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38 results on '"Shieh, Joseph T.C."'

1. Automated syndrome diagnosis by three-dimensional facial imaging

Author

Hallgrímsson, Benedikt, Aponte, J. David, Katz, David C., Bannister, Jordan J., Riccardi, Sheri L., Mahasuwan, Nick, McInnes, Brenda L., Ferrara, Tracey M., Lipman, Danika M., Neves, Amanda B., Spitzmacher, Jared A.J., Larson, Jacinda R., Bellus, Gary A., Pham, Anh M., Aboujaoude, Elias, Benke, Timothy A., Chatfield, Kathryn C., Davis, Shanlee M., Elias, Ellen R., Enzenauer, Robert W., French, Brooke M., Pickler, Laura L., Shieh, Joseph T.C., Slavotinek, Anne, Harrop, A. Robertson, Innes, A. Micheil, McCandless, Shawn E., McCourt, Emily A., Meeks, Naomi J.L., Tartaglia, Nicole R., Tsai, Anne C.-H., Wyse, J. Patrick H., Bernstein, Jonathan A., Sanchez-Lara, Pedro A., Forkert, Nils D., Bernier, Francois P., Spritz, Richard A., and Klein, Ophir D.

Published
2020
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2. Data from Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Author

McKinney, Andrew, primary, Lindberg, Olle R., primary, Engler, Jane R., primary, Chen, Katharine Y., primary, Kumar, Anupam, primary, Gong, Henry, primary, Lu, Kan V., primary, Simonds, Erin F., primary, Cloughesy, Timothy F., primary, Liau, Linda M., primary, Prados, Michael, primary, Bollen, Andrew W., primary, Berger, Mitchel S., primary, Shieh, Joseph T.C., primary, James, C. David, primary, Nicolaides, Theodore P., primary, Yong, William H., primary, Lai, Albert, primary, Hegi, Monika E., primary, Weiss, William A., primary, and Phillips, Joanna J., primary

Published
2023
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3. Supplementary Figure S1 from Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Author

McKinney, Andrew, primary, Lindberg, Olle R., primary, Engler, Jane R., primary, Chen, Katharine Y., primary, Kumar, Anupam, primary, Gong, Henry, primary, Lu, Kan V., primary, Simonds, Erin F., primary, Cloughesy, Timothy F., primary, Liau, Linda M., primary, Prados, Michael, primary, Bollen, Andrew W., primary, Berger, Mitchel S., primary, Shieh, Joseph T.C., primary, James, C. David, primary, Nicolaides, Theodore P., primary, Yong, William H., primary, Lai, Albert, primary, Hegi, Monika E., primary, Weiss, William A., primary, and Phillips, Joanna J., primary

Published
2023
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4. Data from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma

Author

Kumar, Anupam, primary, Mohamed, Esraa, primary, Tong, Schuyler, primary, Chen, Katharine, primary, Mukherjee, Joydeep, primary, Lim, Yunita, primary, Wong, Cynthia M., primary, Boosalis, Zoe, primary, Shai, Anny, primary, Pieper, Russell O., primary, Gupta, Nalin, primary, Perry, Arie, primary, Bollen, Andrew W., primary, Molinaro, Annette M., primary, Solomon, David A., primary, Shieh, Joseph T.C., primary, and Phillips, Joanna J., primary

Published
2023
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5. Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma

Author

Kumar, Anupam, primary, Mohamed, Esraa, primary, Tong, Schuyler, primary, Chen, Katharine, primary, Mukherjee, Joydeep, primary, Lim, Yunita, primary, Wong, Cynthia M., primary, Boosalis, Zoe, primary, Shai, Anny, primary, Pieper, Russell O., primary, Gupta, Nalin, primary, Perry, Arie, primary, Bollen, Andrew W., primary, Molinaro, Annette M., primary, Solomon, David A., primary, Shieh, Joseph T.C., primary, and Phillips, Joanna J., primary

Published
2023
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6. Supplementary Data from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma

Author

Kumar, Anupam, primary, Mohamed, Esraa, primary, Tong, Schuyler, primary, Chen, Katharine, primary, Mukherjee, Joydeep, primary, Lim, Yunita, primary, Wong, Cynthia M., primary, Boosalis, Zoe, primary, Shai, Anny, primary, Pieper, Russell O., primary, Gupta, Nalin, primary, Perry, Arie, primary, Bollen, Andrew W., primary, Molinaro, Annette M., primary, Solomon, David A., primary, Shieh, Joseph T.C., primary, and Phillips, Joanna J., primary

