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2. Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

Author

Standing, Joseph F., Buggiotti, Laura, Guerra-Assuncao, Jose Afonso, Woodall, Maximillian, Ellis, Samuel, Agyeman, Akosua A., Miller, Charles, Okechukwu, Mercy, Kirkpatrick, Emily, Jacobs, Amy I., Williams, Charlotte A., Roy, Sunando, Martin-Bernal, Luz M., Williams, Rachel, Smith, Claire M., Sanderson, Theo, Ashford, Fiona B., Emmanuel, Beena, Afzal, Zaheer M., Shields, Adrian, Richter, Alex G., Dorward, Jienchi, Gbinigie, Oghenekome, Van Hecke, Oliver, Lown, Mark, Francis, Nick, Jani, Bhautesh, Richards, Duncan B., Rahman, Najib M., Yu, Ly-Mee, Thomas, Nicholas P. B., Hart, Nigel D., Evans, Philip, Andersson, Monique, Hayward, Gail, Hood, Kerenza, Nguyen-Van-Tam, Jonathan S., Little, Paul, Hobbs, F. D. Richard, Khoo, Saye, Butler, Christopher, Lowe, David M., and Breuer, Judith

Published
2024
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4. Saliva antiviral antibody levels are detectable but correlate poorly with serum antibody levels following SARS-CoV-2 infection and/or vaccination

Author

Faustini, Siân E., Cook, Alex, Hill, Harriet, Al-Taei, Saly, Heaney, Jennifer, Efstathiou, Elena, Tanner, Chloe, Townsend, Neal, Ahmed, Zahra, Dinally, Mohammad, Hoque, Madeeha, Goodall, Margaret, Stamataki, Zania, Plant, Timothy, Chapple, Iain, Cunningham, Adam F., Drayson, Mark T., Shields, Adrian M., and Richter, Alex G.

Published
2023
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15. SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study

Author

Shields, Adrian M., Faustini, Sian E., Hill, Harriet J., Al-Taei, Saly, Tanner, Chloe, Ashford, Fiona, Workman, Sarita, Moreira, Fernando, Verma, Nisha, Wagg, Hollie, Heritage, Gail, Campton, Naomi, Stamataki, Zania, Klenerman, Paul, Thaventhiran, James E. D., Goddard, Sarah, Johnston, Sarah, Huissoon, Aarnoud, Bethune, Claire, Elcombe, Suzanne, Lowe, David M., Patel, Smita Y., Savic, Sinisa, Burns, Siobhan O., and Richter, Alex G.

Published
2022
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18. Safety and 30-day outcomes of tracheostomy for COVID-19: a prospective observational cohort study

Author

Breik, Omar, Nankivell, Paul, Sharma, Neil, Bangash, Mansoor N., Dawson, Camilla, Idle, Matthew, Isherwood, Peter, Jennings, Christopher, Keene, Damian, Manji, Mav, Martin, Tim, Moss, Rob, Murphy, Nick, Parekh, Dhruv, Parmar, Sat, Patel, Jaimin, Pracy, Paul, Praveen, Prav, Richardson, Carla, Richter, Alex, Sachdeva, Rajneesh, Shields, Adrian, Siddiq, Somiah, Smart, Simon, and Tasker, Laura

Published
2020
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19. Sensitive Detection of SARS-CoV-2-Specific Antibodies in Dried Blood Spot Samples

Author

Morley, Gabriella L., Taylor, Stephen, Jossi, Sian, Perez-Toledo, Marisol, Faustini, Sian E., Marcial-Juarez, Edith, Shields, Adrian M., Goodall, Margaret, Allen, Joel D., Watanabe, Yasunori, Newby, Maddy L., Crispin, Max, Drayson, Mark T., Cunningham, Adam F., Richter, Alex G., and OShea, Matthew K.

Subjects
Blood -- Medical examination, Serodiagnosis -- Methods, Health
Abstract

A confirmed diagnosis of acute coronavirus disease (COVID-19) depends on the detection of RNA from the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, although serologic testing [...]

Published
2020
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20. Changes in immunoglobulin levels during clozapine treatment in schizophrenia

Author

Griffiths, Kira, primary, Mellado, Maria Ruiz, additional, Chung, Raymond, additional, Lally, John, additional, McQueen, Grant, additional, Sendt, Kyra-Verena, additional, Gillespie, Amy, additional, Ibrahim, Muhammad, additional, Richter, Alex, additional, Shields, Adrian, additional, Ponsford, Mark, additional, Jolles, Stephen, additional, Hodsoll, John, additional, Pollak, Thomas, additional, Upthegrove, Rachel, additional, Egerton, Alice, additional, and MacCabe, James H., additional

Published
2023
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24. SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

