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Pulmonary dysfunction is very common in stroke patients. A study has shown that acute stroke patients often cause a series of pulmonary dysfunction due to primary damage to the respiratory center, which is an important reason for hindering disease treatment and recovery. American Thoracic Society (ATS) and the European Respiratory Society (ERS) pointed out that pulmonary rehabilitation (PR) can be applied to the rehabilitation of stroke patients to improve their lung function. PR can improve the respiratory muscle strength of stroke patients, which is beneficial to improving the respiratory function of patients. At the same time, it can also significantly increase the maximum oxygen intake of patients, effectively improve the cardiopulmonary function of stroke patients, and reduce respiratory complications such as aspiration pneumonia. However, the common dysfunction of joints and muscles such as shoulder pain after stroke will affect the process of pulmonary rehabilitation. This is mainly because the changes in the position of the shoulder girdle, the decrease in the range of motion of the cervical and thoracic spine, and the changes in the cervical spondylolisthesis position caused by the elevation of the upper limbs will directly affect the breathing movement during the pulmonary rehabilitation process. The instability of the spine will weaken the deep abdominal muscles and reduce the function of the diaphragm; moreover, changes in the alignment and stability of the cervical and thoracic spine will also lead to wrong breathing methods. Therefore, it is of practical clinical significance to evaluate the functional rehabilitation of shoulder joint muscles and evaluate the efficacy of stroke patients to improve their respiratory function. This article through an extensive review of domestic and foreign literature in recent years, combined with clinical practice experience, summarizes the practical application of chain structure theory in the fields of rehabilitation training, postural adjustment, pain relief, etc., and further studies the functional exercise method based on muscle chain theory. The research on the muscle chain of shoulder pain rehabilitation as a model illustrates the positive effect of reconstructing neuroarticular muscle function on the respiratory system, hoping to provide new ideas for the treatment of respiratory diseases in stroke patients.

Background Renal angiomyolipoma (RAML) is a rare benign kidney tumour comprised of adipose tissue, smooth muscle, and blood vessels. It can cause fatal complications if it ruptures. Although there have been reports of RAMLs rupturing, it is unusual to see RAMLs rupture during pregnancy, especially in pregnant women with tuberous sclerosis (TSC). Moreover, we reported a rare complication after selective arterial embolization (SAE) for the first time, which called aseptic liquefaction necrosis. Case presentation The case is a 16-week-pregnant woman with TSC who presented with severe flank pain, which was secondary to the rupture of a large, previously unknown RAML. This was confirmed by emergency computed tomography and successfully treated with selective arterial embolization after the patient received counselling and provided prior informed written consent for medical termination of pregnancy (MTP). The patient underwent abortion 3 weeks after the SAE. The patient required drainage 2 months after the SAE because of aseptic liquefaction necrosis. During follow-up, the patient’s lesion remained stable. Conclusion RAML rupture is a rare but rather serious complication in pregnant tuberous sclerosis patients. Selective arterial embolization (SAE) should be performed immediately, and the status of the pregnancy needs to be assessed by a multidisciplinary team. We also report for the first time the rare complication of aseptic liquefaction necrosis after SAE of RAML, for which percutaneous drainage is effective.

In individuals with traumatic shoulder instability, there is a loss of proprioception. This paper reviews the academic literature on shoulder instability and functional impairment in recent years and combines it with clinical practice experience to summarize several techniques of proprioceptive regeneration following traumatic shoulder instability. Many issues were discovered, including a lack of literature on the role of sensory input, a lack of basic proprioceptive research, insufficient sample size in proprioceptive research, and a lack of systematic and standardized standards for the evaluation and training of proprioception in clinical practice, among others. In the future, we will need to better understand the mechanism of proprioception and conduct research on various groups of people, with a focus on discussing the optimal intensity, frequency, and duration of various training methods, as well as implementing proprioceptive training in stages throughout the rehabilitation process. The reestablishment of shoulder joint function, the restoration of proprioception, and the enhancement of daily activities are all critical.