Published
2023
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8. CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma

Author

Kumar, Anupam, primary, Mohamed, Esraa, additional, Tong, Schuyler, additional, Chen, Katharine, additional, Mukherjee, Joydeep, additional, Lim, Yunita, additional, Wong, Cynthia M., additional, Boosalis, Zoe, additional, Shai, Anny, additional, Pieper, Russell O., additional, Gupta, Nalin, additional, Perry, Arie, additional, Bollen, Andrew W., additional, Molinaro, Annette M., additional, Solomon, David A., additional, Shieh, Joseph T.C., additional, and Phillips, Joanna J., additional

Published
2022
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11. Correction to:De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy (Genetics in Medicine, (2021), 23, 4, (653-660), 10.1038/s41436-020-01020-w)

Author

Klöckner, Chiara, Sticht, Heinrich, Zacher, Pia, Popp, Bernt, Babcock, Holly E., Bakker, Dewi P., Barwick, Katy, Bonfert, Michaela V., Bönnemann, Carsten G., Brilstra, Eva H., Chung, Wendy K., Clarke, Angus J., Devine, Patrick, Donkervoort, Sandra, Fraser, Jamie L., Friedman, Jennifer, Gates, Alyssa, Ghoumid, Jamal, Hobson, Emma, Horvath, Gabriella, Keller-Ramey, Jennifer, Keren, Boris, Kurian, Manju A., Lee, Virgina, Leppig, Kathleen A., Lundgren, Johan, McDonald, Marie T., McLaughlin, Heather M., McTague, Amy, Mefford, Heather C., Mignot, Cyril, Mikati, Mohamad A., Nava, Caroline, Raymond, F. Lucy, Sampson, Julian R., Sanchis-Juan, Alba, Shashi, Vandana, Shieh, Joseph T.C., Shinawi, Marwan, Slavotinek, Anne, Stödberg, Tommy, Stong, Nicholas, Sullivan, Jennifer A., Taylor, Ashley C., Toler, Tomi L., van den Boogaard, Marie José, van der Crabben, Saskia N., van Gassen, Koen L.I., van Jaarsveld, Richard H., Møller, Rikke S., Lemke, Johannes W, and Platzer, Konrad

Abstract

Unfortunately, in the first sentence in the abstract, a spelling mistake was introduced during the production process after our proofreading. The wording was changed from “aims” to “aimsed.” Heather M. McLaughlin was not listed among the authors. The original article has been corrected.

Published
2021

12. Correction to: De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy

Author

Klöckner, Chiara, primary, Sticht, Heinrich, additional, Zacher, Pia, additional, Popp, Bernt, additional, Babcock, Holly E., additional, Bakker, Dewi P., additional, Barwick, Katy, additional, Bonfert, Michaela V., additional, Bönnemann, Carsten G., additional, Brilstra, Eva H., additional, Chung, Wendy K., additional, Clarke, Angus J., additional, Devine, Patrick, additional, Donkervoort, Sandra, additional, Fraser, Jamie L., additional, Friedman, Jennifer, additional, Gates, Alyssa, additional, Ghoumid, Jamal, additional, Hobson, Emma, additional, Horvath, Gabriella, additional, Keller-Ramey, Jennifer, additional, Keren, Boris, additional, Kurian, Manju A., additional, Lee, Virgina, additional, Leppig, Kathleen A., additional, Lundgren, Johan, additional, McDonald, Marie T., additional, McLaughlin, Heather M., additional, McTague, Amy, additional, Mefford, Heather C., additional, Mignot, Cyril, additional, Mikati, Mohamad A., additional, Nava, Caroline, additional, Raymond, F. Lucy, additional, Sampson, Julian R., additional, Sanchis-Juan, Alba, additional, Shashi, Vandana, additional, Shieh, Joseph T.C., additional, Shinawi, Marwan, additional, Slavotinek, Anne, additional, Stödberg, Tommy, additional, Stong, Nicholas, additional, Sullivan, Jennifer A., additional, Taylor, Ashley C., additional, Toler, Tomi L., additional, van den Boogaard, Marie-José, additional, van der Crabben, Saskia N., additional, van Gassen, Koen L.I., additional, van Jaarsveld, Richard H., additional, Van Ziffle, Jessica, additional, Wadley, Alexandrea F., additional, Wagner, Matias, additional, Wigby, Kristen, additional, Wortmann, Saskia B., additional, Zarate, Yuri A., additional, Møller, Rikke S., additional, Lemke, Johannes R., additional, and Platzer, Konrad, additional

