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1. Association between elevated serum transaminase and moderately increased albuminuria: a cross-sectional study in western Tokushima, Japan

Author

Shoichi Fukuda, Ukyo Shirase, Shigeru Ogimoto, Mai Nakagawa, Kazumi Nakagawa, Ayumu Tominaga, and Hisayoshi Morioka

Subjects
Moderately increased albuminuria, Chronic Kidney Disease, Liver disorder, Fatty liver, Epidemiology, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background This study aimed to identify the factors relating to moderately increased albuminuria among middle-aged and older individuals in Japan. Methods We conducted specific health examinations in which we measured albuminuria levels, and administered a questionnaire survey to record participants’ lifestyles in western Tokushima Prefecture, Japan. A total of 1,660 people whose albuminuria was less than 300 mg/g creatinine (Cr) were analyzed. We divided participants into two groups—those with normal albuminuria ( 300 mg/gCr)—and compared their characteristics. To investigate all relevant factors, we conducted a multivariate logistic regression analysis. Results The moderately increased albuminuria group were significantly older and had, among them, significantly higher percentages of a body mass index (BMI) ≥ 25 kg/m2, diabetes, hypertension, and mild liver disorder (aspartate transaminase ≥ 31 U/L or alanine aminotransferase ≥ 31 U/L or gamma-glutamyl transferase ≥ 51 U/L). (p

Published
2023
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2. Change over Time in the Risk of Death among Japanese COVID-19 Cases Caused by the Omicron Variant Depending on Prevalence of Sublineages

Author

Yuki Takahashi, Hideo Tanaka, Yoshitaka Koga, Shunichi Takiguchi, Shigeru Ogimoto, Shizuyo Inaba, Hiroyuki Matsuoka, Yuka Miyajima, Takeshi Takagi, Fujiko Irie, Yoshihito Bamba, Fuyo Yoshimi, Tomoyuki Suzuki, Isao Araki, Chika Shirai, Sayuri Matsumoto, Motoyuki Shimizu, Toshiyuki Shibata, Hitomi Nagai, Masaru Kinoshita, Rie Fujita, and Tsuyoshi Ogata

Subjects
case fatality rate, SARS-CoV-2, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Japanese, Omicron variant
Abstract

To assess temporal changes to the risk of death in COVID-19 cases caused by the Omicron variant, we calculated age-standardized case fatality rates (CFR) in patients aged ≥40 years over nine diagnostic periods (3 January to 28 August 2022) in ten Japanese prefectures (14.8 million residents). Among 552,581 study subjects, we found that there were 1836 fatalities during the isolation period (up to 28 days from date of onset). The highest age-standardized CFR (0.85%, 95% confidence interval (CI):0.78–0.92) was observed in cases diagnosed in the second 4-week period (January 31 to February 27), after which it declined significantly up to the 6th 4-week period (0.23%, 95% CI: 0.13–0.33, May 23 to June 19). The CFR then increased again but remained at 0.39% in the eighth period (July 18 to August 28). The CFR in cases with the BA.2 or BA.5 sublineages in the age range 60–80 years was significantly lower than that with BA.1 infections (60 years: 0.19%, 0.02%, 0.053%, respectively; 70 years: 0.91%, 0.33%, 0.39%; ≥80 years: 3.78%, 1.96%, 1.81%, respectively). We conclude that the risk of death in Japanese COVID-19 patients infected with Omicron variants declined through February to mid-June 2022.

Published
2023
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