ability of vascular endothelial cells (HUVECs) were also studied. Results indicated that incorporating 5 wt.% and 10 wt.% Cu–nHA into CPC led to a practical short-term antibacterial effect on S. aureus but not on E. coli. These Cu–nHA/CPC slurries remained injectable, anti-disintegrative, and non-toxic. Furthermore, compared with pure CPC, these Cu–nHA/CPC slurries demonstrated positive effects on D1 cells, resulting in better proliferation and mineralization. In addition, these Cu–nHA/CPC slurries were more effective in promoting the migration and angiogenesis of HUVECs. These findings indicate that 10 wt.% Cu–nHA/CPC has great application potential in bone regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Thermal-decomposition and crystallization behaviour of coupling agents for silver paste application

Author

Shao-Ju Shih, Lin Hong-Ching, Ying-Chang Hung, Shih Chi-Jen, and Hsin-Hsien Yeh

Subjects
Exothermic reaction, Anatase, Materials science, Mechanical Engineering, Thermal decomposition, Sintering, Mineralogy, Bioengineering, General Chemistry, law.invention, Chemical engineering, Mechanics of Materials, law, Differential thermal analysis, General Materials Science, Calcination, Electrical and Electronic Engineering, Crystallization, Group 2 organometallic chemistry
Abstract

Coupling agents have been widely used to retard the sintering of silver paste and minimize co-firing defects due to densification mismatch between silver and dielectrics. The thermal-decomposition and crystallization behaviour of the coupling agent is a subject of great concern. Formation of the coupling agent layer is achieved by coating an Ag powder surface with Zr, Al or Ti organometallic compounds. Differential thermal analysis (DTA) detected an exothermic peak in Ag powder surfaces coated with Zr, Al or Ti which was absent in the uncoated silver powder. The exothermic peak clearly indicates the presence of the organic coupling agent on the Ag powder surface. The exothermic peak is absent when the sample is analysed in an N2 atmosphere, which suggests that the exothermic peak is related to oxidation of the coupling agent. To elucidate what is responsible for the oxidation, Ti organometallic compounds were calcined to different temperatures (350, 400, 500, 600 °C) for 2 h and the crystallization behaviour determined by x-ray diffraction (XRD). This demonstrated the presence of an anatase phase until a temperature of greater than 350 °C, and the intensity of the crystalline peak of (101) at 2θ = 25.3° increased continuously with the dwell time. Combining the results of DTA and XRD, it was found that formation of nanocrystallized titania accompanied the combustion of organometallic compounds.

Published
2003
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