Published
2021
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13. De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy

Author

Klöckner, Chiara, primary, Sticht, Heinrich, additional, Zacher, Pia, additional, Popp, Bernt, additional, Babcock, Holly E., additional, Bakker, Dewi P., additional, Barwick, Katy, additional, Bonfert, Michaela V., additional, Bönnemann, Carsten G., additional, Brilstra, Eva H., additional, Chung, Wendy K., additional, Clarke, Angus J., additional, Devine, Patrick, additional, Donkervoort, Sandra, additional, Fraser, Jamie L., additional, Friedman, Jennifer, additional, Gates, Alyssa, additional, Ghoumid, Jamal, additional, Hobson, Emma, additional, Horvath, Gabriella, additional, Keller-Ramey, Jennifer, additional, Keren, Boris, additional, Kurian, Manju A., additional, Lee, Virgina, additional, Leppig, Kathleen A., additional, Lundgren, Johan, additional, McDonald, Marie T., additional, McLaughlin, Heather M., additional, McTague, Amy, additional, Mefford, Heather C., additional, Mignot, Cyril, additional, Mikati, Mohamad A., additional, Nava, Caroline, additional, Raymond, F. Lucy, additional, Sampson, Julian R., additional, Sanchis-Juan, Alba, additional, Shashi, Vandana, additional, Shieh, Joseph T.C., additional, Shinawi, Marwan, additional, Slavotinek, Anne, additional, Stödberg, Tommy, additional, Stong, Nicholas, additional, Sullivan, Jennifer A., additional, Taylor, Ashley C., additional, Toler, Tomi L., additional, van den Boogaard, Marie-José, additional, van der Crabben, Saskia N., additional, van Gassen, Koen L.I., additional, van Jaarsveld, Richard H., additional, Van Ziffle, Jessica, additional, Wadley, Alexandrea F., additional, Wagner, Matias, additional, Wigby, Kristen, additional, Wortmann, Saskia B., additional, Zarate, Yuri A., additional, Møller, Rikke S., additional, Lemke, Johannes R., additional, and Platzer, Konrad, additional

Published
2021
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19. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction

Author

Cohen, Christopher J., Shieh, Joseph T.C., Pickles, Raymond J., Okegawa, Takatsugu, Hsieh, Jer-Tsong, and Bergelson, Jeffrey M.

Subjects
Adenoviruses -- Physiological aspects, Coxsackieviruses -- Physiological aspects, Epithelial cells -- Physiological aspects, Cell research -- Analysis, Science and technology
Abstract

The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described. In nonpolarized cells, CAR localized to homotypic intercellular contacts, mediated homotypic cell aggregation, and recruited the tight junction protein ZO-1 to sites of cell-cell contact. in polarized epithelial cells, CAR and ZO-1 colocalized to tight junctions and could be coprecipitated from cell lysates. CAR expression led to reduced passage of macromolecules and ions across cell monolayers, and soluble CAR inhibited the formation of functional tight junctions. Virus entry into polarized epithelium required disruption of tight junctions. These results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement. Sequestration of CAR in tight junctions may limit virus infection across epithelial surfaces.

Published
2001

23. A vaccine carrier derived from Neisseria meningitidis with mitogenic activity for lymphocytes

Author

Liu, Margaret A., Friedman, Arthur, Oliff, Allen I., Tai, Joseph, Martinez, Douglas, Deck, R. Randall, Shieh, Joseph T.C., Jenkins, Timothy D., Donnelly, John J., and Hawe, Linda A.

Subjects
Immunological adjuvants -- Research, Bacterial vaccines -- Analysis, Mitogens -- Identification and classification, Membrane proteins -- Physiological aspects, Science and technology
Abstract

The outer membrane protein complex (OMPC) of Neisseria meningitidis serogroup B strain B11 was conjugated to the T-cell-independent capsular polysaccharide of Haemophilus influenzae, resulting in a highly immunogenic vaccine. The component of OMPC which enhanced the vaccine's immunogenicity was termed the major immunoenhancing protein (MIEP). It was purified and was shown to be a class 2 porin protein. Evaluation of the MIEP resulted in an unexpected discovery that it could function as a mitogen for lymphocytes. This finding may explain why MIEP can enhance the immunogenicity of the OMPC conjugate.

