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5. Efficient Fabrication of Intrinsic-Josephson-Junction Terahertz Oscillators with Greatly Reduced Self-Heating Effects

Author

Kashiwagi, T., primary, Yamamoto, T., additional, Minami, H., additional, Tsujimoto, M., additional, Yoshizaki, R., additional, Delfanazari, K., additional, Kitamura, T., additional, Watanabe, C., additional, Nakade, K., additional, Yasui, T., additional, Asanuma, K., additional, Saiwai, Y., additional, Shibano, Y., additional, Enomoto, T., additional, Kubo, H., additional, Sakamoto, K., additional, Katsuragawa, T., additional, Marković, B., additional, Mirković, J., additional, Klemm, R. A., additional, and Kadowaki, K., additional

Published
2015
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7. Broadly tunable, high-power terahertz radiation up to 73 K from a stand-alone Bi2Sr2CaCu2O8+δ mesa

Author

Kitamura, T., primary, Kashiwagi, T., additional, Yamamoto, T., additional, Tsujimoto, M., additional, Watanabe, C., additional, Ishida, K., additional, Sekimoto, S., additional, Asanuma, K., additional, Yasui, T., additional, Nakade, K., additional, Shibano, Y., additional, Saiwai, Y., additional, Minami, H., additional, Klemm, R. A., additional, and Kadowaki, K., additional

Published
2014
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8. Computed tomography image using sub-terahertz waves generated from a high-Tc superconducting intrinsic Josephson junction oscillator

Author

Kashiwagi, T., primary, Nakade, K., additional, Saiwai, Y., additional, Minami, H., additional, Kitamura, T., additional, Watanabe, C., additional, Ishida, K., additional, Sekimoto, S., additional, Asanuma, K., additional, Yasui, T., additional, Shibano, Y., additional, Tsujimoto, M., additional, Yamamoto, T., additional, Marković, B., additional, Mirković, J., additional, Klemm, R. A., additional, and Kadowaki, K., additional

Published
2014
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9. Influence of the local heating position on the terahertz emission power from high-T c superconducting Bi2Sr2CaCu2O8+ δ mesas

Author

Watanabe, C., Minami, H., Kitamura, T., Asanuma, K., Nakade, K., Yasui, T., Saiwai, Y., Shibano, Y., Yamamoto, T., Kashiwagi, T., Richard, A. Klemm, and Kadowaki, K.

Abstract

Simultaneous measurements of spectroscopic terahertz emissions from and SiC photoluminescent local temperature T(r) distributions of high transition temperature Tc superconducting Bi2Sr2CaCu2O8+ δ rectangular mesa devices were made. A local region with T(r) > Tc known as a hot spot can emerge with current bias changes. When the hot spot position was moved to a mesa end by locally heating the mesa surface with a laser beam, the intensity of the emission increased, but no changes to its frequency or line width were observed. These results suggest that higher power radiation is attainable by adjusting the hot spot position.

Published
2015

10. Reflection type of terahertz imaging system using a high-Tc superconducting oscillator

Author

Kashiwagi, T., primary, Nakade, K., additional, Marković, B., additional, Saiwai, Y., additional, Minami, H., additional, Kitamura, T., additional, Watanabe, C., additional, Ishida, K., additional, Sekimoto, S., additional, Asanuma, K., additional, Yasui, T., additional, Shibano, Y., additional, Tsujimoto, M., additional, Yamamoto, T., additional, Mirković, J., additional, and Kadowaki, K., additional

Published
2014
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21. Influence of the local heating position on the terahertz emission power from high-Tc superconducting Bi2Sr2CaCu2O8+δ mesas.

Author

Watanabe, C., Minami, H., Kitamura, T., Asanuma, K., Nakade, K., Yasui, T., Saiwai, Y., Shibano, Y., Yamamoto, T., Kashiwagi, T., Klemm, Richard A., and Kadowaki, K.