Author

Ward, Kerensa E, primary, Steadman, Lora, additional, Karim, Abid R, additional, Reynolds, Gary M, additional, Pugh, Matthew, additional, Chua, Winnie, additional, Faustini, Sian E, additional, Veenith, Tonny, additional, Thwaites, Ryan S, additional, Openshaw, Peter J M, additional, Drayson, Mark T, additional, Shields, Adrian M, additional, Cunningham, Adam F, additional, Wraith, David C, additional, and Richter, Alex G, additional

Published
2023
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26. Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens

Author

Moore, Shona C., primary, Kronsteiner, Barbara, additional, Longet, Stephanie, additional, Adele, Sandra, additional, Deeks, Alexandra S., additional, Liu, Chang, additional, Dejnirattisai, Wanwisa, additional, Reyes, Laura Silva, additional, Meardon, Naomi, additional, Faustini, Sian, additional, Al-Taei, Saly, additional, Tipton, Tom, additional, Hering, Luisa M., additional, Angyal, Adrienn, additional, Brown, Rebecca, additional, Nicols, Alexander R., additional, Dobson, Susan L., additional, Supasa, Piyada, additional, Tuekprakhon, Aekkachai, additional, Cross, Andrew, additional, Tyerman, Jessica K., additional, Hornsby, Hailey, additional, Grouneva, Irina, additional, Plowright, Megan, additional, Zhang, Peijun, additional, Newman, Thomas A.H., additional, Nell, Jeremy M., additional, Abraham, Priyanka, additional, Ali, Mohammad, additional, Malone, Tom, additional, Neale, Isabel, additional, Phillips, Eloise, additional, Wilson, Joseph D., additional, Murray, Sam M., additional, Zewdie, Martha, additional, Shields, Adrian, additional, Horner, Emily C., additional, Booth, Lucy H., additional, Stafford, Lizzie, additional, Bibi, Sagida, additional, Wootton, Daniel G., additional, Mentzer, Alexander J., additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Matthews, Philippa C., additional, Pollard, Andrew J., additional, Brown, Anthony, additional, Rowland-Jones, Sarah L., additional, Mongkolsapaya, Juthathip, additional, Payne, Rebecca P., additional, Dold, Christina, additional, Lambe, Teresa, additional, Thaventhiran, James E.D., additional, Screaton, Gavin, additional, Barnes, Eleanor, additional, Hopkins, Susan, additional, Hall, Victoria, additional, Duncan, Christopher J.A., additional, Richter, Alex, additional, Carroll, Miles, additional, de Silva, Thushan I., additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, and Turtle, Lance, additional

Published
2023
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28. Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens

Author

Moore, Shona C, Kronsteiner, Barbara, Longet, Stephanie, Adele, Sandra, Deeks, Alexandra S, Liu, Chang, Dejnirattisai, Wanwisa, Reyes, Laura Silva, Meardon, Naomi, Faustini, Sian, Al-Taei, Saly, Tipton, Tom, Hering, Luisa M, Angyal, Adrienn, Brown, Rebecca, Nicols, Alexander R, Dobson, Susan L, Supasa, Piyada, Tuekprakhon, Aekkachai, Cross, Andrew, Tyerman, Jessica K, Hornsby, Hailey, Grouneva, Irina, Plowright, Megan, Zhang, Peijun, Newman, Thomas AH, Nell, Jeremy M, Abraham, Priyanka, Ali, Mohammad, Malone, Tom, Neale, Isabel, Phillips, Eloise, Wilson, Joseph D, Murray, Sam M, Zewdie, Martha, Shields, Adrian, Horner, Emily C, Booth, Lucy H, Stafford, Lizzie, Bibi, Sagida, Wootton, Daniel G, Mentzer, Alexander J, Conlon, Christopher P, Jeffery, Katie, Matthews, Philippa C, Pollard, Andrew J, Brown, Anthony, Rowland-Jones, Sarah L, Mongkolsapaya, Juthathip, Payne, Rebecca P, Dold, Christina, Lambe, Teresa, Thaventhiran, James ED, Screaton, Gavin, Barnes, Eleanor, Hopkins, Susan, Hall, Victoria, Duncan, Christopher JA, Richter, Alex, Carroll, Miles, De Silva, Thushan I, Klenerman, Paul, Dunachie, Susanna, Turtle, Lance, PITCH Consortium, Nicols, Alexander R [0000-0002-1813-3819], Matthews, Philippa C [0000-0002-4036-4269], Barnes, Eleanor [0000-0002-0860-0831], Dunachie, Susanna [0000-0001-5665-6293], and Apollo - University of Cambridge Repository

Subjects
Vaccines, COVID-19 Vaccines, SARS-CoV-2, Translation to population health, Health Personnel, T cells, COVID-19, COVID vaccine, immunity, Antibodies, Neutralizing, Immunity, Humoral, antibody, ChAdOx1 nCoV-19, Humans, Prospective Studies, BNT162 Vaccine
Abstract