The demand for low-salt foods is increasing due to their health benefits. Umami is known to enhance salty, and a large amount of umami components have been identified in edible fungi. 5'-nucleotides and umami amino acids from nine species of edible fungi were quantified. The equal umami concentration (EUC) in nine edible fungi was within the range of 37.7-1317.72 g MSG/100 g, and umami intensity as determined by electronic tongue and sensory evaluation was within the range of 11.22-13.53 and 2.85-5.55, respectively. Antler fungus had the highest umami intensity. Umami amino acids and nucleotides could increase salty intensity of NaCl at medium and high concentrations. The enzymatic hydrolysate of Antler fungus at higher concentrations could more effectively enhance salty taste of NaCl at lower concentration. This synergistic effect between umami and salty indicates that Antler fungus can potentially be used as an ingredient in low-salt foods.

Background: This study aimed to investigate the loadability and releasing profiles of vinorelbine and raltitrexed by CalliSpheres® Beads (CB) in vitro, and further explored the pharmacokinetic feat...

In order to reduce the energy consumption of nodes and prolong the lifetime of indoor wireless sensor network nodes, it is necessary to establish an optimal bit error rate model under multiple indoor influencing factors so as to maximize the efficiency of receiving and receiving signals. Based on the researching of relationship between indoor factors such as wall and floor reflection, obstacle shadow fading, channel error rate and energy consumption of node signal transceiver and receiver, the energy consumption model of node single frame transmission is given, it is also proved that there exists an optimal bit error rate to minimize the energy consumption of nodes under the condition of co-channel coding. Finally, the simulation experiments are carried out to further analyze and verify the energy consumption of node. The results show that even if the indoor signal interference factors are complex, the minimum energy consumption of receiving and receiving nodes can be found by optimizing the bit error rate adjustment, which shows that the optimization model has engineering application value.

The current research status of reheat crack in welded joint of low alloy heat-resistant steels are outlined. Some new phenomena discovered in engineering in recent years are summarized, and related problems that remain to be studied are also presented. Reheat crack in welded joint is occurred frequently during postweld heat treatment (PWHT) or in service at elevated temperature. Mainly four mechanisms leading to reheat crack, respectively, impurity segregation grain boundary weakening, precipitation hardening, creep rupture and no-precipitation zone weakening have been generally accepted now. Several essential factors consist of parent material chemical composition, microstructure and thickness of welded joint, filler material, preheat and postheat procedures, welding energy input, PWHT parameter, and stress and strain and so on. Theoretical calculation methods, criterion of RoA (Reduction of Area) and several experimental methods are put forward to evaluate reheat crack susceptibility. Based on new issues emerged in engineering, problems of concerning reheat crack are necessary to be researched, which include at least mechanism and influence factors of new multi-element composite strengthening heat-resistant steels, the mitigation measures for increasing wall thickness weldment, the root cause analysis and prevention methods of conventional low alloy heat-resistant steels for long term service.

A concept of heterogeneous welded joint is proposed for researching and describing the characteristics of local postweld heat treatment (PWHT) temperature field for asymmetric thermal conductivity welded joint. Its three types have been classified according to thermal conductivity direction around the weld, separately, welded joint with transverse unidirectional thermal conductivity, transverse bidirectional thermal conductivity, transverse and longitudinal thermal conductivity. Compared with the temperature field of symmetric thermal conductivity welded joint, the highest temperature point of heterogeneous welded joint deviates from the heat device center, and uniform temperature area shrinks. In addition, longitudinal temperature difference and dramatic temperature change zone have arisen for the third type heterogeneous welded joint. In order to improve the temperature distribution, two PWHT methods called temperature compensation method and power compensation method have been put forward and developed. Several engineering applications of two methods are illustrated as examples.