Published
1992

24. Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Author

McKinney, Andrew, primary, Lindberg, Olle R., additional, Engler, Jane R., additional, Chen, Katharine Y., additional, Kumar, Anupam, additional, Gong, Henry, additional, Lu, Kan V., additional, Simonds, Erin F., additional, Cloughesy, Timothy F., additional, Liau, Linda M., additional, Prados, Michael, additional, Bollen, Andrew W., additional, Berger, Mitchel S., additional, Shieh, Joseph T.C., additional, James, C. David, additional, Nicolaides, Theodore P., additional, Yong, William H., additional, Lai, Albert, additional, Hegi, Monika E., additional, Weiss, William A., additional, and Phillips, Joanna J., additional

Published
2019
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26. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma

Author

Phillips, Joanna J., primary, Gong, Henry, additional, Chen, Katharine, additional, Joseph, Nancy M., additional, van Ziffle, Jessica, additional, Bastian, Boris C., additional, Grenert, James P., additional, Kline, Cassie N., additional, Mueller, Sabine, additional, Banerjee, Anuradha, additional, Nicolaides, Theodore, additional, Gupta, Nalin, additional, Berger, Mitchel S., additional, Lee, Han S., additional, Pekmezci, Melike, additional, Tihan, Tarik, additional, Bollen, Andrew W., additional, Perry, Arie, additional, Shieh, Joseph T.C., additional, and Solomon, David A., additional

Published
2018
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27. De novo variants in SNAP25cause an early-onset developmental and epileptic encephalopathy

Author

Klöckner, Chiara, Sticht, Heinrich, Zacher, Pia, Popp, Bernt, Babcock, Holly E., Bakker, Dewi P., Barwick, Katy, Bonfert, Michaela V., Bönnemann, Carsten G., Brilstra, Eva H., Chung, Wendy K., Clarke, Angus J., Devine, Patrick, Donkervoort, Sandra, Fraser, Jamie L., Friedman, Jennifer, Gates, Alyssa, Ghoumid, Jamal, Hobson, Emma, Horvath, Gabriella, Keller-Ramey, Jennifer, Keren, Boris, Kurian, Manju A., Lee, Virgina, Leppig, Kathleen A., Lundgren, Johan, McDonald, Marie T., McLaughlin, Heather M., McTague, Amy, Mefford, Heather C., Mignot, Cyril, Mikati, Mohamad A., Nava, Caroline, Raymond, F. Lucy, Sampson, Julian R., Sanchis-Juan, Alba, Shashi, Vandana, Shieh, Joseph T.C., Shinawi, Marwan, Slavotinek, Anne, Stödberg, Tommy, Stong, Nicholas, Sullivan, Jennifer A., Taylor, Ashley C., Toler, Tomi L., van den Boogaard, Marie-José, van der Crabben, Saskia N., van Gassen, Koen L.I., van Jaarsveld, Richard H., Van Ziffle, Jessica, Wadley, Alexandrea F., Wagner, Matias, Wigby, Kristen, Wortmann, Saskia B., Zarate, Yuri A., Møller, Rikke S., Lemke, Johannes R., and Platzer, Konrad

Abstract

This study aims to provide a comprehensive description of the phenotypic and genotypic spectrum of SNAP25developmental and epileptic encephalopathy (SNAP25-DEE) by reviewing newly identified and previously reported individuals.

Published
2021
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28. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.

Author

Phillips, Joanna J., Gong, Henry, Chen, Katharine, Joseph, Nancy M., van Ziffle, Jessica, Bastian, Boris C., Grenert, James P., Kline, Cassie N., Mueller, Sabine, Banerjee, Anuradha, Nicolaides, Theodore, Gupta, Nalin, Berger, Mitchel S., Lee, Han S., Pekmezci, Melike, Tihan, Tarik, Bollen, Andrew W., Perry, Arie, Shieh, Joseph T.C., and Solomon, David A.

Subjects
ASTROCYTOMAS, CANCER invasiveness, CANCER relapse, DELETION mutation, GENE rearrangement
Abstract