BACKGROUND: Both infection and vaccination, alone or in combination, generate antibody and T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the maintenance of such responses-and hence protection from disease-requires careful characterization. In a large prospective study of UK healthcare workers (HCWs) (Protective Immunity from T Cells in Healthcare Workers [PITCH], within the larger SARS-CoV-2 Immunity and Reinfection Evaluation [SIREN] study), we previously observed that prior infection strongly affected subsequent cellular and humoral immunity induced after long and short dosing intervals of BNT162b2 (Pfizer/BioNTech) vaccination. METHODS: Here, we report longer follow-up of 684 HCWs in this cohort over 6-9 months following two doses of BNT162b2 or AZD1222 (Oxford/AstraZeneca) vaccination and up to 6 months following a subsequent mRNA booster vaccination. FINDINGS: We make three observations: first, the dynamics of humoral and cellular responses differ; binding and neutralizing antibodies declined, whereas T and memory B cell responses were maintained after the second vaccine dose. Second, vaccine boosting restored immunoglobulin (Ig) G levels; broadened neutralizing activity against variants of concern, including Omicron BA.1, BA.2, and BA.5; and boosted T cell responses above the 6-month level after dose 2. Third, prior infection maintained its impact driving larger and broader T cell responses compared with never-infected people, a feature maintained until 6 months after the third dose. CONCLUSIONS: Broadly cross-reactive T cell responses are well maintained over time-especially in those with combined vaccine and infection-induced immunity ("hybrid" immunity)-and may contribute to continued protection against severe disease. FUNDING: Department for Health and Social Care, Medical Research Council.

Published
2023

29. Dose reductions in immunoglobulin replacement are associated with increased antibiotic usage in patients with antibody deficiency.

Author

Elhaj, Mohammed Omer, Richter, Alex G., Goddard, Sarah, and Shields, Adrian M.

Subjects
PELVIC inflammatory disease, PLASMA cell diseases, PRIMARY immunodeficiency diseases, PLASMA products
Abstract

.83 ht 1 Abbreviations: IgG, immunoglobulin G; IgRT, immunoglobulin replacement therapy; IQR, interquartile range. We demonstrate that, in previously stable patients, IgRT dose reductions lead to a reduction in trough IgG, which is associated with an increased frequency of infections requiring outpatient antibiotic use. [Extracted from the article]

Published
2023
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30. Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience

Author

Shields, Adrian M., primary, Tadros, Susan, additional, Al-Hakim, Adam, additional, Nell, Jeremy M., additional, Lin, Me Me Nay, additional, Chan, Michele, additional, Goddard, Sarah, additional, Dempster, John, additional, Dziadzio, Magdalena, additional, Patel, Smita Y., additional, Elkalifa, Shuayb, additional, Huissoon, Aarnoud, additional, Duncan, Christopher J. A., additional, Herwadkar, Archana, additional, Khan, Sujoy, additional, Bethune, Claire, additional, Elcombe, Suzanne, additional, Thaventhiran, James, additional, Klenerman, Paul, additional, Lowe, David M., additional, Savic, Sinisa, additional, Burns, Siobhan O., additional, and Richter, Alex G., additional

Published
2022
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31. Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers

Author

Lugg, Sebastian T, primary, Mackay, William R, additional, Faniyi, Aduragbemi A, additional, Faustini, Sian E, additional, Webster, Craig, additional, Duffy, Joanne E, additional, Hewison, Martin, additional, Shields, Adrian M, additional, Parekh, Dhruv, additional, Richter, Alex G, additional, Scott, Aaron, additional, and Thickett, David R, additional

Published
2022
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32. Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study

Author

Vivaldi, Giulia, primary, Jolliffe, David A, additional, Faustini, Sian, additional, Shields, Adrian M, additional, Holt, Hayley, additional, Perdek, Natalia, additional, Talaei, Mohammad, additional, Tydeman, Florence, additional, Chambers, Emma S, additional, Cai, Weigang, additional, Li, Wenhao, additional, Gibbons, Joseph M, additional, Pade, Corinna, additional, McKnight, Áine, additional, Shaheen, Seif O, additional, Richter, Alex G, additional, and Martineau, Adrian R, additional

Published
2022
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33. SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

Author

Ward, Kerensa E, primary, Steadman, Lora, additional, Karim, Abid R, additional, Reynolds, Gary M, additional, Pugh, Matthew, additional, Chua, Winnie, additional, Faustini, Sian E, additional, Veenith, Tonny, additional, Thwaites, Ryan S, additional, Openshaw, Peter JM, additional, Drayson, Mark T, additional, Shields, Adrian M, additional, Cunningham, Adam F, additional, Wraith, David C., additional, and Richter, Alex G, additional

Published
2022
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34. SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