Subjects
TERAHERTZ spectroscopy, SUPERCONDUCTORS, TRANSITION temperature, TERAHERTZ materials, PHOTOLUMINESCENCE
Abstract

Simultaneous measurements of spectroscopic terahertz emissions from and SiC photoluminescent local temperature T(r) distributions of high transition temperature Tc superconducting Bi2Sr2CaCu2O8+δ rectangular mesa devices were made. A local region with T(r) > Tc known as a hot spot can emerge with current bias changes. When the hot spot position was moved to a mesa end by locally heating the mesa surface with a laser beam, the intensity of the emission increased, but no changes to its frequency or line width were observed. These results suggest that higher power radiation is attainable by adjusting the hot spot position. [ABSTRACT FROM AUTHOR]

Published
2015
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22. Broadly tunable, high-power terahertz radiation up to 73K from a stand-alone Bi2Sr2CaCu2O8+δ mesa.

Author

Kitamura, T., Kashiwagi, T., Yamamoto, T., Tsujimoto, M., Watanabe, C., Ishida, K., Sekimoto, S., Asanuma, K., Yasui, T., Nakade, K., Shibano, Y., Saiwai, Y., Minami, H., Klemm, R. A., and Kadowaki, K.

Subjects
ELECTRIC currents, SUPERCONDUCTIVITY, SUPERCONDUCTORS, ENERGY dissipation, METALLIC films
Abstract

High-power, continuous, broadly tunable THz radiation from 0.29 to 1.06 THz, was obtained from the outer current-voltage characteristic (IVC) branch of a single stand-alone mesa of the high-transition temperature Tc superconductor Bi2Sr2CaCu2O8+δ. The particular metallic film structures placed both beneath and atop the mesas resulted in more efficient heat dissipation, higher allowed applied dc voltages, larger IVC loops, wider emission temperature ranges, and much broader emission frequency tunability than obtained previously. VC 2014 AIP Publishing LLC. [ABSTRACT FROM AUTHOR]

Published
2014
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30. Reflection type of terahertz imaging system using a high-Tc superconducting oscillator.

Author

Kashiwagi, T., Nakade, K., Marković, B., Saiwai, Y., Minami, H., Kitamura, T., Watanabe, C., Ishida, K., Sekimoto, S., Asanuma, K., Yasui, T., Shibano, Y., Tsujimoto, M., Yamamoto, T., Mirković, J., and Kadowaki, K.

Subjects
SUBMILLIMETER wave imaging, IMAGE quality in imaging systems, OPTOELECTRONIC devices, ELECTRIC oscillators, CRYSTALLINE electric field
Abstract

A reflection type of imaging system is shown at sub-terahertz frequencies generated from high-Tcsuperconducting intrinsic Josephson junction mesa structures fabricated by single crystalline Bi2Sr2CaCu2O8+δ to demonstrate how the sub-terahertz imaging technique using monochromatic radiation is powerful and unique for the variety of practical applications. Several examples are discussed in detail and are compared to other terahertz imaging systems. [ABSTRACT FROM AUTHOR]

Published
2014
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42. Altering substrate specificity of Bacillus sp. SAM1606 alpha-glucosidase by comparative site-specific mutagenesis.

Author

Inohara-Ochiai, M, Nakayama, T, Goto, R, Nakao, M, Ueda, T, and Shibano, Y

Abstract

The Bacillus sp. SAM1606 alpha-glucosidase with a broad substrate specificity is the only known alpha-glucosidase that can hydrolyze alpha,alpha'-trehalose efficiently. The enzyme exhibits a very high sequence similarity to the oligo-1,6-glucosidases (O16G) of Bacillus thermoglucosidasius and Bacillus cereus which cannot act on trehalose. These three enzymes share 80% identical residues within the conserved regions (CR), which have been suggested to be located near or at the active site of the alpha-amylase family enzymes. To identify by site-specific mutagenesis the critical residues that determine the broad substrate specificity of the SAM1606 enzyme we compared the CR sequences of these three glucosidases and selected five targets to be mutagenized in SAM1606 alpha-glucosidase, Met76, Arg81, Ala116, Gly273, and Thr342. These residues have been specifically replaced by in vitro mutagenesis with Asn, Ser, Val, Pro, and Asn, respectively, as in the Bacillus O16G. The 12 mutant enzymes with single and multiple substitutions were expressed and characterized kinetically. The results showed that the 5-fold mutation virtually abolished the affinity of the enzyme for alpha, alpha'-trehalose, whereas the specificity constant for the hydrolysis of isomaltose, a good substrate for both the SAM1606 enzyme and O16G, remained essentially unchanged upon the mutation. This loss in affinity for trehalose was critically governed by a Gly273 --> Pro substitution, whose effect was specifically enhanced by the Thr342 --> Asn substitution in the 5-fold and quadruple mutants. These results provide evidence for the differential roles of the amino acid residues in the CR in determining the substrate specificity of the alpha-glucosidase.

