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24 results on '"Shibamura, Hidenori"'

6. Familial abdominal aortic aneurysms: Collection of 233 multiplex families

Author

Kuivaniemi, Helena, Shibamura, Hidenori, Arthur, Claudette, Berguer, Ramon, Cole, C. William, Juvonen, Tatu, Kline, Ronald A., Limet, Raymond, MacKean, Gerry, Norrgård, Örjan, Pals, Gerard, Powell, Janet T., Rainio, Pekka, Sakalihasan, Natzi, van Vlijmen-van Keulen, Clarissa, Verloes, Alain, and Tromp, Gerard

Published
2003

10. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Author

Sakalihasan Natzi, Shibamura Hidenori, Lu Qing, Parrado Antonio R, Lancaster Wayne D, Tromp Gerard, Skunca Magdalena, Goddard Katrina AB, Gregoire Lucie, Ogata Toru, Limet Raymond, MacKean Gerald L, Arthur Claudette, Sueda Taijiro, and Kuivaniemi Helena

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. Methods HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. Results We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). Conclusion This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.

Published
2006
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12. Is Communication to Endocardium Necessary for Angiogenesis in Transmyocardial Laser Revascularization?

Author

Shibamura, Hidenori, Imanishi, Kaoru, Kajihara, Hiroki, Matsuura, Yuichiro, Sueda, Taijiro, and Orihashi, Kazumasa

Subjects
cardiovascular system, Transmyocardial laser revascularization, Angiogenesis, Blood flow through the laser channels
Abstract

There is evidence of angiogenesis being induced after transmyocardial laser revascularization (TMLR), although the precise mechanism has not been fully elucidated. This study was designed to examine whether or not blood flow from the left ventricle through the channels is essential for angiogenesis following TMLR. Ten dogs underwent the creation of two types of laser channels in the left ventricle: 1) a transmural channel (TMC), which penetrates the myocardium, and 2) a non-transmural channel (NTMC), which does not open to the epicardium. The animals were sacrificed on the 28th postoperative day and the vascular density was examined. Vessels with smooth muscle media were seen within or around the channel remnant. The vessel density was compared between TMC and NTMC. The outer and inner halves of the myocardium in the TMC region were compared in the same way. The density of vessels within and around the channel remnants was significantly higher in TMC than in NTMC (1.439 versus 0.685 vessels/microscopic visual field (mvf=40X); p=0.0025). The vascular density was significantly higher in the region adjacent to TMC than in a distant region (>3 mm from the channel center). The vascular density was significantly higher in the outer half than in the inner half of the myocardium (1.730 versus 1.180 vessels/mvf: p=0.0459). These findings demonstrate that communication to the left ventricular lumen enhances angiogenesis of TMLR, although blood flow in the channel did not exist 4 weeks after TMLR and angiogenesis tended to be more highly enhanced in the outer half than in the inner half of the myocardium.

Published
2000

13. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population : a case control study

Author

Ogata, Toru, Gregoire, Lucie, Goddard, Katrina AB, Skunca, Magdalena, Tromp, Gerard, Lancaster, Wayne D, Parrado, Antonio R, Lu, Qing, Shibamura, Hidenori, Sakalihasan, Natzi, Limet, Raymond, MacKean, Gerald L, Arthur, Claudette, Sueda, Taijiro, Kuivaniemi, Helena, Ogata, Toru, Gregoire, Lucie, Goddard, Katrina AB, Skunca, Magdalena, Tromp, Gerard, Lancaster, Wayne D, Parrado, Antonio R, Lu, Qing, Shibamura, Hidenori, Sakalihasan, Natzi, Limet, Raymond, MacKean, Gerald L, Arthur, Claudette, Sueda, Taijiro, and Kuivaniemi, Helena

Abstract

Background: Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. Methods: HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. Results: We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). Conclusion: This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.

