1. Increased circulating fibrocytes are associated with higher reticulocyte percent in children with sickle cell anemia
- Author
-
Robert C. Strunk, Joshua J. Field, Matthew S. Karafin, Mph Michael R. DeBaun Md, Marie D. Burdick, Borna Mehrad, C. Edward Rose, Shibani Dogra, Mark Rodeghier, and Robert M. Strieter
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,Vital capacity ,business.industry ,Interstitial lung disease ,medicine.disease ,Sickle cell anemia ,Pathogenesis ,03 medical and health sciences ,FEV1/FVC ratio ,030104 developmental biology ,0302 clinical medicine ,030228 respiratory system ,Pediatrics, Perinatology and Child Health ,Pulmonary fibrosis ,Immunology ,Fibrocyte ,Medicine ,business ,Asthma - Abstract
Summary Background Interstitial lung disease is common in patients with sickle cell anemia (SCA). Fibrocytes are circulating cells implicated in the pathogenesis of pulmonary fibrosis and airway remodeling in asthma. In this study, we tested the hypotheses that fibrocyte levels are: (1) increased in children with SCA compared to healthy controls, and (2) associated with pulmonary disease. Procedure Cross-sectional cohort study of children with SCA who participated in the Sleep Asthma Cohort Study. Results Fibrocyte levels were obtained from 45 children with SCA and 24 controls. Mean age of SCA cases was 14 years and 53% were female. In children with SCA, levels of circulating fibrocytes were greater than controls (P
- Published
- 2015
- Full Text
- View/download PDF