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Translational medical research literatures have increased rapidly in last decades and there have been fewer attempts or efforts to map global research context of translational medical related research. The main purpose of this study is to evaluate the global progress and to assess the current quantitatively trends on translational medical research by using a scientometric approach to survey translational medicine related literatures in Science Citation Index Expanded (SCI-E), Social Science Citation Index and PubMed database from 1992 to 2012. The scientometric methods and knowledge visualization technologies were employed in this paper. The document types, languages, publication patterns, subject categories, journals, geographic and institutional distributions, top cited papers, and the distribution of keywords as well as MeSH terms were thoroughly examined. Translational medicine research has increased rapidly over past 20 years, most notably in the last 4 years. In total, there are currently 3,627 research articles in 1,062 journals listed in 91 SCI-E subject categories. The top 20 productive countries and institutes were analyzed herein, where 11 key papers in translational medical research and research foci were identified. Research outputs descriptors have suggested that the presence of a solid development in translational medical research, where research in this field has mainly focused on experimental medicine, general internal medicine, and medical laboratory technologies. All these outcomes have been concentrated in several journals such as Translational Research, Translational Oncology, Translational Stroke Research, and Translational Neuroscience. G7 countries make up the leading nations for translational medical research, where the center is located in USA. American institutions have made great advances in paper productions, citations, and cooperation, with overall great strengths and good development prospects. Moreover, the evolution pathway of translational medical research has been summarized as bellows: problems emerged, causes analyzed, challenges faced and solutions proposed, translational medical research programs been formally established, theoretical and applied research, all of which was in full swing. During this process, neoplasms and genomics, interdisciplinary communication between academic medical centers/institutes, drug design and development, cardiovascular and brain diseases, and even biomedical research have been identified as mainstream topics in translational medical research fields.

As a result of population aging, remote electrocardiograph (ECG) monitoring systems have increasingly gained attention. The traditional ECG signal acquisition system has many limitations. This paper presents a high-precision sigma-delta modulator for ECG signal acquisition. The circuit is implemented in a SMIC-EE 0.18 µm process. Simulation results indicate that the signal-to-noise ratios with and without the SMIC-EE 0.18 µm model are 105 and 81.2 dB, respectively, and the corresponding effect numbers of bits are 17.15 and 13.2 bits, respectively, which meet the requirements of a remote ECG monitoring system.

Background & objectives: Artemisinin was first extracted from the herb Artemisia annua which has been used formany centuries in Chinese traditional medicine as a treatment for fever and malaria. It has been given the 2011Lasker-DeBakey clinical medical research award. In this paper, knowledge map of artemisinin research wasdrawn to provide some information for global researchers interested in artemisinin and its relevant references.Methods: In this work, bibliometric analysis and knowledge visualization technology were applied to evaluateglobal scientific production and developing trend of artemisinin research through Science Citation Index (SCI)papers and Medline papers with online version published as following aspects: publication outputs, subjectcategories, journals, countries, international collaboration, citations, authorship and co-authorship, author keywords and co-words analysis. The Thomson Data Analyzer (TDA), Netdraw and Aureka software were employedto analyze the SCI as well as Medline papers data for knowledge mapping.Results: Global literature of artemisinin research has increased rapidly over the past 30 years and has boosted inrecent years. Seen from the statistical study in many aspects, Pharmacology & Pharmacy, and Chemistry are stillthe main subjects of artemisinin research with parasitology and tropical medicine increasing quickly. MalariaJournal and American Journal of Tropical Medicine are top productive journals both in SCI and Medline databases.Quantity and quality of papers in US are in a leading position, although papers quantity and active degree indeveloping countries such as P.R. China, Thailand and India are relatively high, the quality of papers from thesecountries needs to be improved. New emerging key words and co-words remind us that mechanism of action,pharmacokinetics, artemisinin-based alternatives, etc. are the future trends of artemisinin research.Conclusion: Through bibliometric analysis the development trends of artemisinin research are predicted. Withfurther development of artemisinin research, it is presumed that scientists might concentrate mainly on the synthesisof new compounds with activity, action mechanism, new artemisinin-based combination therapy regimens, etc.

To investigate the in vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose (FG) from traditional Chinese medicine Radix isatidis, dog kidney cells (MDCK) were with treated with either FG and then with virus (Group A); virus and then with FG (Group B); or FG and virus simultaneous-ly (Group C). Results showed the in vitro cell protection rate and virus inhibition rate increased significantly with the increase of FG concentration when compared with cells without FG treatment (p

The recent progresses on chemical components and pharmacological activities of the genus Valerianawere summarized.Besides-essential oil, the chemical composition of Valerianais mainly focused on monoterpenoids,sesquiterpenoids,lignans, flavonoids, alkaloids, etc. Iridoids are the main chemical components ofmonoterpenoids. There are two types ofiridoidson the basis of the cyclopentane open or not. The Valerianahas been drawmuch attention for their significant sedation,spasmolysis,antidepression,antitumor, against adenosine A1 receptors and cytotoxicityactivity,and had certain function for cardiovascular disease treatment. Given to the fact of the lack of systematic review and summary of studies on the Valeriana, we summarized and analyze the study literatures on the pharmacological activity of Valerianain recent years, and providedsome basisfor further study.