Author

Lamerton, Rachel E., primary, Marcial-Juarez, Edith, additional, Faustini, Sian E., additional, Perez-Toledo, Marisol, additional, Goodall, Margaret, additional, Jossi, Siân E., additional, Newby, Maddy L., additional, Chapple, Iain, additional, Dietrich, Thomas, additional, Veenith, Tonny, additional, Shields, Adrian M., additional, Harper, Lorraine, additional, Henderson, Ian R., additional, Rayes, Julie, additional, Wraith, David C., additional, Watson, Steve P., additional, Crispin, Max, additional, Drayson, Mark T., additional, Richter, Alex G., additional, and Cunningham, Adam F., additional

Published
2022
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35. Evolution of long-term vaccine induced and hybrid immunity in healthcare workers after different COVID-19 vaccination regimens: a longitudinal observational cohort study

Author

Moore, Shona C., primary, Kronsteiner, Barbara, additional, Longet, Stephanie, additional, Adele, Sandra, additional, Deeks, Alexandra S., additional, Liu, Chang, additional, Dejnirattisai, Wanwisa, additional, Reyes, Laura Silva, additional, Meardon, Naomi, additional, Faustini, Sian, additional, Al-Taei, Saly, additional, Tipton, Tom, additional, Hering, Luisa M, additional, Angyal, Adrienn, additional, Brown, Rebecca, additional, Nicols, Alexander R, additional, Dobson, Susan L, additional, Supasa, Piyada, additional, Tuekprakhon, Aekkachai, additional, Cross, Andrew, additional, Tyerman, Jessica K, additional, Hornsby, Hailey, additional, Grouneva, Irina, additional, Plowright, Megan, additional, Zhang, Peijun, additional, Newman, Thomas A.H., additional, Nell, Jeremy M., additional, Abraham, Priyanka, additional, Ali, Mohammad, additional, Malone, Tom, additional, Neale, Isabel, additional, Phillips, Eloise, additional, Wilson, Joseph D., additional, Murray, Sam M., additional, Zewdie, Martha, additional, Shields, Adrian, additional, Horner, Emily C., additional, Booth, Lucy H., additional, Stafford, Lizzie, additional, Bibi, Sagida, additional, Wootton, Daniel G., additional, Mentzer, Alexander J., additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Matthews, Philippa C., additional, Pollard, Andrew J., additional, Brown, Anthony, additional, Rowland-Jones, Sarah L., additional, Mongkolsapaya, Juthathip, additional, Payne, Rebecca P., additional, Dold, Christina, additional, Lambe, Teresa, additional, Thaventhiran, James E.D., additional, Screaton, Gavin, additional, Barnes, Eleanor, additional, Hopkins, Susan, additional, Hall, Victoria, additional, Duncan, Christopher JA, additional, Richter, Alex, additional, Carroll, Miles, additional, de Silva, Thushan I., additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, and Turtle, Lance, additional

Published
2022
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37. SARS‐CoV‐2‐specific IgG1/IgG3 but not IgM in children with Pediatric Inflammatory Multi‐System Syndrome

Author

Perez‐toledo, Marisol, Faustini, Sian E., Jossi, Sian E., Shields, Adrian M., Marcial‐juarez, Edith, Kanthimathinathan, Hari Krishnan, Allen, Joel D., Watanabe, Yasunori, Goodall, Margaret, Willcox, Benjamin E., Willcox, Carrie R., Salim, Mahboob, Wraith, David C., Veenith, Tonny V., Syrimi, Eleni, Drayson, Mark T., Jyothish, Deepthi, Al‐abadi, Eslam, Chikermane, Ashish, Welch, Steven B., Masilamani, Kavitha, Hackett, Scott, Crispin, Max, Scholefield, Barnaby R., Cunningham, Adam F., Richter, Alex G., and Genuneit, Jon

Subjects
2019-20 coronavirus outbreak, biology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, medicine.disease, Virology, Immunoglobulin G, Systemic inflammatory response syndrome, Immunoglobulin M, Pediatrics, Perinatology and Child Health, biology.protein, Immunology and Allergy, Medicine, business, Letters to the Editor, Letter to the Editor
Abstract