Pleomorphic xanthoastrocytoma (PXA) is an astrocytic neoplasm that is typically well circumscribed and can have a relatively favorable prognosis. Tumor progression to anaplastic PXA (WHO grade III), however, is associated with a more aggressive biologic behavior and worse prognosis. The factors that drive anaplastic progression are largely unknown. We performed comprehensive genomic profiling on a set of 23 PXAs from 19 patients, including 15 with anaplastic PXA. Four patients had tumor tissue from multiple recurrences, including two with anaplastic progression. We find that PXAs are genetically defined by the combination of CDKN2A biallelic inactivation and RAF alterations that were present in all 19 cases, most commonly as CDKN2A homozygous deletion and BRAF p.V600E mutation but also occasionally BRAF or RAF1 fusions or other rearrangements. The third most commonly altered gene in anaplastic PXA was TERT, with 47% (7/15) harboring TERT alterations, either gene amplification (n = 2) or promoter hotspot mutation (n = 5). In tumor pairs analyzed before and after anaplastic progression, two had increased copy number alterations and one had TERT promoter mutation at recurrence. Less commonly altered genes included TP53,BCOR,BCORL1,ARID1A,ATRX,PTEN, and BCL6. All PXA in this cohort were IDH and histone H3 wildtype, and did not contain alterations in EGFR. Genetic profiling performed on six regions from the same tumor identified intratumoral genomic heterogeneity, likely reflecting clonal evolution during tumor progression. Overall, anaplastic PXA is characterized by the combination of CDKN2A biallelic inactivation and oncogenic RAF kinase signaling as well as a relatively small number of additional genetic alterations, with the most common being TERT amplification or promoter mutation. These data define a distinct molecular profile for PXA and suggest additional genetic alterations, including TERT, may be associated with anaplastic progression. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Systemic hyalinosis: a distinctive early childhood-onset disorder characterized by mutations in the anthrax toxin receptor 2 gene (ANTRX2)

Author

Shieh, Joseph T.C., Swidler, Petra, Martignetti, John A., Ramirez, Maria Celeste M., Balboni, Imelda, Kaplan, Julie, Kennedy, Jeanette, Omar, Abdul-Rahman, Enns, Gregory M., Sandborg, Christy, Slavotinek, Anne, and Hoyme, H. Eugene

Subjects
Genetic disorders -- Diagnosis, Genetic disorders -- Analysis
Abstract

OBJECTIVE. We sought to further characterize the phenotype and facilitate clinical recognition of systemic hyalinosis in children who present with chronic pain and progressive contractures in early childhood. PATIENTS AND METHODS. We report on 3 children who presented in infancy with symptoms and signs that initially were not recognized to be those of systemic hyalinosis. Although the children were evaluated for a variety of problems, including lysosomal storage disorders and nonaccidental trauma, all eventually underwent genetic analysis of the anthrax toxin receptor 2 gene (ANTRX2) and were diagnosed as having systemic hyalinosis. RESULTS. We describe the recognizable but variable clinical phenotype of systemic hyalinosis and associated mutations in ANTRX2. Affected individuals presented in early infancy with severe pain and progressive contractures. Initial diagnostic evaluations were unrevealing; however, hyperpigmented skin over bony prominences, skin nodules, and fleshy perianal masses suggested a diagnosis of systemic hyalinosis. ANTRX2 analysis confirmed the diagnosis in each case. Although 2 of the children died in infancy as a result of complications of chronic diarrhea, the third child has survived into midchildhood. These data suggest that some ANTRX2 mutations, such as that identified in the long-term survivor, may be associated with a less severe course of disease. CONCLUSIONS. Although some aspects of systemic hyalinosis may resemble lysosomal storage disorders, the clinical features of systemic hyalinosis are distinctive, and detection of an ANTRX2 mutation can confirm the diagnosis. Early recognition of affected individuals should allow for aggressive pain control and expectant management of the multiple associated problems, including gastrointestinal dysfunction. KEY WORDS. hyalinosis, chronic pain, progressive childhood contractures, gingival hypertrophy, anthrax toxin receptor 2 gene, genetic testing, fibromatosis., URL: www.pediatrics.org/cgi/doi/10.1542/peds.2006 0824 Joseph T. C. Shieh, MD, PhD, Petra Swidler, MD, John A. Martignetti, MD, PhD, Maria Celeste M. Ramirez, BS, Imelda Balboni, MD, PhD, Julie Kaplan, MD, Jeanette [...]