Due to the difficulties in diagnosing arrhythmia and patients' enthusiasm to attach greater attention to their health, traditional electrocardiogram (ECG) monitoring is facing many challenges. In addition, medical resource distribution problems are particularly obvious. Therefore, the ECG network system for medical resource comprehensive application is proposed in this paper. It is conducive to increasing the cure rate significantly and reducing imbalance of distribution in medical resources. The network system can also effectively improve medical services. The initial implementation proves that ECG network system proposed in this paper is feasible and reasonable.

The aim of this study is to analyze the research trends of medical informatics over the last 12 years. A new method based on MeSH terms was proposed to identify emerging topics and trends of medical informatics research. Informetric methods and visualization technologies were applied to investigate research trends of medical informatics. The metric of perspective factor (PF) embedding MeSH terms was appropriately employed to assess the perspective quality for journals. The emerging MeSH terms have changed dramatically over the last 12 years, identifying two stages of medical informatics: the ‘‘medical imaging stage’’ and the ‘‘medical informatics stage’’. The focus of medical informatics has shifted from acquisition and storage of healthcare data by integrating computational, informational, cognitive and organizational sciences to semantic analysis for problem solving and clinical decision-making. About 30 core journals were determined by Bradford’s Law in the last 3 years in this area. These journals, with high PF values, have relative high perspective quality and lead the trend of medical informatics.

Artemisinin was first extracted from the herb Artemisia annua which has been used for many centuries in Chinese traditional medicine as a treatment for fever and malaria. It has been given the 2011 Lasker-DeBakey clinical medical research award. In this paper, knowledge map of artemisinin research was drawn to provide some information for global researchers interested in artemisinin and its relevant references.In this work, bibliometric analysis and knowledge visualization technology were applied to evaluate global scientific production and developing trend of artemisinin research through Science Citation Index (SCI) papers and Medline papers with online version published as following aspects: publication outputs, subject categories, journals, countries, international collaboration, citations, authorship and co-authorship, author key words and co-words analysis. The Thomson Data Analyzer (TDA), Netdraw and Aureka software were employed to analyze the SCI as well as Medline papers data for knowledge mapping.Global literature of artemisinin research has increased rapidly over the past 30 years and has boosted in recent years. Seen from the statistical study in many aspects, PharmacologyPharmacy, and Chemistry are still the main subjects of artemisinin research with parasitology and tropical medicine increasing quickly. Malaria Journal and American Journal of Tropical Medicine are top productive journals both in SCI and Medline databases. Quantity and quality of papers in US are in a leading position, although papers quantity and active degree in developing countries such as P.R. China, Thailand and India are relatively high, the quality of papers from these countries needs to be improved. New emerging key words and co-words remind us that mechanism of action, pharmacokinetics, artemisinin-based alternatives, etc. are the future trends of artemisinin research.Through bibliometric analysis the development trends of artemisinin research are predicted. With further development of artemisinin research, it is presumed that scientists might concentrate mainly on the synthesis of new compounds with activity, action mechanism, new artemisinin-based combination therapy regimens, etc.

To investigate the in vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose (FG) from traditional Chinese medicine Radix isatidis, dog kidney cells (MDCK) were with treated with either FG and then with virus (Group A); virus and then with FG (Group B); or FG and virus simultaneous-ly (Group C). Results showed the in vitro cell protection rate and virus inhibition rate increased significantly with the increase of FG concentration when compared with cells without FG treatment (p

Background Translational medical research literature has increased rapidly in the last few decades and played a more and more important role during the development of medicine science. The main aim of this study is to evaluate the global performance of translational medical research during the past few decades. Methods Bibliometric, social network analysis, and visualization technologies were used for analyzing translational medical research performance from the aspects of subject categories, journals, countries, institutes, keywords, and MeSH terms. Meanwhile, the co-author, co-words and cluster analysis methods were also used to trace popular topics in translational medical research related work. Results Research output suggested a solid development in translational medical research, in terms of increasing scientific production and research collaboration. We identified the core journals, mainstream subject categories, leading countries, and institutions in translational medical research. There was an uneven distribution of publications at authorial, institutional, and national levels. The most commonly used keywords that appeared in the articles were “translational research”, “translational medicine”, “biomarkers”, “stroke”, “inflammation”, “cancer”, and “breast cancer”. Conclusions The subject categories of “Research & Experimental Medicine”, “Medical Laboratory Technology”, and “General & Internal Medicine” play a key role in translational medical research both in production and in its networks. Translational medical research and CTS, etc. are core journals of translational research. G7 countries are the leading nations for translational medical research. Some developing countries, such as P.R China, also play an important role in the communication of translational research. The USA and its institutions play a dominant role in the production, collaboration, citations and high quality articles. The research trends in translational medical research involve drug design and development, pathogenesis and treatment of disease, disease model research, evidence-based research, and stem and progenitor cells.