SummaryCirculating microRNAs (miRNAs) have recently emerged as promising biomarkers for ischaemic stroke (IS). However, the expression patterns of specific miRNAs in transient ischaemic attack (TIA) patients have not been investigated. Their predictive values for the presence of IS and TIA and their relationships to the neurological deficit severity of IS and the subsequent stroke risk after TIA remain unclear exactly. In this study, 754 miRNAs were initially screened by the TaqMan Low Density Array (TLDA) in two pooled serum samples from 50 IS patients and 50 controls. Markedly altered miRNAs were subsequently validated by individual quantitative reverse-transcription PCR (qRT-PCR) assays first in the same cohort of TLDA and further confirmed in another larger cohort including 177 IS, 81 TIA patients and 42 controls. Consequently, TLDA screening showed that 71 miRNAs were up-regulated and 49 miRNAs were down-regulated in IS patients. QRT-PCR validation confirmed that serum levels of miR-23b-3p, miR-29b-3p, miR-181a-5p and miR-21–5p were significantly increased in IS patients. Strikingly, serum levels of miR-23b-3p, miR-29b-3p and miR-181a-5p were also significantly elevated in TIA patients. Furthermore, up-regulated miR-23b-3p, miR-29b-3p and miR-21–5p could clearly differentiate between IS and TIA patients. Logistic regression and receiver-operating characteristic curve analyses demonstrated that these altered miRNAs may function as predictive and discriminative biomarkers for IS and TIA, and their distinctive expression signatures may contribute to assessing neurological deficit severity of IS and subsequent stroke risk after TIA.Supplementary Material to this article is available online at www.thrombosis-online.com.

In recent years, pedestrian detection is a hot research topic in the field of computer vision and artificial intelligence, It is widely used in the fields of automatic driving safety and security and pedestrian analysis. But pedestrians as transfigure change target, and because the pedestrian dress differ in thousands ways, lead to the traditional pedestrian detection technology detection accuracy is not high, it restricts the development of pedestrian detection technology. With the development of deep learning, the pedestrian detection method based on deep learning greatly improves the accuracy of pedestrian detection. For the problem of low detection accuracy of small targets in SSD, this paper proposes an improved SSD pedestrian detection method based on the context information, by extracting the shallow features in the SSD convolutional neural network, fuses the shallow semantic information in the convolutional layer with the deep semantic information, and then detects the size of the pedestrian in the image. Features Redesigned pre-selection boxes with different aspect ratios, improve the SSD model test result is superior to the standard model of the SSD.

New type of liquid embolic agents based on a liquid crystalline material of glyceryl monooleate (GMO) was developed and evaluated in this study. Ternary phase diagram of GMO, water and ethanol was constructed and three isotropic liquids (ILs, GMO:ethanol:water=49:21:30, 60:20:20 and 72:18:10 (w/w/w)) were selected as potential liquid embolic agents, which could spontaneously form viscous gel cast when contacting with water or physiological fluid. The ILs exhibited excellent microcatheter deliverability due to low viscosity, and were proved to successfully block the saline flow when performed in a device to simulate embolization in vitro. The ILs also showed good cytocompatibility on L929 mouse fibroblast cell line. The embolization of ILs to rabbit kidneys was performed successfully under monitoring of digital subtraction angiography (DSA), and embolic degree was affected by the initial formulation composition and used volume. At 5th week after embolization, DSA and computed tomography (CT) confirmed the renal arteries embolized with IL did not recanalize in follow-up period, and an obvious atrophy of the embolized kidney was observed. Therefore, the GMO-based liquid embolic agents showed feasible and effective to embolize, and potential use in clinical interventional embolization therapy.

The electric vehicle has the advantages of energy-saving, environmental protection, low-carbon economy etc, and the charging system is an indispensable subsystem of electric vehicle. It’s the charging long time and inconvenience of traditional charging mode that makes contactless charging system become the trend of future electric vehicle charging technology development. Firstly, this paper introduces the principle of contactless charging of electric vehicle, analysis the three kinds of charging mode, and then combined with the development of domestic and international situation, puts forward some inevitable problems in reality. Finally, discusses the contactless charging device for electric vehicle application.

