Search

Your search keyword '"Shi, Zhumei"' showing total 193 results
Start Over Author "Shi, Zhumei"
193 results on '"Shi, Zhumei"'

1. IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages

Author

Li, Daqi, Wang, Xiefeng, Chen, Kexin, Shan, Danyang, Cui, Gaoyuan, Yuan, Wei, Lin, Qiankun, Gimple, Ryan C., Dixit, Deobrat, Lu, Chenfei, Gu, Danling, You, Hao, Gao, Jiancheng, Li, Yangqing, Kang, Tao, Yang, Junlei, Yu, Hang, Song, Kefan, Shi, Zhumei, Fan, Xiao, Wu, Qiulian, Gao, Wei, Zhu, Zhe, Man, Jianghong, Wang, Qianghu, Lin, Fan, Tao, Weiwei, Mack, Stephen C., Chen, Yun, Zhang, Junxia, Li, Chaojun, Zhang, Nu, You, Yongping, Qian, Xu, Yang, Kailin, Rich, Jeremy N., Zhang, Qian, and Wang, Xiuxing

Published
2024
Full Text
View/download PDF

13. Figure S1-S6, Table S1 from β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, primary, Li, Lu, primary, Chen, Kexin, primary, Yang, Junlei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Ci, Shusheng, primary, Lu, Chenfei, primary, Hu, Lang, primary, Gao, Jiancheng, primary, Shan, Danyang, primary, Li, Yangqing, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Gu, Danling, primary, Yuan, Wei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguan, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Shi, Yu, primary, You, Yongping, primary, Zhang, Nu, primary, Rich, Jeremy N., primary, and Wang, Xiuxing, primary

Published
2023
Full Text
View/download PDF

14. Data from β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, primary, Li, Lu, primary, Chen, Kexin, primary, Yang, Junlei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Ci, Shusheng, primary, Lu, Chenfei, primary, Hu, Lang, primary, Gao, Jiancheng, primary, Shan, Danyang, primary, Li, Yangqing, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Gu, Danling, primary, Yuan, Wei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguan, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Shi, Yu, primary, You, Yongping, primary, Zhang, Nu, primary, Rich, Jeremy N., primary, and Wang, Xiuxing, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Data 1 from Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages

Author

Yuan, Wei, primary, Zhang, Qian, primary, Gu, Danling, primary, Lu, Chenfei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Gao, Yisu, primary, Gao, Jiancheng, primary, Li, Daqi, primary, Shan, Danyang, primary, Hu, Lang, primary, Li, Lu, primary, Li, Yangqing, primary, Ci, Shusheng, primary, You, Hao, primary, Yan, Linping, primary, Chen, Kexin, primary, Zhao, Ningwei, primary, Xu, Chuanhai, primary, Lan, Jianyun, primary, Liu, Dong, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguang, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Mack, Stephen C., primary, Zhang, Nu, primary, You, Yongping, primary, Rich, Jeremy N., primary, Sun, Guan, primary, and Wang, Xiuxing, primary

Published
2023
Full Text
View/download PDF

17. Data from Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages

Author

Yuan, Wei, primary, Zhang, Qian, primary, Gu, Danling, primary, Lu, Chenfei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Gao, Yisu, primary, Gao, Jiancheng, primary, Li, Daqi, primary, Shan, Danyang, primary, Hu, Lang, primary, Li, Lu, primary, Li, Yangqing, primary, Ci, Shusheng, primary, You, Hao, primary, Yan, Linping, primary, Chen, Kexin, primary, Zhao, Ningwei, primary, Xu, Chuanhai, primary, Lan, Jianyun, primary, Liu, Dong, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguang, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Mack, Stephen C., primary, Zhang, Nu, primary, You, Yongping, primary, Rich, Jeremy N., primary, Sun, Guan, primary, and Wang, Xiuxing, primary

Published
2023
Full Text
View/download PDF

20. Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly.