During the COVID-19 outbreak, reports have surfaced of children who present with features of a multisystem inflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome - Paediatric Inflammatory Multisystem Syndrome- temporally associated with SARS-CoV-2 pandemic (PIMS-TS). Initial reports find that many of the children are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this syndrome is a late complication of viral infection in an age group largely spared the worst consequences of this infection, or if this syndrome reflects enhanced surveillance.Children hospitalised for symptoms consistent with PIMS-TS between 28 April and 8 May 2020, and who were PCR-negative for SARS-CoV-2, were tested for antibodies to viral spike glycoprotein using an ELISA test.Eight patients (age range 7-14 years, 63% male) fulfilled case-definition for PIMS-TS during the study period. Six of the eight patients required admission to intensive care. All patients exhibited significant IgG and IgA responses to viral spike glycoprotein. Further assessment showed that the IgG isotypes detected in children with PIMS-TS were of the IgG1 and IgG3 subclasses, a distribution similar to that observed in samples from hospitalised adult COVID-19 patients. In contrast, IgG2 and IgG4 were not detected in children or adults. IgM was not detected in children, which contrasts with adult hospitalised adult COVID-19 patients of whom all had positive IgM responses.Strong IgG antibody responses can be detected in PCR-negative children with PIMS-TS. The low detection rate of IgM in these patients is consistent with infection having occurred weeks previously and that the syndrome onset occurs well after the control of SARS-CoV-2 viral load. This implies that the disease is largely immune-mediated. Lastly, this indicates that serology can be an appropriate diagnostic tool in select patient groups.

Published
2021

38. Changes in immunoglobulin levels during clozapine treatment in schizophrenia

Author

Griffiths, Kira, primary, Mellado, Maria Ruiz, additional, Chung, Raymond, additional, Lally, John, additional, McQueen, Grant, additional, Sendt, Kyra-Verena, additional, Gillespie, Amy, additional, Ibrahim, Muhammad, additional, Richter, Alex, additional, Shields, Adrian, additional, Ponsford, Mark, additional, Jolles, Stephen, additional, Hodsoll, John, additional, Pollak, Thomas, additional, Upthegrove, Rachel, additional, Egerton, Alice, additional, and MacCabe, James H, additional

Published
2022
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39. Increased seroprevalence and improved antibody responses following third primary SARS-CoV-2 immunisation: an update from the COV-AD study

Author

Shields, Adrian M, primary, Faustini, Sian E., additional, Hill, Harriet J., additional, Al-Taei, Saly, additional, Tanner, Chloe, additional, Ashford, Fiona, additional, Workman, Sarita, additional, Moreira, Fernando, additional, Verma, Nisha, additional, Wagg, Hollie, additional, Heritage, Gail, additional, Campton, Naomi, additional, Stamataki, Zania, additional, Drayson, Mark T., additional, Klenerman, Paul, additional, Thaventhiran, James E. D., additional, Elkhalifa, Shuayb, additional, Goddard, Sarah, additional, Johnston, Sarah, additional, Huissoon, Aarnoud, additional, Bethune, Claire, additional, Elcombe, Suzanne, additional, Lowe, David M., additional, Patel, Smita Y., additional, Savic, Sinisa, additional, Richter, Alex G., additional, Burns, Siobhan O., additional, and Consortium, COVAD, additional

Published
2022
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40. Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals

Author

Faustini, Sian, primary, Shields, Adrian, additional, Banham, Gemma, additional, Wall, Nadezhda, additional, Al-Taei, Saly, additional, Tanner, Chloe, additional, Ahmed, Zahra, additional, Efstathiou, Elena, additional, Townsend, Neal, additional, Goodall, Margaret, additional, Plant, Tim, additional, Perez-Toledo, Marisol, additional, Jasiulewicz, Aleksandra, additional, Price, Ruth, additional, McLaughlin, James, additional, Farnan, John, additional, Moore, Julie, additional, Robertson, Louise, additional, Nesbit, Andrew, additional, Curry, Grace, additional, Black, Amy, additional, Cunningham, Adam, additional, Harper, Lorraine, additional, Moore, Tara, additional, Drayson, Mark, additional, and Richter, Alex, additional

Published
2022
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41. Treatment of chronic or relapsing COVID-19 in immunodeficiency

Author

Brown, Li-An K., primary, Moran, Ed, additional, Goodman, Anna, additional, Baxendale, Helen, additional, Bermingham, William, additional, Buckland, Matthew, additional, AbdulKhaliq, Iman, additional, Jarvis, Hannah, additional, Hunter, Michael, additional, Karanam, Surendra, additional, Patel, Aisha, additional, Jenkins, Megan, additional, Robbins, Alexander, additional, Khan, Sujoy, additional, Simpson, Thomas, additional, Jolles, Stephen, additional, Underwood, Jonathan, additional, Savic, Sinisa, additional, Richter, Alex, additional, Shields, Adrian, additional, Brown, Michael, additional, and Lowe, David M., additional

Published
2022
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42. Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK

Author

Shields, Adrian M, primary, Anantharachagan, Ariharan, additional, Arumugakani, Gururaj, additional, Baker, Kenneth, additional, Bahal, Sameer, additional, Baxendale, Helen, additional, Bermingham, William, additional, Bhole, Malini, additional, Boules, Evon, additional, Bright, Philip, additional, Chopra, Charu, additional, Cliffe, Lucy, additional, Cleave, Betsy, additional, Dempster, John, additional, Devlin, Lisa, additional, Dhalla, Fatima, additional, Diwakar, Lavanya, additional, Drewe, Elizabeth, additional, Duncan, Christopher, additional, Dziadzio, Magdalena, additional, Elcombe, Suzanne, additional, Elkhalifa, Shuayb, additional, Gennery, Andrew, additional, Ghanta, Harichandrana, additional, Goddard, Sarah, additional, Grigoriadou, Sofia, additional, Hackett, Scott, additional, Hayman, Grant, additional, Herriot, Richard, additional, Herwadkar, Archana, additional, Huissoon, Aarnoud, additional, Jain, Rashmi, additional, Jolles, Stephen, additional, Johnston, Sarah, additional, Khan, Sujoy, additional, Laffan, James, additional, Lane, Peter, additional, Leeman, Lucy, additional, Lowe, David M, additional, Mahabir, Shanti, additional, Lochlainn, Dylan James Mac, additional, McDermott, Elizabeth, additional, Misbah, Siraj, additional, Moghaddas, Fiona, additional, Morsi, Hadeil, additional, Murng, Sai, additional, Noorani, Sadia, additional, O’Brien, Rachael, additional, Patel, Smita, additional, Price, Arthur, additional, Rahman, Tasneem, additional, Seneviratne, Suranjith, additional, Shrimpton, Anna, additional, Stroud, Catherine, additional, Thomas, Moira, additional, Townsend, Katie, additional, Vaitla, Prashantha, additional, Verma, Nisha, additional, Williams, Anthony, additional, Burns, Siobhan O, additional, Savic, Sinisa, additional, and Richter, Alex G, additional

Published
2022
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43. SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings From The COV-AD Study

Author

Shields, Adrian M, primary, Faustini, Sian E., additional, Hill, Harriet J., additional, Al-Taei, Saly, additional, Tanner, Chloe, additional, Ashford, Fiona, additional, Workman, Sarita, additional, Moreira, Fernando, additional, Verma, Nisha, additional, Wagg, Hollie, additional, Heritage, Gail, additional, Campton, Naomi, additional, Stamataki, Zania, additional, Klenerman, Paul, additional, Goddard, Sarah, additional, Johnston, Sarah, additional, Huissoon, Aarnoud, additional, Bethune, Claire, additional, Elcombe, Suzanne, additional, Lowe, David M., additional, Patel, Smita Y., additional, Savic, Sinisa, additional, Burns, Siobhan O., additional, Richter, Alex G., additional, and Consortium, COV-AD, additional

Published
2022
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44. T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Author