Objective To evaluate the diagnostic value of 64-slice spiral CT angiography (CTA) in multiple intracranial aneurysms (MIA). Methods Twenty-five patients (9 males and 16 females, aged from 17 to 68 years) with suspected MIA underwent 64-slice spiral CTA with slice thickness of 0.625mm. The data of all patients were reconstructed with multiplanar reconstruction (MPR), 3-dimensional shade surface display (3-SSD), volume rendering (VR) and maximum intensity projection (MIP). The clinical diagnostic value was evaluated with the results of surgery or interventional embolization therapy. Results A total of 61 aneurysms were detected by 64-slice spiral CTA in 25 patients, among them 17 patients were with 2 aneurysms, 6 patients with 3 aneurysms, 1 patient with 4 aneurysms and 1 patient with 5 aneurysms. The 64-slice spiral CTA could not only clearly demonstrate MIA, but also the size, neck, axis point and parent artery of each aneurysm, and the spatial relationship between aneurysm and the adjacent vessels and bone structures. Twenty-one patients underwent microsurgery and four underwent embolization, the location, size and shape of aneurysm and its spatial relationship with adjacent structures were in accordance with the findings of 64-slice spiral CTA. Conclusion The 64-slice spiral CTA could be used as the first choice in the diagnosis of MIA for its high accuracy, and may be an important adjunct to digital subtraction angiography (DSA) in MIA treatment.

The existing roads, railways can no longer meet the growing expansion of the traffic needs, some newly built roads, railways must be crossed with the old lines, the difficulty of construction is considerable, especially Pro tight both line and rock blasting operations, it is necessary to consider boththe safety of the line, but also to ensure that the construction schedule. Based on an example of the rebuilding of the railway grade crossing to interchange from Loudi Prefecture in Zhuliu highway to dragon section of the sand Huaihua, Hunan Province, the article describes the safety and protection measures construction blasting in conditions close to the complexity of the existing lines, the construction of similar projects the organization, management provide some reference.

Based on model tests, the wave function expansion method was used to study scattering on the interaction of explosive stress waves and the underground chamber, and analyze the influence of the incident angle, frequency and diameter on blasting vibration velocity of underground chamber. It is obtained that when the cavern was under the plane waves of the vault, the radial vibration velocity of the vault is the largest among the four measured data, and it is the most intense vibrating place. When the incidence direction offsets from the vault to the horizontal direction on the left, the radial velocity facing burst are all larger than the radial velocity back of the burst. When the incident direction is on the dome, the tangential vibration velocity will increase first and then decrease from the vault to the side wall. When the incident direction is at the haunch, the tangential vibration velocity in the corner should be noticed. With increasing of the frequency, the radial vibration velocity and tangential vibration velocity increase accordingly. At the forward part of the burst, the larger the chamber diameter is, the bigger the radial and tangential velocities are. At the back side of the burst, the bigger the chamber diameter is, the smaller the radial and tangential vibration velocities are.

To assess the correlation between serum 25-hydroxy vitamin D [25(OH)D] status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically. We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile women vitamin D

To develop and investigate the properties of MRI-traceable Eudragit-E liquid embolic agent (MR-E).Polyethylene glycol-modified superparamagnetic iron oxides (PEG-SPIO) was synthesized by chemical co-precipitation method. MR-E was prepared by mixing PEG-SPIO and Eudragit-E liquid embolic agent homogeneously. An in vitro MR phantom study was carried out to measure MR traceability of MR-E and to determine the concentration of PEG-SPIO for further studies. The microcatheter deliverability and sol-gel transition process of MR-E were investigated. MR-E was injected into the kidney of a Japanese white big ear rabbit via an angiographic microcatheter, and detected by MRI.A PEG-SPIO concentration of 2 g/L was considered to be suitable for further studies. MR-E was injected through the microcatheter without any difficulty. MR-E instantly solidified on release into saline. Then 0.2 mL of MR-E effectively embolized distal renal arteries, and MR-E could be detected by MRI in the embolized kidney.MR-E seems to be a promising MRI-traceable liquid embolic agent.