Author

Yin, Jianxing, Ge, Xin, Ding, Fangshu, He, Liuguijie, Song, Keying, Shi, Zhumei, Ge, Zehe, Zhang, Junxia, Ji, Jing, Wang, Xiefeng, Zhao, Ningwei, Shu, Chuanjun, Lin, Fan, Wang, Qianghu, Zhou, Qigang, Cao, Yuandong, Liu, Wentao, Ye, Dan, Rich, Jeremy N., and Wang, Xiuxing

Subjects
GLIOMAS, STEM cells, METHYLGUANINE, BRAIN tumors, DRUGS, GLIOBLASTOMA multiforme
Abstract

Glioblastoma, the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in glioblastomas, the function and regulation of PTEN in PTEN-intact GSCs are unknown. Here, we found that PTEN directly interacted with MMS19 and competitively disrupted MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery in differentiated glioma cells. PTEN was specifically succinated at cysteine (C) 211 in GSCs compared with matched differentiated glioma cells. Isotope tracing coupled with mass spectrometry analysis confirmed that fumarate, generated by adenylosuccinate lyase (ADSL) in the de novo purine synthesis pathway that is highly activated in GSCs, promoted PTEN C211 succination. This modification abrogated the interaction between PTEN and MMS19, reactivating the CIA machinery pathway in GSCs. Functionally, inhibiting PTEN C211 succination by reexpressing a PTEN C211S mutant, depleting ADSL by shRNAs, or consuming fumarate by the US Food and Drug Administration–approved prescription drug N-acetylcysteine (NAC) impaired GSC maintenance. Reexpressing PTEN C211S or treating with NAC sensitized GSC-derived brain tumors to temozolomide and irradiation, the standard-of-care treatments for patients with glioblastoma, by slowing CIA machinery–mediated DNA damage repair. These findings reveal an immediately practicable strategy to target GSCs to treat glioblastoma by combination therapy with repurposed NAC. Editor's summary: Glioma stem cells promote glioblastoma growth and therapy resistance but are hard to target. Yin et al. report that posttranslational succination of PTEN at residue 211 (cysteine) promotes glioma stem cell maintenance by reactivating cytosolic iron-sulfur cluster assembly formation. This PTEN succination was driven by purine biosynthesis–derived fumarate. Administration of N-acetylcysteine to deplete the fumarate sensitized xenografted tumors in mice to both standard-of-care temozolomide and irradiation, indicating potential translational relevance for this difficult-to-treat cancer. —Catherine Charneski [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Supplementary Table S7 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

Author

Zhao, Mengjie, primary, Li, Yanhui, primary, Lu, Chenfei, primary, Ding, Fangshu, primary, Xu, Miao, primary, Ge, Xin, primary, Li, Mengdie, primary, Wang, Zhen, primary, Yin, Jianxing, primary, Zhang, Junxia, primary, Wang, Xiefeng, primary, Ge, Zehe, primary, Xiao, Hong, primary, Xiao, Yong, primary, Liu, Hongyi, primary, Liu, Wentao, primary, Cao, Yuandong, primary, Wang, Qianghu, primary, You, Yongping, primary, Wang, Xiuxing, primary, Yang, Kun, primary, Shi, Zhumei, primary, and Qian, Xu, primary

Published
2023
Full Text
View/download PDF

22. Data from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

Author

Zhao, Mengjie, primary, Li, Yanhui, primary, Lu, Chenfei, primary, Ding, Fangshu, primary, Xu, Miao, primary, Ge, Xin, primary, Li, Mengdie, primary, Wang, Zhen, primary, Yin, Jianxing, primary, Zhang, Junxia, primary, Wang, Xiefeng, primary, Ge, Zehe, primary, Xiao, Hong, primary, Xiao, Yong, primary, Liu, Hongyi, primary, Liu, Wentao, primary, Cao, Yuandong, primary, Wang, Qianghu, primary, You, Yongping, primary, Wang, Xiuxing, primary, Yang, Kun, primary, Shi, Zhumei, primary, and Qian, Xu, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figures from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

Author

Zhao, Mengjie, primary, Li, Yanhui, primary, Lu, Chenfei, primary, Ding, Fangshu, primary, Xu, Miao, primary, Ge, Xin, primary, Li, Mengdie, primary, Wang, Zhen, primary, Yin, Jianxing, primary, Zhang, Junxia, primary, Wang, Xiefeng, primary, Ge, Zehe, primary, Xiao, Hong, primary, Xiao, Yong, primary, Liu, Hongyi, primary, Liu, Wentao, primary, Cao, Yuandong, primary, Wang, Qianghu, primary, You, Yongping, primary, Wang, Xiuxing, primary, Yang, Kun, primary, Shi, Zhumei, primary, and Qian, Xu, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figure from β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, primary, Li, Lu, primary, Chen, Kexin, primary, Yang, Junlei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Ci, Shusheng, primary, Lu, Chenfei, primary, Hu, Lang, primary, Gao, Jiancheng, primary, Shan, Danyang, primary, Li, Yangqing, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Gu, Danling, primary, Yuan, Wei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguang, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Shi, Yu, primary, You, Yongping, primary, Zhang, Nu, primary, Rich, Jeremy N., primary, and Wang, Xiuxing, primary