Angyal, Adrienn, primary, Longet, Stephanie, additional, Moore, Shona C, additional, Payne, Rebecca P, additional, Harding, Adam, additional, Tipton, Tom, additional, Rongkard, Patpong, additional, Ali, Mohammad, additional, Hering, Luisa M, additional, Meardon, Naomi, additional, Austin, James, additional, Brown, Rebecca, additional, Skelly, Donal, additional, Gillson, Natalie, additional, Dobson, Sue L, additional, Cross, Andrew, additional, Sandhar, Gurjinder, additional, Kilby, Jonathan A, additional, Tyerman, Jessica K, additional, Nicols, Alexander R, additional, Spegarova, Jarmila S, additional, Mehta, Hema, additional, Hornsby, Hailey, additional, Whitham, Rachel, additional, Conlon, Christopher P, additional, Jeffery, Katie, additional, Goulder, Philip, additional, Frater, John, additional, Dold, Christina, additional, Pace, Matthew, additional, Ogbe, Ane, additional, Brown, Helen, additional, Ansari, M Azim, additional, Adland, Emily, additional, Brown, Anthony, additional, Chand, Meera, additional, Shields, Adrian, additional, Matthews, Philippa C, additional, Hopkins, Susan, additional, Hall, Victoria, additional, James, William, additional, Rowland-Jones, Sarah L, additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Richter, Alex, additional, Duncan, Christopher J A, additional, Barnes, Eleanor, additional, Carroll, Miles, additional, Turtle, Lance, additional, de Silva, Thushan I, additional, Watson, Adam, additional, Angyal, Adrienn, additional, Alhussni, Ahmed, additional, Nicols, Alexander, additional, Deeks, Alexandra, additional, Webb-Bridges, Alice, additional, Jämsén, Anni, additional, Chawla, Anu, additional, Duncan, Christopher, additional, Conlon, Christopher, additional, O'Donnell, Denise, additional, Weeks, Esme, additional, Abuelgasim, Hibatullah, additional, Xiao, Huiyuan, additional, Spegarova, Jarmila, additional, Holmes, Jennifer, additional, Haworth, Jenny, additional, Tyerman, Jessica, additional, Kilby, Jonathan, additional, Cutteridge, Joseph, additional, Lillie, Katy, additional, Romaniuk, Leigh, additional, Denly, Lucy, additional, Hering, Luisa, additional, Ansari, M. Azim, additional, Kasanyinga, Mwila, additional, Matthews, Philippa, additional, Payne, Rebecca, additional, Wilson, Robert, additional, Rowland-Jones, Sarah, additional, Thomas, Sarah, additional, Moore, Shona, additional, Gardiner, Siobhan, additional, Tucker, Stephanie, additional, Dobson, Sue, additional, Adlou, Syed, additional, de Silva, Thushan, additional, Lawrie, Allan, additional, Smith, Nikki, additional, Turton, Helena, additional, Zawia, Amira, additional, Bayley, Martin, additional, Fairman, Alex, additional, Harrington, Kate, additional, Kirk, Rosemary, additional, Marsh, Louise, additional, Watson, Lisa, additional, Wood, Steven, additional, Diffey, Benjamin, additional, Jones, Chris, additional, Lett, Lauren, additional, Platt, Gareth, additional, Subramaniam, Krishanthi, additional, Wootton, Daniel, additional, Payne, Brendan, additional, Hambleton, Sophie, additional, Kelly, Sinead, additional, Marston, Judith, additional, Poolan, Sonia, additional, Turner, Dianne, additional, Haniffa, Muzlifah, additional, Stephenson, Emily, additional, Adele, Sandra, additional, Akhter, Hossain Delowar, additional, Chinnakannan, Senthil, additional, de Lara, Catherine, additional, Donnison, Timothy, additional, Hackstein, Carl-Philipp, additional, Lee, Lian, additional, Lim, Nicholas, additional, Malone, Tom, additional, Phillips, Eloise, additional, Ramamurthy, Narayan, additional, Robinson, Nichola, additional, Sampson, Oliver, additional, Eyre, David, additional, Simmons, Beatrice, additional, Stafford, Lizzie, additional, Mentzer, Alexander, additional, Amini, Ali, additional, Arancibia-Cárcamo, Carolina, additional, Provine, Nicholas, additional, Travis, Simon, additional, Dimitriadis, Stavros, additional, Johnson, Sile, additional, Foulkes, Sarah, additional, Khawam, Jameel, additional, Wellington, Edgar, additional, Gilbert-Jaramillo, Javier, additional, Knight, Michael, additional, Dupont, Maeva, additional, Horner, Emily, additional, Thaventhiran, James, additional, and Chalk, Jeremy, additional

Published
2022
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45. Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose

Author

Faustini, Sian E, primary, Shields, Adrian M, additional, Banham, Gemma, additional, Wall, Nadezhda, additional, Al-Taei, Saly, additional, Tanner, Chloe, additional, Ahmed, Zahra, additional, Efstathiou, Elena, additional, Townsend, Neal, additional, Plant, Tim, additional, Perez-Toledo, Marisol, additional, Jasiulewicz, Aleksandra, additional, Price, Ruth, additional, McLaughlin, James, additional, Farnan, John, additional, Moore, Julie, additional, Robertson, Louise, additional, Nesbit, Andrew, additional, Curry, Grace, additional, Black, Amy, additional, Cunningham, Adam F, additional, Harper, Lorraine, additional, Moore, Tara, additional, Drayson, Mark T, additional, and Richter, Alex G, additional

Published
2022
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46. Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study

Author

Moore, Shona, primary, Kronsteiner, Barbara, additional, Longet, Stephanie, additional, Adele, Sandra, additional, Deeks, Alexandra, additional, Liu, Chang, additional, Dejnirattisai, Wanwisa, additional, Silva Reyes, Laura, additional, Meardon, Naomi, additional, Faustini, Sian, additional, Al-Taei, Saly, additional, Tipton, Tom, additional, Hering, Luisa M., additional, Angyal, Adrienn, additional, Brown, Rebecca, additional, Nicols, Alexander R., additional, Dobson, Sue L., additional, Supasa, Piyada, additional, Tuekprakhon, Aekkachai, additional, Cross, Andrew, additional, Tyerman, Jessica K., additional, Hornsby, Hailey, additional, Grouneva, Irina, additional, Plowright, Megan, additional, Zhang, Peijun, additional, Newman, Thomas, additional, Nell, Jeremy M., additional, Abraham, Priyanka, additional, Ali, Mohammad, additional, Malone, Tom, additional, Neale, Isabel, additional, Phillips, Eloise, additional, Wilson, Joseph D., additional, Murray, Sam M., additional, Shields, Adrian, additional, Horner, Emily C., additional, Booth, Lucy H., additional, Stafford, Lizzie, additional, Bibi, Sagida, additional, Wootton, Dan G., additional, Mentzer, Alexander J., additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Matthews, Philippa C., additional, Pollard, Andrew J., additional, Brown, Anthony, additional, Rowland-Jones, Sarah L., additional, Mongkolspaya, Juthathip, additional, Payne, Rebecca P., additional, Dold, Christina, additional, Lambe, Teresa, additional, Thaventhiran, James, additional, Screaton, Gavin R., additional, Barnes, Eleanor, additional, Hopkins, Susan, additional, Hall, Victoria Jane, additional, Duncan, Christopher JA, additional, Richter, Alex G., additional, Carroll, Miles W., additional, de Silva, Thushan I., additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Turtle, Lance, additional, and Consortium, PITCH, additional