To prepare doxorubicin-loaded polyvinylalcohol-acrylic acid (PVA-AA) microspheres and evaluate properties of this chemoembolic agent.PVA-AA microspheres were synthesized by inverse suspension polymerization method and then verified by infrared spectroscopy. drug loading (DL) and entrapment efficiency (EE%) were measured after doxorubicinwas loaded on PVA-AA microspheres. Their morphology and elasticity were investigated by optical microscope, environmental scanning electron microscope and texture analyzer, respectively. T-cell apparatus was used to evaluate the in vitro release behavior of doxorubicin-loaded microspheres.The external carotid of the rabbit was chosen as an embolization site to evaluate the in vivo embolic property of the microspheres.PVA-AA microspheres, which were transparent spheres,turned into red spheres after doxorubicin loading. DL of the microspheres was (20.56 ± 0.69)g/L and (23.25 ± 0.27) g/L,and EE% was 82.22% ± 2.76% and 93.00% ± 1.06% within 20 min and 6 h, respectively. The in vitro release results showed a significantly delayed release of the drug for 10.32% ± 0.47% after 24 h. The Young's modulus was (178.30 ± 12.33) kPa and (213.29 ± 15.61) kPa for blank microspheres and doxorubicin-loaded microspheres, respectively. Both blank microspheres and doxorubicin-loaded microspheres exhibited good elasticity. In vivo embolization showed that 0.3 mL of microspheres could produce distal embolic efficiency.The doxorubicin-loaded microspheres are expected to be a promising new chemoembolic agent.

Hemangioblastoma is a rare neoplasm occurred in soft tissue. Herein, we present an intriguing case of sporadic hemangioblastoma in the retroperitoneum occurring in a 59-year-old male. The tumor was characterized by an alternation of cellular and paucicellular areas surrounded by a thick fibrous capsule. The stromal cells showed a pale cytoplasm exhibiting occasional lipid droplets and hyperchromatic, irregularly nuclei. CD56, NSE, a-inhibin and S100 were positive in tumor cells. This is the third reported case of a hemangioblastoma in the retroperitoneum. Based on clinical examination, computed tomography imaging, surgical operation, and histopathologic studies, a definitive diagnosis was made. Further characteristic images and pathology of this disease are discussed.

To investigate the value of susceptibility weighted imaging(SWI)in the diagnosis of hemorrhagic foci early after blast injury and its role in the outcome prediction.Totally 30 rabbits with blast-induced cerebral blast injury were used in this study. After routine CT/MRI and SWI scanning,quantified analysis was performed in regions of interest using post-processing technology. After dissecting the brains of the experimental rabbits,the cerebral histopathological changes were observed,and the results were compared with SWI findings.In these 30 rabbits,22,102,221,and 738 hemorrhagic foci were detected by CT,T1WI,T2WI,and SWI,respectively. The number of cerebral microbleeds detected by SWI was significantly larger than those revealed by conventional T1WI and T2WI(Χ(2)=10.00,P0.01). Furthermore,the SWI imaging displayed the punctiform(n=315,42.7%),lamellar(n=218,29.5%),slinar(n=205,27.8%)hypointense foci,with clear margin. The number of hemorrhagic foci detected by SWI was positively correlated with survival(r=-0.667,P0.05).SWI remarkably increases the detection rate of hemorrhagic foci(particularly microbleeds)in rabbits with cerebral blast injury. The number of cerebral microbleeds and location of foci are closely related with the outcomes and therefore may facilitate clinical managment.

The Hot-line Working Robot is a kind of live working equipment developed for distribution live line work which is safe, reliable. A force feedback master-slave teleoperation system is designed, which consists of a force feedback master-hand, a slave-hand, and force-feedback control module of master-slave pattern. Design and control method of the force-feedback master-hand, slave-hand and motion control system are introduced in detail, mainly including hardware selection of controller, hydraulic motor, sensors and so on and the flow chart of control system. Finally, introduce the system's position servo control and bilateral force feedback control in particular, and comparing two control methods of position tracking through the MATLAB simulation, which have the certain reference value for the teleoperation robot research.