Published
2006

15. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Author

Ogata, Toru, primary, Gregoire, Lucie, additional, Goddard, Katrina AB, additional, Skunca, Magdalena, additional, Tromp, Gerard, additional, Lancaster, Wayne D, additional, Parrado, Antonio R, additional, Lu, Qing, additional, Shibamura, Hidenori, additional, Sakalihasan, Natzi, additional, Limet, Raymond, additional, MacKean, Gerald L, additional, Arthur, Claudette, additional, Sueda, Taijiro, additional, and Kuivaniemi, Helena, additional

Published
2006
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20. Genome Scan for Familial Abdominal Aortic Aneurysm Using Sex and Family History as Covariates Suggests Genetic Heterogeneity and Identifies Linkage to Chromosome 19q13

Author

Shibamura, Hidenori, primary, Olson, Jane M., additional, van Vlijmen-van Keulen, Clarissa, additional, Buxbaum, Sarah G., additional, Dudek, Doreen M., additional, Tromp, Gerard, additional, Ogata, Toru, additional, Skunca, Magdalena, additional, Sakalihasan, Natzi, additional, Pals, Gerard, additional, Limet, Raymond, additional, MacKean, Gerald L., additional, Defawe, Olivier, additional, Verloes, Alain, additional, Arthur, Claudette, additional, Lossing, Alan G., additional, Burnett, Marjorie, additional, Sueda, Taijiro, additional, and Kuivaniemi, Helena, additional

Published
2004
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22. Surgical strategies for organ malperfusions in acute type B aortic dissection.

Author

Uchida, Naomichi, Shibamura, Hidenori, Katayama, Akira, Aishin, Keishi, Sutoh, Miwa, and Kuraoka, Masatsugu

Abstract

This study is retrospectively to evaluate strategies for organ malperfusion on the view point of two mechanisms (true lumen collapse in the aorta=Ao type, or branch dissection=Br type) in acute type B aortic dissection. There were 16 of Ao type and 4 of Br type in 20 patients with organ malperfusion. In Ao type, we performed entry closure in 12 patients, surgical bypass grafting in two to superior mesenteric artery (SMA) in one and femoral artery in two, and surgical fenestration in two. In Br type, we performed interventional non-covered stenting to the orifice of visceral arteries in two patients, surgical bypass to SMA with ileum resection in one, and surgical bypass to SAM and renal arteries in one. Five patients in 16 of Ao type died within 30 days that had two multiple organ failure after entry closure, one aortic injury during endovascular stent graft repair, two more multiple organ failure after femoral bypass, however, all four patients in Br type were rescued. Central aortic operation to true lumen collapse with entry closure for Ao type ischemia and organ reperfusion with extra-anatomical bypass or non-covered stent to ischemic arteries for Br type ischemia should be performed before catastrophic status.

Published
2009
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23. Shrinkage of excluded aneurysmal spaces: The excellent results of endovascular stent grafting through the aortic arch for distal arch aneurysm

Author

Kenji Okada, Masanobu Watari, Hiroshi Sakai, Taijiro Sueda, Osamu Ishii, Katsuhiko Imai, Kazumasa Orihashi, Hideichi Wada, and Shibamura Hidenori

Subjects
Aortic arch, Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, education, Aneurysm, medicine.artery, medicine, Arch aneurysm, Humans, health care economics and organizations, Shrinkage, Aged, Aorta, Aortic Aneurysm, Thoracic, Vascular disease, business.industry, Follow up studies, Stent grafting, Middle Aged, medicine.disease, Angioscopy, humanities, Surgery, Female, Stents, Radiology, business, Cardiology and Cardiovascular Medicine, Vascular Surgical Procedures
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24. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population : a case control study

Author

Ogata, Toru, Gregoire, Lucie, Goddard, Katrina AB, Skunca, Magdalena, Tromp, Gerard, Lancaster, Wayne D, Parrado, Antonio R, Lu, Qing, Shibamura, Hidenori, Sakalihasan, Natzi, Limet, Raymond, MacKean, Gerald L, Arthur, Claudette, Sueda, Taijiro, Kuivaniemi, Helena, Ogata, Toru, Gregoire, Lucie, Goddard, Katrina AB, Skunca, Magdalena, Tromp, Gerard, Lancaster, Wayne D, Parrado, Antonio R, Lu, Qing, Shibamura, Hidenori, Sakalihasan, Natzi, Limet, Raymond, MacKean, Gerald L, Arthur, Claudette, Sueda, Taijiro, and Kuivaniemi, Helena

Abstract

Background: Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. Methods: HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. Results: We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). Conclusion: This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.

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