Published
2022
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47. COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience

Author

Shields, Adrian M., primary, Burns, Siobhan O., additional, Savic, Sinisa, additional, Richter, Alex G., additional, Anantharachagan, Ariharan, additional, Arumugakani, Gururaj, additional, Baker, Kenneth, additional, Bahal, Sameer, additional, Bermingham, William, additional, Bhole, Malini, additional, Boules, Evon, additional, Bright, Philip, additional, Burns, Siobhan, additional, Cleave, Betsy, additional, Dempster, John, additional, Devlin, Lisa, additional, Dhalla, Fatima, additional, Drewe, Elizabeth, additional, Duncan, Christopher, additional, Dziadzio, Magdalena, additional, Elkhalifa, Shuayb, additional, Gennery, Andrew, additional, Goddard, Sarah, additional, Grigoriadou, Sofia, additional, Hayman, Grant, additional, Herwadkar, Archana, additional, Huissoon, Aarnoud, additional, Jain, Rashmi, additional, Jolles, Stephen, additional, Johnston, Sarah, additional, Leeman, Lucy, additional, Mahabir, Shanti, additional, MacLochlainn, Dylan, additional, McDermott, Elizabeth, additional, Misbah, Siraj, additional, Morsi, Hadeil, additional, Murng, Sai, additional, Noorani, Sadia, additional, O’Brien, Rachael, additional, Patel, Smita, additional, Price, Arthur, additional, Richter, Alex, additional, Seneviratne, Suranjith, additional, Shields, Adrian, additional, Shrimpton, Anna, additional, Stroud, Catherine, additional, Vaitla, Prashantha, additional, and Verma, Nisha, additional

Published
2021
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48. SARS-CoV-2 vaccine responses following CD20-depletion treatment in patients with haematological and rheumatological disease: a West Midlands Research Consortium study

Author

Shields, Adrian M, primary, Venkatachalam, Srinivasan, additional, Shafeek, Salim, additional, Paneesha, Shankara, additional, Ford, Mark, additional, Sheeran, Tom, additional, Kelly, Melanie, additional, Qureshi, Iman, additional, Salhan, Beena, additional, Karim, Farheen, additional, De Silva, Neelakshi, additional, Stones, Jacqueline, additional, Lee, Sophie, additional, Khawaja, Jahanzeb, additional, Kaudlay, Praveen Kumar, additional, Whitmill, Richard, additional, Kakepoto, Ghulam Nabi, additional, Parry, Helen M, additional, Moss, Paul, additional, Faustini, Sian E, additional, Richter, Alex G, additional, Drayson, Mark T, additional, and Basu, Supratik, additional

Published
2021
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49. In vitro, classical complement activation differs by disease severity and between SARS-CoV-2 antigens

Author

Lamerton, Rachel E, primary, Marcial Juarez, Edith, additional, Faustini, Sian E, additional, Perez-Toledo, Marisol E, additional, Goodall, Margaret, additional, Jossi, Sian E, additional, Newby, Maddy L, additional, Chapple, Iain, additional, Dietrich, Thomas, additional, Veenith, Tonny, additional, Shields, Adrian M, additional, Harper, Lorraine, additional, Henderson, Ian R, additional, Rayes, Julie, additional, Wraith, David C, additional, Watson, Steve P, additional, Crispin, Max, additional, Drayson, Mark T, additional, Richter, Alex G, additional, and Cunningham, Adam F, additional

Published
2021
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50. Vaccine Efficacy after Rituximab Exposure: First Interim Analysis of Virtue Project on Behalf of West Midlands Research Consortium, UK

Author

Shields, Adrian M, primary, Venkatachalam, Srinivasan, additional, Paneesha, Shankara, additional, Ford, Mark, additional, Sheeran, Tom, additional, Kelly, Melanie, additional, Karim, Farheen, additional, Qureshi, Iman, additional, Salhan, Beena, additional, DeSilva, Neelakshi, additional, Stones, Jacqueline, additional, Lee, Sophie, additional, Khawaja, Jahanzeb, additional, Kaudlay, Praveen Kumar, additional, Whitmill, Richard, additional, Nabikakepoto, Ghulam, additional, Faustini, Sian E, additional, Richter, Alex G, additional, Drayson, Mark T, additional, and Basu, Supratik, additional

Published
2021
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