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1. Ankle-Brachial Index Is a Powerful Predictor of Renal Outcome and Cardiovascular Events in Patients with Chronic Kidney Disease

Author

Fu-An Chen, Chih-Yu Yang, Wu-Chang Yang, Jinn-Yang Chen, Yee-Yung Ng, Szu-Yuan Li, Wen-Sheng Liu, Shiao-Ti Cheng, Yu-Jen Wang, and Chih-Ching Lin

Subjects
Technology, Medicine, Science
Abstract

Ankle-brachial index (ABI) is an accurate tool to diagnose peripheral arterial disease. The aim of this study was to evaluate whether ABI is also a good predictor of renal outcome and cardiovascular events in patients with chronic kidney disease (CKD). We enrolled 436 patients with stage 3–5 CKD who had not been undergoing dialysis. Patients were stratified into two groups according to the ABI value with a cut point of 0.9. The composite renal outcome, including doubling of serum creatinine level and commencement of dialysis, and the incidence of cardiovascular events were compared between the two groups. After a median follow-up period of 13 months, the lower ABI group had a poorer composite renal outcome (OR=2.719, P=0.015) and a higher incidence of cardiovascular events (OR=3.260, P=0.001). Our findings illustrated that ABI is a powerful predictor of cardiovascular events and renal outcome in patients with CKD.

Published
2012
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2. Ankle-Brachial Index Is a Powerful Predictor of Renal Outcome and Cardiovascular Events in Patients with Chronic Kidney Disease

Author

Szu Yuan Li, Jinn Yang Chen, Fu An Chen, Yee Yung Ng, Chih Ching Lin, Shiao Ti Cheng, Wen Sheng Liu, Yu Jen Wang, Chih Yu Yang, and Wu Chang Yang

Subjects
Male, medicine.medical_treatment, lcsh:Medicine, Kaplan-Meier Estimate, urologic and male genital diseases, lcsh:Technology, chemistry.chemical_compound, Prospective Studies, Stage (cooking), Prospective cohort study, lcsh:Science, General Environmental Science, Incidence (epidemiology), General Medicine, Prognosis, Treatment Outcome, Cardiovascular Diseases, Creatinine, Predictive value of tests, Cardiology, Female, medicine.medical_specialty, Article Subject, education, behavioral disciplines and activities, General Biochemistry, Genetics and Molecular Biology, Predictive Value of Tests, Renal Dialysis, Internal medicine, medicine, Humans, Ankle Brachial Index, Dialysis, Aged, Proportional Hazards Models, Proportional hazards model, business.industry, lcsh:T, lcsh:R, medicine.disease, Surgery, body regions, Logistic Models, chemistry, Clinical Study, Kidney Failure, Chronic, lcsh:Q, business, Kidney disease
Abstract

Ankle-brachial index (ABI) is an accurate tool to diagnose peripheral arterial disease. The aim of this study was to evaluate whether ABI is also a good predictor of renal outcome and cardiovascular events in patients with chronic kidney disease (CKD). We enrolled 436 patients with stage 3–5 CKD who had not been undergoing dialysis. Patients were stratified into two groups according to the ABI value with a cut point of 0.9. The composite renal outcome, including doubling of serum creatinine level and commencement of dialysis, and the incidence of cardiovascular events were compared between the two groups. After a median follow-up period of 13 months, the lower ABI group had a poorer composite renal outcome (OR=2.719,P=0.015) and a higher incidence of cardiovascular events (OR=3.260,P=0.001). Our findings illustrated that ABI is a powerful predictor of cardiovascular events and renal outcome in patients with CKD.

Published
2012

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