Published
2006

32. Copy Number Variation Analysis in 98 Individuals with PHACE Syndrome

Author

Siegel, Dawn H., primary, Shieh, Joseph T.C., additional, Kwon, Eun-kyung, additional, Baselga, Eulalia, additional, Blei, Francine, additional, Cordisco, Maria, additional, Dobyns, William B., additional, Duffy, Kelly J., additional, Garzon, Maria C., additional, Gibbs, David L., additional, Grimmer, Johannes F., additional, Hayflick, Susan J., additional, Krol, Alfons L., additional, Kwok, Pui-Yan, additional, Lorier, Rachel, additional, Matter, Andrea, additional, McWeeney, Shannon, additional, Metry, Denise, additional, Mitchell, Sheri, additional, Pope, Elena, additional, Santoro, Jennifer L., additional, Stevenson, David A., additional, Bayrak-Toydemir, Pinar, additional, Wilmot, Beth, additional, Worthey, Elizabeth A., additional, Frieden, Ilona J., additional, Drolet, Beth A., additional, and Broeckel, Ulrich, additional

Published
2013
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33. Uveal Ganglioneuroma due to Germline PTENMutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma

Author

DeParis, Sarah W., Bloomer, Michele, Han, Ying, Vagefi, M. Reza, Shieh, Joseph T.C., Solomon, David A., Grenert, James, and de Alba Campomanes, Alejandra G.

Abstract

Purpose:Uveal ganglioneuroma is a rare tumor that usually occurs in association with neurofibromatosis type 1. Here, we present a rare case of a uveal ganglioneuroma leading to a diagnosis of the tumor predisposition condition Cowden syndrome. Procedures:A 5-year-old girl with unilateral refractory glaucoma secondary to diffuse iris and choroidal thickening developed a blind, painful eye. Enucleation was performed, and histopathology revealed infiltration of the entire uveal tract by neoplastic spindle cells containing admixed ganglion cells diagnostic of uveal ganglioneuroma. Targeted next-generation sequencing of 510 cancer-associated genes was performed on tumor tissue and peripheral blood. Results:A germline nonsense mutation in the PTENgene was found, accompanied by loss of heterozygosity in the tumor. A diagnosis of Cowden syndrome was made, for which the family sought genetic counseling and initiated the recommended cancer screening. Conclusions:A novel association is found between uveal ganglioneuroma and Cowden syndrome, emphasizing the value of genetic tissue testing in managing patients with rare ocular tumors.

Published
2017
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37. CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1.

Author

Schweighardt, Becky, Shieh, Joseph T.C., and Atwood, Walter J.

Subjects
*HIV infections, *ASTROCYTES, *CELL lines, *HIV, *DISEASE susceptibility, *T cells
Abstract

HIV-1 establishes a low-level persistent infection in astrocytes. In this study, we studied the susceptibility of a human astrocyte cell line (SVG-A) to infection with luciferase expressing reporter viruses pseudotyped with envelopes derived from five isolates of HIV-1. SVG-A cells were susceptible to infection by a T-cell tropic isolate and the infection was both CD4 and CXCR4 independent. These data confirm the susceptibility of astrocytes to infection with T-tropic strains of HIV-1 and suggest a novel mechanism by which T-tropic strains of HIV can infect cells. [ABSTRACT FROM AUTHOR]

Published
2001
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38. Correction to: De novo variants in SNAP25cause an early-onset developmental and epileptic encephalopathy

Author

Klöckner, Chiara, Sticht, Heinrich, Zacher, Pia, Popp, Bernt, Babcock, Holly E., Bakker, Dewi P., Barwick, Katy, Bonfert, Michaela V., Bönnemann, Carsten G., Brilstra, Eva H., Chung, Wendy K., Clarke, Angus J., Devine, Patrick, Donkervoort, Sandra, Fraser, Jamie L., Friedman, Jennifer, Gates, Alyssa, Ghoumid, Jamal, Hobson, Emma, Horvath, Gabriella, Keller-Ramey, Jennifer, Keren, Boris, Kurian, Manju A., Lee, Virgina, Leppig, Kathleen A., Lundgren, Johan, McDonald, Marie T., McLaughlin, Heather M., McTague, Amy, Mefford, Heather C., Mignot, Cyril, Mikati, Mohamad A., Nava, Caroline, Raymond, F. Lucy, Sampson, Julian R., Sanchis-Juan, Alba, Shashi, Vandana, Shieh, Joseph T.C., Shinawi, Marwan, Slavotinek, Anne, Stödberg, Tommy, Stong, Nicholas, Sullivan, Jennifer A., Taylor, Ashley C., Toler, Tomi L., van den Boogaard, Marie-José, van der Crabben, Saskia N., van Gassen, Koen L.I., van Jaarsveld, Richard H., Van Ziffle, Jessica, Wadley, Alexandrea F., Wagner, Matias, Wigby, Kristen, Wortmann, Saskia B., Zarate, Yuri A., Møller, Rikke S., Lemke, Johannes R., and Platzer, Konrad

Published
2021
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