Published
2023
Full Text
View/download PDF

25. SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake

Author

Gu, Danling, primary, Zhou, Fengqi, additional, You, Hao, additional, Gao, Jiancheng, additional, Kang, Tao, additional, Dixit, Deobrat, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Ci, Shusheng, additional, Shan, Danyang, additional, Fan, Xiao, additional, Yuan, Wei, additional, Zhang, Qian, additional, Lu, Chenfei, additional, Li, Daqi, additional, Zhao, Ningwei, additional, Shi, Zhumei, additional, Gao, Wei, additional, Lin, Fan, additional, Man, Jianghong, additional, Wang, Qianghu, additional, Qian, Xu, additional, Mack, Stephen C, additional, Tao, Weiwei, additional, Agnihotri, Sameer, additional, Zhang, Nu, additional, You, Yongping, additional, Rich, Jeremy N, additional, Zhang, Junxia, additional, and Wang, Xiuxing, additional

Published
2023
Full Text
View/download PDF

26. PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

Author

Zhao, Mengjie, primary, Li, Yanhui, additional, Lu, Chenfei, additional, Ding, Fangshu, additional, Xu, Miao, additional, Ge, Xin, additional, Li, Mengdie, additional, Wang, Zhen, additional, Yin, Jianxing, additional, Zhang, Junxia, additional, Wang, Xiefeng, additional, Ge, Zehe, additional, Xiao, Hong, additional, Xiao, Yong, additional, Liu, Hongyi, additional, Liu, Wentao, additional, Cao, Yuandong, additional, Wang, Qianghu, additional, You, Yongping, additional, Wang, Xiuxing, additional, Yang, Kun, additional, Shi, Zhumei, additional, and Qian, Xu, additional

Published
2023
Full Text
View/download PDF

36. β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, additional, Li, Lu, additional, Chen, Kexin, additional, Yang, Junlei, additional, Dixit, Deobrat, additional, Gimple, Ryan C., additional, Ci, Shusheng, additional, Lu, Chenfei, additional, Hu, Lang, additional, Gao, Jiancheng, additional, Shan, Danyang, additional, Li, Yangqing, additional, Zhang, Junxia, additional, Shi, Zhumei, additional, Gu, Danling, additional, Yuan, Wei, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Zhao, Linjie, additional, Qiu, Zhixin, additional, Lv, Deguang, additional, Gao, Wei, additional, Yang, Hui, additional, Lin, Fan, additional, Wang, Qianghu, additional, Man, Jianghong, additional, Li, Chaojun, additional, Tao, Weiwei, additional, Agnihotri, Sameer, additional, Qian, Xu, additional, Shi, Yu, additional, You, Yongping, additional, Zhang, Nu, additional, Rich, Jeremy N., additional, and Wang, Xiuxing, additional

Published
2022
Full Text
View/download PDF

47. Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth

Author

Wang, Min, primary, Ge, Xin, additional, Zheng, Jitai, additional, Li, Dongmei, additional, Liu, Xue, additional, Wang, Lin, additional, Jiang, Chengfei, additional, Shi, Zhumei, additional, Qin, Lianju, additional, Liu, Jiayin, additional, Yang, Hushan, additional, Liu, Ling-Zhi, additional, He, Jun, additional, Zhen, Linlin, additional, and Jiang, Bing-Hua, additional

Published
2016
Full Text
View/download PDF

48. GSK-3β regulates tumor growth and angiogenesis in human glioma cells

Author

Zhao, Peng, primary, Li, Qi, additional, Shi, Zhumei, additional, Li, Charlie, additional, Wang, Lin, additional, Liu, Xue, additional, Jiang, Chengfei, additional, Qian, Xu, additional, You, Yongping, additional, Liu, Ning, additional, Liu, Ling-Zhi, additional, Ding, Lianshu, additional, and Jiang, Bing-Hua, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results