Published
1997

44. Changes in deoxyribonucleic acid polymerase activities in synthesis of deoxyribonucleic acid during sporulation of Bacillus subtilis

Author

Honjo, M, Shibano, Y, and Komano, T

Abstract

The deoxyribonucleic acid (DNA) polymerase activities in Bacillus subtilis strains Marburg 168 (thy-trp2) and D22, a DNA polymerase I-deficient mutant, were measured at various stages of sporulation. The DNA polymerase I activity, which had decreased after the exponential growth, began to increase at the early stage of sporulation, reached a maximum and then again decreased. The activity of neither DNA polymerase II nor III was observed to change so drastically as that of DNA polymerase I during sporulation. The incorporation of [3H]deoxythymidine 5'-triphosphate ([3H]dTTP) into Brij 58-treated permeable cells increased during sporulation. The stimulation of [3H]dTTP incorporation into the cells by irradiation with ultraviolet light was also observed to coincide with DNA polymerase I activity. In strain D22 the activities of DNA polymerase II and III were almost constant with time. Neither change of [3H]dTTP incorporation into Brij 58-treated cells nor stimulation of incorporation by irradiation with ultraviolet light was observed.

Published
1976
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49. Multiple Scedosporium apiospermum abscesses in a woman survivor of a tsunami in northeastern Japan: a case report

Author

Nakamura Yutaka, Utsumi Yu, Suzuki Naomi, Nakajima Yoshio, Murata Okinori, Sasaki Nobuhito, Nitanai Hiroo, Nagashima Hiromi, Miyamoto Shinya, Yaegashi Jun, Hatakeyama Tomoki, Shibano Yoshihiro, Yarita Kyoko, Kamei Katsuhiko, Nakadate Toshihide, Endo Shigeatsu, Terayama Yasuo, and Yamauchi Kohei

Subjects
Medicine
Abstract

Abstract Introduction Scedosporium apiospermum is increasingly recognized as a cause of localized and disseminated mycotic infections in near-drowning victims. Case presentation We report the case of a 59-year-old Japanese woman who was a survivor of a tsunami in northeastern Japan and who had lung and brain abscesses caused by S. apiospermum. Initially, an aspergillus infection was suspected, so she was treated with micafungin. However, computed tomography scans of her chest revealed lung abscesses, and magnetic resonance images demonstrated multiple abscesses in her brain. S. apiospermum was cultured from her bronchoalveolar lavage fluid, and antimycotic therapy with voriconazole was initiated. Since she developed an increase in the frequency of premature ventricular contractions, an adverse drug reaction to the voriconazole was suspected. She was started on a treatment of a combination of low-dose voriconazole and liposomal amphotericin B. After combination therapy, further computed tomography scans of the chest and magnetic resonance images of her brain showed a demarcation of abscesses. Conclusions Voriconazole appeared to have a successful record in treating scedosporiosis after a near drowning but, owing to several adverse effects, may possibly not be recommended. Thus, a combination treatment of low-dose voriconazole and liposomal amphotericin B may be a safe and effective treatment for an S. apiospermum infection. Even though a diagnosis of scedosporiosis may be difficult, a fast and correct etiological diagnosis could improve the patient's chance of recovery in any case.

Published
2011
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